|
Name |
Accession |
Description |
Interval |
E-value |
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1327-1539 |
1.27e-113 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
:
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 357.32 E-value: 1.27e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1327 PHPSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGL 1406
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1407 DKLHNLTTgtTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSN 1485
Cdd:cd00087 80 EKIHLLTS--QGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 223460685 1486 CALTHHGGWWYKNCHLANPNGKYGETKH----SEGVNWEPWKGHEFSIPYVELKIRPF 1539
Cdd:cd00087 158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRPK 215
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
264-332 |
5.01e-15 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 71.68 E-value: 5.01e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223460685 264 APQGLQLLKSTENSLLVSWEP----SSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
972-1049 |
3.91e-13 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 66.28 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDP---VQADIDRYVVRYTSADGES--KEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1047 ESK 1049
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
532-608 |
9.59e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
:
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 65.33 E-value: 9.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVEAD-----IDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 607 ES 608
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
796-875 |
3.40e-12 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 3.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVE---ADIDRYVVRYTSVDGET--REFLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 223460685 871 ESRKT 875
Cdd:pfam00041 81 EGPPS 85
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1060-1136 |
4.22e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
:
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 63.40 E-value: 4.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDPVQAD-----IDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1135 ES 1136
Cdd:smart00060 82 EG 83
|
|
| FN3 super family |
cl27307 |
Fibronectin type 3 domain [General function prediction only]; |
857-1371 |
5.06e-12 |
|
Fibronectin type 3 domain [General function prediction only];
The actual alignment was detected with superfamily member COG3401:
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.80 E-value: 5.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 857 VEYQVDVWAQKGTQESRKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDG-ETKEVPVSKDKSS 935
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPtATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 936 TVLR--GLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESK 1013
Cdd:COG3401 104 GGATntGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1014 EFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTEGHTDI----DSPKNLVTNQVTENTATISWDPVQA-DIDR 1088
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTEsDATG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1089 YMV-RYTSADGETREIPVRKEKSSTVlTGLRPGVEYTVQVWAQKGA----RESKKAKTKAPTEI-DSPKNLVTNRVTENT 1162
Cdd:COG3401 264 YRVyRSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYYYRVTAVDAAgnesAPSNVVSVTTDLTPpAAPSGLTATAVGSSS 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1163 ATISWDPVR-ANIDRYMV-RYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQ-KGARESKKADTKALTEIDPPR 1239
Cdd:COG3401 343 ITLSWTASSdADVTGYNVyRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAAS 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1240 NL---RPFGVTHSGGVLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVaFKGNQRSRTVS 1316
Cdd:COG3401 423 GEsltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS-VTTGSLVGGSG 501
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1317 TTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGW 1371
Cdd:COG3401 502 ASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
620-696 |
2.26e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
:
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.09 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDPVQAN-----IDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 695 ES 696
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
710-781 |
4.47e-11 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 4.47e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223460685 710 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 781
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
359-434 |
1.67e-10 |
|
Fibronectin type III domain;
:
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.97 E-value: 1.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 359 VNEETETSLDVEWENPLT---EVDYYKLRYGPLTGQEV-TEVTVPKSrdpKSRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:pfam00041 8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
444-529 |
1.15e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
:
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 444 DGPTNVVTNQVTEDTASVSWDPVRAD---IDKYVVRYIAPDGETKEKAVPKDQSST--VLTGLKPGEAYKVFVWAERGNQ 518
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 519 GSKKADTKALT 529
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| EGF_Tenascin super family |
cl46594 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
171-198 |
1.38e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
The actual alignment was detected with superfamily member pfam18720:
Pssm-ID: 480934 Cd Length: 29 Bit Score: 46.14 E-value: 1.38e-06
10 20
....*....|....*....|....*...
gi 223460685 171 CPGACNGHGRCVDGQCVCDAPYVGVDCA 198
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| C_rich_MXAN6577 super family |
cl49352 |
MXAN_6577-like cysteine-rich domain; |
171-237 |
3.45e-05 |
|
MXAN_6577-like cysteine-rich domain;
The actual alignment was detected with superfamily member NF041328:
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 45.52 E-value: 3.45e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223460685 171 CPGACNGHGRCVDGQCVCDAPYV--GVDCAY--------AACPQDCSGHGVCVQGVCqchedftAEDCSE--QRCPGDC 237
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACVDtasdpahcGACGAACAPGQVCEGGAC-------REACSEglTRCGGAC 116
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
236-259 |
5.90e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 41.18 E-value: 5.90e-05
10 20
....*....|....*....|....*.
