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Conserved domains on  [gi|38571756|gb|AAH62807|]
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CD3 antigen, delta polypeptide [Mus musculus]

Protein Classification

Ig_4 and ITAM domain-containing protein( domain architecture ID 11245011)

Ig_4 and ITAM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 30-92 4.04e-23

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


:

Pssm-ID: 465231  Cd Length: 63  Bit Score: 86.54  E-value: 4.04e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38571756    30 EDKVFVTCNT---SVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEqlaKVVSSVQVHYRM 92
Cdd:pfam16680   1 DGKVLLTCNSsskSITWLKDGKGIKSTNTKTLDLGKFSEDPRGLYQCQGEK---KKSSTLQVYYRM 63
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 146-165 9.79e-06

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


:

Pssm-ID: 426646  Cd Length: 20  Bit Score: 40.44  E-value: 9.79e-06
                          10        20
                  ....*....|....*....|
gi 38571756   146 EQLYQPLRDREDTQYSRLGG 165
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Name Accession Description Interval E-value
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 30-92 4.04e-23

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 86.54  E-value: 4.04e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38571756    30 EDKVFVTCNT---SVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEqlaKVVSSVQVHYRM 92
Cdd:pfam16680   1 DGKVLLTCNSsskSITWLKDGKGIKSTNTKTLDLGKFSEDPRGLYQCQGEK---KKSSTLQVYYRM 63
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 26-94 2.88e-19

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409488  Cd Length: 69  Bit Score: 76.81  E-value: 2.88e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38571756  26 VTEYEDKVFVTCN--TSVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEQlakVVSSVQVHYRMCQ 94
Cdd:cd07691   2 VKENEDKVFLKCNsaSSITWKKGTEGIEASDKTDLDLGSRINDPRGTYQCKGSEN---KEKTLQVHYRMCQ 69
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 146-165 9.79e-06

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 40.44  E-value: 9.79e-06
                          10        20
                  ....*....|....*....|
gi 38571756   146 EQLYQPLRDREDTQYSRLGG 165
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 146-166 7.81e-05

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 38.13  E-value: 7.81e-05
                           10        20
                   ....*....|....*....|.
gi 38571756    146 EQLYQPLRDREDTQYSRLGGN 166
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
Ig_4 pfam16680
T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is ...
 30-92 4.04e-23

T-cell surface glycoprotein CD3 delta chain; This is an immunoglobulin-like domain. It is found on the T-cell surface glycoprotein CD3 delta chain. CD3delta and CD3epsilon complex together as part of the T-cell receptor complex.


Pssm-ID: 465231  Cd Length: 63  Bit Score: 86.54  E-value: 4.04e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38571756    30 EDKVFVTCNT---SVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEqlaKVVSSVQVHYRM 92
Cdd:pfam16680   1 DGKVLLTCNSsskSITWLKDGKGIKSTNTKTLDLGKFSEDPRGLYQCQGEK---KKSSTLQVYYRM 63
IgC1_CD3_gamma_delta cd07691
Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; ...
 26-94 2.88e-19

Immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains; member of the C1-set of IgSF domains; The members here are composed of immunoglobulin (Ig)-like domain of Cluster of Differentiation (CD) 3 gamma and delta chains. CD3 is a T cell surface receptor that is associated with alpha/beta T cell receptors (TCRs). The CD3 complex consists of one gamma, one delta, two epsilon, and two zeta chains. The CD3 subunits form heterodimers as gamma/epsilon, delta/epsilon, and zeta/zeta. The gamma, delta, and epsilon chains each contain an extracellular Ig domain, whereas the extracellular domains of the zeta chains are very small and have unknown structure. The CD3 domain participates in intracellular signaling once the TCR has bound an MHC/antigen complex.


Pssm-ID: 409488  Cd Length: 69  Bit Score: 76.81  E-value: 2.88e-19
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 38571756  26 VTEYEDKVFVTCN--TSVMHLDGTVEGWFAKNKTLNLGKGVLDPRGIYLCNGTEQlakVVSSVQVHYRMCQ 94
Cdd:cd07691   2 VKENEDKVFLKCNsaSSITWKKGTEGIEASDKTDLDLGSRINDPRGTYQCKGSEN---KEKTLQVHYRMCQ 69
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 146-165 9.79e-06

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 40.44  E-value: 9.79e-06
                          10        20
                  ....*....|....*....|
gi 38571756   146 EQLYQPLRDREDTQYSRLGG 165
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 146-166 7.81e-05

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 38.13  E-value: 7.81e-05
                           10        20
                   ....*....|....*....|.
gi 38571756    146 EQLYQPLRDREDTQYSRLGGN 166
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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