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Conserved domains on  [gi|77748370|gb|AAI05909|]
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Biphenyl hydrolase-like (serine hydrolase) [Rattus norvegicus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-291 1.81e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 155.54  E-value: 1.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  40 TSAKAAVNGIHLHYQRVGEGEHAVLLLPGMLGSGkTDFAPQLQSLnKKRFTLVAWDPRGYGESRPPDRDFPrdfFERDAK 119
Cdd:COG0596   3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSS-YEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 120 DAVDLMKALQFKQVSLLGWSDGGITALIAAAKYPSYIRKMVIwganayVTEEDSRIYQGIRDVSKWSEKARKPLEALYGH 199
Cdd:COG0596  78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 200 DYfaktcekwvdginqfkhlpdgnicRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGSRLHLMPEGKHNLHLRFA 279
Cdd:COG0596 152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                       250
                ....*....|..
gi 77748370 280 DEFNRLVEDFLQ 291
Cdd:COG0596 208 EAFAAALRDFLA 219
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-291 1.81e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 155.54  E-value: 1.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  40 TSAKAAVNGIHLHYQRVGEGEHAVLLLPGMLGSGkTDFAPQLQSLnKKRFTLVAWDPRGYGESRPPDRDFPrdfFERDAK 119
Cdd:COG0596   3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSS-YEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 120 DAVDLMKALQFKQVSLLGWSDGGITALIAAAKYPSYIRKMVIwganayVTEEDSRIYQGIRDVSKWSEKARKPLEALYGH 199
Cdd:COG0596  78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 200 DYfaktcekwvdginqfkhlpdgnicRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGSRLHLMPEGKHNLHLRFA 279
Cdd:COG0596 152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                       250
                ....*....|..
gi 77748370 280 DEFNRLVEDFLQ 291
Cdd:COG0596 208 EAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 62-276 1.13e-23

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 96.42  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370    62 AVLLLPGMLGSGKtDFAPQLQSLNKKRFTLVAWDPRGYGESRPP--DRDFPRDFFerdAKDAVDLMKALQFKQVSLLGWS 139
Cdd:pfam00561   2 PVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDL---AEDLEYILEALGLEKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   140 DGGITALIAAAKYPSYIRKMVIWGANAYVTEEDSRIYQGIRDVSKWSEKAR----KPLEALYGHDYFAKTC--------- 206
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVadfaPNPLGRLVAKLLALLLlrlrllkal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   207 -----EKWVDGINQFKHLPDGNI----------CRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGSRLHLMPEGK 271
Cdd:pfam00561 158 pllnkRFPSGDYALAKSLVTGALlfietwstelRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*
gi 77748370   272 HNLHL 276
Cdd:pfam00561 238 HFAFL 242
PRK06489 PRK06489
hypothetical protein; Provisional
 51-153 4.98e-03

hypothetical protein; Provisional


Pssm-ID: 235815 [Multi-domain]  Cd Length: 360  Bit Score: 38.04  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   51 LHYQRVGE------GE--HAVLLLPGMLGSGKT----DFAPQL----QSLNKKRFTLVAWDPRGYGESRPPDrDFPRDFF 114
Cdd:PRK06489  52 LHYTTLGTphrnadGEidNAVLVLHGTGGSGKSflspTFAGELfgpgQPLDASKYFIILPDGIGHGKSSKPS-DGLRAAF 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 77748370  115 ER-DAKDAVD-----LMKALQFKQVSL-LGWSDGGITALIAAAKYP 153
Cdd:PRK06489 131 PRyDYDDMVEaqyrlVTEGLGVKHLRLiLGTSMGGMHAWMWGEKYP 176
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 40-291 1.81e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 155.54  E-value: 1.81e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  40 TSAKAAVNGIHLHYQRVGEGEHAVLLLPGMLGSGkTDFAPQLQSLnKKRFTLVAWDPRGYGESRPPDRDFPrdfFERDAK 119
Cdd:COG0596   3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSS-YEWRPLIPAL-AAGYRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 120 DAVDLMKALQFKQVSLLGWSDGGITALIAAAKYPSYIRKMVIwganayVTEEDSRIYQGIRDVSKWSEKARKPLEALYGH 199
Cdd:COG0596  78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 200 DYfaktcekwvdginqfkhlpdgnicRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGSRLHLMPEGKHNLHLRFA 279
Cdd:COG0596 152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                       250
                ....*....|..
gi 77748370 280 DEFNRLVEDFLQ 291
Cdd:COG0596 208 EAFAAALRDFLA 219
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
59-291 1.69e-24