gi 223460685 236 DCSGNGFCD--TGECYCEMGFTGPDC 259
Cdd:pfam07974 1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
142-166 |
2.60e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
:
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 2.60e-04
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1327-1539 |
1.27e-113 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 357.32 E-value: 1.27e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1327 PHPSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGL 1406
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1407 DKLHNLTTgtTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSN 1485
Cdd:cd00087 80 EKIHLLTS--QGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 223460685 1486 CALTHHGGWWYKNCHLANPNGKYGETKH----SEGVNWEPWKGHEFSIPYVELKIRPF 1539
Cdd:cd00087 158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRPK 215
|
|
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1328-1539 |
2.84e-102 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 325.39 E-value: 2.84e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1328 HPSDCSQVQQNTNAASGLYTIYLNGdASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLD 1407
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1408 KLHNLTtgTTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDA-LTYHNGWKFTTFDRDNDIALSN 1485
Cdd:smart00186 80 NIHLLT--SQGKYELRIDLEDWeGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDAsLTYHNGMQFSTYDRDNDKYSGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1486 CALTHHGGWWYKNCHLANPNGKYG-ETKHSEGVNWEPWKGHEFSIPYVELKIRPF 1539
Cdd:smart00186 158 CAEEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1329-1538 |
5.66e-85 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 277.10 E-value: 5.66e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1329 PSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMK-EFWLGLD 1407
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGA-TKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPgEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1408 KLHNLTTgtTTRYEVRADLQTFN-ESAYAVYDFFQVASSKERYKLSVGKYRGTAGDAL-------TYHNGWKFTTFDRDN 1479
Cdd:pfam00147 81 KIHLLTK--QGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtagrsmTYHNGMQFSTWDRDN 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223460685 1480 DIALSNCALTHHGGWWYKNCHLANPNGKY--GETKHSE-GVNWEPWKGHEFSIPYVELKIRP 1538
Cdd:pfam00147 159 DSPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRP 220
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
264-332 |
5.01e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 71.68 E-value: 5.01e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223460685 264 APQGLQLLKSTENSLLVSWEP----SSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
972-1049 |
3.91e-13 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 66.28 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDP---VQADIDRYVVRYTSADGES--KEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1047 ESK 1049
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
532-608 |
9.59e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 65.33 E-value: 9.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVEAD-----IDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 607 ES 608
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
796-875 |
3.40e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 3.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVE---ADIDRYVVRYTSVDGET--REFLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 223460685 871 ESRKT 875
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
532-609 |
3.94e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 3.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVE---ADIDRYVVSYTSVDGET--KQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 607 ESK 609
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1060-1136 |
4.22e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 63.40 E-value: 4.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDPVQAD-----IDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1135 ES 1136
Cdd:smart00060 82 EG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
857-1371 |
5.06e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.80 E-value: 5.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 857 VEYQVDVWAQKGTQESRKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDG-ETKEVPVSKDKSS 935
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPtATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 936 TVLR--GLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESK 1013
Cdd:COG3401 104 GGATntGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1014 EFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTEGHTDI----DSPKNLVTNQVTENTATISWDPVQA-DIDR 1088
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTEsDATG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1089 YMV-RYTSADGETREIPVRKEKSSTVlTGLRPGVEYTVQVWAQKGA----RESKKAKTKAPTEI-DSPKNLVTNRVTENT 1162
Cdd:COG3401 264 YRVyRSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYYYRVTAVDAAgnesAPSNVVSVTTDLTPpAAPSGLTATAVGSSS 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1163 ATISWDPVR-ANIDRYMV-RYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQ-KGARESKKADTKALTEIDPPR 1239
Cdd:COG3401 343 ITLSWTASSdADVTGYNVyRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAAS 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1240 NL---RPFGVTHSGGVLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVaFKGNQRSRTVS 1316
Cdd:COG3401 423 GEsltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS-VTTGSLVGGSG 501
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1317 TTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGW 1371
Cdd:COG3401 502 ASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1148-1224 |
6.55e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 62.63 E-value: 6.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1148 DSPKNLVTNRVTENTATISWDPVRAN-----IDRYMVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1222
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1223 ES 1224
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1148-1225 |
9.29e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 9.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1148 DSPKNLVTNRVTENTATISWDP---VRANIDRYMVRYTSADGET--KEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1222
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1223 ESK 1225
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
972-1048 |
1.52e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.86 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDPVQAD-----IDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1047 ES 1048
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1060-1137 |
1.64e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDP---VQADIDRYMVRYTSADGET--REIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1135 ESK 1137
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
620-696 |
2.26e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.09 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDPVQAN-----IDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 695 ES 696
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
532-617 |
2.66e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.36 E-value: 2.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVEAD---IDRYVVSYTSVDGET-KQVPVKK-DQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 607 ESKKANTKAPT 617
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
593-1094 |
2.91e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 68.11 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 593 VEYKVYVWAEKGDRESKKANTKAPTDID----SPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADG-ETREVPVPK 667
Cdd:COG3401 20 NTAVNALSKAGGSGKTILVYLAVVLSVTtkesPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPtATGLTTLTG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 668 EKSSTVLTGLRPGVEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGE 747
Cdd:COG3401 100 SGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 748 TKEVPVSKDKSSTVLRGLR--PGVEYKVDVWAQKGAQDSRKANTKAPTDI----DSPKNLVTEQVTESTATVSWDPV-EA 820
Cdd:COG3401 180 VATTSLTVTSTTLVDGGGDiePGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVtES 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 821 DIDRYVVRYTSVDGETREFLVGKDQTSTVLTGMRPG--VEYQVDVWAQKGTqESRKTST-KAPTDI---DGPKNLVTDQV 894
Cdd:COG3401 260 DATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGttYYYRVTAVDAAGN-ESAPSNVvSVTTDLtppAAPSGLTATAV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 895 TETTLSVSWDPV-EADIDRYMV-RYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYK-----VDVWAQKGAQDSRKANTKA 967
Cdd:COG3401 339 GSSSITLSWTASsDADVTGYNVyRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGNESAPSEEVSATTA 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 968 PTD--------IDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIGkeqrsTVLTGLRPGVEYKVEV 1039
Cdd:COG3401 419 SAAsgesltasVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTV-----TATTTDTTTANLSVTT 493
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1040 WAQKGARESKKANTEGHTDIDSPKNLVTNQVTENTATISWDPVQADIDRYMVRYT 1094
Cdd:COG3401 494 GSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLIT 548
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
710-781 |
4.47e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 4.47e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223460685 710 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 781
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
708-784 |
5.18e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.32 E-value: 5.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 708 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 783 DS 784
Cdd:smart00060 82 EG 83
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1332-1371 |
5.67e-11 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 58.73 E-value: 5.67e-11
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 223460685 1332 CSQV-QQNTNAASGLYTIYLNGD-ASRPMQVYCDMDTDGGGW 1371
Cdd:NF040941 2 CWEIlQAGPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
796-872 |
5.89e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 59.94 E-value: 5.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVEAD-----IDRYVVRYTSVDGETREFLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 871 ES 872
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1060-1145 |
6.09e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.20 E-value: 6.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDPVQAD---IDRYMVRYTSADGET-REIPVRKEKS-STVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 1135 ESKKAKTKAPT 1145
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1148-1233 |
9.00e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.82 E-value: 9.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1148 DSPKNLVTNRVTENTATISWDPVR---ANIDRYMVRYTSADGET-KEIPVSK-DQSSTILTGLKPGMEYTIHVWAQKGAR 1222
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 1223 ESKKADTKALT 1233
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
620-692 |
9.48e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 9.48e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDP---VQANIDRYMVSYTSADGET--REVPVPKEKSSTVLTGLRPGVEYKVHVWAQKG 692
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
264-342 |
1.24e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 264 APQGLQLLKSTENSLLVSWEPS----SEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDIS 339
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
...
