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Conserved domains on  [gi|47480808|gb|AAH69521|]
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Zona pellucida glycoprotein 4 [Homo sapiens]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 11247761)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
189-460 2.98e-72

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 230.96  E-value: 2.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   189 CTREgHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAF--VLFQFPFTSCGTTRQITGDRAVYENELVATRD-V 265
Cdd:pfam00100   1 CTPD-TMTVSISKCLLVPSGLLSSLSLLGGLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDlR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   266 KNGSRGSVTRDSIFRLHVSCSYSVSSNSLPInvqvfTLPPPFPETQPGPLTLELQIAKDKNYGSYYGvgDYPVVKLLRDP 345
Cdd:pfam00100  80 SGIIRRTITRRLPFSCSYPRSSLVSLLVVAP-----PSPVPITVSGSGVFLVSMDLYYDSSYTSPYS--PYPVTVLLGDP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   346 IYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVqkaldlPFPSHHQRFSIFTFSFV 425
Cdd:pfam00100 153 LYVEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLS------NGPSHYVRFSFKAFRFV 226

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47480808   426 NPTvekqalRGPVHLHCSVSVCqPAETPSCVVTCP 460
Cdd:pfam00100 227 GSS------ISQVYLHCSVSVC-SSDSNSCGKSCS 254
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 141-185 2.88e-11

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


:

Pssm-ID: 197472  Cd Length: 46  Bit Score: 58.55  E-value: 2.88e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 47480808    141 DWCdSIPARDRLPCAPSPISRGDCEGLGCCYSSE--EVNSCYYGNTV 185
Cdd:smart00018   1 AQC-SVPPSERINCGPPGITEAECEARGCCFDSSisGVPWCFYPNTV 46
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
189-460 2.98e-72

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 230.96  E-value: 2.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   189 CTREgHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAF--VLFQFPFTSCGTTRQITGDRAVYENELVATRD-V 265
Cdd:pfam00100   1 CTPD-TMTVSISKCLLVPSGLLSSLSLLGGLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDlR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   266 KNGSRGSVTRDSIFRLHVSCSYSVSSNSLPInvqvfTLPPPFPETQPGPLTLELQIAKDKNYGSYYGvgDYPVVKLLRDP 345
Cdd:pfam00100  80 SGIIRRTITRRLPFSCSYPRSSLVSLLVVAP-----PSPVPITVSGSGVFLVSMDLYYDSSYTSPYS--PYPVTVLLGDP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   346 IYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVqkaldlPFPSHHQRFSIFTFSFV 425
Cdd:pfam00100 153 LYVEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLS------NGPSHYVRFSFKAFRFV 226

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47480808   426 NPTvekqalRGPVHLHCSVSVCqPAETPSCVVTCP 460
Cdd:pfam00100 227 GSS------ISQVYLHCSVSVC-SSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 188-460 2.02e-63

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 207.62  E-value: 2.02e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808    188 HCTrEGHFSIAVSRNVTSPP-LLLDSVRLalrNDSACNPVM--ATQAFVLFQFPFTSCGTTRQITGDRAVYENELVatrd 264
Cdd:smart00241   1 QCG-EDQMVVSVSTDLLFPGgINVKGLTL---GDPSCRPQFtdATSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLV---- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808    265 VKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPiNVQVFTLPPPFPE-TQPGPLTLELQIAKDKNYGSYYGVGDYPvvklLR 343
Cdd:smart00241  73 VSPFHPGFITRDDRAAYHFQCFYPENEKVSL-NLDVSTIPPTELSsVSEGPLTCSYRLYKDDSFGSPYQSADYV----LG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808    344 DPIYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYigDNYQTQLIPVQkaldlPFPSHHQRFSIFTFS 423
Cdd:smart00241 148 DPVYHEWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPV--DGYLDSTIPYN-----SNPLHRARFSVKVFK 220

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 47480808    424 FVNptvekqalRGPVHLHCSVSVCQPAETPSCV-VTCP 460
Cdd:smart00241 221 FAD--------RSLVYFHCQIRLCDKDDGSSCDgPACS 250
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 141-185 2.88e-11

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 58.55  E-value: 2.88e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 47480808    141 DWCdSIPARDRLPCAPSPISRGDCEGLGCCYSSE--EVNSCYYGNTV 185
Cdd:smart00018   1 AQC-SVPPSERINCGPPGITEAECEARGCCFDSSisGVPWCFYPNTV 46
Trefoil pfam00088
Trefoil (P-type) domain;
143-182 5.59e-11

