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Conserved domains on  [gi|187955788|gb|AAI47851|]
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Sphingosine-1-phosphate phosphotase 2 [Mus musculus]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130232)

type 2 phosphatidic acid phosphatase (PAP2) family protein is a type 2 lipid phosphate phosphatase, such as mammalian sphingosine-1-phosphate phosphatases and fungal dihydrosphingosine 1-phosphate phosphatase

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 39-188 6.91e-69

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


:

Pssm-ID: 239482  Cd Length: 151  Bit Score: 212.86  E-value: 6.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  39 YFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKR-IIAEYGM 117
Cdd:cd03388    1 PFLDYYFAFTALLGTHTFYILFLPFLFWNGDPYVGRDLVVVLALGMYIGQFIKDLFCLPRPSSPPVVRLTMSsAALEYGF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187955788 118 PSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:cd03388   81 PSTHAMNATAISFYLLIYLYDRYQYPFVLGLILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVLILLFRF 151
 
Name Accession Description Interval E-value
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 39-188 6.91e-69

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 212.86  E-value: 6.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  39 YFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKR-IIAEYGM 117
Cdd:cd03388    1 PFLDYYFAFTALLGTHTFYILFLPFLFWNGDPYVGRDLVVVLALGMYIGQFIKDLFCLPRPSSPPVVRLTMSsAALEYGF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187955788 118 PSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:cd03388   81 PSTHAMNATAISFYLLIYLYDRYQYPFVLGLILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVLILLFRF 151
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 56-305 4.68e-25

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 104.05  E-value: 4.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  56 FYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRL-----EKRIIAEYGMPSTHAMAATAISF 130
Cdd:PLN02525  20 FYTAFLPLLFWSGHGKLARQMTLLMAFCDYVGNCIKDVVSAPRPSCPPVRRVtatkdEEENAMEYGLPSSHTLNTVCLSG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788 131 TLLISTMDRYQYP----FILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALtypaW--------TLIDSLD 198
Cdd:PLN02525 100 YLLHYVLSYLQNVdasvIFAGLALFCLLVALVGFGRLYLGMHSPIDIIAGLAIGLVILAF----WltvdeyvdAFITSGQ 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788 199 SASPLFpvcvIVVPFLLCYNYPVSDYYSPTRADTTtivaAGAGVTLGFWI---NHFFQLVSKPTPSLPViqniPPLTTDM 275
Cdd:PLN02525 176 NVTPFW----AALSFLLLFAYPTPEFPTPSFEYHT----AFNGVAFGIVAgvqQTYSQFHHEAAPRIFS----PQLPIAA 243

                        250       260       270
                 ....*....|....*....|....*....|
gi 187955788 276 LvlgLTKFMVGIMLILLVRQLVQKLSLQVL 305
Cdd:PLN02525 244 F---LGRVAVGIPTILAVKFCSKALAKWLL 270
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 76-188 7.40e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.45  E-value: 7.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788   76 LVVIWVLVMYIGQVAKDILKWPRPSF-----PPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMM 150
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFlllegGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLALL 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 187955788  151 AVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:pfam01569  82 LLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 55-191 8.12e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 57.74  E-value: 8.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  55 VFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLi 134
Cdd:COG0671   57 LLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALALVLA- 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 187955788 135 stmdrYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAW 191
Cdd:COG0671  136 -----LLLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
acidPPc smart00014
Acid phosphatase homologues;
81-188 7.90e-09

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 53.12  E-value: 7.90e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788    81 VLVMYIGQVAKDILKW----PRPSF------PPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMM 150
Cdd:smart00014   1 ALLAVVSQLFNGVIKNyfgrPRPFFlsigdaCCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLLIFLLL 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 187955788   151 AVVFstLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:smart00014  81 LLAL--VVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
 
Name Accession Description Interval E-value
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 39-188 6.91e-69

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 212.86  E-value: 6.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  39 YFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKR-IIAEYGM 117
Cdd:cd03388    1 PFLDYYFAFTALLGTHTFYILFLPFLFWNGDPYVGRDLVVVLALGMYIGQFIKDLFCLPRPSSPPVVRLTMSsAALEYGF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187955788 118 PSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:cd03388   81 PSTHAMNATAISFYLLIYLYDRYQYPFVLGLILALFYSTLVCLSRIYMGMHSVLDVIAGSLIGVLILLFRF 151
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 56-305 4.68e-25

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 104.05  E-value: 4.68e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  56 FYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRL-----EKRIIAEYGMPSTHAMAATAISF 130
Cdd:PLN02525  20 FYTAFLPLLFWSGHGKLARQMTLLMAFCDYVGNCIKDVVSAPRPSCPPVRRVtatkdEEENAMEYGLPSSHTLNTVCLSG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788 131 TLLISTMDRYQYP----FILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALtypaW--------TLIDSLD 198
Cdd:PLN02525 100 YLLHYVLSYLQNVdasvIFAGLALFCLLVALVGFGRLYLGMHSPIDIIAGLAIGLVILAF----WltvdeyvdAFITSGQ 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788 199 SASPLFpvcvIVVPFLLCYNYPVSDYYSPTRADTTtivaAGAGVTLGFWI---NHFFQLVSKPTPSLPViqniPPLTTDM 275
Cdd:PLN02525 176 NVTPFW----AALSFLLLFAYPTPEFPTPSFEYHT----AFNGVAFGIVAgvqQTYSQFHHEAAPRIFS----PQLPIAA 243

