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Conserved domains on  [gi|30802062|gb|AAH51433|]
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Ipo5 protein, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 466-575 8.53e-44

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


:

Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.41  E-value: 8.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062   466 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 545
Cdd:pfam18829   1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 30802062   546 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 575
Cdd:pfam18829  81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 super family cl40101
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 6-58 7.60e-19

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


The actual alignment was detected with superfamily member pfam18808:

Pssm-ID: 408579  Cd Length: 90  Bit Score: 81.74  E-value: 7.60e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 30802062     6 IPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLP 58
Cdd:pfam18808  38 VPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLACRLGGKALLP 90
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-335 3.89e-10

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 63.42  E-value: 3.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062   2 IAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNPDWKYRHAGLM 81
Cdd:COG5215 319 VADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSESWANREAAVM 388

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062  82 ALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQTMEDqgNQRV 159
Cdd:COG5215 389 AFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLIGLMD--CPFR 466

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062 160 QAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADTAEEKFVPYYD 233
Cdd:COG5215 467 SINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDAVSDILAGFYD 544

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062 234 LFMPSLKH---IVENAVQKELRLLRGKTIE--CISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDMEDDdpqISYM 305
Cdd:COG5215 545 YTSKKLDEcisVLGQILATEDQLLVEELQSnyIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTAFGD---VYTA 621

                       330       340       350
                ....*....|....*....|....*....|
gi 30802062 306 ISAwarMCKILGKEFQQYLPVVMgPLMKTA 335
Cdd:COG5215 622 ISA---LSTSLEERFEQYASKFI-PYLTRA 647
Importin_rep_5 super family cl40106
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 706-752 1.58e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


The actual alignment was detected with superfamily member pfam18816:

Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.55  E-value: 1.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30802062   706 DKEEAVQTFSYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 752
Cdd:pfam18816   1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 620-667 2.14e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 39.66  E-value: 2.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 30802062   620 PEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENV 667
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 466-575 8.53e-44

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.41  E-value: 8.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062   466 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 545
Cdd:pfam18829   1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 30802062   546 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 575
Cdd:pfam18829  81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 6-58 7.60e-19

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 81.74  E-value: 7.60e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 30802062     6 IPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLP 58
Cdd:pfam18808  38 VPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLACRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-335 3.89e-10

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 63.42  E-value: 3.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062   2 IAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNPDWKYRHAGLM 81
Cdd:COG5215 319 VADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSESWANREAAVM 388

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062  82 ALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQTMEDqgNQRV 159
Cdd:COG5215 389 AFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLIGLMD--CPFR 466

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062 160 QAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADTAEEKFVPYYD 233
Cdd:COG5215 467 SINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDAVSDILAGFYD 544

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062 234 LFMPSLKH---IVENAVQKELRLLRGKTIE--CISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDMEDDdpqISYM 305
Cdd:COG5215 545 YTSKKLDEcisVLGQILATEDQLLVEELQSnyIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTAFGD---VYTA 621

                       330       340       350
                ....*....|....*....|....*....|
gi 30802062 306 ISAwarMCKILGKEFQQYLPVVMgPLMKTA 335
Cdd:COG5215 622 ISA---LSTSLEERFEQYASKFI-PYLTRA 647
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 73-127 1.59e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 54.30  E-value: 1.59e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30802062    73 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 127
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 706-752 1.58e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.55  E-value: 1.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30802062   706 DKEEAVQTFSYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 752
Cdd:pfam18816   1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 620-667 2.14e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 39.66  E-value: 2.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 30802062   620 PEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENV 667
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
 
Name Accession Description Interval E-value
Importin_rep_6 pfam18829
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 466-575 8.53e-44

Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.