gi 223460685 340 SSP 342
Cdd:cd00063 83 SPP 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
972-1054 |
1.29e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDPVQAD---IDRYVVRYTSADGESKEFLIGK--EQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*...
gi 223460685 1047 ESKKANTE 1054
Cdd:cd00063 82 ESPPSESV 89
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
796-881 |
1.54e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.05 E-value: 1.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVEAD---IDRYVVRYTSVDGETREFLVGK--DQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 871 ESRKTSTKAPT 881
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
359-434 |
1.67e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.97 E-value: 1.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 359 VNEETETSLDVEWENPLT---EVDYYKLRYGPLTGQEV-TEVTVPKSrdpKSRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:pfam00041 8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
620-696 |
8.07e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 8.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDPVQ---ANIDRYMVSYTSADGET-REVPVPKEKS-STVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 223460685 695 ES 696
Cdd:cd00063 82 ES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
444-529 |
1.15e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 444 DGPTNVVTNQVTEDTASVSWDPVRAD---IDKYVVRYIAPDGETKEKAVPKDQSST--VLTGLKPGEAYKVFVWAERGNQ 518
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 519 GSKKADTKALT 529
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
446-517 |
1.35e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 56.27 E-value: 1.35e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223460685 446 PTNVVTNQVTEDTASVSWDP---VRADIDKYVVRYIAPDGET--KEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGN 517
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
359-434 |
1.43e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.35 E-value: 1.43e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223460685 359 VNEETETSLDVEWENPL---TEVDYYKLRYGPLTGQEVTEVTVPKSRDPksRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:cd00063 9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
708-784 |
2.98e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.58 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 708 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 223460685 783 DS 784
Cdd:cd00063 82 ES 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
264-332 |
3.42e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 54.93 E-value: 3.42e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223460685 264 APQGLQLLKSTENSLLVSWEPSSE--VDYYLLSYYPLGKEQAT--KQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDdgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
444-520 |
1.06e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.77 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 444 DGPTNVVTNQVTEDTASVSWDPVRAD-----IDKYVVRYIAPDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQ 518
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 519 GS 520
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
359-432 |
6.69e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 48.38 E-value: 6.69e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 359 VNEETETSLDVEWENPLTEV-DYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEG 432
Cdd:smart00060 9 VTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
171-198 |
1.38e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 46.14 E-value: 1.38e-06
10 20
....*....|....*....|....*...
gi 223460685 171 CPGACNGHGRCVDGQCVCDAPYVGVDCA 198
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
171-237 |
3.45e-05 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 45.52 E-value: 3.45e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223460685 171 CPGACNGHGRCVDGQCVCDAPYV--GVDCAY--------AACPQDCSGHGVCVQGVCqchedftAEDCSE--QRCPGDC 237
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACVDtasdpahcGACGAACAPGQVCEGGAC-------REACSEglTRCGGAC 116
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
236-259 |
5.90e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 41.18 E-value: 5.90e-05
10 20
....*....|....*....|....*.
gi 223460685 236 DCSGNGFCD--TGECYCEMGFTGPDC 259
Cdd:pfam07974 1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
202-229 |
1.24e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 40.36 E-value: 1.24e-04
10 20
....*....|....*....|....*...
gi 223460685 202 CPQDCSGHGVCVQGVCQCHEDFTAEDCS 229
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
142-166 |
2.60e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 2.60e-04
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
181-260 |
2.23e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.13 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 181 CVDGQCVCDAPYVGVDCAYA---ACPQDCSGHGVCVQGVCQCHEDftAEDCSEQrC------PGDCSGNGF-CDTGECyC 250
Cdd:NF041328 21 CPEGLSVCGGACVDLRSDPSncgACGVACGAGQTCVAGACGCGPG--TVACGGA-CvdtasdPAHCGACGAaCAPGQV-C 96
|
90
....*....|
gi 223460685 251 EMGFTGPDCS 260
Cdd:NF041328 97 EGGACREACS 106
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
233-261 |
9.93e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 35.79 E-value: 9.93e-03
10 20 30
....*....|....*....|....*....|.
gi 223460685 233 CPGDCSGNGFCD--TGECYCEMGFTGPDCSQ 261
Cdd:cd00055 4 CNGHGSLSGQCDpgTGQCECKPNTTGRRCDR 34
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| FReD |
cd00087 |
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ... |
1327-1539 |
1.27e-113 |
|
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Pssm-ID: 238040 [Multi-domain] Cd Length: 215 Bit Score: 357.32 E-value: 1.27e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1327 PHPSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGL 1406
Cdd:cd00087 1 PLPRDCSEVLQRGGRTSGVYTIQPPGS-NEPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1407 DKLHNLTTgtTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDNDIALSN 1485
Cdd:cd00087 80 EKIHLLTS--QGPYELRIDLEDWeGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 223460685 1486 CALTHHGGWWYKNCHLANPNGKYGETKH----SEGVNWEPWKGHEFSIPYVELKIRPF 1539
Cdd:cd00087 158 CAESYSGGWWYNSCHASNLNGRYYSGGHrneyDNGINWATWKGSTYSLKFTEMKIRPK 215
|
|
| FBG |
smart00186 |
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ... |
1328-1539 |
2.84e-102 |
|
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.
