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Conserved domains on  [gi|59808742|gb|AAH89785|]
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SEC14-like 2 (S. cerevisiae) [Rattus norvegicus]

Protein Classification

SEC14 family lipid-binding protein( domain architecture ID 11280085)

SEC14 family lipid-binding protein contains a lipid-binding domain that is found in secretory proteins and in lipid regulated proteins

Gene Ontology:  GO:1902936|GO:0008289
PubMed:  12767229|17428729

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
76-244 3.59e-44

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


:

Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 150.53  E-value: 3.59e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742     76 PPEVIQQYLSGGRcGYDLDGCPVWYDIIGPLDAKgllfSASKQDLLRTKMRDCELLLQEcthqtAKLGKKIETITMIYDC 155
Cdd:smart00516   1 ELELLKAYIPGGR-GYDKDGRPVLIERAGRFDLK----SVTLEELLRYLVYVLEKILQE-----EKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742    156 EGLGLKHlwkPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPD 235
Cdd:smart00516  71 KGLSMSN---PDLSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIDKE 147

                   ....*....
gi 59808742    236 QLPVEYGGT 244
Cdd:smart00516 148 QLPEELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
13-59 3.26e-12

CRAL/TRIO, N-terminal domain;


:

Pssm-ID: 215024  Cd Length: 48  Bit Score: 60.64  E-value: 3.26e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 59808742     13 EEALAKFRENVQDVLPALP-NPDDYFLLRWLRARSFDLQKSEAMLRKH 59
Cdd:smart01100   1 EEALEELRELLEKHPDLLPpRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
 
Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
76-244 3.59e-44

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 150.53  E-value: 3.59e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742     76 PPEVIQQYLSGGRcGYDLDGCPVWYDIIGPLDAKgllfSASKQDLLRTKMRDCELLLQEcthqtAKLGKKIETITMIYDC 155
Cdd:smart00516   1 ELELLKAYIPGGR-GYDKDGRPVLIERAGRFDLK----SVTLEELLRYLVYVLEKILQE-----EKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742    156 EGLGLKHlwkPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPD 235
Cdd:smart00516  71 KGLSMSN---PDLSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIDKE 147

                   ....*....
gi 59808742    236 QLPVEYGGT 244
Cdd:smart00516 148 QLPEELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
86-243 1.73e-39

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 138.16  E-value: 1.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742    86 GGRCGYDLDGCPVWYDIIGPLDAKgllfSASKQDLLRTKMRDCELLLQECTHqtaklgKKIETITMIYDCEGLGLKHLWK 165
Cdd:pfam00650   4 VYLHGRDKEGRPVLYLRLGRHDPK----KSSEEELVRFLVLVLERALLLMPE------GQVEGLTVIIDLKGLSLSNMDW 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59808742   166 PAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQLPVEYGG 243
Cdd:pfam00650  74 WSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPPEQLPKEYGG 151
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
77-244 4.21e-38

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 134.77  E-value: 4.21e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742  77 PEVIQQYLSG--GRCGYDLDGCPVWYDIIGpLDAKGLLFSaskQDLLRTKMRDCELLLQECTHQtaklgkkIETITMIYD 154
Cdd:cd00170   1 LEELLELLGGigYLGGRDKEGRPVLVFRAG-WDPPKLLDL---EELLRYLVYLLEKALRELEEQ-------VEGFVVIID 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742 155 CEGLGLKHLWkpAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEvLLKHISP 234
Cdd:cd00170  70 LKGFSLSNLS--DLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEE-LLEYIDP 146
                       170
                ....*....|
gi 59808742 235 DQLPVEYGGT 244
Cdd:cd00170 147 DQLPKELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
13-59 3.26e-12

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 60.64  E-value: 3.26e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 59808742     13 EEALAKFRENVQDVLPALP-NPDDYFLLRWLRARSFDLQKSEAMLRKH 59
Cdd:smart01100   1 EEALEELRELLEKHPDLLPpRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
15-58 1.41e-04

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 39.18  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 59808742    15 ALAKFRENVQDVLPALPN---------PDDYFLLRWLRARSFDLQKSEAMLRK 58
Cdd:pfam03765   1 AYDELLELLKDEDEETDRekfwltredHDDVCLLRFLRARKWDVEKAIKMLED 53
 
