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Conserved domains on  [gi|28422294|gb|AAH44196|]
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Phosphogluconate hydrogenase [Danio rerio]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 30-497 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 907.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  30 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAV 109
Cdd:COG0362   1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 110 DDFIDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIA 189
Cdd:COG0362  81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 190 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILK 269
Cdd:COG0362 161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 270 FKDADSTN-LLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFL 348
Cdd:COG0362 240 KKDPETGKpLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 349 EDIRKALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQ 428
Cdd:COG0362 320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28422294 429 DCQDSWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNW 497
Cdd:COG0362 400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 30-497 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 907.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  30 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAV 109
Cdd:COG0362   1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 110 DDFIDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIA 189
Cdd:COG0362  81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 190 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILK 269
Cdd:COG0362 161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 270 FKDADSTN-LLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFL 348
Cdd:COG0362 240 KKDPETGKpLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 349 EDIRKALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQ 428
Cdd:COG0362 320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28422294 429 DCQDSWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNW 497
Cdd:COG0362 400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
42-501 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 865.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   42 MGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAVDDFIDKLVPLLE 121
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  122 PGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKVGTGEPCCDW 201
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  202 VGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILKFKDADSTN-LLP 280
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKpLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  281 KIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQgVKFTGNKAQFLEDIRKALYASKI 360
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPA-AKFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  361 ISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQDCQDSWRRVVST 440
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28422294  441 GVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNWTGHG 501
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFF-HTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 33-499 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 816.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294    33 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAVDDF 112
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   113 IDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKV 192
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   193 GtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILKFKD 272
Cdd:TIGR00873 161 D-GEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   273 ADSTNLLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFLEDIR 352
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   353 KALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQDCQD 432
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28422294   433 SWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNP-GTFIHTNWTG 499
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPrGEFFHTNWTG 467
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 208-497 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 572.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   208 GHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILKFKDA-DSTNLLPKIRDSA 286
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPeDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   287 GQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFLEDIRKALYASKIISYAQG 366
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   367 FMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQDCQDSWRRVVSTGVQQGI 446
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28422294   447 PMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNW 497
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFF-HTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 30-497 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 907.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  30 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAV 109
Cdd:COG0362   1 AKADIGVIGLAVMGRNLALNIADHGFSVAVYNRTAEKTDAFLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 110 DDFIDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIA 189
Cdd:COG0362  81 DAVIEQLLPLLEPGDIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 190 AKVGtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILK 269
Cdd:COG0362 161 AKVD-GEPCVTYIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILR 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 270 FKDADSTN-LLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFL 348
Cdd:COG0362 240 KKDPETGKpLVDVILDKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEGDKEAFI 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 349 EDIRKALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQ 428
Cdd:COG0362 320 EDLRDALYASKIVSYAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALK 399

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28422294 429 DCQDSWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNW 497
Cdd:COG0362 400 KAQPAWRRVVATAALAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFF-HTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
42-501 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 865.59  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   42 MGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAVDDFIDKLVPLLE 121
Cdd:PRK09287   1 MGKNLALNIASHGYTVAVYNRTPEKTDEFLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  122 PGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKVGTGEPCCDW 201
Cdd:PRK09287  81 KGDIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDGEPCVTY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  202 VGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILKFKDADSTN-LLP 280
Cdd:PRK09287 161 IGPDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKpLVD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  281 KIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQgVKFTGNKAQFLEDIRKALYASKI 360
Cdd:PRK09287 241 VILDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPA-AKFEGDKAEFIEDVRQALYASKI 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  361 ISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQDCQDSWRRVVST 440
Cdd:PRK09287 320 VSYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVAL 399

