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Conserved domains on  [gi|169642269|gb|AAI60891|]
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Wbscr22 protein [Rattus norvegicus]

Protein Classification

18S rRNA (guanine-N(7))-methyltransferase family protein( domain architecture ID 18602768)

18S rRNA (guanine-N(7))-methyltransferase family protein is a class I SAM-dependent methyltransferase, similar to Saccharomyces cerevisiae 18S rRNA (guanine(1575)-N(7))-methyltransferase that specifically methylates the N(7) position of guanine 1575 (m7G1575) in 18S rRNA

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:0008757|GO:1904047|GO:0032259
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 204-279 1.53e-24

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


:

Pssm-ID: 432656  Cd Length: 81  Bit Score: 93.85  E-value: 1.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  204 LFSGP-STSLPKGLTES-QEADQASESAFTSERAPHKKARRDLVKK---SREWVLEKKERRRRQGKEVRPDTQYTGRKRK 278
Cdd:pfam12589   1 LFVGGvQQQLPKGLGEDgEECSEEQNTVKYERRRRPRKKRKKKGKKavkGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 169642269  279 P 279
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 41-184 1.59e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.34  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  41 ERALELLCLPEGQPsyLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEG----DLLLGDMGQgVPFRPGSF 116
Cdd:COG2226   12 EALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAglnvEFVVGDAED-LPFPDGSF 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 169642269 117 DGCISISAVQWLcnankkSDIPArrlycFFSSLYSALVRGAR-AVLQLYPENSEQLELIttqATRAGFT 184
Cdd:COG2226   89 DLVISSFVLHHL------PDPER-----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 204-279 1.53e-24

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 93.85  E-value: 1.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  204 LFSGP-STSLPKGLTES-QEADQASESAFTSERAPHKKARRDLVKK---SREWVLEKKERRRRQGKEVRPDTQYTGRKRK 278
Cdd:pfam12589   1 LFVGGvQQQLPKGLGEDgEECSEEQNTVKYERRRRPRKKRKKKGKKavkGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 169642269  279 P 279
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 41-184 1.59e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.34  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  41 ERALELLCLPEGQPsyLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEG----DLLLGDMGQgVPFRPGSF 116
Cdd:COG2226   12 EALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAglnvEFVVGDAED-LPFPDGSF 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 169642269 117 DGCISISAVQWLcnankkSDIPArrlycFFSSLYSALVRGAR-AVLQLYPENSEQLELIttqATRAGFT 184
Cdd:COG2226   89 DLVISSFVLHHL------PDPER-----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-128 5.98e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 63.45  E-value: 5.98e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169642269   58 LDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDL--LLGDMGQgVPFRPGSFDGCISISAVQWL 128
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLtfVVGDAED-LPFPDNSFDLVLSSEVLHHV 72
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 35-153 3.67e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 61.53  E-value: 3.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269   35 IQTKMTERALELL-CLPEGQPSYLLDIGCGSGLSGDYISEEGHY--WVGIDISPAMLDAALDRDTEGDL-LLGDMGQgVP 110
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 169642269  111 FRPGSFDGCISISAVQWLCNANKksdiparrlycFFSSLYSAL 153
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 34-130 2.75e-10

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 59.39  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  34 DIQTKMTERALELLclPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMgQGVPFRP 113
Cdd:PRK10258  25 ELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLAT 101

                         90
                 ....*....|....*..
gi 169642269 114 GSFDGCISISAVQWlCN 130
Cdd:PRK10258 102 ATFDLAWSNLAVQW-CG 117
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-164 3.20e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 3.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  57 LLDIGCGSGLSGDYISE-EGHYWVGIDISPAMLDAALDRDTEG-----DLLLGDMGQGVPFRPGSFDGCISISAVQWLcn 130
Cdd:cd02440    2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 169642269 131 ankksdipARRLYCFFSSLYSALVRGARAVLQLY 164
Cdd:cd02440   80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 204-279 1.53e-24

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 93.85  E-value: 1.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  204 LFSGP-STSLPKGLTES-QEADQASESAFTSERAPHKKARRDLVKK---SREWVLEKKERRRRQGKEVRPDTQYTGRKRK 278
Cdd:pfam12589   1 LFVGGvQQQLPKGLGEDgEECSEEQNTVKYERRRRPRKKRKKKGKKavkGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 169642269  279 P 279
Cdd:pfam12589  81 P 81
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 41-184 1.59e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 77.34  E-value: 1.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  41 ERALELLCLPEGQPsyLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEG----DLLLGDMGQgVPFRPGSF 116
Cdd:COG2226   12 EALLAALGLRPGAR--VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAglnvEFVVGDAED-LPFPDGSF 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 169642269 117 DGCISISAVQWLcnankkSDIPArrlycFFSSLYSALVRGAR-AVLQLYPENSEQLELIttqATRAGFT 184
Cdd:COG2226   89 DLVISSFVLHHL------PDPER-----ALAEIARVLKPGGRlVVVDFSPPDLAELEEL---LAEAGFE 143
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
53-162 8.82e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 71.01  E-value: 8.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  53 QPSYLLDIGCGSGLSGDYISEE--GHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQGVPfrPGSFDGCISISAVQWLcn 130
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP--PEPFDLVVSNAALHWL-- 76