Pssm-ID: 214548 [Multi-domain] Cd Length: 212 Bit Score: 325.39 E-value: 2.84e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1328 HPSDCSQVQQNTNAASGLYTIYLNGdASRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLD 1407
Cdd:smart00186 1 LPRDCSDVLQNGGKTSGLYTIYPDG-SSRPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1408 KLHNLTtgTTTRYEVRADLQTF-NESAYAVYDFFQVASSKERYKLSVGKYRGTAGDA-LTYHNGWKFTTFDRDNDIALSN 1485
Cdd:smart00186 80 NIHLLT--SQGKYELRIDLEDWeGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDAsLTYHNGMQFSTYDRDNDKYSGN 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1486 CALTHHGGWWYKNCHLANPNGKYG-ETKHSEGVNWEPWKGHEFSIPYVELKIRPF 1539
Cdd:smart00186 158 CAEEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRPL 212
|
|
| Fibrinogen_C |
pfam00147 |
Fibrinogen beta and gamma chains, C-terminal globular domain; |
1329-1538 |
5.66e-85 |
|
Fibrinogen beta and gamma chains, C-terminal globular domain;
Pssm-ID: 395095 [Multi-domain] Cd Length: 221 Bit Score: 277.10 E-value: 5.66e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1329 PSDCSQVQQNTNAASGLYTIYLNGDaSRPMQVYCDMDTDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMK-EFWLGLD 1407
Cdd:pfam00147 2 GRDCSDVYNKGAKTSGLYTIRPDGA-TKPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNLSPgEFWLGND 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1408 KLHNLTTgtTTRYEVRADLQTFN-ESAYAVYDFFQVASSKERYKLSVGKYRGTAGDAL-------TYHNGWKFTTFDRDN 1479
Cdd:pfam00147 81 KIHLLTK--QGPYVLRIDLEDWNgETVFALYDSFKVTNENDKYRLHVENYIGDAGDALdtagrsmTYHNGMQFSTWDRDN 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223460685 1480 DIALSNCALTHHGGWWYKNCHLANPNGKY--GETKHSE-GVNWEPWKGHEFSIPYVELKIRP 1538
Cdd:pfam00147 159 DSPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRP 220
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
264-332 |
5.01e-15 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 71.68 E-value: 5.01e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223460685 264 APQGLQLLKSTENSLLVSWEP----SSEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:pfam00041 2 APSNLTVTDVTSTSLTVSWTPppdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
972-1049 |
3.91e-13 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 66.28 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDP---VQADIDRYVVRYTSADGES--KEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1047 ESK 1049
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
532-608 |
9.59e-13 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 65.33 E-value: 9.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVEAD-----IDRYVVSYTSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 607 ES 608
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
796-875 |
3.40e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 3.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVE---ADIDRYVVRYTSVDGET--REFLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
....*
gi 223460685 871 ESRKT 875
Cdd:pfam00041 81 EGPPS 85
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
532-609 |
3.94e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 63.59 E-value: 3.94e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVE---ADIDRYVVSYTSVDGET--KQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 607 ESK 609
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1060-1136 |
4.22e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 63.40 E-value: 4.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDPVQAD-----IDRYMVRYTSADGETREIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1135 ES 1136
Cdd:smart00060 82 EG 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
857-1371 |
5.06e-12 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 70.80 E-value: 5.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 857 VEYQVDVWAQKGTQESRKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDG-ETKEVPVSKDKSS 935
Cdd:COG3401 24 NALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPtATGLTTLTGSGSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 936 TVLR--GLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESK 1013
Cdd:COG3401 104 GGATntGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1014 EFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGARESKKANTEGHTDI----DSPKNLVTNQVTENTATISWDPVQA-DIDR 1088
Cdd:COG3401 184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTEsDATG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1089 YMV-RYTSADGETREIPVRKEKSSTVlTGLRPGVEYTVQVWAQKGA----RESKKAKTKAPTEI-DSPKNLVTNRVTENT 1162
Cdd:COG3401 264 YRVyRSNSGDGPFTKVATVTTTSYTD-TGLTNGTTYYYRVTAVDAAgnesAPSNVVSVTTDLTPpAAPSGLTATAVGSSS 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1163 ATISWDPVR-ANIDRYMV-RYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQ-KGARESKKADTKALTEIDPPR 1239
Cdd:COG3401 343 ITLSWTASSdADVTGYNVyRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPSEEVSATTASAAS 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1240 NL---RPFGVTHSGGVLTWLPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVaFKGNQRSRTVS 1316
Cdd:COG3401 423 GEsltASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS-VTTGSLVGGSG 501
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1317 TTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTDGGGW 1371
Cdd:COG3401 502 ASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTS 556
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1148-1224 |
6.55e-12 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 62.63 E-value: 6.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1148 DSPKNLVTNRVTENTATISWDPVRAN-----IDRYMVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1222
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1223 ES 1224
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1148-1225 |
9.29e-12 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 62.43 E-value: 9.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1148 DSPKNLVTNRVTENTATISWDP---VRANIDRYMVRYTSADGET--KEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGAR 1222
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1223 ESK 1225
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
972-1048 |
1.52e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.86 E-value: 1.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDPVQAD-----IDRYVVRYTSADGESKEFLIGKEQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1047 ES 1048
Cdd:smart00060 82 EG 83
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1060-1137 |
1.64e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 61.66 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDP---VQADIDRYMVRYTSADGET--REIPVRKEKSSTVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
|
...
