|
Name |
Accession |
Description |
Interval |
E-value |
| BACK_KBTBD11_CMLAP |
cd18484 |
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ... |
236-311 |
2.48e-35 |
|
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.
:
Pssm-ID: 350559 Cd Length: 77 Bit Score: 127.50 E-value: 2.48e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 133777198 236 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDS 311
Cdd:cd18484 1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELNDVFER 77
|
|
| NanM |
COG3055 |
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
316-535 |
2.95e-21 |
|
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
:
Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 94.07 E-value: 2.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 316 CYDDEQDVWRPLARMPPEAVSRGCAIcSLFNYLFVVSGCQG--PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVAL 393
Cdd:COG3055 42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTGanPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 394 DGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAhTATVRAKEIFVTGGslrfllFRFSAQEQRWWAGPTG 469
Cdd:COG3055 121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLAPL 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133777198 470 GSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPyPDAFQCAVVDNLIYCVG 535
Cdd:COG3055 194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTP-RHGHAAVLTDGKVYVIG 258
|
|
| PHA03378 super family |
cl33729 |
EBNA-3B; Provisional |
110-234 |
2.00e-03 |
|
EBNA-3B; Provisional
The actual alignment was detected with superfamily member PHA03378:
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.21 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 110 GRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTrgfsrkesllQIAENPELQLQPDGFR 189
Cdd:PHA03378 692 GTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRAR----------PPAAAPGRARPPAAAP 761
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 133777198 190 LPAPPcpdPGALPGLGRSSREPHVQPVAGTNFFHIPlTPASAPQV 234
Cdd:PHA03378 762 GRARP---PAAAPGAPTPQPPPQAPPAPQQRPRGAP-TPQPPPQA 802
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BACK_KBTBD11_CMLAP |
cd18484 |
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ... |
236-311 |
2.48e-35 |
|
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.
Pssm-ID: 350559 Cd Length: 77 Bit Score: 127.50 E-value: 2.48e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 133777198 236 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDS 311
Cdd:cd18484 1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELNDVFER 77
|
|
| NanM |
COG3055 |
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
316-535 |
2.95e-21 |
|
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 94.07 E-value: 2.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 316 CYDDEQDVWRPLARMPPEAVSRGCAIcSLFNYLFVVSGCQG--PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVAL 393
Cdd:COG3055 42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTGanPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 394 DGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAhTATVRAKEIFVTGGslrfllFRFSAQEQRWWAGPTG 469
Cdd:COG3055 121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLAPL 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133777198 470 GSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPyPDAFQCAVVDNLIYCVG 535
Cdd:COG3055 194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTP-RHGHAAVLTDGKVYVIG 258
|
|
| PHA03098 |
PHA03098 |
kelch-like protein; Provisional |
337-535 |
3.24e-11 |
|
kelch-like protein; Provisional
Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 65.94 E-value: 3.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 337 RGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYD 412
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWK 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 413 PRLDRWDFAPPLPSDTFALAhtATVRAKEIFVTGGSLRF-----LLFRFSAQEQRWWAG-PT-----GGSKDRTAEMVAV 481
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNdellkTVECFSLNTNKWSKGsPLpishyGGCAIYHDGKIYV 442
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 133777198 482 NGFLYRFDLNRSLGIaVYRCSASTRLWYECATYRTPYPDAFQCaVVDNLIYCVG 535
Cdd:PHA03098 443 IGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLC-IFNNKIYVVG 494
|
|
| Kelch_1 |
pfam01344 |
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
384-425 |
3.35e-09 |
|
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 52.61 E-value: 3.35e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 133777198 384 ARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLP 425
Cdd:pfam01344 1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
|
|
| Kelch |
smart00612 |
Kelch domain; |
396-426 |
1.62e-06 |
|
Kelch domain;
Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 44.86 E-value: 1.62e-06
10 20 30
....*....|....*....|....*....|....*
gi 133777198 396 HLYAIGG----ECLNSVERYDPRLDRWDFAPPLPS 426
Cdd:smart00612 1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPT 35
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
110-234 |
2.00e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.21 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 110 GRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTrgfsrkesllQIAENPELQLQPDGFR 189
Cdd:PHA03378 692 GTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRAR----------PPAAAPGRARPPAAAP 761
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 133777198 190 LPAPPcpdPGALPGLGRSSREPHVQPVAGTNFFHIPlTPASAPQV 234
Cdd:PHA03378 762 GRARP---PAAAPGAPTPQPPPQAPPAPQQRPRGAP-TPQPPPQA 802
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BACK_KBTBD11_CMLAP |
cd18484 |
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ... |
236-311 |
2.48e-35 |
|
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.
