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Conserved domains on  [gi|50368984|gb|AAH75825|]
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ALS2CL protein, partial [Homo sapiens]

Protein Classification

PLN03185 and VPS9 domain-containing protein( domain architecture ID 13409328)

protein containing domains PLN03185, COG4642, and VPS9

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
65-265 2.52e-29

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 117.36  E-value: 2.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  65 TYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASE-----DKFDCYKCHWREGSMCGYGICEYSTDEV 139
Cdd:COG4642  70 GGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGgvlegDDGGGYGGGTADGGRGGGGIYTFPNGDV 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984 140 YKGYFQEGLRHGFGVLESGPQApqpfRYTGHWERGQRSGYGIEEDGDrGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQ 219
Cdd:COG4642 150 YEGEFKNGKPHGQGTLTYADGD----RYEGEFKNGKRHGQGTLTYAN-GDVYEGEFKNGQRHGQGTYTYADGDRYEGEFK 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 50368984 220 ADKTVGPGILLSEDDSLYEGTFTRDLtLMGKGKVTFPNGFTLEGSF 265
Cdd:COG4642 225 NGKRHGQGTLTYADGDRYEGEFKNGK-RHGQGTMTYADGSVYEGEW 269
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 544-646 1.46e-18

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


:

Pssm-ID: 460489  Cd Length: 104  Bit Score: 81.10  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   544 SATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRvLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPNHT 623
Cdd:pfam02204   3 QAQQELKKLNEAKSPREKLKCLLRTCKLITEALSK-SNRDESLGADDLLPILIYVLIRANPPNLYSNLQFISEFRDPDLL 81

                          90       100
                  ....*....|....*....|...
gi 50368984   624 GGLYDFLLTALESCYEHIQKEDM 646
Cdd:pfam02204  82 SGEEGYYLTTLEAALEFIESLDP 104
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
65-265 2.52e-29

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 117.36  E-value: 2.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  65 TYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASE-----DKFDCYKCHWREGSMCGYGICEYSTDEV 139
Cdd:COG4642  70 GGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGgvlegDDGGGYGGGTADGGRGGGGIYTFPNGDV 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984 140 YKGYFQEGLRHGFGVLESGPQApqpfRYTGHWERGQRSGYGIEEDGDrGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQ 219
Cdd:COG4642 150 YEGEFKNGKPHGQGTLTYADGD----RYEGEFKNGKRHGQGTLTYAN-GDVYEGEFKNGQRHGQGTYTYADGDRYEGEFK 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 50368984 220 ADKTVGPGILLSEDDSLYEGTFTRDLtLMGKGKVTFPNGFTLEGSF 265
Cdd:COG4642 225 NGKRHGQGTLTYADGDRYEGEFKNGK-RHGQGTMTYADGSVYEGEW 269
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 544-646 1.46e-18

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 81.10  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   544 SATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRvLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPNHT 623
Cdd:pfam02204   3 QAQQELKKLNEAKSPREKLKCLLRTCKLITEALSK-SNRDESLGADDLLPILIYVLIRANPPNLYSNLQFISEFRDPDLL 81

                          90       100
                  ....*....|....*....|...
gi 50368984   624 GGLYDFLLTALESCYEHIQKEDM 646
Cdd:pfam02204  82 SGEEGYYLTTLEAALEFIESLDP 104
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 65-218 3.43e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 82.57  E-value: 3.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   65 TYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASedkfdCYKCHWREGSMCGYGICEYSTDEVYKGYF 144
Cdd:PLN03185  33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGT-----TYKGRWRLNLKHGLGYQRYPNGDVFEGSW 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50368984  145 QEGLRHGFG--VLESGPQapqpfrYTGHWERGQRSGYGIEEdGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTF 218
Cdd:PLN03185 108 IQGLQEGPGkyTWANGNV------YLGDMKGGKMSGKGTLT-WVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTW 176
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 66-86 1.39e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 1.39e-04
                          10        20
                  ....*....|....*....|.
gi 50368984    66 YEGEWCRGRPHGKGTLKWPDG 86
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
64-85 6.48e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 6.48e-04
                           10        20
                   ....*....|....*....|..
gi 50368984     64 ATYEGEWCRGRPHGKGTLKWPD 85
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
65-265 2.52e-29

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 117.36  E-value: 2.52e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  65 TYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASE-----DKFDCYKCHWREGSMCGYGICEYSTDEV 139
Cdd:COG4642  70 GGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGgvlegDDGGGYGGGTADGGRGGGGIYTFPNGDV 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984 140 YKGYFQEGLRHGFGVLESGPQApqpfRYTGHWERGQRSGYGIEEDGDrGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQ 219
Cdd:COG4642 150 YEGEFKNGKPHGQGTLTYADGD----RYEGEFKNGKRHGQGTLTYAN-GDVYEGEFKNGQRHGQGTYTYADGDRYEGEFK 224