                         90       100       110
                 ....*....|....*....|....*....|..
gi 169642269 131 ankkSDIPArrlycFFSSLYSALVRGARAVLQ 162
Cdd:COG4106   77 ----PDHAA-----LLARLAAALAPGGVLAVQ 99
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
46-184 3.53e-14

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 68.87  E-value: 3.53e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  46 LLCLPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMGQgVPFRPGSFDGCISISAV 125
Cdd:COG4976   39 LARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLAD-LAEPDGRFDLIVAADVL 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 169642269 126 QWLcnankkSDIPArrlycFFSSLYSALVRGARAVLQLYPENSEQ-----LELITTQATRAGFT 184
Cdd:COG4976  118 TYL------GDLAA-----VFAGVARALKPGGLFIFSVEDADGSGryahsLDYVRDLLAAAGFE 170
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 36-162 6.18e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 67.65  E-value: 6.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  36 QTKMTERALELLCLPEGQPsyLLDIGCGSGLSGDYISEE-GHYWVGIDISPAMLDAALDRDTEGDL------LLGDMGQg 108
Cdd:COG2230   36 QEAKLDLILRKLGLKPGMR--VLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAGLadrvevRLADYRD- 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 169642269 109 vPFRPGSFDGCISISAVQWLCNANKKSdiparrlycFFSSLYSALVRGARAVLQ 162
Cdd:COG2230  113 -LPADGQFDAIVSIGMFEHVGPENYPA---------YFAKVARLLKPGGRLLLH 156
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-128 5.98e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 63.45  E-value: 5.98e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 169642269   58 LDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDL--LLGDMGQgVPFRPGSFDGCISISAVQWL 128
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLtfVVGDAED-LPFPDNSFDLVLSSEVLHHV 72
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-128 9.05e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 62.97  E-value: 9.05e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 169642269   58 LDIGCGSGLSGDYISEE-GHYWVGIDISPAMLDAA----LDRDTEGDLLLGDMgQGVPFRPGSFDGCISISAVQWL 128
Cdd:pfam13649   2 LDLGCGTGRLTLALARRgGARVTGVDLSPEMLERAreraAEAGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL 76
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 57-161 1.39e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 60.42  E-value: 1.39e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  57 LLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDR--DTEGDLLLGDMgQGVPFRPGSFDGCISISAVQWLcnankk 134
Cdd:COG2227   28 VLDVGCGTGRLALALARRGADVTGVDISPEALEIARERaaELNVDFVQGDL-EDLPLEDGSFDLVICSEVLEHL------ 100

                         90       100
                 ....*....|....*....|....*..
gi 169642269 135 SDIPArrlycFFSSLYSALVRGARAVL 161
Cdd:COG2227  101 PDPAA-----LLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 43-192 1.81e-11

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 61.86  E-value: 1.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  43 ALELLCLPEGQPsyLLDIGCGSGLSGDYISEEGHYWV-GIDISPAMLDAALDRDTEG-----DLLLGDMGQGVPFRPGSF 116
Cdd:COG0500   18 LALLERLPKGGR--VLDLGCGTGRNLLALAARFGGRViGIDLSPEAIALARARAAKAglgnvEFLVADLAELDPLPAESF 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 169642269 117 DGCISISAVQWlcnankksdIPARRLYCFFSSLYSALVRGARAVLQLYPENSEQLELITTQATRAGFTGGVVVDFP 192
Cdd:COG0500   96 DLVVAFGVLHH---------LPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLRL 162
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 35-153 3.67e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 61.53  E-value: 3.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269   35 IQTKMTERALELL-CLPEGQPSYLLDIGCGSGLSGDYISEEGHY--WVGIDISPAMLDAALDRDTEGDL-LLGDMGQgVP 110
Cdd:TIGR02072  15 IQREMAKRLLALLkEKGIFIPASVLDIGCGTGYLTRALLKRFPQaeFIALDISAGMLAQAKTKLSENVQfICGDAEK-LP 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 169642269  111 FRPGSFDGCISISAVQWLCNANKksdiparrlycFFSSLYSAL 153
Cdd:TIGR02072  94 LEDSSFDLIVSNLALQWCDDLSQ-----------ALSELARVL 125
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 34-130 2.75e-10

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 59.39  E-value: 2.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  34 DIQTKMTERALELLclPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDRDTEGDLLLGDMgQGVPFRP 113
Cdd:PRK10258  25 ELQRQSADALLAML--PQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLAT 101