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 98.86  E-value: 1.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  59 GEHAVLLLPGmLGSGKTDFAPQLQSLNKKRFTLVAWDPRGYGESRPPDRDF-PRDFFErDAKDAVDLMKAlQFKQVSLLG 137
Cdd:COG1647  14 GRKGVLLLHG-FTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTtWEDWLE-DVEEAYEILKA-GYDKVIVIG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 138 WSDGGITALIAAAKYPSyIRKMVIWGANAYVTEEDSRI----YQGIRDVSKWSEKARKPLEALYGHDYFaktcekWVDGI 213
Cdd:COG1647  91 LSMGGLLALLLAARYPD-VAGLVLLSPALKIDDPSAPLlpllKYLARSLRGIGSDIEDPEVAEYAYDRT------PLRAL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 214 NQFKHLpdGNICRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGS--RLHLMPEGKHNLHL-RFADEFNRLVEDFL 290
Cdd:COG1647 164 AELQRL--IREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPdkELVWLEDSGHVITLdKDREEVAEEILDFL 241


                .
gi 77748370 291 Q 291
Cdd:COG1647 242 E 242
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 62-276 1.13e-23

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 96.42  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370    62 AVLLLPGMLGSGKtDFAPQLQSLNKKRFTLVAWDPRGYGESRPP--DRDFPRDFFerdAKDAVDLMKALQFKQVSLLGWS 139
Cdd:pfam00561   2 PVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDL---AEDLEYILEALGLEKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   140 DGGITALIAAAKYPSYIRKMVIWGANAYVTEEDSRIYQGIRDVSKWSEKAR----KPLEALYGHDYFAKTC--------- 206
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVadfaPNPLGRLVAKLLALLLlrlrllkal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   207 -----EKWVDGINQFKHLPDGNI----------CRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGSRLHLMPEGK 271
Cdd:pfam00561 158 pllnkRFPSGDYALAKSLVTGALlfietwstelRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*
gi 77748370   272 HNLHL 276
Cdd:pfam00561 238 HFAFL 242
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
45-291 4.13e-23

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 94.30  E-value: 4.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  45 AVNGIHLHYQR---VGEGEHAVLLLPGMLGSGKTdFAPQLQSLNKKRFTLVAWDPRGYGESRPPDRDFPR-DFFERDAKD 120
Cdd:COG2267  10 TRDGLRLRGRRwrpAGSPRGTVVLVHGLGEHSGR-YAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSfDDYVDDLRA 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 121 AVDLMKALQFKQVSLLGWSDGGITALIAAAKYPSYIRKMVIWGAnAYVTEEDSRIYQGirdvskwsekarkplealyghd 200
Cdd:COG2267  89 ALDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP-AYRADPLLGPSAR---------------------- 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 201 yfaktcekWVDGINQFKHLPDgnicrhllplIQCPTLIVHGEKDPLVPRFHADFLLEHV-KGSRLHLMPEGKHNLHL-RF 278
Cdd:COG2267 146 --------WLRALRLAEALAR----------IDVPVLVLHGGADRVVPPEAARRLAARLsPDVELVLLPGARHELLNePA 207

                       250
                ....*....|...
gi 77748370 279 ADEFNRLVEDFLQ 291
Cdd:COG2267 208 REEVLAAILAWLE 220
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
62-290 9.44e-20

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 85.84  E-value: 9.44e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  62 AVLLLPGMLGSGKTDFAPQLQSLNKKRFTLVAWDPRGYGESRppdRDFPRDFFErDAKDAVDLMKALQF---KQVSLLGW 138
Cdd:COG1506  25 VVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESA---GDWGGDEVD-DVLAAIDYLAARPYvdpDRIGIYGH 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 139 SDGGITALIAAAKYPSYIRKMVIWGANAYVTEEDSRIYQGIRDVSKWSEKARKPLEALYGHDYFAKtcekwvdginqfkh 218
Cdd:COG1506 101 SYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERLMGGPWEDPEAYAARSPLAYADK-------------- 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 77748370 219 lpdgnicrhllplIQCPTLIVHGEKDPLVPRFHA----DFLLEHVKGSRLHLMPEGKHNLHLRFADEFNRLVEDFL 290
Cdd:COG1506 167 -------------LKTPLLLIHGEADDRVPPEQAerlyEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILDFL 229
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 62-291 1.21e-14