Name Accession Description Interval E-value
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
76-244 3.59e-44

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 150.53  E-value: 3.59e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742     76 PPEVIQQYLSGGRcGYDLDGCPVWYDIIGPLDAKgllfSASKQDLLRTKMRDCELLLQEcthqtAKLGKKIETITMIYDC 155
Cdd:smart00516   1 ELELLKAYIPGGR-GYDKDGRPVLIERAGRFDLK----SVTLEELLRYLVYVLEKILQE-----EKKTGGIEGFTVIFDL 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742    156 EGLGLKHlwkPAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPD 235
Cdd:smart00516  71 KGLSMSN---PDLSVLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVGNDSKEELLEYIDKE 147

                   ....*....
gi 59808742    236 QLPVEYGGT 244
Cdd:smart00516 148 QLPEELGGT 156
CRAL_TRIO pfam00650
CRAL/TRIO domain;
86-243 1.73e-39

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 138.16  E-value: 1.73e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742    86 GGRCGYDLDGCPVWYDIIGPLDAKgllfSASKQDLLRTKMRDCELLLQECTHqtaklgKKIETITMIYDCEGLGLKHLWK 165
Cdd:pfam00650   4 VYLHGRDKEGRPVLYLRLGRHDPK----KSSEEELVRFLVLVLERALLLMPE------GQVEGLTVIIDLKGLSLSNMDW 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 59808742   166 PAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQLPVEYGG 243
Cdd:pfam00650  74 WSISLLKKIIKILQDNYPERLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKNSNEEELEKYIPPEQLPKEYGG 151
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
77-244 4.21e-38

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 134.77  E-value: 4.21e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742  77 PEVIQQYLSG--GRCGYDLDGCPVWYDIIGpLDAKGLLFSaskQDLLRTKMRDCELLLQECTHQtaklgkkIETITMIYD 154
Cdd:cd00170   1 LEELLELLGGigYLGGRDKEGRPVLVFRAG-WDPPKLLDL---EELLRYLVYLLEKALRELEEQ-------VEGFVVIID 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742 155 CEGLGLKHLWkpAVEAYGEFLTMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEvLLKHISP 234
Cdd:cd00170  70 LKGFSLSNLS--DLSLLKKLLKILQDHYPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSDLEE-LLEYIDP 146
                       170
                ....*....|
gi 59808742 235 DQLPVEYGGT 244
Cdd:cd00170 147 DQLPKELGGT 156
CRAL_TRIO_N smart01100
CRAL/TRIO, N-terminal domain;
13-59 3.26e-12

CRAL/TRIO, N-terminal domain;


Pssm-ID: 215024  Cd Length: 48  Bit Score: 60.64  E-value: 3.26e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 59808742     13 EEALAKFRENVQDVLPALP-NPDDYFLLRWLRARSFDLQKSEAMLRKH 59
Cdd:smart01100   1 EEALEELRELLEKHPDLLPpRLDDAFLLRFLRARKFDVEKAKEMLEKY 48
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
129-244 3.20e-05

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 43.47  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 59808742   129 ELLLQECTHqtaKLGKKIET--ITMIYDCEGLGLKHLwkpaveAYGEFLT----MFEENYPETLKRLFVVKAPKLFPVAY 202
Cdd:pfam13716  23 DRLLFYLLK---TLSEKLKGkpFVVVVDHTGVTSENF------PSLSFLKkaydLLPRAFKKNLKAVYVVHPSTFLRTFL 93
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 59808742   203 N-LIKPFLSEDTRKKIMVLGAnwKEVLLKHISPDQLPVEYGGT 244
Cdd:pfam13716  94 KtLGSLLGSKKLRKKVHYVSS--LSELWEGIDREQLPTELPGV 134
CRAL_TRIO_N pfam03765
CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.
15-58 1.41e-04

CRAL/TRIO, N-terminal domain; This all-alpha domain is found to the N-terminus of pfam00650.


Pssm-ID: 461043  Cd Length: 53  Bit Score: 39.18  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 59808742    15 ALAKFRENVQDVLPALPN---------PDDYFLLRWLRARSFDLQKSEAMLRK 58
Cdd:pfam03765   1 AYDELLELLKDEDEETDRekfwltredHDDVCLLRFLRARKWDVEKAIKMLED 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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