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Conserved domains on  [gi|22137791|gb|AAH36377|]
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WD repeat domain 69 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
87-415 1.42e-115

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 343.43  E-value: 1.42e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 166
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Cdd:COG2319 152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 406
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                ....*....
gi 22137791 407 KDNTCRIWR 415
Cdd:COG2319 392 ADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
87-415 1.42e-115

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 343.43  E-value: 1.42e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 166
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Cdd:COG2319 152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 406
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                ....*....
gi 22137791 407 KDNTCRIWR 415
Cdd:COG2319 392 ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-415 4.56e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 284.23  E-value: 4.56e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 126 ELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22137791 366 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 98-302 4.67e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.97  E-value: 4.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791   98 VALNKSGSCFITGSYDRTCKLWDTAS----GEELN----TLEGhRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 169
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELAS-RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  170 YHTFRGHTAEIVCLSFNPQS-TLVATGSMDTTAKLWDIQNGEEVYTLRGhSAEIISLSF-NTSGDRIITGSFDHTVVVWD 247
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22137791  248 ADTGR-KVNILIGHCAEISSASFnWDCSLILTGSMDKTCKLWDAT------NGKCVATLTGH 302
Cdd:PLN00181 647 LRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 334-373 6.27e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 6.27e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791    334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-205 2.39e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22137791   167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
87-415 1.42e-115

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 343.43  E-value: 1.42e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 166
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS-PDGKTLASGSADGTVRLWDLAT 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Cdd:COG2319 152 GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Cdd:COG2319 232 DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT 311

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 406
Cdd:COG2319 312 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                ....*....
gi 22137791 407 KDNTCRIWR 415
Cdd:COG2319 392 ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
87-415 1.73e-105

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 317.62  E-value: 1.73e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCKLWSVET 166
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS 406
Cdd:COG2319 270 VRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349


                ....*....
gi 22137791 407 KDNTCRIWR 415
Cdd:COG2319 350 DDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
87-376 7.80e-105

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 316.08  E-value: 7.80e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVET 166
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PDGKLLASGSDDGTVRLWDLAT 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Cdd:COG2319 194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Cdd:COG2319 274 DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22137791 327 ARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376
Cdd:COG2319 354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-415 4.56e-94

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 284.23  E-value: 4.56e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 126 ELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSS 365
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22137791 366 DKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-373 5.42e-91

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 276.52  E-value: 5.42e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCKLWS 163
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 164 VETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTV 243
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 244 VVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASA 323
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22137791 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Cdd:cd00200 240 DGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
109-414 1.85e-90

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 279.10  E-value: 1.85e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Cdd:COG2319  11 AASADLALALLAAALGALLLLLLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS 268
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 269 FNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEI 348
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22137791 349 SKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Cdd:COG2319 250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
86-334 2.64e-83

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 260.61  E-value: 2.64e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCKLWSVE 165
Cdd:COG2319 156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF-SPDGKLLASGSADGTVRLWDLA 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVV 245
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADG 394


                ....*....
gi 22137791 326 TARIFSAAT 334
Cdd:COG2319 395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
147-415 5.80e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 239.04  E-value: 5.80e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLS 226
Cdd:COG2319   6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
Cdd:COG2319  86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH 386
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                       250       260
                ....*....|....*....|....*....
gi 22137791 387 TDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
54-292 2.48e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.40  E-value: 2.48e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  54 LLTASRTEQVKLLiqrlqeklgqnSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGH 133
Cdd:COG2319 177 LASGSDDGTVRLW-----------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH 245

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 134 RNVVYAIAFnNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213
Cdd:COG2319 246 SGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 324

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22137791 214 TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATN 292
Cdd:COG2319 325 TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
184-414 1.09e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 196.67  E-value: 1.09e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 184 SFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE 263
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 264 ISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEG 343
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22137791 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-247 7.93e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 154.42  E-value: 7.93e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFnNPYGDKIATGSFDKTCK 160
Cdd:cd00200 124 TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIK 202