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 71.87  E-value: 1.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  62 AVLLLPGMlGSGKTDFAPQLQSLNKKRFTLVAWDPRGYGES--RPPDRDFPRdffERDAKDAVDLMKALQF---KQVSLL 136
Cdd:COG1073  39 AVVVAHGN-GGVKEQRALYAQRLAELGFNVLAFDYRGYGESegEPREEGSPE---RRDARAAVDYLRTLPGvdpERIGLL 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 137 GWSDGGITALIAAAKYPsyirkmviwGANAYVTeeDS---RIYQGIRDVSKWSEKARKPLEALYGHDYFAKTCEKWVDGI 213
Cdd:COG1073 115 GISLGGGYALNAAATDP---------RVKAVIL--DSpftSLEDLAAQRAKEARGAYLPGVPYLPNVRLASLLNDEFDPL 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 214 NQfkhlpdgnicrhlLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGS-RLHLMPEGKHN-LHLRFADEFNRLVEDFLQ 291
Cdd:COG1073 184 AK-------------IEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPkELLIVPGAGHVdLYDRPEEEYFDKLAEFFK 250
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 63-285 5.14e-12

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 64.03  E-value: 5.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370    63 VLLLPGMlgsgkTDFAPQLQSLNKKRFTLVAWDPRGYGESRPPDRDFPrdfferDAKDAVDLMKAL-QFKQVSLLGWSDG 141
Cdd:pfam12697   1 VVLVHGA-----GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLA------DLADLAALLDELgAARPVVLVGHSLG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   142 GITALIAAAkypSYIRKMVIWGANAYVTEEDSRIYQGIRDVSKWSEKARKPLEALYGHDYFAKTC--EKWVDGINQFKHL 219
Cdd:pfam12697  70 GAVALAAAA---AALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPadAEWAAALARLAAL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77748370   220 PDGNICRHLLPLIQCP-TLIVHGEKDPLVPRFHADfLLEHVKGSRLHLMPEGKHNLHLRfADEFNRL 285
Cdd:pfam12697 147 LAALALLPLAAWRDLPvPVLVLAEEDRLVPELAQR-LLAALAGARLVVLPGAGHLPLDD-PEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 62-275 1.84e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 56.84  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370    62 AVLLLPGMLG-SGKtdFAPQLQSLNKKRFTLVAWDPRGYGESRPPDRDFPR-DFFERDAKDAVDLMKALQ-FKQVSLLGW 138
Cdd:pfam12146   6 VVVLVHGLGEhSGR--YAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSfDDYVDDLDTFVDKIREEHpGLPLFLLGH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   139 SDGGITALIAAAKYPSYIRKMVIWGANAYVTEED------------SRIYQGIR--------DVSKWSEKARKplealYG 198
Cdd:pfam12146  84 SMGGLIAALYALRYPDKVDGLILSAPALKIKPYLappilkllakllGKLFPRLRvpnnllpdSLSRDPEVVAA-----YA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   199 HDyfaktceKWVDG---INQFKHLPD-GNICRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGS--RLHLMPEGKH 272
Cdd:pfam12146 159 AD-------PLVHGgisARTLYELLDaGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTdkTLKLYPGLYH 231


                  ...
gi 77748370   273 NLH 275
Cdd:pfam12146 232 ELL 234
YpfH COG0400
Predicted esterase [General function prediction only];
57-164 2.88e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 41.05  E-value: 2.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  57 GEGEHAVLLLPGmLGSGKTDFAPQLQSLNKKRFTLVAwdPRG----YGESR--PPDRDFPRDFFERDAKDAVDLMKA--- 127
Cdd:COG0400   2 GPAAPLVVLLHG-YGGDEEDLLPLAPELALPGAAVLA--PRApvpeGPGGRawFDLSFLEGREDEEGLAAAAEALAAfid 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 77748370 128 -------LQFKQVSLLGWSDGGITALIAAAKYPSYIRKMVIWGA 164
Cdd:COG0400  79 elearygIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSG 122
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
62-290 5.10e-04