Pssm-ID: 465881  Cd Length: 110  Bit Score: 153.41  E-value: 8.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062   466 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 545
Cdd:pfam18829   1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 30802062   546 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 575
Cdd:pfam18829  81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 6-58 7.60e-19

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 81.74  E-value: 7.60e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 30802062     6 IPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLP 58
Cdd:pfam18808  38 VPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLACRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-335 3.89e-10

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 63.42  E-value: 3.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062   2 IAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNPDWKYRHAGLM 81
Cdd:COG5215 319 VADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSESWANREAAVM 388

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062  82 ALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQTMEDqgNQRV 159
Cdd:COG5215 389 AFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLIGLMD--CPFR 466

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062 160 QAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADTAEEKFVPYYD 233
Cdd:COG5215 467 SINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDAVSDILAGFYD 544

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062 234 LFMPSLKH---IVENAVQKELRLLRGKTIE--CISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDMEDDdpqISYM 305
Cdd:COG5215 545 YTSKKLDEcisVLGQILATEDQLLVEELQSnyIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTAFGD---VYTA 621

                       330       340       350
                ....*....|....*....|....*....|
gi 30802062 306 ISAwarMCKILGKEFQQYLPVVMgPLMKTA 335
Cdd:COG5215 622 ISA---LSTSLEERFEQYASKFI-PYLTRA 647
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 73-127 1.59e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 54.30  E-value: 1.59e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 30802062    73 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 127
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
28-167 2.07e-09

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 56.56  E-value: 2.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062  28 LEDDDFD--SNAVAgesALdrmacglgGKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFV 105
Cdd:COG1413  25 LADEDPDvrAAAAR---AL--------GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPAL 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30802062 106 LLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhEKVIAALLQTMEDQgNQRVQAHAAAAL 167
Cdd:COG1413  84 IAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDP-DWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
62-185 1.38e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.25  E-value: 1.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062  62 EHIMQMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhE 141
Cdd:COG1413  19 PALIAALADEDPDVRAAAARALGRLGDP----------RAVPALLEALKDPDPEVRAAAAEALGRIGD-----------P 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 30802062 142 KVIAALLQTMEDQgNQRVQAHAAAALINFTEDCPKSLLIPYLDN 185
Cdd:COG1413  78 EAVPALIAALKDE-DPEVRRAAAEALGRLGDPAAVPALLEALKD 120
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 66-167 3.75e-08

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 51.57  E-value: 3.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062    66 QMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhEKVIA 145
Cdd:pfam13646   7 ALLRDPDPEVRAAAIRALGRIGDP----------EAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEALP 65

                          90       100
                  ....*....|....*....|..
gi 30802062   146 ALLQTMEDQGNQRVQAHAAAAL 167
Cdd:pfam13646  66 ALLELLRDDDDDVVRAAAAEAL 87
Importin_rep_5 pfam18816
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 706-752 1.58e-06

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.


Pssm-ID: 465877  Cd Length: 52  Bit Score: 45.55  E-value: 1.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 30802062   706 DKEEAVQTFSYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 752
Cdd:pfam18816   1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
Vac14_Fab1_bd pfam12755
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ...
 75-123 9.97e-06

Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.


Pssm-ID: 403838  Cd Length: 97  Bit Score: 44.89  E-value: 9.97e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 30802062    75 YRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNA 123
Cdd:pfam12755   2 ARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACES 50
HEAT COG1413
HEAT repeat [General function prediction only];
76-185 2.75e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.62  E-value: 2.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30802062  76 RHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMAtdfapgfqkkfHEKVIAALLQTMEDQg 155
Cdd:COG1413   2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDP- 59

                        90       100       110
                ....*....|....*....|....*....|
gi 30802062 156 NQRVQAHAAAALINFTEDCPKSLLIPYLDN 185
Cdd:COG1413  60 DPEVRAAAAEALGRIGDPEAVPALIAALKD 89
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 620-667 2.14e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 39.66  E-value: 2.14e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 30802062   620 PEVRQAAAYGLGVMAQFGGDNYRPFCTDALPLLVRVIQAPEAKTKENV 667
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 101-128 3.06e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 38.66  E-value: 3.06e-04
                          10        20
                  ....*....|....*....|....*...
gi 30802062   101 IVNFVLLFLQDPHPRVRYAACNAVGQMA 128
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 114-170 4.88e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 4.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 30802062   114 PRVRYAACNAVGQMAtDFAPGFQKKFHEKVIAALLQTMEDqGNQRVQAHAAAALINF 170
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLND-DSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
62-128 5.47e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 5.47e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30802062  62 EHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMA 128
Cdd:COG1413  81 PALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 607-636 2.96e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.97  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 30802062   607 FISPMLQYVCDNSPEVRQAAAYGLGVMAQF 636
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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