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Conserved domains on  [gi|118763811|gb|AAI28588|]
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ATG9B protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATG9 super family cl04403
Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 59-162 3.97e-19

Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.


The actual alignment was detected with superfamily member pfam04109:

Pssm-ID: 461177  Cd Length: 478  Bit Score: 89.09  E-value: 3.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118763811   59 RSFIPEEQCQGRaPQLLLQTALAHMHYLPEEPgpggRDRA-----YRQMAQLLQYRAVslleellsplltplfllfWF-- 131
Cdd:pfam04109 375 RGMIPDENLVFD-PEQLLREVIQHTHYLPDEW----KGKLhtdevRAEFSELFQLKIVifleells--iiltpfilWFsl 447

                          90       100       110
                  ....*....|....*....|....*....|.
gi 118763811  132 RPRALEIIDFFHHFTVDVAGVGDICSFALMD 162
Cdd:pfam04109 448 PKCSDEIIDFFREFTVHVDGLGYVCSFAVFD 478
 
Name Accession Description Interval E-value
ATG9 pfam04109
Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 59-162 3.97e-19

Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.


Pssm-ID: 461177  Cd Length: 478  Bit Score: 89.09  E-value: 3.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118763811   59 RSFIPEEQCQGRaPQLLLQTALAHMHYLPEEPgpggRDRA-----YRQMAQLLQYRAVslleellsplltplfllfWF-- 131
Cdd:pfam04109 375 RGMIPDENLVFD-PEQLLREVIQHTHYLPDEW----KGKLhtdevRAEFSELFQLKIVifleells--iiltpfilWFsl 447

                          90       100       110
                  ....*....|....*....|....*....|.
gi 118763811  132 RPRALEIIDFFHHFTVDVAGVGDICSFALMD 162
Cdd:pfam04109 448 PKCSDEIIDFFREFTVHVDGLGYVCSFAVFD 478
 
Name Accession Description Interval E-value
ATG9 pfam04109
Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 59-162 3.97e-19

Autophagy protein ATG9; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.


Pssm-ID: 461177  Cd Length: 478  Bit Score: 89.09  E-value: 3.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 118763811   59 RSFIPEEQCQGRaPQLLLQTALAHMHYLPEEPgpggRDRA-----YRQMAQLLQYRAVslleellsplltplfllfWF-- 131
Cdd:pfam04109 375 RGMIPDENLVFD-PEQLLREVIQHTHYLPDEW----KGKLhtdevRAEFSELFQLKIVifleells--iiltpfilWFsl 447

                          90       100       110
                  ....*....|....*....|....*....|.
gi 118763811  132 RPRALEIIDFFHHFTVDVAGVGDICSFALMD 162
Cdd:pfam04109 448 PKCSDEIIDFFREFTVHVDGLGYVCSFAVFD 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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