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 40.72  E-value: 5.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  62 AVLLLPGMLGSGKT--DFAPQLQSLNkkrFTLVAWDPRGYGESRPPDRD-------FPRDFFERDAKDAVDLMKALQF-- 130
Cdd:COG0412  31 GVVVLHEIFGLNPHirDVARRLAAAG---YVVLAPDLYGRGGPGDDPDEaralmgaLDPELLAADLRAALDWLKAQPEvd 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 131 -KQVSLLGWSDGGITALIAAAKYPsyirkmviwGANAYVteedsriyqgirdvskwsekarkpleALYGHdyfaktcekw 209
Cdd:COG0412 108 aGRVGVVGFCFGGGLALLAAARGP---------DLAAAV--------------------------SFYGG---------- 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370 210 vdginqfkhlPDGNICRHLLPLIQCPTLIVHGEKDPLVPRFHADFLLEHVKGS----RLHLMPEGKHNLHLRFADEFN-- 283
Cdd:COG0412 143 ----------LPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALAAAgvdvELHVYPGAGHGFTNPGRPRYDpa 212

                       250
                ....*....|...
gi 77748370 284 ------RLVEDFL 290
Cdd:COG0412 213 aaedawQRTLAFL 225
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 235-248 3.96e-03

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 37.93  E-value: 3.96e-03
                          10
                  ....*....|....
gi 77748370   235 PTLIVHGEKDPLVP 248
Cdd:pfam20434 191 PFLIIHGDKDPLVP 204
PRK06489 PRK06489
hypothetical protein; Provisional
 51-153 4.98e-03

hypothetical protein; Provisional


Pssm-ID: 235815 [Multi-domain]  Cd Length: 360  Bit Score: 38.04  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370   51 LHYQRVGE------GE--HAVLLLPGMLGSGKT----DFAPQL----QSLNKKRFTLVAWDPRGYGESRPPDrDFPRDFF 114
Cdd:PRK06489  52 LHYTTLGTphrnadGEidNAVLVLHGTGGSGKSflspTFAGELfgpgQPLDASKYFIILPDGIGHGKSSKPS-DGLRAAF 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 77748370  115 ER-DAKDAVD-----LMKALQFKQVSL-LGWSDGGITALIAAAKYP 153
Cdd:PRK06489 131 PRyDYDDMVEaqyrlVTEGLGVKHLRLiLGTSMGGMHAWMWGEKYP 176
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
225-291 8.40e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 37.05  E-value: 8.40e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 77748370 225 CRHLLPLIQCPTLIVHGEKDPLVPrfHADFLLEHVKGSRLHLM----------PEGKHNLHLRFADefNRLVEdFLQ 291
Cdd:COG0429 249 ALPFLPQIRVPTLILNAADDPFLP--PECLPEAAELNPNVTLEltkhgghvgfISGKSPGRRYWLE--RRILE-FLD 320
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
234-291 9.24e-03

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 36.68  E-value: 9.24e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 77748370 234 CPTLIVHGEKDPLVPRFHADFLLEHVKGS-RLHLMPEGKHNLHlRFADEFNRLVEDFLQ 291
Cdd:COG2945 143 APTLVIHGEQDEVVPPAEVLDWARPLSPPlPVVVVPGADHFFH-GKLDELKELVARYLP 200
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 61-160 9.73e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.19  E-value: 9.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 77748370  61 HAVLLLPGMLGSGKTdFAPQLQSLNKKRFTLVAWDprgYgesrpPDRDFPRDFFERDAKDAVD-LMKALQFKQVSLLGWS 139
Cdd:COG1075   6 YPVVLVHGLGGSAAS-WAPLAPRLRAAGYPVYALN---Y-----PSTNGSIEDSAEQLAAFVDaVLAATGAEKVDLVGHS 76

                        90       100
                ....*....|....*....|...
gi 77748370 140 DGGITALIAAAKY--PSYIRKMV 160
Cdd:COG1075  77 MGGLVARYYLKRLggAAKVARVV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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