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Conserved domains on  [gi|187952355|gb|AAI39338|]
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WD repeat domain 26 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10652957)

WD40 repeat domain-containing protein with a CTLH (C-terminal to LisH) motif, similar to human WD repeat-containing protein 26 (WDR26), a Gbeta-like protein that suppresses MAPK signaling pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-494 3.91e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 3.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 200 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 279
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 280 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 356
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 357 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 432
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187952355 433 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 9-84 1.22e-05

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 42.56  E-value: 1.22e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187952355     9 EHPSATKFRNHVMEGDWDKAENDLNELKPlvhsphaivvrgaleisqTLLGIIVRMKFLLLQQKYLEYLEDGKVLE 84
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKP------------------PLLERNSKLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-494 3.91e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 3.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 200 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 279
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 280 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 356
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 357 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 432
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187952355 433 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-494 1.89e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.57  E-value: 1.89e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 202 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDSYLVACGPDDCseLW 281
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 282 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 348
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 349 DGKTVLASDTHQRVRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 427
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187952355 428 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 494
Cdd:cd00200  226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 458-494 6.80e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 6.80e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187952355   458 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
458-494 4.27e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 187952355  458 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 430-494 4.74e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 4.74e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187952355 430 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 494
Cdd:PTZ00420  85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 9-84 1.22e-05

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 42.56  E-value: 1.22e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187952355     9 EHPSATKFRNHVMEGDWDKAENDLNELKPlvhsphaivvrgaleisqTLLGIIVRMKFLLLQQKYLEYLEDGKVLE 84
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKP------------------PLLERNSKLEFELRKQKFLELVRQGKLEE 58
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
200-494 3.91e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 3.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 200 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsE 279
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 280 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 356
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 357 DTHQRVRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 432
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187952355 433 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
201-494 2.75e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.32  E-value: 2.75e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 201 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPdthlLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDDcsEL 280
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 281 WLWNVQTGELRTKMSqSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLASD 357
Cdd:COG2319  145 RLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGhtGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 358 THQRVRGYnfeDLTDRNIVQE----DHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFGG 433
Cdd:COG2319  224 ADGTVRLW---DLATGKLLRTltghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187952355 434 hNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:COG2319  299 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-494 1.89e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.57  E-value: 1.89e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 202 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDSYLVACGPDDCseLW 281
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 282 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 348
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 349 DGKTVLASDTHQRVRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 427
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187952355 428 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 494
Cdd:cd00200  226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
204-494 1.58e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 1.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 204 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDSYLVACGPDdcSELWLW 283
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLL----DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--GTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 284 NVQTGELRTKmSQSHEDSLTSVAWNPDGKRFVTGgqrgqfyqcdldgnlldswegvrvqclwclSDGKTVlasdthqrvr 363
Cdd:COG2319  106 DLATGLLLRT-LTGHTGAVRSVAFSPDGKTLASG------------------------------SADGTV---------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 364 gynfedltdrnivqedhpimsftiskngrlallnvatqgvHLWDLQDRVLVRKYQGVTQGFYTIhsCFGgHNEDFIASGS 443
Cdd:COG2319  145 ----------------------------------------RLWDLATGKLLRTLTGHSGAVTSV--AFS-PDGKLLASGS 181

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 187952355 444 EDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 198-319 7.62e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.01  E-value: 7.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 198 CYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPdDSYLVACGPDDC 277
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW----DLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 187952355 278 SeLWLWNVQTGELrTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 319
Cdd:cd00200  242 T-IRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSA 281
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 204-331 5.90e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 55.06  E-value: 5.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 204 LTEHCNEVWFCKFSNDGTKLA-TGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSyiaWSPDDSYLV-ACGPDDCSELW 281
Cdd:COG0823   26 LTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPS---WSPDGKRLAfVSRSDGRFDIY 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 187952355 282 LWNVQTGELRTkmsqsHEDSLTSVAWNPDGKRFV---TGGQRGQFYQCDLDGN 331
Cdd:COG0823  103 VLDLDGGAPRR-----LTDGPGSPSWSPDGRRIVfssDRGGRPDLYVVDLDGR 150
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 458-494 6.80e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 6.80e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 187952355   458 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
458-494 4.27e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 187952355  458 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 430-494 4.74e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 4.74e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 187952355 430 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 494
Cdd:PTZ00420  85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 9-84 1.22e-05