gi 223460685 1135 ESK 1137
Cdd:pfam00041 81 EGP 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
620-696 |
2.26e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 61.09 E-value: 2.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDPVQAN-----IDRYMVSYTSADGETREVPVPKEKSSTVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 695 ES 696
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
532-617 |
2.66e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 61.36 E-value: 2.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 532 DSPENLVTDRVTENSLSVSWDPVEAD---IDRYVVSYTSVDGET-KQVPVKK-DQRSTVLTGLSPGVEYKVYVWAEKGDR 606
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 607 ESKKANTKAPT 617
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
593-1094 |
2.91e-11 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 68.11 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 593 VEYKVYVWAEKGDRESKKANTKAPTDID----SPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTSADG-ETREVPVPK 667
Cdd:COG3401 20 NTAVNALSKAGGSGKTILVYLAVVLSVTtkesPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPtATGLTTLTG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 668 EKSSTVLTGLRPGVEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDGE 747
Cdd:COG3401 100 SGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 748 TKEVPVSKDKSSTVLRGLR--PGVEYKVDVWAQKGAQDSRKANTKAPTDI----DSPKNLVTEQVTESTATVSWDPV-EA 820
Cdd:COG3401 180 VATTSLTVTSTTLVDGGGDiePGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVtES 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 821 DIDRYVVRYTSVDGETREFLVGKDQTSTVLTGMRPG--VEYQVDVWAQKGTqESRKTST-KAPTDI---DGPKNLVTDQV 894
Cdd:COG3401 260 DATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGttYYYRVTAVDAAGN-ESAPSNVvSVTTDLtppAAPSGLTATAV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 895 TETTLSVSWDPV-EADIDRYMV-RYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYK-----VDVWAQKGAQDSRKANTKA 967
Cdd:COG3401 339 GSSSITLSWTASsDADVTGYNVyRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYykvtaVDAAGNESAPSEEVSATTA 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 968 PTD--------IDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIGkeqrsTVLTGLRPGVEYKVEV 1039
Cdd:COG3401 419 SAAsgesltasVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTV-----TATTTDTTTANLSVTT 493
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 1040 WAQKGARESKKANTEGHTDIDSPKNLVTNQVTENTATISWDPVQADIDRYMVRYT 1094
Cdd:COG3401 494 GSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLIT 548
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
886-957 |
4.47e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 4.47e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223460685 886 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 957
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
710-781 |
4.47e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 60.51 E-value: 4.47e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223460685 710 PKNLVTDQVTETTLSVSWDPVE---ADIDRYMVRYTSPDGET--KEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGA 781
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
708-784 |
5.18e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.32 E-value: 5.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 708 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 783 DS 784
Cdd:smart00060 82 EG 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
884-960 |
5.18e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 60.32 E-value: 5.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 884 DGPKNLVTDQVTETTLSVSWDPVEAD-----IDRYMVRYTSPDGETKEVPVSKDKSSTVLRGLRPGVEYKVDVWAQKGAQ 958
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 959 DS 960
Cdd:smart00060 82 EG 83
|
|
| GGGWT_bact |
NF040941 |
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ... |
1332-1371 |
5.67e-11 |
|
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.
Pssm-ID: 468872 [Multi-domain] Cd Length: 46 Bit Score: 58.73 E-value: 5.67e-11
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 223460685 1332 CSQV-QQNTNAASGLYTIYLNGD-ASRPMQVYCDMDTDGGGW 1371
Cdd:NF040941 2 CWEIlQAGPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
796-872 |
5.89e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 59.94 E-value: 5.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVEAD-----IDRYVVRYTSVDGETREFLVGKDQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 871 ES 872
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1060-1145 |
6.09e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 60.20 E-value: 6.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1060 DSPKNLVTNQVTENTATISWDPVQAD---IDRYMVRYTSADGET-REIPVRKEKS-STVLTGLRPGVEYTVQVWAQKGAR 1134
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 1135 ESKKAKTKAPT 1145
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1148-1233 |
9.00e-11 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.82 E-value: 9.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1148 DSPKNLVTNRVTENTATISWDPVR---ANIDRYMVRYTSADGET-KEIPVSK-DQSSTILTGLKPGMEYTIHVWAQKGAR 1222
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 1223 ESKKADTKALT 1233
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
620-692 |
9.48e-11 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 59.35 E-value: 9.48e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDP---VQANIDRYMVSYTSADGET--REVPVPKEKSSTVLTGLRPGVEYKVHVWAQKG 692
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
264-342 |
1.24e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 264 APQGLQLLKSTENSLLVSWEPS----SEVDYYLLSYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDIS 339
Cdd:cd00063 3 PPTNLRVTDVTSTSVTLSWTPPeddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82
|
...
gi 223460685 340 SSP 342
Cdd:cd00063 83 SPP 85
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
972-1054 |
1.29e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.43 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 972 DSPKNLAIDQVTETTLSVSWDPVQAD---IDRYVVRYTSADGESKEFLIGK--EQRSTVLTGLRPGVEYKVEVWAQKGAR 1046
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
....*...
gi 223460685 1047 ESKKANTE 1054
Cdd:cd00063 82 ESPPSESV 89
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
796-881 |
1.54e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 59.05 E-value: 1.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 796 DSPKNLVTEQVTESTATVSWDPVEAD---IDRYVVRYTSVDGETREFLVGK--DQTSTVLTGMRPGVEYQVDVWAQKGTQ 870
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTpgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 871 ESRKTSTKAPT 881
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
359-434 |
1.67e-10 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 58.97 E-value: 1.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 359 VNEETETSLDVEWENPLT---EVDYYKLRYGPLTGQEV-TEVTVPKSrdpKSRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:pfam00041 8 VTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPwNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
620-696 |
8.07e-10 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 57.12 E-value: 8.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 620 DSPKNLVTDQVTENTLSVSWDPVQ---ANIDRYMVSYTSADGET-REVPVPKEKS-STVLTGLRPGVEYKVHVWAQKGTQ 694
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDwKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 223460685 695 ES 696
Cdd:cd00063 82 ES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
444-529 |
1.15e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.74 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 444 DGPTNVVTNQVTEDTASVSWDPVRAD---IDKYVVRYIAPDGETKEKAVPKDQSST--VLTGLKPGEAYKVFVWAERGNQ 518
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETsyTLTGLKPGTEYEFRVRAVNGGG 81
|
90
....*....|.
