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Conserved domains on  [gi|52139023|gb|AAH82548|]
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Gcn1l1 protein, partial [Mus musculus]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 11444215)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

CATH:  1.25.10.110
Gene Ontology:  GO:0005515
PubMed:  35552740|10378263
SCOP:  4001283

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
995-1167 1.02e-05

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.55  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  995 RKGAAYGLAglvkglgilSLKQQEMMAALTDAIQDKkNFRRREGALFAfemlctmLGKLFEPYVVhvlPHLLLCFGDGNQ 1074
Cdd:COG1413    2 RRAAARALG---------RLGDPAAVPALIAALADE-DPDVRAAAARA-------LGRLGDPRAV---PALLEALKDPDP 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1075 YVREAAddcAKAvmsnLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYcapkqlssclPNIVPKLTEVLTDSHVK 1154
Cdd:COG1413   62 EVRAAA---AEA----LGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWE 124
                        170
                 ....*....|...
gi 52139023 1155 VQKAGQQALRQIG 1167
Cdd:COG1413  125 VRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
1138-1285 8.51e-04

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1138 PNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVirnpeilAIAPVLLDALTDPSRKTQK-CLQTLLDTKFVHFIDApslal 1216
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGDP-------RAVPALLEALKDPDPEVRAaAAEALGRIGDPEAVPA----- 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52139023 1217 impiVQRAFQDRSTDTRKMAAQIIGNMYSltdqkdlapylPSVTPGLKASLLDPVPEVRTVSAKALGAM 1285
Cdd:COG1413   83 ----LIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
995-1167 1.02e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.55  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  995 RKGAAYGLAglvkglgilSLKQQEMMAALTDAIQDKkNFRRREGALFAfemlctmLGKLFEPYVVhvlPHLLLCFGDGNQ 1074
Cdd:COG1413    2 RRAAARALG---------RLGDPAAVPALIAALADE-DPDVRAAAARA-------LGRLGDPRAV---PALLEALKDPDP 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1075 YVREAAddcAKAvmsnLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYcapkqlssclPNIVPKLTEVLTDSHVK 1154
Cdd:COG1413   62 EVRAAA---AEA----LGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWE 124
                        170
                 ....*....|...
gi 52139023 1155 VQKAGQQALRQIG 1167
Cdd:COG1413  125 VRRAAARALGRLG 137
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
849-1188 1.36e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 46.38  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023   849 LDSSQVKPLFQFfvpdaLNDRNPDVRKcmldAALATLNAHgkenvnsLLPVFEEFLKDAPND-------ASYDAVRQSVV 921
Cdd:PRK13800  618 LDAPSVAELAPY-----LADPDPGVRR----TAVAVLTET-------TPPGFGPALVAALGDgaaavrrAAAEGLRELVE 681
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023   922 VLMG--SLAKHLDKSDPKVKPIVAKLIAALSTpsqqvqesvasclpplvpavkedagGMIQRLMQQLLESDkYAERKGAA 999
Cdd:PRK13800  682 VLPPapALRDHLGSPDPVVRAAALDVLRALRA-------------------------GDAALFAAALGDPD-HRVRIEAV 735
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  1000 YGLAGLvkglgilslkqqEMMAALTDAIQDKKnfrrREGALFAFEMLCTMlgklfEPYVVHVLPHLLLCFGDGNQYVREA 1079
Cdd:PRK13800  736 RALVSV------------DDVESVAGAATDEN----REVRIAVAKGLATL-----GAGGAPAGDAVRALTGDPDPLVRAA 794
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  1080 AddcakavMSNLSAHGV-KLVLPSLLAALEEESWRTKAGSVELLGAMAycapkqlsscLPNIVPKLTEVLTDSHVKVQKA 1158
Cdd:PRK13800  795 A-------LAALAELGCpPDDVAAATAALRASAWQVRQGAARALAGAA----------ADVAVPALVEALTDPHLDVRKA 857
                         330       340       350
                  ....*....|....*....|....*....|
gi 52139023  1159 GQQALrqigsvIRNPEILAIAPVLLDALTD 1188
Cdd:PRK13800  858 AVLAL------TRWPGDPAARDALTTALTD 881
HEAT COG1413
HEAT repeat [General function prediction only];
1138-1285 8.51e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1138 PNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVirnpeilAIAPVLLDALTDPSRKTQK-CLQTLLDTKFVHFIDApslal 1216
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGDP-------RAVPALLEALKDPDPEVRAaAAEALGRIGDPEAVPA----- 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52139023 1217 impiVQRAFQDRSTDTRKMAAQIIGNMYSltdqkdlapylPSVTPGLKASLLDPVPEVRTVSAKALGAM 1285
Cdd:COG1413   83 ----LIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
1112-1166 3.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 3.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 52139023   1112 WRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQI 1166
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
995-1167 1.02e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.55  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  995 RKGAAYGLAglvkglgilSLKQQEMMAALTDAIQDKkNFRRREGALFAfemlctmLGKLFEPYVVhvlPHLLLCFGDGNQ 1074
Cdd:COG1413    2 RRAAARALG---------RLGDPAAVPALIAALADE-DPDVRAAAARA-------LGRLGDPRAV---PALLEALKDPDP 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1075 YVREAAddcAKAvmsnLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAYcapkqlssclPNIVPKLTEVLTDSHVK 1154
Cdd:COG1413   62 EVRAAA---AEA----LGRIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWE 124
                        170
                 ....*....|...
gi 52139023 1155 VQKAGQQALRQIG 1167
Cdd:COG1413  125 VRRAAARALGRLG 137
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
849-1188 1.36e-04