Pssm-ID: 350559 Cd Length: 77 Bit Score: 127.50 E-value: 2.48e-35
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 133777198 236 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDS 311
Cdd:cd18484 1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELNDVFER 77
|
|
| NanM |
COG3055 |
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
316-535 |
2.95e-21 |
|
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 94.07 E-value: 2.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 316 CYDDEQDVWRPLARMPPEAVSRGCAIcSLFNYLFVVSGCQG--PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVAL 393
Cdd:COG3055 42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTGanPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 394 DGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAhTATVRAKEIFVTGGslrfllFRFSAQEQRWWAGPTG 469
Cdd:COG3055 121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGG------RNGSGFSNTWTTLAPL 193
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133777198 470 GSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPyPDAFQCAVVDNLIYCVG 535
Cdd:COG3055 194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWTALGELPTP-RHGHAAVLTDGKVYVIG 258
|
|
| NanM |
COG3055 |
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
324-447 |
5.96e-14 |
|
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 72.50 E-value: 5.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 324 WRPLARMPpEAVSRGCAiCSLFNYLFVVSGCQGPGhqPSSRVFCYNPLTGIWSEVCPLN-QARPHCRLVALDGHLYAIGG 402
Cdd:COG3055 3 WSSLPDLP-TPRSEAAA-ALLDGKVYVAGGLSGGS--ASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 133777198 403 --------ECLNSVERYDPRLDRWDFAPPLPSDTFalAHTATVRAKEIFVTGG 447
Cdd:COG3055 79 ftganpssTPLNDVYVYDPATNTWTKLAPMPTPRG--GATALLLDGKIYVVGG 129
|
|
| NanM |
COG3055 |
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
294-450 |
9.67e-12 |
|
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 65.95 E-value: 9.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 294 LRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMpPEAVSRGCAICSLFNYLFVVSGCQGPGHqpssrvfcynplTG 373
Cdd:COG3055 119 LLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPL-PTPRDHLAAAVLPDGKILVIGGRNGSGF------------SN 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 374 IWSEVCPLNQARPHCRLVALDGHLYAIGGEC--LNSVERYDPRLDRWDFAPPLPsdtFALAHTATVRAK-EIFVTGGSLR 450
Cdd:COG3055 186 TWTTLAPLPTARAGHAAAVLGGKILVFGGESgfSDEVEAYDPATNTWTALGELP---TPRHGHAAVLTDgKVYVIGGETK 262
|
|
| PHA03098 |
PHA03098 |
kelch-like protein; Provisional |
337-535 |
3.24e-11 |
|
kelch-like protein; Provisional
Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 65.94 E-value: 3.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 337 RGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYD 412
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWK 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 413 PRLDRWDFAPPLPSDTFALAhtATVRAKEIFVTGGSLRF-----LLFRFSAQEQRWWAG-PT-----GGSKDRTAEMVAV 481
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNdellkTVECFSLNTNKWSKGsPLpishyGGCAIYHDGKIYV 442
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 133777198 482 NGFLYRFDLNRSLGIaVYRCSASTRLWYECATYRTPYPDAFQCaVVDNLIYCVG 535
Cdd:PHA03098 443 IGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLC-IFNNKIYVVG 494
|
|
| NanM |
COG3055 |
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; |
375-535 |
1.68e-10 |
|
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 62.10 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 375 WSEVCPLNQARPHCRLVALDGHLYAIGGEC----LNSVERYDPRLDRWDFAPPLPsdTFALAHTATVRAK-EIFVTGG-- 447
Cdd:COG3055 3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSggsaSNSFEVYDPATNTWSELAPLP--GPPRHHAAAVAQDgKLYVFGGft 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 448 ----SLRFL--LFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF---DLNRSLGiAVYRCSASTRLWYECATYRTPy 518
Cdd:COG3055 81 ganpSSTPLndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVggwDDGGNVA-WVEVYDPATGTWTQLAPLPTP- 158
|
170
....*....|....*...