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 42.56  E-value: 1.22e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187952355     9 EHPSATKFRNHVMEGDWDKAENDLNELKPlvhsphaivvrgaleisqTLLGIIVRMKFLLLQQKYLEYLEDGKVLE 84
Cdd:smart00668   1 EFDERKRIRELILKGDWDEALEWLSSLKP------------------PLLERNSKLEFELRKQKFLELVRQGKLEE 58
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-235 1.80e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.80e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 187952355   202 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 235
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
202-238 2.72e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.72e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 187952355 202 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVD 238
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
201-235 5.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 187952355  201 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 235
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 439-494 6.76e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 6.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 187952355 439 IASGSEDHKVYIWHKRS-ELPIAELTGHTRTVNCVSWNPQipSMMASASDDGTVRIW 494
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLW 687
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 458-494 1.06e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 1.06e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 187952355 458 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 494
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVW 36
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 430-494 2.05e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 2.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187952355 430 CFGGHNEDFIASGSEDHKVYIWH-KRSELpIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 494
Cdd:PLN00181 539 CWNSYIKSQVASSNFEGVVQVWDvARSQL-VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 215-312 2.69e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355  215 KFSNDGTKLATGSKDTTviIW----------QVDPDthllkllktleGHAYGVSYIAWSPDDSYLV--ACGPDDCSELWL 282
Cdd:COG4946   395 VWSPDGKKIAFTDNRGR--LWvvdlasgkvrKVDTD-----------GYGDGISDLAWSPDSKWLAysKPGPNQLSQIFL 461

                          90       100       110
                  ....*....|....*....|....*....|
gi 187952355  283 WNVQTGELrTKMSQSHEDSlTSVAWNPDGK 312
Cdd:COG4946   462 YDVETGKT-VQLTDGRYDD-GSPAFSPDGK 489
PTZ00421 PTZ00421
coronin; Provisional
 219-346 4.77e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355 219 DGTKLATGSKDTTVIIWQVDPDTHLLKLLK---TLEGHAYGVSYIAWSPDDSYLVACGPDDcSELWLWNVQTGELRTKMS 295
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLTQNISDpivHLQGHTKKVGIVSFHPSAMNVLASAGAD-MVVNVWDVERGKAVEVIK 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 187952355 296 qSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCD-LDGNLLDSWE---GVRVQ-CLWC 346
Cdd:PTZ00421 166 -CHSDQITSLEWNLDGSLLCTTSKDKKLNIIDpRDGTIVSSVEahaSAKSQrCLWA 220
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 260-316 1.38e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 39.95  E-value: 1.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 187952355  260 IAWSPDDSYLVACGPDDCS-ELWLWNVQTgelRTKMSQSHEDSLTSVAWNPDGKRFVT 316
Cdd:pfam08662 106 IFWSPFGRLVLLAGFGNLAgDIEFWDVVN---KKKIATAEASNATLCEWSPDGRYFLT 160
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 216-312 2.56e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.79  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187952355  216 FSNDGTKLA-----TGSKDttviIWQVDPDTHLLKLLKTLEGHAYgVSYIAWSPDDSYLVACgpDDCSELWLWNVQTGEL 290
Cdd:COG4946   350 WSPDGKSIAyfsdaSGEYE----LYIAPADGSGEPKQLTLGDLGR-VFNPVWSPDGKKIAFT--DNRGRLWVVDLASGKV 422

                          90       100
                  ....*....|....*....|..
gi 187952355  291 RTKMSQSHEDSLTSVAWNPDGK 312
Cdd:COG4946   423 RKVDTDGYGDGISDLAWSPDSK 444
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-236 3.17e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 3.17e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 187952355 202 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ 236
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 458-494 4.44e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 4.44e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 187952355 458 PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 494
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVW 102
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 278-330 7.97e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.34  E-value: 7.97e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 187952355 278 SELWLWNVQTGELRTKMSQSHEDslTSVAWNPDGKRFV---TGGQRGQFYQCDLDG 330
Cdd:COG0823   11 SDIYVVDLDGGEPRRLTNSPGID--TSPAWSPDGRRIAftsDRGGGPQIYVVDADG 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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