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Conserved domains on  [gi|14334688|gb|AAK59522|]
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putative pyruvate dehydrogenase kinase [Arabidopsis thaliana]

Protein Classification

PDK/BCKDK family protein kinase( domain architecture ID 13768654)

PDK/BCKDK family protein kinase contains a histidine kinase-like ATPase domain and catalyzes the phosphorylation of protein substrates, such as branched-chain alpha-ketoacid dehydrogenase (BCKD) kinase that catalyzes the phosphorylation and inactivation of the BCKD complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways

CATH:  3.30.565.10|1.20.140.20
EC:  2.7.11.-
Gene Ontology:  GO:0004672|GO:0005524|GO:0006468
PubMed:  10339418|10637609

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 189-356 5.00e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


:

Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 254.96  E-value: 5.00e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 189 SPMEVARNASEDARSICFREYGSAPEINIYGDPSFTFPYVPTHLHLMMYELVKNSLRAVQERFVDSDRVAPPIRIIVADG 268
Cdd:cd16929   1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 269 IEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPLEEDV-DLGIADVPVTMAGYGYGLPISRLYARYFGGDLQIISMEGY 347
Cdd:cd16929  81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDDFsDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                ....*....
gi 14334688 348 GTDAYLHLS 356
Cdd:cd16929 161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 28-185 4.66e-68

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


:

Pssm-ID: 463093  Cd Length: 158  Bit Score: 211.21  E-value: 4.66e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688    28 GVSLRYMMEFGSKPTERNLLISAQFLHKELPIRVARRAIELQTLPYGLSDKPAVLKVRDWYLESFRDMRAFPEIKDSgDE 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILE-DN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688   108 KDFTQMIKAVKVRHNNVVPMMALGVNQLKKGMNSgnlDEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGY 183
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSP---EEIQSFLDRFLRSRIGIRLLAEQHIALTeqsnNPSHPPDYVGI 156


                  ..
gi 14334688   184 IH 185
Cdd:pfam10436 157 ID 158
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 189-356 5.00e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 254.96  E-value: 5.00e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 189 SPMEVARNASEDARSICFREYGSAPEINIYGDPSFTFPYVPTHLHLMMYELVKNSLRAVQERFVDSDRVAPPIRIIVADG 268
Cdd:cd16929   1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 269 IEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPLEEDV-DLGIADVPVTMAGYGYGLPISRLYARYFGGDLQIISMEGY 347
Cdd:cd16929  81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDDFsDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                ....*....
gi 14334688 348 GTDAYLHLS 356
Cdd:cd16929 161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 28-185 4.66e-68

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 211.21  E-value: 4.66e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688    28 GVSLRYMMEFGSKPTERNLLISAQFLHKELPIRVARRAIELQTLPYGLSDKPAVLKVRDWYLESFRDMRAFPEIKDSgDE 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILE-DN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688   108 KDFTQMIKAVKVRHNNVVPMMALGVNQLKKGMNSgnlDEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGY 183
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSP---EEIQSFLDRFLRSRIGIRLLAEQHIALTeqsnNPSHPPDYVGI 156


                  ..
gi 14334688   184 IH 185
Cdd:pfam10436 157 ID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 229-355 6.47e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 78.46  E-value: 6.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688    229 PTHLHLMMYELVKNSLRAVQERfvdsdrvaPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPleedvd 308
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG--------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRS------ 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 14334688    309 lgiadvpVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:smart00387  69 -------RKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 228-355 1.61e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 74.71  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688   228 VPTHLHLMMYELVKNSLRAVQErfvdsdrvAPPIRIIVADGiEDVTIKVSDEGGGIARSGLPRIFTYLYSTARnpleedv 307
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAK--------AGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADK------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 14334688   308 dlgiadvpVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:pfam02518  66 --------RGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
201-355 4.67e-09