gi 223460685 519 GSKKADTKALT 529
Cdd:cd00063 82 ESPPSESVTVT 92
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
446-517 |
1.35e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 56.27 E-value: 1.35e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223460685 446 PTNVVTNQVTEDTASVSWDP---VRADIDKYVVRYIAPDGET--KEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGN 517
Cdd:pfam00041 3 PSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
359-434 |
1.43e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 56.35 E-value: 1.43e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223460685 359 VNEETETSLDVEWENPL---TEVDYYKLRYGPLTGQEVTEVTVPKSRDPksRYDITGLQPGTEYKITVVPIRGDLEGKP 434
Cdd:cd00063 9 VTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSET--SYTLTGLKPGTEYEFRVRAVNGGGESPP 85
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
411-683 |
1.61e-09 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 62.33 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 411 TGLQPGTEYKITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYIAPDGETKEKAVP 490
Cdd:COG3401 109 TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVT 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 491 KDQSSTVLTGLKPGEAYKVFVWAERGNQGSKKAD----TKALTEIDSPENLVTDRVTENSLSVSWDPV-EADIDRYVVSY 565
Cdd:COG3401 189 STTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNevsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVtESDATGYRVYR 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 566 TSVDGETKQVPVKKDQRSTVLTGLSPGVEYKVYVWAEKGD-RESKKANT-KAPTDI---DSPKNLVTDQVTENTLSVSWD 640
Cdd:COG3401 269 SNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVvSVTTDLtppAAPSGLTATAVGSSSITLSWT 348
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 223460685 641 PV-QANIDRYMVSY-TSADGETREVPVPKEKSSTVLTGLRPGVEY 683
Cdd:COG3401 349 ASsDADVTGYNVYRsTSGGGTYTKIAETVTTTSYTDTGLTPGTTY 393
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
708-784 |
2.98e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.58 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 708 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 782
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 223460685 783 DS 784
Cdd:cd00063 82 ES 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
884-960 |
2.98e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 55.58 E-value: 2.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 884 DGPKNLVTDQVTETTLSVSWDPVEAD---IDRYMVRYTSPDGET-KEVPVSK-DKSSTVLRGLRPGVEYKVDVWAQKGAQ 958
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDwKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 223460685 959 DS 960
Cdd:cd00063 82 ES 83
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
264-332 |
3.42e-09 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 54.93 E-value: 3.42e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 223460685 264 APQGLQLLKSTENSLLVSWEPSSE--VDYYLLSYYPLGKEQAT--KQVRVPKEQHTYDITGLLPGTKYIVTLR 332
Cdd:smart00060 3 PPSNLRVTDVTSTSVTLSWEPPPDdgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
1236-1309 |
7.59e-09 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 53.96 E-value: 7.59e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223460685 1236 DPPRNLRPFGVTHSGGVLTWLPP---SAQIDGYILTYQFPNGT--VKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGN 1309
Cdd:pfam00041 1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
444-520 |
1.06e-08 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 53.77 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 444 DGPTNVVTNQVTEDTASVSWDPVRAD-----IDKYVVRYIAPDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVWAERGNQ 518
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 519 GS 520
Cdd:smart00060 82 EG 83
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
714-911 |
2.11e-07 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 56.11 E-value: 2.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 714 VTDQVTETTLSVSWDPVEADIdRYMVRYTSPDGETKEVPVSkDKSSTVLRGLRPGvEYKVDVWAqKGAQDSRKANTKAPT 793
Cdd:COG4733 545 VAQGTAVTTLTVSWDAPAGAV-AYEVEWRRDDGNWVSVPRT-SGTSFEVPGIYAG-DYEVRVRA-INALGVSSAWAASSE 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 794 -----DIDSP---KNLVTEQVTEStATVSWD-PVEADIDRYVVRY-TSVDGETREFLVGKDQTST-VLTGMRPGVEYQVD 862
Cdd:COG4733 621 ttvtgKTAPPpapTGLTATGGLGG-ITLSWSfPVDADTLRTEIRYsTTGDWASATVAQALYPGNTyTLAGLKAGQTYYYR 699
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 223460685 863 VWA--QKGTQESRKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADID 911
Cdd:COG4733 700 ARAvdRSGNVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT 750
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
359-432 |
6.69e-07 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 48.38 E-value: 6.69e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223460685 359 VNEETETSLDVEWENPLTEV-DYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEG 432
Cdd:smart00060 9 VTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
171-198 |
1.38e-06 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 46.14 E-value: 1.38e-06
10 20
....*....|....*....|....*...
gi 223460685 171 CPGACNGHGRCVDGQCVCDAPYVGVDCA 198
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
301-575 |
3.19e-06 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 52.25 E-value: 3.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 301 EQATKQVRV----PKEQHTYDITGLL--PGtKYIVTLRNVKKDISssPQHLLATTDLAVVGTAWVNEETETSLDVEWENP 374
Cdd:COG4733 485 ELETQLFRVvsieENEDGTYTITAVQhaPE-KYAAIDAGAFDDVP--PQWPPVNVTTSESLSVVAQGTAVTTLTVSWDAP 561
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 375 lTEVDYYKLRYGPLTGqevTEVTVPksRDPKSRYDITGLQPGTeYKITVVPI-RGDLEGKP-----ILLNGRteIDGPTN 448
Cdd:COG4733 562 -AGAVAYEVEWRRDDG---NWVSVP--RTSGTSFEVPGIYAGD-YEVRVRAInALGVSSAWaasseTTVTGK--TAPPPA 632
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 449 VVTNQVTEDT--ASVSWD-PVRADIDKYVVRYI-APDGETKEKAVPKDQSST-VLTGLKPGEAYKVFVWAE--RGNQGSK 521
Cdd:COG4733 633 PTGLTATGGLggITLSWSfPVDADTLRTEIRYStTGDWASATVAQALYPGNTyTLAGLKAGQTYYYRARAVdrSGNVSAW 712
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 223460685 522 KADTKALTEIDSPENLVTDRVTENSLSVSWDPVEADIDRYVVSYTSVDGETKQV 575
Cdd:COG4733 713 WVSGQASADAAGILDAITGQILETELGQELDAIIQNATVAEVVAATVTDVTAQI 766
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
894-1127 |
1.22e-05 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 50.33 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 894 VTETTLSVSWDPVEADIDRYMVRYTSPDGETKEVPV----SKDKSSTVLRGlrpgVEYKVDVWAQK--GAQDSRKANTkA 967
Cdd:COG4733 458 VAGRTLTVSTAYSETPEAGAVWAFGPDELETQLFRVvsieENEDGTYTITA----VQHAPEKYAAIdaGAFDDVPPQW-P 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 968 PTDIDSPKNLAI--DQVTETTLSVSWDPVQADIdRYVVRYTSADGESKeFLIGKEQRSTVLTGLRPGvEYKVEVWA-QKG 1044
Cdd:COG4733 533 PVNVTTSESLSVvaQGTAVTTLTVSWDAPAGAV-AYEVEWRRDDGNWV-SVPRTSGTSFEVPGIYAG-DYEVRVRAiNAL 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1045 ARESKKANTEGHT---DIDSPKNLVTNQVTENT--ATISWD-PVQADIDRYMVRY-TSADGETREIPVRKEKSST-VLTG 1116
Cdd:COG4733 610 GVSSAWAASSETTvtgKTAPPPAPTGLTATGGLggITLSWSfPVDADTLRTEIRYsTTGDWASATVAQALYPGNTyTLAG 689
|
250
....*....|.
