NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|51259494|gb|AAH79409|]
View 

Tetratricopeptide repeat domain 12 [Rattus norvegicus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-205 3.35e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 3.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                        90       100
                ....*....|....*....|..
gi 51259494 184 LALKNYSKSKECYQKIGEINPK 205
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPD 108
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-205 3.35e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 3.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                        90       100
                ....*....|....*....|..
gi 51259494 184 LALKNYSKSKECYQKIGEINPK 205
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPD 108
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 104-254 1.13e-12

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 69.82  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51259494  184 LALKNYSKSKECYQKIGEI---NPKLKAQVKEhLNQVTLREKADLQEKK--ARESLDSGKNTAMTTRNLLETLSKP 254
Cdd:PLN03088  81 MKLEEYQTAKAALEKGASLapgDSRFTKLIKE-CDEKIAEEEKDLVQPVpsDLPSSVTAPPVEEADATPVVPPSKP 155
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 49-236 5.08e-11

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 65.78  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494    49 EREQEEDGCRTTLNKTMISPPQAPENAN----EMNPDAFLASVEKDAKErakrrrENRVLADALKEKGNEAFVKGDYETA 124
Cdd:TIGR00990  73 ERRKRKQAEKETEGKTEEKKSTAPKNAPvepaDELPEIDESSVANLSEE------ERKKYAAKLKEKGNKAYRNKDFNKA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494   125 IFFYSEGLgKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTK-------AYFHMGKAHLALKNYSKSkeCYq 197
Cdd:TIGR00990 147 IKLYSKAI-ECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTAS--CI- 222

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 51259494   198 kIGEINPKLKAQVKEHLnqvtLREKAdlqEKKARESLDS 236
Cdd:TIGR00990 223 -IDGFRNEQSAQAVERL----LKKFA---ESKAKEILET 253
TPR_1 pfam00515
Tetratricopeptide repeat;
142-172 2.97e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.25  E-value: 2.97e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 51259494   142 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 172
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 142-172 3.77e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.89  E-value: 3.77e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 51259494    142 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 172
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-205 3.35e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 70.04  E-value: 3.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:COG0457   7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAL 86

                        90       100
                ....*....|....*....|..
gi 51259494 184 LALKNYSKSKECYQKIGEINPK 205
Cdd:COG0457  87 QALGRYEEALEDYDKALELDPD 108
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 104-254 1.13e-12

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 69.82  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTAC 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 51259494  184 LALKNYSKSKECYQKIGEI---NPKLKAQVKEhLNQVTLREKADLQEKK--ARESLDSGKNTAMTTRNLLETLSKP 254
Cdd:PLN03088  81 MKLEEYQTAKAALEKGASLapgDSRFTKLIKE-CDEKIAEEEKDLVQPVpsDLPSSVTAPPVEEADATPVVPPSKP 155
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 49-236 5.08e-11

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 65.78  E-value: 5.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494    49 EREQEEDGCRTTLNKTMISPPQAPENAN----EMNPDAFLASVEKDAKErakrrrENRVLADALKEKGNEAFVKGDYETA 124
Cdd:TIGR00990  73 ERRKRKQAEKETEGKTEEKKSTAPKNAPvepaDELPEIDESSVANLSEE------ERKKYAAKLKEKGNKAYRNKDFNKA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494   125 IFFYSEGLgKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTK-------AYFHMGKAHLALKNYSKSkeCYq 197
Cdd:TIGR00990 147 IKLYSKAI-ECKPDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYSKalnrranAYDGLGKYADALLDLTAS--CI- 222

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 51259494   198 kIGEINPKLKAQVKEHLnqvtLREKAdlqEKKARESLDS 236
Cdd:TIGR00990 223 -IDGFRNEQSAQAVERL----LKKFA---ESKAKEILET 253
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
81-236 1.23e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 61.85  E-value: 1.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  81 DAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLgKLK-DMKVLYTNRAQAYIKLGDYQKAL 159
Cdd:COG4785  49 AAAALAAAALAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQAL-ELDpDLAEAYNNRGLAYLLLGDYDAAL 127

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 51259494 160 VDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPKLKAQV-KEHLNQvtlrekADLQEKKARESLDS 236
Cdd:COG4785 128 EDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERAlWLYLAE------RKLDPEKALALLLE 199
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-232 3.42e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.18  E-value: 3.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 105 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 184
Cdd:COG0457  76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 51259494 185 ALKNYSKSKECYQKIGEINPKLKAQVKEHLNQVTLREKADLQEKKARE 232
Cdd:COG0457 156 KLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLAL 203
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 91-216 1.18e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.94  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  91 AKERAKRRRENrvlADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDE 170
Cdd:COG4235   6 LRQALAANPND---AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 51259494 171 NCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPK--LKAQVKEHLNQ 216
Cdd:COG4235  83 DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAdaPARLLEASIAE 130
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 105-205 4.89e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 4.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 105 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 184
Cdd:COG4783  38 PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYR 117

                        90       100
                ....*....|....*....|.
gi 51259494 185 ALKNYSKSKECYQKIGEINPK 205
Cdd:COG4783 118 ALGRPDEAIAALEKALELDPD 138
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 105-236 4.96e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 4.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 105 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 184
Cdd:COG2956 110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYL 189