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD 240
Cdd:cd00200 203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                ....*..
gi 22137791 241 HTVVVWD 247
Cdd:cd00200 283 GTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
226-415 4.22e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 4.22e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE 305
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791 306 ILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 385
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190
                ....*....|....*....|....*....|
gi 22137791 386 HTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 98-302 4.67e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.97  E-value: 4.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791   98 VALNKSGSCFITGSYDRTCKLWDTAS----GEELN----TLEGhRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC 169
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESiikdGRDIHypvvELAS-RSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  170 YHTFRGHTAEIVCLSFNPQS-TLVATGSMDTTAKLWDIQNGEEVYTLRGhSAEIISLSF-NTSGDRIITGSFDHTVVVWD 247
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYD 646

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22137791  248 ADTGR-KVNILIGHCAEISSASFnWDCSLILTGSMDKTCKLWDAT------NGKCVATLTGH 302
Cdd:PLN00181 647 LRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH 707
PTZ00421 PTZ00421
coronin; Provisional
 175-302 2.96e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 64.91  E-value: 2.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  175 GHTAEIVCLSFNP-QSTLVATGSMDTTAKLWDI------QN-GEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVV 245
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltQNiSDPIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMVVNV 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 22137791  246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGH 302
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
PTZ00421 PTZ00421
coronin; Provisional
 299-413 7.67e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 63.76  E-value: 7.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  299 LTGHDDEILDSCFD-YTGKLIATASADGTarIF------SAATRKC---IAKLEGHEGEISKISFNPQGNHLL-TGSSDK 367
Cdd:PTZ00421  71 LLGQEGPIIDVAFNpFDPQKLFTASEDGT--IMgwgipeEGLTQNIsdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADM 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 22137791  368 TARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRI 413
Cdd:PTZ00421 149 VVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 334-373 6.27e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 6.27e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791    334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 166-205 9.19e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 9.19e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791    166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
167-205 2.39e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22137791   167 GKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 376-414 2.44e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.44e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 22137791    376 TGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 176-409 3.17e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.94  E-value: 3.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  176 HTAEIVC-LSFNPQSTLVATGSMDTTAKLWD----IQNGEEVY----TLRGHSaEIISLSFNTS-GDRIITGSFDHTVVV 245
Cdd:PLN00181 481 NSSNLVCaIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRS-KLSGICWNSYiKSQVASSNFEGVVQV 559

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  246 WDADTGRKVNILIGH-----CAEISSAsfnwDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEildSCFDY---TGKL 317
Cdd:PLN00181 560 WDVARSQLVTEMKEHekrvwSIDYSSA----DPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI---CCVQFpseSGRS 632

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  318 IATASADGTARIFSAATRKC-IAKLEGHEGEISKISFnPQGNHLLTGSSDKTARIWDAQTGQC------LQVLEGHTDEI 390
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVK 711

                        250
                 ....*....|....*....
gi 22137791  391 FSCAFNYKGNIVITGSKDN 409
Cdd:PLN00181 712 NFVGLSVSDGYIATGSETN 730
WD40 pfam00400
WD domain, G-beta repeat;
335-373 7.21e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 7.21e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22137791   335 RKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
377-414 9.49e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.81  E-value: 9.49e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 22137791   377 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 208-247 2.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791    208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
209-247 1.15e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.15e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22137791   209 GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 94-280 1.21e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791   94 PLTNVALNK-SGSCFITGSYDRTCKLWDT-ASGEELNT------LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVE 165
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGIpEEGLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  166 TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAE-------------IISLSFNTSGD 232
Cdd:PTZ00421 157 RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwakrkdlIITLGCSKSQQ 236

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 22137791  233 RiitgsfdhTVVVWDAdtgRKVNILIgHCAEISSAS------FNWDCSLILTGS 280
Cdd:PTZ00421 237 R--------QIMLWDT---RKMASPY-STVDLDQSSalfipfFDEDTNLLYIGS 278
PTZ00421 PTZ00421
coronin; Provisional
 215-350 2.39e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  215 LRGHSAEIISLSFNTSGD-RIITGSFDHTVVVWDADT-GRKVNI------LIGHCAEISSASFNWDCSLIL-TGSMDKTC 285
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPqKLFTASEDGTIMGWGIPEeGLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLaSAGADMVV 150

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22137791  286 KLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISK 350
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQ 215
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-331 3.27e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791    292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 123-163 4.26e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 22137791    123 SGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 250-289 7.60e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 7.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791    250 TGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
293-331 1.72e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22137791   293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
124-163 1.87e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 22137791   124 GEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCKLWS 163
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
251-289 2.50e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 22137791   251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 150-285 4.32e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.06  E-value: 4.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791   150 IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIqngeevytLRGHSAEIISLSFNT 229
Cdd:pfam20426  97 ISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV--------LRGRSSEKRSRNTQT 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 22137791   230 SGDRIitgsfDHTVVvwdadtGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTC 285
Cdd:pfam20426 169 EFPRK-----DHVIA------ETPFHILCGHDDIITCLYVSVELDIVISGSKDGTC 213
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 81-120 4.42e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 22137791     81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 120
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 292-411 4.56e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 45.06  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791   292 NGKCVATLTGHDDEILDSCFDYTGKLIATASADGtarifsaatrKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARI 371
Cdd:pfam20426  81 GAQCFATLQTPSENFLISCGNWENSFQVISLNDG----------RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22137791   372 WDAQTGQCLQ-----------------------VLEGHTDEIFSCAFNYKGNIVITGSKDNTC 411
Cdd:pfam20426 151 WEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIITCLYVSVELDIVISGSKDGTC 213
PTZ00420 PTZ00420
coronin; Provisional
 130-232 5.18e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 5.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV--------ETGKCYHTFRGHTAEIVCLSFNPQST-LVATGSMDTT 200
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYyIMCSSGFDSF 149

                         90       100       110
                 ....*....|....*....|....*....|..
gi 22137791  201 AKLWDIQNGEEVYTLRgHSAEIISLSFNTSGD 232
Cdd:PTZ00420 150 VNIWDIENEKRAFQIN-MPKKLSSLKWNIKGN 180
WD40 pfam00400
WD domain, G-beta repeat;
86-120 1.59e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.59e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 22137791    86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD 120
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 317-390 4.88e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791   317 LIATASADGTA--------RIFSAAtrkciakLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTD 388
Cdd:pfam12894   9 LIALATEDGELllhrlnwqRVWTLS-------PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81


                  ..
gi 22137791   389 EI 390
Cdd:pfam12894  82 LI 83
PTZ00420 PTZ00420
coronin; Provisional
 212-294 1.64e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791  212 VYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWD-ADTGRKVN-------ILIGHCAEISSASFNWDCSLILTGS-M 281
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWEiPHNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMCSSgF 146

                         90
                 ....*....|...
gi 22137791  282 DKTCKLWDATNGK 294
Cdd:PTZ00420 147 DSFVNIWDIENEK 159
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 160-228 2.81e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22137791   160 KLWSVETGKcyhtfrgHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFN 228
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 291-354 3.01e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 3.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22137791   291 TNGKCV--ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN 354
Cdd:pfam12894  24 LNWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 94-216 7.43e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.13  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22137791    94 PLT-NVALnkSGSCFIT-----GSYDRTCKLWDTA-------SGEELNTLEGHRNVVYAIAFNnPYGDKIATGSFDKTCK 160
Cdd:pfam20426  73 PLAeNVEL--GAQCFATlqtpsENFLISCGNWENSfqvislnDGRMVQSIRQHKDVVSCVAVT-SDGSILATGSYDTTVM 149

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22137791   161 LWSVETGKC-----------------------YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Cdd:pfam20426 150 VWEVLRGRSsekrsrntqtefprkdhviaetpFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIR 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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