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Conserved domains on  [gi|219518368|gb|AAI44720|]
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Ryr3 protein [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ins145_P3_rec super family cl48031
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 14-125 2.10e-33

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


The actual alignment was detected with superfamily member pfam08709:

Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 116.44  E-value: 2.10e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219518368   14 FLRTEDEVVLQCIANIhkeqrKFCLAAEGLGNRLCFLEPTSEAKYIPP-DLCVCNFVLEQSLSVRALQEML-ANTVENGG 91
Cdd:pfam08709   4 FLHIGDIVSLSCEESV-----NGFISALGLGNDRCFVENKAGDLNDPPkKFRDCVFKICPANSYAAQKELWsAGNRSPNG 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 219518368   92 EGLSDLSEWAAQGGGHRTLLYGHAILLRHSFSGM 125
Cdd:pfam08709  79 NSLTDALKHASNIEGHQNLQYGSAILLLHVKSNM 112
 
Name Accession Description Interval E-value
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 14-125 2.10e-33

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 116.44  E-value: 2.10e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219518368   14 FLRTEDEVVLQCIANIhkeqrKFCLAAEGLGNRLCFLEPTSEAKYIPP-DLCVCNFVLEQSLSVRALQEML-ANTVENGG 91
Cdd:pfam08709   4 FLHIGDIVSLSCEESV-----NGFISALGLGNDRCFVENKAGDLNDPPkKFRDCVFKICPANSYAAQKELWsAGNRSPNG 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 219518368   92 EGLSDLSEWAAQGGGHRTLLYGHAILLRHSFSGM 125
Cdd:pfam08709  79 NSLTDALKHASNIEGHQNLQYGSAILLLHVKSNM 112
 
Name Accession Description Interval E-value
Ins145_P3_rec pfam08709
Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding ...
 14-125 2.10e-33

Inositol 1,4,5-trisphosphate/ryanodine receptor; This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor. Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity.


Pssm-ID: 462572 [Multi-domain]  Cd Length: 212  Bit Score: 116.44  E-value: 2.10e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219518368   14 FLRTEDEVVLQCIANIhkeqrKFCLAAEGLGNRLCFLEPTSEAKYIPP-DLCVCNFVLEQSLSVRALQEML-ANTVENGG 91
Cdd:pfam08709   4 FLHIGDIVSLSCEESV-----NGFISALGLGNDRCFVENKAGDLNDPPkKFRDCVFKICPANSYAAQKELWsAGNRSPNG 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 219518368   92 EGLSDLSEWAAQGGGHRTLLYGHAILLRHSFSGM 125
Cdd:pfam08709  79 NSLTDALKHASNIEGHQNLQYGSAILLLHVKSNM 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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