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 51259494 185 ALKNYSKSKECYQKIGEINPKlKAQVKEHLNQVTLREKadlQEKKARESLDS 236
Cdd:COG2956 190 EQGDYEEAIAALERALEQDPD-YLPALPRLAELYEKLG---DPEEALELLRK 237
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 65-204 7.70e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.35  E-value: 7.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  65 MISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTN 144
Cdd:COG5010  14 LLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYN 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 145 RAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINP 204
Cdd:COG5010  94 LALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 105-205 8.23e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 8.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 105 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 184
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                        90       100
                ....*....|....*....|.
gi 51259494 185 ALKNYSKSKECYQKIGEINPK 205
Cdd:COG4783  84 KAGDYDEALALLEKALKLDPE 104
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 105-205 9.21e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.85  E-value: 9.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 105 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 184
Cdd:COG3914 112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                        90       100
                ....*....|....*....|.
gi 51259494 185 ALKNYSKSKECYQKIGEINPK 205
Cdd:COG3914 192 DLGRLEEAIAAYRRALELDPD 212
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
118-206 1.86e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 52.48  E-value: 1.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 118 KGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALvDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQ 197
Cdd:COG3063   5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                ....*....
gi 51259494 198 KIGEINPKL 206
Cdd:COG3063  84 RALELDPSA 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 93-205 1.83e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 1.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  93 ERAKRRRENRvlADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENC 172
Cdd:COG2956  66 QKLLERDPDR--AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                        90       100       110
                ....*....|....*....|....*....|...
gi 51259494 173 TKAYFHMGKAHLALKNYSKSKECYQKIGEINPK 205
Cdd:COG2956 144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPD 176
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 89-204 3.35e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.42  E-value: 3.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  89 KDAKERAKR-RRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALK 167
Cdd:COG2956 127 EKAIEVLERlLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 51259494 168 CDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINP 204
Cdd:COG2956 207 QDPDYLPALPRLAELYEKLGDPEEALELLRKALELDP 243
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 105-235 4.13e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 4.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 105 ADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHL 184
Cdd:COG2956  42 VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYE 121

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 51259494 185 ALKNYSKSKECYQKIGEINPKlKAQVKEHLNQVTLREKadlQEKKARESLD 235
Cdd:COG2956 122 QEGDWEKAIEVLERLLKLGPE-NAHAYCELAELYLEQG---DYDEAIEALE 168
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
65-205 6.96e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.68  E-value: 6.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  65 MISPPQAPENANEMNPDAFLASVEKDAKERAKRrreNRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYtN 144
Cdd:COG4785   3 ALALALLLALALAAAAASKAAILLAALLFAAVL---ALAIALADLALALAAAALAAAALAAERIDRALALPDLAQLYY-E 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 51259494 145 RAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPK 205
Cdd:COG4785  79 RGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 65-227 1.68e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 1.68e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494  65 MISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTN 144
Cdd:COG3914   4 AALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLEL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 145 RAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEINPKLkAQVkeHLNQ-VTLREKA 223
Cdd:COG3914  84 AALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF-AEA--YLNLgEALRRLG 160


                ....
gi 51259494 224 DLQE 227
Cdd:COG3914 161 RLEE 164
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 104-204 6.72e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 6.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494   104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:TIGR00990 330 EAIALNLRGTFKCLKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLH 409

                          90       100
                  ....*....|....*....|.
gi 51259494   184 LALKNYSKSKECYQKIGEINP 204
Cdd:TIGR00990 410 FIKGEFAQAGKDYQKSIDLDP 430
TPR_1 pfam00515
Tetratricopeptide repeat;
142-172 2.97e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.25  E-value: 2.97e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 51259494   142 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 172
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 142-172 3.77e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 40.89  E-value: 3.77e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 51259494    142 YTNRAQAYIKLGDYQKALVDCDWALKCDENC 172
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 104-235 1.30e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.03  E-value: 1.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 104 LADALKEKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAH 183
Cdd:COG5010  19 KLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 51259494 184 LALKNYSKSKECYQKIGEINPKLkAQVKEHLNQVTLREKadlQEKKARESLD 235
Cdd:COG5010  99 SRSGDKDEAKEYYEKALALSPDN-PNAYSNLAALLLSLG---QDDEAKAALQ 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 110-235 4.04e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 4.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 110 EKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNY 189
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 51259494 190 SKSKECYQKIGEINPKlKAQVKEHLNQVTLREKadlQEKKARESLD 235
Cdd:COG2956  93 DRAEELLEKLLELDPD-DAEALRLLAEIYEQEG---DWEKAIEVLE 134
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 114-199 7.81e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 39.59  E-value: 7.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 114 EAFVKGDYETAIFFYSEGLGKLKDMKVL---YTNRAQAYIKLGDYQKALVDCDWALKCDENCTK---AYFHMGKAHLALK 187
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLKRYPNSPLApdaLYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELG 81

                        90
                ....*....|..
gi 51259494 188 NYSKSKECYQKI 199
Cdd:COG1729  82 DYDKARATLEEL 93
TPR_1 pfam00515
Tetratricopeptide repeat;
174-205 1.32e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.63  E-value: 1.32e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 51259494   174 KAYFHMGKAHLALKNYSKSKECYQKIGEINPK 205
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 51-204 2.77e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.22  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494    51 EQEEDGCRTTLNKTMISPP--------QAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYE 122
Cdd:TIGR02917 478 KGDLAKAREAFEKALSIEPdffpaaanLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLE 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494   123 TAIffyseglGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKECYQKIGEI 202
Cdd:TIGR02917 558 KAA-------ELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLAL 630


                  ..
gi 51259494   203 NP 204
Cdd:TIGR02917 631 QP 632
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
148-235 3.13e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 3.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 51259494 148 AYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKSKEcYQKIGEINPKlKAQVKEHLNQVTLREKadlQE 227
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPN-NAEALLNLAELLLELG---DY 75


                ....*...
gi 51259494 228 KKARESLD 235
Cdd:COG3063  76 DEALAYLE 83
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 174-205 3.96e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.19  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 51259494   174 KAYFHMGKAHLALKNYSKSKECYQKIGEINPK 205
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH