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Conserved domains on  [gi|23273930|gb|AAH35022|]
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T-complex-associated-testis-expressed 1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 10061432)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-489 2.72e-68

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 221.85  E-value: 2.72e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 179 DLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 257
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 258 --WNLFLFTYRDC---LSLAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGARGAA 328
Cdd:cd00116  79 kgCGLQELDLSDNalgPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 329 KLLSH-SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 406
Cdd:cd00116 159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 407 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 486
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                ...
gi 23273930 487 FMS 489
Cdd:cd00116 317 DSF 319
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-489 2.72e-68

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 221.85  E-value: 2.72e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 179 DLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 257
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 258 --WNLFLFTYRDC---LSLAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGARGAA 328
Cdd:cd00116  79 kgCGLQELDLSDNalgPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 329 KLLSH-SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 406
Cdd:cd00116 159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 407 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 486
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                ...
gi 23273930 487 FMS 489
Cdd:cd00116 317 DSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 268-474 2.17e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 136.84  E-value: 2.17e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 268 CLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH-SRLRVLNLANNQV 346
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNnTTVETLYLSGNQI 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 347 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 23273930 427 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV-AQESEYLIgQALYANR 474
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALI-DALQTNR 404
LRR_6 pfam13516
Leucine Rich repeat;
360-383 2.95e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 2.95e-04
                          10        20
                  ....*....|....*....|....
gi 23273930   360 HNTNLISLNLRLNCIEDEGGQALA 383
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
306-333 4.29e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 4.29e-03
                           10        20
                   ....*....|....*....|....*...
gi 23273930    306 HPVLEELDLSQNLIGDRGARGAAKLLSH 333
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 179-489 2.72e-68

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 221.85  E-value: 2.72e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 179 DLLPLCRNYVRRVHVDQFLPPVQLPAQLRPGDQSDSGSEGEMEEPTVDHYQ-LGDLVAGLSHLEELDLVydVKDCGMNFE 257
Cdd:cd00116   1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPsLKELCLSLNETGRIPRG--LQSLLQGLT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 258 --WNLFLFTYRDC---LSLAAAIKACH---TLKIFKLTRSKVDDDKARIIIRSLLDHPV-LEELDLSQNLIGDRGARGAA 328
Cdd:cd00116  79 kgCGLQELDLSDNalgPDGCGVLESLLrssSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 329 KLLSH-SRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSE-PT 406
Cdd:cd00116 159 KALRAnRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDaGA 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 407 ATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANREaaRQRALNPSH 486
Cdd:cd00116 239 AALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGN--ELESLWVKD 316


                ...
gi 23273930 487 FMS 489
Cdd:cd00116 317 DSF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 268-474 2.17e-35

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 136.84  E-value: 2.17e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 268 CLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSH-SRLRVLNLANNQV 346
Cdd:COG5238 197 IEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNnTTVETLYLSGNQI 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 347 RAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLS 426
Cdd:COG5238 277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLS 356

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 23273930 427 CNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDV-AQESEYLIgQALYANR 474
Cdd:COG5238 357 DNQIGDEGAIALAKYLEGNTTLRELNLGKNNIgKQGAEALI-DALQTNR 404
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 279-473 4.03e-31

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 124.90  E-value: 4.03e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 279 HTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHS-RLRVLNLANNQVRAPGAQSLAHA 357
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNkSLTTLDLSNNQIGDEGVIALAEA 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 358 LAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQ 437
Cdd:COG5238 260 LKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIA 339

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 23273930 438 LLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYAN 473
Cdd:COG5238 340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGN 375
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 309-474 1.14e-29

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 120.67  E-value: 1.14e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 309 LEELDLSQNLIGDRGARGAAK-LLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ 387
Cdd:COG5238 182 VETVYLGCNQIGDEGIEELAEaLTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 388 TNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIG 467
Cdd:COG5238 262 NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALA 341


                ....*..
gi 23273930 468 QALYANR 474
Cdd:COG5238 342 KALQENT 348
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 294-473 6.50e-23

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 101.02  E-value: 6.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 294 DKARIIIRSLLDHPVLEE--LDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAHNTNLISLNLRL 371
Cdd:COG5238 138 PRRINLIQVLKDPLGGNAvhLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKR 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 372 NCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEF 451
Cdd:COG5238 218 NPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSL 297

                       170       180
                ....*....|....*....|..
gi 23273930 452 DLRLSDVAQESEYLIGQALYAN 473
Cdd:COG5238 298 DLSVNRIGDEGAIALAEGLQGN 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 339-474 4.91e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.81  E-value: 4.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 339 LNLANNQVRAPGAQsLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQ-----------TNKCLTTLHLGGNELSEPTA 407
Cdd:COG5238 119 LRRIMAKTLEDSLI-LYLALPRRINLIQVLKDPLGGNAVHLLGLAARLGllaaismakalQNNSVETVYLGCNQIGDEGI 197

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23273930 408 TLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANR 474
Cdd:COG5238 198 EELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNT 264
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 230-360 9.45e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.49  E-value: 9.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 230 LGDLVAGLSHLEELDLVYD-VKDCGMNFewnlflftyrdclsLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPV 308
Cdd:COG5238 312 LAEGLQGNKTLHTLNLAYNgIGAQGAIA--------------LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTT 377

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 23273930 309 LEELDLSQNLIGDRGARGAAKLLSHSRLRVLNLANNQVRAPGAQSLAHALAH 360
Cdd:COG5238 378 LRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLER 429
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-475 4.07e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 4.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 230 LGDLVAGLSHLEELDLVYDvkdcgmNFEwnlflftyrdclSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPVL 309
Cdd:COG4886 128 LPEELANLTNLKELDLSNN------QLT------------DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNL 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 310 EELDLSQNLIGDrgarGAAKLLSHSRLRVLNLANNQVRapgaqSLAHALAHNTNLISLNLRLNCIEDeggqalAHALQTN 389
Cdd:COG4886 185 KELDLSNNQITD----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLTD------LPELGNL 249

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 390 KCLTTLHLGGNELSEPTAtllsqvLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQA 469
Cdd:COG4886 250 TNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323


                ....*.
gi 23273930 470 LYANRE 475
Cdd:COG4886 324 LLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
255-430 5.84e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 5.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 255 NFEWNLFLFTYRDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNligdrgargaAKLLSHS 334
Cdd:COG4886  44 SLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----------EELSNLT 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 335 RLRVLNLANNQVrapgaQSLAHALAHNTNLISLNLRLNCIEDeggqaLAHALQTNKCLTTLHLGGNELSEptatlLSQVL 414
Cdd:COG4886 114 NLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEEL 178

                       170
                ....*....|....*.
gi 23273930 415 AINTTLTSINLSCNHI 430
Cdd:COG4886 179 GNLTNLKELDLSNNQI 194
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
229-473 7.87e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 7.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 229 QLGDLVAGLSHLEELDLvydvKDCGMNfewnlflftyrdclSLAAAIKACHTLKIFKLTRSKVDDdkariIIRSLLDHPV 308
Cdd:COG4886 150 DLPEPLGNLTNLKSLDL----SNNQLT--------------DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTN 206

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 309 LEELDLSQNLIGDRGargaAKLLSHSRLRVLNLANNQVRapgaqSLAhALAHNTNLISLNLRLNCIEDEGgqalahALQT 388
Cdd:COG4886 207 LEELDLSGNQLTDLP----EPLANLTNLETLDLSNNQLT-----DLP-ELGNLTNLEELDLSNNQLTDLP------PLAN 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 389 NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 468
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350


                ....*
gi 23273930 469 ALYAN 473
Cdd:COG4886 351 TLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
309-473 2.54e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 309 LEELDLSQNLIGDrgargAAKLLSHSRLRVLNLANNQVRAPGAqslahaLAHNTNLISLNLRLNCIEDEGGQALAHALQT 388
Cdd:COG4886 230 LETLDLSNNQLTD-----LPELGNLTNLEELDLSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGL 298

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 389 NKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQ 468
Cdd:COG4886 299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378


                ....*
gi 23273930 469 ALYAN 473
Cdd:COG4886 379 LLTLA 383
LRR_6 pfam13516
Leucine Rich repeat;
360-383 2.95e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 2.95e-04
                          10        20
                  ....*....|....*....|....
gi 23273930   360 HNTNLISLNLRLNCIEDEGGQALA 383
Cdd:pfam13516   1 SNTHLTTLDLSDNDIGDEGAEALA 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 309-400 2.98e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 309 LEELDLS-QNLigDRGAR-----GAAKLLSHSrLRVLNLANNQVRapgaqSLAhALAHNTNLISLNLRLNCIEDegGQAL 382
Cdd:cd21340  92 LEELHIEnQRL--PPGEKltfdpRSLAALSNS-LRVLNISGNNID-----SLE-PLAPLRNLEQLDASNNQISD--LEEL 160

                        90
                ....*....|....*...
gi 23273930 383 AHALQTNKCLTTLHLGGN 400
Cdd:cd21340 161 LDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
270-456 2.34e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 2.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 270 SLAAAIKACHTLKIFKLTRSKVDDdkariiIRSLLDHPVLEELDLSQNLIGDrgargAAKLLSHSRLRVLNLANNQVRAP 349
Cdd:COG4886 219 DLPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD-----LPPLANLTNLKTLDLSNNQLTDL 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23273930 350 GAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNH 429
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367

                       170       180
                ....*....|....*....|....*..
gi 23273930 430 IGLDGGKQLLEGMSDNKTLLEFDLRLS 456
Cdd:COG4886 368 TLGLLGLLEATLLTLALLLLTLLLLLL 394
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
306-333 4.29e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 4.29e-03
                           10        20
                   ....*....|....*....|....*...
gi 23273930    306 HPVLEELDLSQNLIGDRGARGAAKLLSH 333
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
333-360 5.13e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.31  E-value: 5.13e-03
                           10        20
                   ....*....|....*....|....*...
gi 23273930    333 HSRLRVLNLANNQVRAPGAQSLAHALAH 360
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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