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 57.23  E-value: 4.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 201 ARSICFREYGSAPEINIYGDPsftfpyvpTHLHLMMYELVKNSLRAVQErfvdsdrvAPPIRIIVADGIEDVTIKVSDEG 280
Cdd:COG0642 201 EKGIELELDLPDDLPTVRGDP--------DRLRQVLLNLLSNAIKYTPE--------GGTVTVSVRREGDRVRISVEDTG 264

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14334688 281 GGIARSGLPRIFTYLYSTARNPLEEdvdlgiadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:COG0642 265 PGIPPEDLERIFEPFFRTDPSRRGG--------------GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
PRK15347 PRK15347
two component system sensor kinase;
274-366 1.39e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 43.86  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688  274 IKVSDEGGGIARSGLPRIFTYLYSTARNpleedvdlgiadvpvtMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYL 353
Cdd:PRK15347 547 FTVEDTGCGIDIQQQQQIFTPFYQADTH----------------SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610

                         90
                 ....*....|...
gi 14334688  354 HLSrLGDSQEPLP 366
Cdd:PRK15347 611 VLP-LNEYAPPEP 622
 
Name Accession Description Interval E-value
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 189-356 5.00e-85

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 254.96  E-value: 5.00e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 189 SPMEVARNASEDARSICFREYGSAPEINIYGDPSFTFPYVPTHLHLMMYELVKNSLRAVQERFVDSDRVAPPIRIIVADG 268
Cdd:cd16929   1 SPKKVVEDASEEARVLCDDYYLSSPELEIEGDPSIRFPYVPSHLYYILFELLKNAMRATVESHGDDSDDLPPIKVTVAKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 269 IEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPLEEDV-DLGIADVPVTMAGYGYGLPISRLYARYFGGDLQIISMEGY 347
Cdd:cd16929  81 DEDLTIKISDRGGGIPREDLARLFSYMYSTAPQPSLDDFsDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGY 160


                ....*....
gi 14334688 348 GTDAYLHLS 356
Cdd:cd16929 161 GTDVYIYLK 169
BCDHK_Adom3 pfam10436
Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of ...
 28-185 4.66e-68

Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c pfam02518 which is towards the C-terminal.


Pssm-ID: 463093  Cd Length: 158  Bit Score: 211.21  E-value: 4.66e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688    28 GVSLRYMMEFGSKPTERNLLISAQFLHKELPIRVARRAIELQTLPYGLSDKPAVLKVRDWYLESFRDMRAFPEIKDSgDE 107
Cdd:pfam10436   1 PLSLRQLLDFGRSLSEEKLLKSANFLREELPVRLAHRIRELQNLPYILVSNPSISKVYEWYLQSFEELLSFPPPILE-DN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688   108 KDFTQMIKAVKVRHNNVVPMMALGVNQLKKGMNSgnlDEIHQFLDRFYLSRIGIRMLIGQHVELH----NPNPPLHTVGY 183
Cdd:pfam10436  80 EKFTELLEEILDRHNDVVPTLAQGVLELKKYLSP---EEIQSFLDRFLRSRIGIRLLAEQHIALTeqsnNPSHPPDYVGI 156


                  ..
gi 14334688   184 IH 185
Cdd:pfam10436 157 ID 158
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 229-355 6.47e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 78.46  E-value: 6.47e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688    229 PTHLHLMMYELVKNSLRAVQERfvdsdrvaPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNPleedvd 308
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEG--------GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRS------ 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 14334688    309 lgiadvpVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:smart00387  69 -------RKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 228-355 1.61e-16

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 74.71  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688   228 VPTHLHLMMYELVKNSLRAVQErfvdsdrvAPPIRIIVADGiEDVTIKVSDEGGGIARSGLPRIFTYLYSTARnpleedv 307
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAK--------AGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADK------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 14334688   308 dlgiadvpVTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:pfam02518  66 --------RGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTL 105
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
201-355 4.67e-09

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 57.23  E-value: 4.67e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 201 ARSICFREYGSAPEINIYGDPsftfpyvpTHLHLMMYELVKNSLRAVQErfvdsdrvAPPIRIIVADGIEDVTIKVSDEG 280
Cdd:COG0642 201 EKGIELELDLPDDLPTVRGDP--------DRLRQVLLNLLSNAIKYTPE--------GGTVTVSVRREGDRVRISVEDTG 264