                         90
                 ....*....|....*..
gi 169642269 114 GSFDGCISISAVQWlCN 130
Cdd:PRK10258 102 ATFDLAWSNLAVQW-CG 117
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 57-164 3.20e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 3.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  57 LLDIGCGSGLSGDYISE-EGHYWVGIDISPAMLDAALDRDTEG-----DLLLGDMGQGVPFRPGSFDGCISISAVQWLcn 130
Cdd:cd02440    2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHL-- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 169642269 131 ankksdipARRLYCFFSSLYSALVRGARAVLQLY 164
Cdd:cd02440   80 --------VEDLARFLEEARRLLKPGGVLVLTLV 105
PRK08317 PRK08317
hypothetical protein; Provisional
 41-128 8.47e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 57.64  E-value: 8.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  41 ERALELLCLPEGQPsyLLDIGCGSGLS----GDYISEEGHYwVGIDISPAMLDAALDRdTEGDLL-----LGDmGQGVPF 111
Cdd:PRK08317   9 ARTFELLAVQPGDR--VLDVGCGPGNDarelARRVGPEGRV-VGIDRSEAMLALAKER-AAGLGPnvefvRGD-ADGLPF 83

                         90
                 ....*....|....*..
gi 169642269 112 RPGSFDGCISISAVQWL 128
Cdd:PRK08317  84 PDGSFDAVRSDRVLQHL 100
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 58-94 8.93e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.21  E-value: 8.93e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 169642269   58 LDIGCGSGLSGDYISEEGHYW--VGIDISPAMLDAALDR 94
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARER 39
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 41-110 4.49e-05

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 43.78  E-value: 4.49e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 169642269  41 ER---ALELLC-LPEGQPSYLLDIGCGSGLSGDYISEEghyW-----VGIDISPAMLDAALDRDTEGDLLLGDMGQGVP 110
Cdd:PRK01683  15 ERtrpARDLLArVPLENPRYVVDLGCGPGNSTELLVER---WpaariTGIDSSPAMLAEARSRLPDCQFVEADIASWQP 90
PRK14968 PRK14968
putative methyltransferase; Provisional
 58-117 7.49e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.58  E-value: 7.49e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 169642269  58 LDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALD-------RDTEGDLLLGDMGQgvPFRPGSFD 117
Cdd:PRK14968  28 LEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCnaklnniRNNGVEVIRSDLFE--PFRGDKFD 92
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 48-123 9.77e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.83  E-value: 9.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  48 CLPEGQPSYLLDIGCGSG-LSGDYI---SEEGHYWvGIDISPAMLDAALDRDTEG------DLLLGDmGQGVPFRPGSFD 117
Cdd:PRK00216  46 WLGVRPGDKVLDLACGTGdLAIALAkavGKTGEVV-GLDFSEGMLAVGREKLRDLglsgnvEFVQGD-AEALPFPDNSFD 123


                 ....*.
gi 169642269 118 gCISIS 123
Cdd:PRK00216 124 -AVTIA 128
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 21-94 7.29e-04

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 39.78  E-value: 7.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 169642269   21 NEARKYVRNSRmidiqTKMTERALELLclPEGQPS--YLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALDR 94
Cdd:TIGR02021  28 SRVRQTVREGR-----AAMRRKLLDWL--PKDPLKgkRVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNR 96
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 42-93 5.20e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 36.64  E-value: 5.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 169642269   42 RALELLCLPEGQPSYLLDIGCGSGLSGDYISEEGHYWVGIDISPAMLDAALD 93
Cdd:pfam13489  11 DLLLRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALL 62
PLN02244 PLN02244
tocopherol O-methyltransferase
 10-117 6.57e-03

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 37.42  E-value: 6.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169642269  10 HSGppelFYDQNEARKYVRNSrmidiQTKMTERALELLCLP---EGQPSYLLDIGCGSGLSGDYISEE-GHYWVGIDISP 85
Cdd:PLN02244  81 HHG----YYDPGASRGDHRQA-----QIRMIEESLAWAGVPdddEKRPKRIVDVGCGIGGSSRYLARKyGANVKGITLSP 151

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 169642269  86 amLDAALDRDTEGDLLLGDMGQ-------GVPFRPGSFD 117
Cdd:PLN02244 152 --VQAARANALAAAQGLSDKVSfqvadalNQPFEDGQFD 188
PRK05785 PRK05785
hypothetical protein; Provisional
 52-121 7.95e-03

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 36.97  E-value: 7.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 169642269  52 GQPSYLLDIGCGSG-LSGDYISEEGHYWVGIDISPAMLDAALdrdTEGDLLLGdMGQGVPFRPGSFDGCIS 121
Cdd:PRK05785  50 GRPKKVLDVAAGKGeLSYHFKKVFKYYVVALDYAENMLKMNL---VADDKVVG-SFEALPFRDKSFDVVMS 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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