                        250       260       270
                 ....*....|....*....|....*....|
gi 187955788 276 LvlgLTKFMVGIMLILLVRQLVQKLSLQVL 305
Cdd:PLN02525 244 F---LGRVAVGIPTILAVKFCSKALAKWLL 270
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 76-188 4.79e-15

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 70.57  E-value: 4.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  76 LVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRII----AEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMMA 151
Cdd:cd01610    8 LLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLllteGGYSFPSGHAAFAFALALFLALLLPRRLLRLLLGLLLLL 87

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 187955788 152 VVFstLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:cd01610   88 LAL--LVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 76-188 7.40e-14

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.45  E-value: 7.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788   76 LVVIWVLVMYIGQVAKDILKWPRPSF-----PPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMM 150
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFlllegGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRRLRKIVRVLLALL 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 187955788  151 AVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:pfam01569  82 LLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVY 119
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 60-186 1.09e-12

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 64.32  E-value: 1.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  60 FLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAE-YGMPSTHAMAATAISFTLLISTMD 138
Cdd:cd03393    2 VLSLIYWLVDKRLGRYLGLALCASGYLNAALKEVFKIPRPFTYDGIQAIYEESAGgYGFPSGHAQTSATFWGSLMLHVRK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 187955788 139 RYQYpfilglMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIAL 186
Cdd:cd03393   82 KWFT------LIGVVLVVLISFSRLYLGVHWPSDVIGGVLIGLLVLVL 123
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 55-191 8.12e-10

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 57.74  E-value: 8.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  55 VFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLi 134
Cdd:COG0671   57 LLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELLLGTAGGYSFPSGHAAAAFALALVLA- 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 187955788 135 stmdrYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAW 191
Cdd:COG0671  136 -----LLLPRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
acidPPc smart00014
Acid phosphatase homologues;
81-188 7.90e-09

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 53.12  E-value: 7.90e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788    81 VLVMYIGQVAKDILKW----PRPSF------PPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMM 150
Cdd:smart00014   1 ALLAVVSQLFNGVIKNyfgrPRPFFlsigdaCCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLLIFLLL 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 187955788   151 AVVFstLVCLSRLYTGMHTVLDILGGVLITAVLIALTY 188
Cdd:smart00014  81 LLAL--VVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 74-194 1.06e-07

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 51.46  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  74 RRLVVIWVLVMYIGQVAKDILKW----PRPSFPPVVRLEKriiaeYGMPSTHAMAATAISFTLLI-----STMDRYQYPF 144
Cdd:cd03392   61 RRAALFLLLALLGGGALNTLLKLlvqrPRPPLHLLVPEGG-----YSFPSGHAMGATVLYGFLAYllarrLPRRRVRILL 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 187955788 145 ILGlmmAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAWTLI 194
Cdd:cd03392  136 LIL---AAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLILLYRRL 182
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 56-194 2.75e-06

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 47.26  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  56 FYITFLPFTHWNIDPNLsRRLVVIWVLVMYIGQVAKDILK----WPRPSFPPVVRLEKRIIAE---YGMPSTHAmaatAI 128
Cdd:cd03395   39 FLLLALFILFRKGPIGL-LILLLVLLAVGFADQLASGFLKplvaRLRPCNALDGVRLVVLGDQggsYSFASSHA----AN 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187955788 129 SFTLLISTMDRYQYPFILGLMMAVVFstLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAWTLI 194
Cdd:cd03395  114 SFALALFIWLFFRRGLFSPVLLLWAL--LVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLFSWL 177
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 55-183 3.10e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 46.50  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  55 VFYITFLPFThwnidpnlsRRLVVIWVLvmyIGQVA--------KDILKWPRPSFPpvvrlEKRIIAEYGMPSTHA--MA 124
Cdd:cd03382   30 VGYATLILFR---------RELEAIYLF---IGLLAnealnyvlKRIIKEPRPCSG-----AYFVRSGYGMPSSHSqfMG 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 187955788 125 ATAISFTLLISTMDRYQYPFILGLMMAVVF---STLVCLSRLYTGMHTVLDILGGVLITAVL 183
Cdd:cd03382   93 FFAVYLLLFIYLRLGRLNSLVSRFLLSLGLlllALLVSYSRVYLGYHTVSQVVVGAIVGILL 154
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 70-188 9.99e-05

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 41.86  E-value: 9.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187955788  70 PNLSRRLVVIWVLV-----MYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLIstmdrYQYPF 144
Cdd:cd03385   27 GGEKQRKVVLFATIavavaLLINYIIGLLYFHPRPFVVGLGHNLLPHAADSSFPSDHTTLFFSIAFSLLL-----RRRKW 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 187955788 145 ILGLMMAVVFstLVCLSRLYTGMHTVLDILGGVLItAVLIALTY 188
Cdd:cd03385  102 AGWILLILAL--LVAWSRIYLGVHYPLDMLGAALV-AVLSALLV 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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