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14334688 281 GGIARSGLPRIFTYLYSTARNPLEEdvdlgiadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:COG0642 265 PGIPPEDLERIFEPFFRTDPSRRGG--------------GTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
212-355 2.70e-08

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 54.14  E-value: 2.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 212 APEINIYGDPsftfpyvpTHLHLMMYELVKNSLRAVQErfvdsdrvAPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRI 291
Cdd:COG2205 121 PELPLVYADP--------ELLEQVLANLLDNAIKYSPP--------GGTITISARREGDGVRISVSDNGPGIPEEELERI 184

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14334688 292 FTYLYSTARNPLEEdvdlgiadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:COG2205 185 FERFYRGDNSRGEG--------------GTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 229-349 4.82e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 47.80  E-value: 4.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 229 PTHLHLMMYELVKNSLRAVQERfvdsdrvaPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTArnpleedvd 308
Cdd:cd16943   1 PSQLNQVLLNLLVNAAQAMEGR--------GRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTK--------- 63

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 14334688 309 lgiadvPVTmAGYGYGLPISRLYARYFGGDLQIISMEGYGT 349
Cdd:cd16943  64 ------PVG-EGTGLGLSLSYRIIQKHGGTIRVASVPGGGT 97
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 200-362 6.14e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 50.73  E-value: 6.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 200 DARSICFREYGSAPEINIYGDPsftfpyvpTHLHLMMYELVKNSLRAVQERfvdsdrvaPPIRIIVADGIEDVTIKVSDE 279
Cdd:COG5000 294 KEKDIRLELDLDPDLPEVLADR--------DQLEQVLINLLKNAIEAIEEG--------GEIEVSTRREDGRVRIEVSDN 357

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 280 GGGIARSGLPRIFTYLYSTARNpleedvdlgiadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHLSRLG 359
Cdd:COG5000 358 GPGIPEEVLERIFEPFFTTKPK------------------GTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419


                ...
gi 14334688 360 DSQ 362
Cdd:COG5000 420 EAE 422
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 239-349 3.60e-06

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 48.26  E-value: 3.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 239 LVKNSLRAVQERFvdsdrvAPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTarNPLEEdvdlgiadvpvtm 318
Cdd:COG4191 264 LLINAIDAMEEGE------GGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTT--KPVGK------------- 322

                        90       100       110
                ....*....|....*....|....*....|.
gi 14334688 319 aGYGYGLPISRLYARYFGGDLQIISMEGYGT 349
Cdd:COG4191 323 -GTGLGLSISYGIVEKHGGRIEVESEPGGGT 352
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 236-348 4.74e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 44.76  E-value: 4.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 236 MYELVKNSLRAVQERFVdsdrvaPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTArnpleedvdlgiadvP 315
Cdd:cd16976   5 LMNLLQNALDAMGKVEN------PRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTK---------------P 63

                        90       100       110
                ....*....|....*....|....*....|...
gi 14334688 316 VTmAGYGYGLPISRLYARYFGGDLQIISMEGYG 348
Cdd:cd16976  64 VG-KGTGLGLSISYGIVEEHGGRLSVANEEGAG 95
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
200-355 1.28e-04

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 43.77  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 200 DARSICFREYGSAPEINIYGDPSftfpyvptHLHLMMYELVKNSLRAVQERfvdsdrvaPPIRIIVADGIEDVTIKVSDE 279
Cdd:COG5002 258 EEKGIELELDLPEDPLLVLGDPD--------RLEQVLTNLLDNAIKYTPEG--------GTITVSLREEDDQVRISVRDT 321

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14334688 280 GGGIARSGLPRIFTYLY--STARNPleedvdlgiadvpvTMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:COG5002 322 GIGIPEEDLPRIFERFYrvDKSRSR--------------ETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
PRK15347 PRK15347
two component system sensor kinase;
274-366 1.39e-04