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28422294  441 GVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNWTGHG 501
Cdd:PRK09287 400 AVQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFF-HTEWSEDG 459
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 33-499 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 816.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294    33 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAVDDF 112
Cdd:TIGR00873   1 DIGVIGLAVMGQNLALNMEDHGFTVSVYNRTPSKTDEFLAEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   113 IDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKV 192
Cdd:TIGR00873  81 IDSLLPLLEKGDIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   193 GtGEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILKFKD 272
Cdd:TIGR00873 161 D-GEPCCTWVGPGGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   273 ADSTNLLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFLEDIR 352
Cdd:TIGR00873 240 EDGNPLVDKILDTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPEAPKKGVDKEEFIEDVR 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   353 KALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQDCQD 432
Cdd:TIGR00873 320 QALYASKIISYAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQS 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28422294   433 SWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNP-GTFIHTNWTG 499
Cdd:TIGR00873 400 GWRKVVALAITYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPrGEFFHTNWTG 467
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 31-498 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 723.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   31 QADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAK-GTKVIGAESLEDMVSKLKKPRRIILLVKAGQAV 109
Cdd:PTZ00142   1 MSDIGLIGLAVMGQNLALNIASRGFKISVYNRTYEKTEEFVKKAKEgNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  110 DDFIDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIA 189
Cdd:PTZ00142  81 DETIDNLLPLLEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  190 AKVGTgEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANIL- 268
Cdd:PTZ00142 161 AKVGD-SPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILa 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  269 KFKDADSTNLLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGV--KFTGNKAQ 346
Cdd:PTZ00142 240 KKDDLGEEHLVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNPAnkTETEDKKY 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  347 FLEDIRKALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKA 426
Cdd:PTZ00142 320 FIDDLKNALYCSKIISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28422294  427 VQDCQDSWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNWT 498
Cdd:PTZ00142 400 LKNKQPSWRKVVSMATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAF-HTNWE 470
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 29-498 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 619.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   29 MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAK--GTKVIGAESLEDMVSKLKKPRRIILLVKAG 106
Cdd:PLN02350   4 AALSRIGLAGLAVMGQNLALNIAEKGFPISVYNRTTSKVDETVERAKKegNLPLYGFKDPEDFVLSIQKPRSVIILVKAG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  107 QAVDDFIDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQ 186
Cdd:PLN02350  84 APVDQTIKALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  187 SIAAKVGTGePCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITAN 266
Cdd:PLN02350 164 KVAAQVDDG-PCVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITAD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  267 ILKFKD-ADSTNLLPKIRDSAGQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGP-----QGVKF 340
Cdd:PLN02350 243 IFSVKDdKGDGYLVDKILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAglediLSADS 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  341 TGNKAQFLEDIRKALYASKIISYAQGFMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLD 420
Cdd:PLN02350 323 GVDKKQLIDDVRQALYASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVD 402

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28422294  421 SFFSKAVQDCQDSWRRVVSTGVQQGIPMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNWT 498
Cdd:PLN02350 403 PEFAKEMVERQAAWRRVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSF-HTEWT 479
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 208-497 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 572.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   208 GHFVKMVHNGIEYGDMQLICEAYHLMKDVLCMNHDEMAQVFEQWNKTELDSFLIEITANILKFKDA-DSTNLLPKIRDSA 286
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPeDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   287 GQKGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKDERVQASKSLSGPQGVKFTGNKAQFLEDIRKALYASKIISYAQG 366
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPALFEGDKEAFIEDLRQALYASKIISYAQG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   367 FMLLRQAALEFGWSLNYGAIALMWRGGCIIRSVFLGKIKEAFDRNPELQSLLLDSFFSKAVQDCQDSWRRVVSTGVQQGI 446
Cdd:pfam00393 161 FALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAGI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28422294   447 PMPSFTTALSFYDGYRHEMLPANLLQAQRDYFGAHTYELLSNPGTFiHTNW 497
Cdd:pfam00393 241 PVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFF-HTEW 290
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
34-324 5.31e-87

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 269.65  E-value: 5.31e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  34 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVhdflnNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAVDDFI 113
Cdd:COG1023   3 IGMIGLGKMGGNMARRLLRHGHEVVGYDRNPEAV-----AALAAEGATGADSLEELVAKLPAPRVVWLMVPAGEITDQVI 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 114 DKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKVG 193
Cdd:COG1023  78 EELAPLLEPGDIVIDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALAPGAE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 194 TGepccdWV--GDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKdvlcmnHDE----MAQVFEQWNK-TELDSFLIEITAN 266
Cdd:COG1023 158 NG-----YLhcGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLE------ASEfdldLAEVAEVWRRgSVIRSWLLDLTAD 226

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28422294 267 ILKfKDADSTNLLPKIRDSagqkGTGKWTAISALEYGTPVTLIGEAVFARcLSSLKDE 324
Cdd:COG1023 227 ALA-EDPKLEGISGYVEDS----GEGRWTVEEAIELGVPAPVITAALFAR-FRSRQED 278
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
33-325 1.43e-86

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 268.54  E-value: 1.43e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   33 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVhdflnNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGQAVDDF 112
Cdd:PRK09599   2 QLGMIGLGRMGGNMARRLLRGGHEVVGYDRNPEAV-----EALAEEGATGADSLEELVAKLPAPRVVWLMVPAGEITDAT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  113 IDKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKV 192
Cdd:PRK09599  77 IDELAPLLSPGDIVIDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  193 GTGepccdWV--GDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKdvlcmNHD---EMAQVFEQWNK-TELDSFLIEITAN 266
Cdd:PRK09599 157 EDG-----YLhaGPVGAGHFVKMVHNGIEYGMMQAYAEGFELLE-----ASRfdlDLAAVAEVWRRgSVIRSWLLDLTAD 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 28422294  267 ILKfKDADSTNLLPKIRDSagqkGTGKWTAISALEYGTPVTLIGEAVFARcLSSLKDER 325
Cdd:PRK09599 227 ALA-EDPKLDEISGYVEDS----GEGRWTVEEAIDLAVPAPVIAAALFMR-FRSRQEDS 279
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 33-203 1.40e-61