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 50368984 220 ADKTVGPGILLSEDDSLYEGTFTRDLtLMGKGKVTFPNGFTLEGSF 265
Cdd:COG4642 225 NGKRHGQGTLTYADGDRYEGEFKNGK-RHGQGTMTYADGSVYEGEW 269
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
64-218 3.28e-27

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 111.59  E-value: 3.28e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  64 ATYEGEWCRGRPHGKGTLKWPDGrnhvgnfcqglehgfgirllpqasedkfDCYKCHWREGSMCGYGICEYSTDEVYKGY 143
Cdd:COG4642 148 DVYEGEFKNGKPHGQGTLTYADG----------------------------DRYEGEFKNGKRHGQGTLTYANGDVYEGE 199

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50368984 144 FQEGLRHGFGVLESgpqaPQPFRYTGHWERGQRSGYGIEEDGDrGERYIGMWQAGQRHGPGVMVTQAGVCYQGTF 218
Cdd:COG4642 200 FKNGQRHGQGTYTY----ADGDRYEGEFKNGKRHGQGTLTYAD-GDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
VPS9 pfam02204
Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). ...
 544-646 1.46e-18

Vacuolar sorting protein 9 (VPS9) domain; This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind.


Pssm-ID: 460489  Cd Length: 104  Bit Score: 81.10  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   544 SATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRvLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPNHT 623
Cdd:pfam02204   3 QAQQELKKLNEAKSPREKLKCLLRTCKLITEALSK-SNRDESLGADDLLPILIYVLIRANPPNLYSNLQFISEFRDPDLL 81

                          90       100
                  ....*....|....*....|...
gi 50368984   624 GGLYDFLLTALESCYEHIQKEDM 646
Cdd:pfam02204  82 SGEEGYYLTTLEAALEFIESLDP 104
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 65-218 3.43e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 82.57  E-value: 3.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   65 TYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASedkfdCYKCHWREGSMCGYGICEYSTDEVYKGYF 144
Cdd:PLN03185  33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGT-----TYKGRWRLNLKHGLGYQRYPNGDVFEGSW 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 50368984  145 QEGLRHGFG--VLESGPQapqpfrYTGHWERGQRSGYGIEEdGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTF 218
Cdd:PLN03185 108 IQGLQEGPGkyTWANGNV------YLGDMKGGKMSGKGTLT-WVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTW 176
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 66-258 6.59e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 65.62  E-value: 6.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   66 YEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQ--ASEDKFDCykchwreGSMCGYGICEYSTDEVYKGY 143
Cdd:PLN03185  11 YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSgaTYEGEFSG-------GYMHGSGTYTGTDGTTYKGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  144 FQEGLRHGFGVlesgPQAPQPFRYTGHWERGQRSGYGiEEDGDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKT 223
Cdd:PLN03185  84 WRLNLKHGLGY----QRYPNGDVFEGSWIQGLQEGPG-KYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMM 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 50368984  224 VGPGILLSEDDSLYEGTFTRDLTlMGKGkVTFPNG 258
Cdd:PLN03185 159 HGFGVYTWSDGGCYVGTWTRGLK-DGKG-VFYPAG 191
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 64-205 2.46e-10

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 63.70  E-value: 2.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984   64 ATYEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQAsedkfDCYKCHWREGSMCGYGICEYSTDEVYKGY 143
Cdd:PLN03185  55 ATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNG-----DVFEGSWIQGLQEGPGKYTWANGNVYLGD 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50368984  144 FQEGLRHGFGVLE--SGPqapqpfRYTGHWERGQRSGYGIEEDGDrGERYIGMWQAGQRHGPGV 205
Cdd:PLN03185 130 MKGGKMSGKGTLTwvSGD------SYEGQWLDGMMHGFGVYTWSD-GGCYVGTWTRGLKDGKGV 186
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 115-275 4.18e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 50.22  E-value: 4.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  115 DCYKCHWREGSMCGYGICEYSTDEVYKGYFQEGLRHGFGVLesgpQAPQPFRYTGHWERGQRSGYGIEEDGDrGERYIGM 194
Cdd:PLN03185   9 DFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKI----SWPSGATYEGEFSGGYMHGSGTYTGTD-GTTYKGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50368984  195 WQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFtRDLTLMGKGKVTFPNGFTLEGSFGSGA--GRG 272
Cdd:PLN03185  84 WRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDM-KGGKMSGKGTLTWVSGDSYEGQWLDGMmhGFG 162


                 ...
gi 50368984  273 LHT 275
Cdd:PLN03185 163 VYT 165
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 66-86 1.39e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 1.39e-04
                          10        20
                  ....*....|....*....|.
gi 50368984    66 YEGEWCRGRPHGKGTLKWPDG 86
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
64-85 6.48e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 6.48e-04
                           10        20
                   ....*....|....*....|..
gi 50368984     64 ATYEGEWCRGRPHGKGTLKWPD 85
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 211-275 6.65e-04

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 42.90  E-value: 6.65e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50368984  211 GVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRDLTlMGKGKVTFPNGFTLEGSFGSGAGRGLHT 275
Cdd:PLN03185   8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMR-HGNGKISWPSGATYEGEFSGGYMHGSGT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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