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 46.38  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023   849 LDSSQVKPLFQFfvpdaLNDRNPDVRKcmldAALATLNAHgkenvnsLLPVFEEFLKDAPND-------ASYDAVRQSVV 921
Cdd:PRK13800  618 LDAPSVAELAPY-----LADPDPGVRR----TAVAVLTET-------TPPGFGPALVAALGDgaaavrrAAAEGLRELVE 681
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023   922 VLMG--SLAKHLDKSDPKVKPIVAKLIAALSTpsqqvqesvasclpplvpavkedagGMIQRLMQQLLESDkYAERKGAA 999
Cdd:PRK13800  682 VLPPapALRDHLGSPDPVVRAAALDVLRALRA-------------------------GDAALFAAALGDPD-HRVRIEAV 735
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  1000 YGLAGLvkglgilslkqqEMMAALTDAIQDKKnfrrREGALFAFEMLCTMlgklfEPYVVHVLPHLLLCFGDGNQYVREA 1079
Cdd:PRK13800  736 RALVSV------------DDVESVAGAATDEN----REVRIAVAKGLATL-----GAGGAPAGDAVRALTGDPDPLVRAA 794
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023  1080 AddcakavMSNLSAHGV-KLVLPSLLAALEEESWRTKAGSVELLGAMAycapkqlsscLPNIVPKLTEVLTDSHVKVQKA 1158
Cdd:PRK13800  795 A-------LAALAELGCpPDDVAAATAALRASAWQVRQGAARALAGAA----------ADVAVPALVEALTDPHLDVRKA 857
                         330       340       350
                  ....*....|....*....|....*....|
gi 52139023  1159 GQQALrqigsvIRNPEILAIAPVLLDALTD 1188
Cdd:PRK13800  858 AVLAL------TRWPGDPAARDALTTALTD 881
HEAT COG1413
HEAT repeat [General function prediction only];
1076-1243 1.86e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 42.69  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1076 VREAAddcAKAvmsnLSAHGVKLVLPSLLAALEEESWRTKAGSVELLGAMAycapkqlsscLPNIVPKLTEVLTDSHVKV 1155
Cdd:COG1413    1 VRRAA---ARA----LGRLGDPAAVPALIAALADEDPDVRAAAARALGRLG----------DPRAVPALLEALKDPDPEV 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1156 QKAGQQALRQIGSVirnpeilAIAPVLLDALTDPSRKTQK-CLQTLldtkfvHFIDAPSlalIMPIVQRAFQDRSTDTRK 1234
Cdd:COG1413   64 RAAAAEALGRIGDP-------EAVPALIAALKDEDPEVRRaAAEAL------GRLGDPA---AVPALLEALKDPDWEVRR 127

                 ....*....
gi 52139023 1235 MAAQIIGNM 1243
Cdd:COG1413  128 AAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
1138-1285 8.51e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52139023 1138 PNIVPKLTEVLTDSHVKVQKAGQQALRQIGSVirnpeilAIAPVLLDALTDPSRKTQK-CLQTLLDTKFVHFIDApslal 1216
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGDP-------RAVPALLEALKDPDPEVRAaAAEALGRIGDPEAVPA----- 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 52139023 1217 impiVQRAFQDRSTDTRKMAAQIIGNMYSltdqkdlapylPSVTPGLKASLLDPVPEVRTVSAKALGAM 1285
Cdd:COG1413   83 ----LIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
1112-1166 3.77e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 3.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 52139023   1112 WRTKAGSVELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQI 1166
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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