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 198.85  E-value: 1.40e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294    33 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAkgtkvIGAESLEDMVSKLkkpRRIILLVKAGQAVDDF 112
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGA-----IAAASPAEFVAGL---DVVITMVPAGAAVDAV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   113 I--DKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGP-SLMPGGHKDAWPHLKDIFQSIA 189
Cdd:pfam03446  73 IfgEGLLPGLKPGDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMG 152

                         170
                  ....*....|....
gi 28422294   190 AkvgtgepCCDWVG 203
Cdd:pfam03446 153 A-------CVTYIG 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 34-323 7.79e-52

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 178.12  E-value: 7.79e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294    34 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVhdflnNEAKGTKVIGAESLEDMVSKLKKPRRIILLVKAGqAVDDFI 113
Cdd:TIGR00872   3 LGLIGLGRMGANIVRRLAKRGHDCVGYDHDQDAV-----KAMKEDRTTGVANLRELSQRLSAPRVVWVMVPHG-IVDAVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   114 DKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGPSLMPGGHKDAWPHLKDIFQSIAAKvg 193
Cdd:TIGR00872  77 EELAPTLEKGDIVIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPE-- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   194 tgEPCCDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMKDV-LCMNHDEMAQVFEQwnKTELDSFLIEITANILKfKD 272
Cdd:TIGR00872 155 --EQGYLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVARVWRR--GSVIRSWLLDLTAIAFR-ES 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28422294   273 ADSTNLLPKIRDSagqkGTGKWTAISALEYGTPVTLIGEAVFARCLSSLKD 323
Cdd:TIGR00872 230 PDLAEFSGRVSDS----GEGRWTVIAAIDLGVPAPVIATSLQSRFASRDLD 276
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 34-234 1.92e-22

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 97.11  E-value: 1.92e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  34 IALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFlnnEAKGTKVigAESLEDMVSKLkkpRRIILLVKAGQAVDDFI 113
Cdd:COG2084   4 VGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEAL---VAAGARV--AASPAEAAAAA---DVVITMLPDDAAVEEVL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294 114 ---DKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGP-SLMPGGHKDAWPHLKDIFQSIA 189
Cdd:COG2084  76 lgeDGLLAALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVLEAMG 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 28422294 190 AKVgtgepccDWVGDEGAGHFVKMVHNGIEYGDMQLICEAYHLMK 234
Cdd:COG2084 156 KRI-------VHVGDAGAGQAAKLANNLLLAGTMAALAEALALAE 193
garR PRK11559
tartronate semialdehyde reductase; Provisional
 33-213 4.68e-09

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 57.75  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   33 DIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVHDFLNNEAKgtkviGAESLEDMVSKLKKprrIILLVKAGQAVDDF 112
Cdd:PRK11559   4 KVGFIGLGIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAE-----TASTAKAVAEQCDV---IITMLPNSPHVKEV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  113 I---DKLVPLLEPGDIIIDgGNSEYRDTTRRC-KSLKEKNLLFVGSGVSGGEDGARYGP-SLMPGGHKDAWPHLKDIFQS 187
Cdd:PRK11559  76 AlgeNGIIEGAKPGTVVID-MSSIAPLASREIaAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDLMKA 154

                        170       180
                 ....*....|....*....|....*.
gi 28422294  188 IAAKVgtgepccDWVGDEGAGHFVKM 213
Cdd:PRK11559 155 MAGSV-------VHTGDIGAGNVTKL 173
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
34-229 7.12e-04

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 41.55  E-value: 7.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294   34 IALIGLAVMGQNLILNMNDHGFVVCAfnRTVSKVHDFLNNeakgtkvIGAESLEDMVSKLKKPRRIILLVKAGQAVDDFI 113
Cdd:PRK15059   3 LGFIGLGIMGTPMAINLARAGHQLHV--TTIGPVADELLS-------LGAVSVETARQVTEASDIIFIMVPDTPQVEEVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28422294  114 ---DKLVPLLEPGDIIIDGGNSEYRDTTRRCKSLKEKNLLFVGSGVSGGEDGARYGP-SLMPGGHKDAWPHLKDIFQSIA 189
Cdd:PRK15059  74 fgeNGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELLG 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 28422294  190 AKVgtgepccDWVGDEGAGHFVKMVHNGIEYGDMQLICEA 229
Cdd:PRK15059 154 KNI-------TLVGGNGDGQTCKVANQIIVALNIEAVSEA 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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