gi 223460685 1117 LRPGVEYTVQV 1127
Cdd:COG4733 690 LKAGQTYYYRA 700
|
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
1236-1312 |
1.62e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 44.53 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1236 DPPRNLRPFGVTHSGGVLTWLPPSAQ-----IDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYPVSLVAFKGNQ 1310
Cdd:smart00060 2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
|
..
gi 223460685 1311 RS 1312
Cdd:smart00060 82 EG 83
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
1236-1312 |
1.87e-05 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 44.79 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1236 DPPRNLRPFGVTHSGGVLTWLPPS---AQIDGYILTYQ-FPNGTVKEVELPRGQQ-RFELQDLEQGVTYPVSLVAFKGNQ 1310
Cdd:cd00063 2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPGSEtSYTLTGLKPGTEYEFRVRAVNGGG 81
|
..
gi 223460685 1311 RS 1312
Cdd:cd00063 82 ES 83
|
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
264-559 |
2.85e-05 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 48.85 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 264 APQGLQLLKSTENSLLVSWEPSSEVDyylLSYYPL--GKEQATKQVRVPKEQHT-YDITGLLPGTKY--IVTLRNVKKDI 338
Cdd:COG3401 235 APTGLTATADTPGSVTLSWDPVTESD---ATGYRVyrSNSGDGPFTKVATVTTTsYTDTGLTNGTTYyyRVTAVDAAGNE 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 339 SSSPQHLLATTDL----AVVGTAwVNEETETSLDVEWENPLTE-VDYYKLRYGPLTGQEVTEVTVPKSrdpKSRYDITGL 413
Cdd:COG3401 312 SAPSNVVSVTTDLtppaAPSGLT-ATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGGTYTKIAETVT---TTSYTDTGL 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 414 QPGTEYKITVVPIRGDLEGKPillngrteidgPTNVVTnqVTEDTASVSWDPVRADIDKYVVRYIAPDGETKEKAVPKDQ 493
Cdd:COG3401 388 TPGTTYYYKVTAVDAAGNESA-----------PSEEVS--ATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVS 454
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 223460685 494 SSTVLTGLKPGEAYKvfVWAERGNQGSKKADTKALTEIDSPENLVTDRVTENSLSVSWDPVEADID 559
Cdd:COG3401 455 AAVLADGGDTGNAVP--FTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
171-237 |
3.45e-05 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 45.52 E-value: 3.45e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 223460685 171 CPGACNGHGRCVDGQCVCDAPYV--GVDCAY--------AACPQDCSGHGVCVQGVCqchedftAEDCSE--QRCPGDC 237
Cdd:NF041328 45 CGVACGAGQTCVAGACGCGPGTVacGGACVDtasdpahcGACGAACAPGQVCEGGAC-------REACSEglTRCGGAC 116
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
236-259 |
5.90e-05 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 41.18 E-value: 5.90e-05
10 20
....*....|....*....|....*.
gi 223460685 236 DCSGNGFCD--TGECYCEMGFTGPDC 259
Cdd:pfam07974 1 ICSGRGTCVnqCGKCVCDSGYQGATC 26
|
|
| DUF4998 |
pfam16389 |
Domain of unknown function; This family around 200 residues locates in the N-terminal of some ... |
1073-1212 |
7.65e-05 |
|
Domain of unknown function; This family around 200 residues locates in the N-terminal of some uncharacterized proteins in various Bacteroides and Parabacteroides species. The function of this family remains unknown.
Pssm-ID: 435316 [Multi-domain] Cd Length: 199 Bit Score: 45.38 E-value: 7.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1073 NTATISW----DPVQADIDRYmvrytsADGETREIPVRKeksstvltgLRPGVeYTVQVWAqkgarESKKAKTKAPTEI- 1147
Cdd:pfam16389 48 VKAKIFWnnglDSLEVPITRT------AGVDTISVIIDN---------LPEGS-YTFSIRT-----YDKKGNSSVPSEVt 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223460685 1148 -----DSPKNLVTNRV-------TENTATISWDPVRANIDRY-MVRYTSADGETKEIPVSKDQSSTILTGLKPGMEYT 1212
Cdd:pfam16389 107 gtvygDSYQASLTNRSlksveitAGSNLTINWSPVLASALVGtEVTYTNNDGKVKTVRIKNGETQTVLPDFKPGTSFK 184
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
174-197 |
1.03e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 40.79 E-value: 1.03e-04
10 20
....*....|....*....|....*.
gi 223460685 174 ACNGHGRCVD--GQCVCDAPYVGVDC 197
Cdd:pfam07974 1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
202-229 |
1.24e-04 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 40.36 E-value: 1.24e-04
10 20
....*....|....*....|....*...
gi 223460685 202 CPQDCSGHGVCVQGVCQCHEDFTAEDCS 229
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
142-166 |
2.60e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.64 E-value: 2.60e-04
|
| FN3 |
COG3401 |
Fibronectin type 3 domain [General function prediction only]; |
264-465 |
1.34e-03 |
|
Fibronectin type 3 domain [General function prediction only];
Pssm-ID: 442628 [Multi-domain] Cd Length: 603 Bit Score: 43.45 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 264 APQGLQLLKSTENSLLVSWEPSSEVD--YYLLsYYPLGKEQATKQVRVPKEQHTYDITGLLPGTKYIVTLRNVKKDISSS 341
Cdd:COG3401 329 APSGLTATAVGSSSITLSWTASSDADvtGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNES 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 342 PQhllattDLAVVGTAWVNEETETSLDVEWENPLTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLqPGTEYKI 421
Cdd:COG3401 408 AP------SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTT-SSTVTAT 480
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 223460685 422 TVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDP 465
Cdd:COG3401 481 TTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAP 524
|
|
| EB |
pfam01683 |
EB module; This domain has no known function. It is found in several C. elegans proteins. The ... |
181-233 |
1.47e-03 |
|
EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.
Pssm-ID: 460294 Cd Length: 52 Bit Score: 38.18 E-value: 1.47e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 223460685 181 CVDGQCVCDAPYvGVDCAYaacPQDCSGHGVCVQGVCQCHEDFTAEDcseQRC 233
Cdd:pfam01683 7 LVNGQCVPKVAP-GESCEA---DEQCPGGSVCVNGVCQCPPGFTPVN---GRC 52
|
|
| EGF_Tenascin |
pfam18720 |
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins. |
233-260 |
2.08e-03 |
|
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 2.08e-03
10 20
....*....|....*....|....*...
gi 223460685 233 CPGDCSGNGFCDTGECYCEMGFTGPDCS 260
Cdd:pfam18720 2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
1143-1324 |
2.19e-03 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 42.62 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1143 APTEIDSPKNLVTNR--VTENTATISWDPVRANIdRYMVRYTSADGETKEIPVSkDQSSTILTGLKPGmEYTIHVWA--- 1217
Cdd:COG4733 532 PPVNVTTSESLSVVAqgTAVTTLTVSWDAPAGAV-AYEVEWRRDDGNWVSVPRT-SGTSFEVPGIYAG-DYEVRVRAina 608
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 1218 --QKGARESKKADTKALTEIDPPrnlRPFGVTHSGGV----LTW-LPPSAQIDGYILTYQ----FPNGTVKEVELPrgQQ 1286
Cdd:COG4733 609 lgVSSAWAASSETTVTGKTAPPP---APTGLTATGGLggitLSWsFPVDADTLRTEIRYSttgdWASATVAQALYP--GN 683
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 223460685 1287 RFELQDLEQGVT--YPVSLVAFKGNQRSRTVSTTlSTVDA 1324
Cdd:COG4733 684 TYTLAGLKAGQTyyYRARAVDRSGNVSAWWVSGQ-ASADA 722
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
181-260 |
2.23e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.13 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 181 CVDGQCVCDAPYVGVDCAYA---ACPQDCSGHGVCVQGVCQCHEDftAEDCSEQrC------PGDCSGNGF-CDTGECyC 250
Cdd:NF041328 21 CPEGLSVCGGACVDLRSDPSncgACGVACGAGQTCVAGACGCGPG--TVACGGA-CvdtasdPAHCGACGAaCAPGQV-C 96
|
90
....*....|
gi 223460685 251 EMGFTGPDCS 260
Cdd:NF041328 97 EGGACREACS 106
|
|
| COG4733 |
COG4733 |
Phage-related protein, tail protein J [Mobilome: prophages, transposons]; |
273-660 |
8.77e-03 |
|
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
Pssm-ID: 443767 [Multi-domain] Cd Length: 978 Bit Score: 40.70 E-value: 8.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 273 STENSLLVSWEPSSEVDYYLLSYYPLGKEQatkqVRVPKEQHT-YDITGLLPGTkYIVTLR-----NVKKDISSSPQHLL 346
Cdd:COG4733 549 TAVTTLTVSWDAPAGAVAYEVEWRRDDGNW----VSVPRTSGTsFEVPGIYAGD-YEVRVRainalGVSSAWAASSETTV 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 347 --------ATTDLAVVGTAWvneetetSLDVEWENPL-TEVDYYKLRYGplTGQEVTEVTVPKSRDPKSRYDITGLQPGT 417
Cdd:COG4733 624 tgktapppAPTGLTATGGLG-------GITLSWSFPVdADTLRTEIRYS--TTGDWASATVAQALYPGNTYTLAGLKAGQ 694
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 418 EYKITV--VPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDkyVVRYIAPDGETKEKAVPKDQSS 495
Cdd:COG4733 695 TYYYRAraVDRSGNVSAWWVSGQASADAAGILDAITGQILETELGQELDAIIQNAT--VAEVVAATVTDVTAQIDTAVLF 772
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 496 TVLTGLKPGEAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTDrvTENSLSVSWDPVEADIDRYVVSYTSVDGETKQV 575
Cdd:COG4733 773 AGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTA--GTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDA 850
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223460685 576 pvkkdQRSTVLTGLSPGVEYKVYVWAEKGDRESkkantkaPTDIDSPKNLVTDQVTENTLSVSWDPVQANIDRYMVSYTS 655
Cdd:COG4733 851 -----IIESGNTGDIVATGDIASAAAGAVATTV-------SGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTRE 918
|
....*
gi 223460685 656 ADGET 660
Cdd:COG4733 919 PAGDI 923
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
233-261 |
9.93e-03 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 35.79 E-value: 9.93e-03
10 20 30
....*....|....*....|....*....|.
gi 223460685 233 CPGDCSGNGFCD--TGECYCEMGFTGPDCSQ 261
Cdd:cd00055 4 CNGHGSLSGQCDpgTGQCECKPNTTGRRCDR 34
|
|
| |