gi 133777198 519 PDAFQCAVV-DNLIYCVG 535
Cdd:COG3055 159 RDHLAAAVLpDGKILVIG 176
|
|
| Kelch_1 |
pfam01344 |
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
384-425 |
3.35e-09 |
|
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 52.61 E-value: 3.35e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 133777198 384 ARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLP 425
Cdd:pfam01344 1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
|
|
| PHA03098 |
PHA03098 |
kelch-like protein; Provisional |
316-426 |
9.69e-08 |
|
kelch-like protein; Provisional
Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 54.77 E-value: 9.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 316 CYDDEQDVWRPLARMPpEAVSRGCAIcSLFNYLFVVSGCQ-GPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALD 394
Cdd:PHA03098 410 CFSLNTNKWSKGSPLP-ISHYGGCAI-YHDGKIYVIGGISyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFN 487
|
90 100 110
....*....|....*....|....*....|....*.
gi 133777198 395 GHLYAIGGECLNS----VERYDPRLDRWDFAPPLPS 426
Cdd:PHA03098 488 NKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFPK 523
|
|
| BACK_KLHL42_KLHDC5 |
cd18478 |
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ... |
236-328 |
2.11e-07 |
|
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.
Pssm-ID: 350553 Cd Length: 103 Bit Score: 49.38 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 236 LDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAeRELILQRRLRGRQYLVV----ADVCPKEDS 311
Cdd:cd18478 1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSL-KQQLRERRLRGTPALVAlgdfLGTPLDPYQ 79
|
90 100
....*....|....*....|
gi 133777198 312 GGLCC---YDDEQDVWRPLA 328
Cdd:cd18478 80 DEPWSmlrYDEVEQRWLPLA 99
|
|
| Kelch |
smart00612 |
Kelch domain; |
396-426 |
1.62e-06 |
|
Kelch domain;
Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 44.86 E-value: 1.62e-06
10 20 30
....*....|....*....|....*....|....*
gi 133777198 396 HLYAIGG----ECLNSVERYDPRLDRWDFAPPLPS 426
Cdd:smart00612 1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPT 35
|
|
| BACK |
cd14733 |
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ... |
237-276 |
2.55e-05 |
|
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.
Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 41.88 E-value: 2.55e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 133777198 237 DLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPD 276
Cdd:cd14733 1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE 40
|
|
| Kelch_6 |
pfam13964 |
Kelch motif; |
390-425 |
1.15e-04 |
|
Kelch motif;
Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 40.01 E-value: 1.15e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 133777198 390 LVALDGHLYAIGGEC-----LNSVERYDPRLDRWDFAPPLP 425
Cdd:pfam13964 7 VVSVGGYIYVFGGYTnaspaLNKLEVYNPLTKSWEELPPLP 47
|
|
| Kelch |
smart00612 |
Kelch domain; |
348-395 |
3.37e-04 |
|
Kelch domain;
Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 38.69 E-value: 3.37e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 133777198 348 LFVVSGCqgPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDG 395
Cdd:smart00612 2 IYVVGGF--DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
|
|
| Kelch_1 |
pfam01344 |
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ... |
337-378 |
6.90e-04 |
|
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 37.59 E-value: 6.90e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 133777198 337 RGCAICSLFNYLFVVSGCQGpgHQPSSRVFCYNPLTGIWSEV 378
Cdd:pfam01344 3 SGAGVVVVGGKIYVIGGFDG--NQSLNSVEVYDPETNTWSKL 42
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
110-234 |
2.00e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.21 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133777198 110 GRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTrgfsrkesllQIAENPELQLQPDGFR 189
Cdd:PHA03378 692 GTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRAR----------PPAAAPGRARPPAAAP 761
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 133777198 190 LPAPPcpdPGALPGLGRSSREPHVQPVAGTNFFHIPlTPASAPQV 234
Cdd:PHA03378 762 GRARP---PAAAPGAPTPQPPPQAPPAPQQRPRGAP-TPQPPPQA 802
|
|
| Kelch_6 |
pfam13964 |
Kelch motif; |
346-385 |
6.16e-03 |
|
Kelch motif;
Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 35.00 E-value: 6.16e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 133777198 346 NYLFVVSGcQGPGHQPSSRVFCYNPLTGIWSEVCPLNQAR 385
Cdd:pfam13964 12 GYIYVFGG-YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
|
|
| |