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 57.33  E-value: 5.59e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 47480808   143 CDSIPARDRLPCAPSPISRGDCEGLGCCYSSEE---VNSCYYG 182
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVdpgVPWCFYP 43
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 141-183 9.91e-11

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 56.97  E-value: 9.91e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47480808 141 DWCdSIPARDRLPCAPSPISRGDCEGLGCCYSSE--EVNSCYYGN 183
Cdd:cd00111   1 EWC-SVPPSERIDCGPPGITQEECEARGCCFDPSisGVPWCFYPK 44
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
189-460 2.98e-72

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 230.96  E-value: 2.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   189 CTREgHFSIAVSRNVTSPPLLLDSVRLALRNDSACNPVMATQAF--VLFQFPFTSCGTTRQITGDRAVYENELVATRD-V 265
Cdd:pfam00100   1 CTPD-TMTVSISKCLLVPSGLLSSLSLLGGLDPSCKPVSNTNGSpaVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDlR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   266 KNGSRGSVTRDSIFRLHVSCSYSVSSNSLPInvqvfTLPPPFPETQPGPLTLELQIAKDKNYGSYYGvgDYPVVKLLRDP 345
Cdd:pfam00100  80 SGIIRRTITRRLPFSCSYPRSSLVSLLVVAP-----PSPVPITVSGSGVFLVSMDLYYDSSYTSPYS--PYPVTVLLGDP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808   346 IYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYIGDNYQTQLIPVqkaldlPFPSHHQRFSIFTFSFV 425
Cdd:pfam00100 153 LYVEVSLLSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTYPVSSLS------NGPSHYVRFSFKAFRFV 226

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47480808   426 NPTvekqalRGPVHLHCSVSVCqPAETPSCVVTCP 460
Cdd:pfam00100 227 GSS------ISQVYLHCSVSVC-SSDSNSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 188-460 2.02e-63

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 207.62  E-value: 2.02e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808    188 HCTrEGHFSIAVSRNVTSPP-LLLDSVRLalrNDSACNPVM--ATQAFVLFQFPFTSCGTTRQITGDRAVYENELVatrd 264
Cdd:smart00241   1 QCG-EDQMVVSVSTDLLFPGgINVKGLTL---GDPSCRPQFtdATSAFVSFEVPLNGCGTRRQVNPDGIVYSNTLV---- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808    265 VKNGSRGSVTRDSIFRLHVSCSYSVSSNSLPiNVQVFTLPPPFPE-TQPGPLTLELQIAKDKNYGSYYGVGDYPvvklLR 343
Cdd:smart00241  73 VSPFHPGFITRDDRAAYHFQCFYPENEKVSL-NLDVSTIPPTELSsVSEGPLTCSYRLYKDDSFGSPYQSADYV----LG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47480808    344 DPIYVEVSILHRTDPYLGLLLQQCWATPSTDPLSQPQWPILVKGCPYigDNYQTQLIPVQkaldlPFPSHHQRFSIFTFS 423
Cdd:smart00241 148 DPVYHEWECDGADDPPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPV--DGYLDSTIPYN-----SNPLHRARFSVKVFK 220

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 47480808    424 FVNptvekqalRGPVHLHCSVSVCQPAETPSCV-VTCP 460
Cdd:smart00241 221 FAD--------RSLVYFHCQIRLCDKDDGSSCDgPACS 250
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 141-185 2.88e-11

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 58.55  E-value: 2.88e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 47480808    141 DWCdSIPARDRLPCAPSPISRGDCEGLGCCYSSE--EVNSCYYGNTV 185
Cdd:smart00018   1 AQC-SVPPSERINCGPPGITEAECEARGCCFDSSisGVPWCFYPNTV 46
Trefoil pfam00088
Trefoil (P-type) domain;
143-182 5.59e-11

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 57.33  E-value: 5.59e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 47480808   143 CDSIPARDRLPCAPSPISRGDCEGLGCCYSSEE---VNSCYYG 182
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVdpgVPWCFYP 43
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 141-183 9.91e-11

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 56.97  E-value: 9.91e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 47480808 141 DWCdSIPARDRLPCAPSPISRGDCEGLGCCYSSE--EVNSCYYGN 183
Cdd:cd00111   1 EWC-SVPPSERIDCGPPGITQEECEARGCCFDPSisGVPWCFYPK 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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