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 43.86  E-value: 1.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688  274 IKVSDEGGGIARSGLPRIFTYLYSTARNpleedvdlgiadvpvtMAGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYL 353
Cdd:PRK15347 547 FTVEDTGCGIDIQQQQQIFTPFYQADTH----------------SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSL 610

                         90
                 ....*....|...
gi 14334688  354 HLSrLGDSQEPLP 366
Cdd:PRK15347 611 VLP-LNEYAPPEP 622
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 272-355 1.70e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 43.42  E-value: 1.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 272 VTIKVSDEGGGIARSGLPRIFTYLYSTARNpleedvdlgiadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGTDA 351
Cdd:COG5809 413 VVISVTDEGCGIPEERLKKLGEPFYTTKEK------------------GTGLGLMVSYKIIEEHGGKITVESEVGKGTTF 474


                ....
gi 14334688 352 YLHL 355
Cdd:COG5809 475 SITL 478
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 239-349 2.29e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 42.91  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 239 LVKNSLRAVQErfvdSDRVAPPIRI-IVADGiEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNpleedvdlgiadvpvt 317
Cdd:COG3290 289 LLDNAIEAVEK----LPEEERRVELsIRDDG-DELVIEVEDSGPGIPEELLEKIFERGFSTKLG---------------- 347

                        90       100       110
                ....*....|....*....|....*....|..
gi 14334688 318 mAGYGYGLPISRLYARYFGGDLQIISMEGYGT 349
Cdd:COG3290 348 -EGRGLGLALVKQIVEKYGGTIEVESEEGEGT 378
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-349 5.40e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 38.92  E-value: 5.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 239 LVKNSLRAVQERFVDSDRVAppIRIIVADGIEdVTIKVSDEGGGIARSGLPRIFTYLYSTARNpleedvdlgiadvpvtm 318
Cdd:cd16920   8 LVRNGIEAMSEGGCERRELT--IRTSPADDRA-VTISVKDTGPGIAEEVAGQLFDPFYTTKSE----------------- 67

                        90       100       110
                ....*....|....*....|....*....|.
gi 14334688 319 aGYGYGLPISRLYARYFGGDLQIISMEGYGT 349
Cdd:cd16920  68 -GLGMGLSICRSIIEAHGGRLSVESPAGGGA 97
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 261-355 6.47e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 38.98  E-value: 6.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 261 IRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTARnPLEEDVDLGIadvpvtmagygyGLPISRLYARYFGGDLQ 340
Cdd:cd16945  26 IALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPR-PHSGQKSTGL------------GLAFVQEVAQLHGGRIT 92

                        90
                ....*....|....*
gi 14334688 341 IISMEGyGTDAYLHL 355
Cdd:cd16945  93 LRNRPD-GVLAFLTL 106
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
161-355 1.68e-03

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 39.83  E-value: 1.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 161 IRMLIGQHVELHNPNPPLHTVGYIHtkmspmEVARNA-----SEDARSICF-REY-GSAPEIniYGDPsftfpyvpTHLH 233
Cdd:COG3852 183 LNNLVDRLLSFSRPRPPEREPVNLH------EVLERVlellrAEAPKNIRIvRDYdPSLPEV--LGDP--------DQLI 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 234 LMMYELVKNSLRAVQE----RFvdSDRVAPPIRIIVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYSTARNpleedvdl 309
Cdd:COG3852 247 QVLLNLVRNAAEAMPEggtiTI--RTRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKEK-------- 316

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 14334688 310 giadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGTDAYLHL 355
Cdd:COG3852 317 ----------GTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 264-349 2.58e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 39.92  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688  264 IVADGIEDVTIKVSDEGGGIARSGLPRIFTYLYStarnpleedVDLGIADVPVTmaGYGYGLPISRLYARYFGGDLQIIS 343
Cdd:PRK11091 423 VRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQ---------VKDSHGGKPAT--GTGIGLAVSKRLAQAMGGDITVTS 491


                 ....*.
gi 14334688  344 MEGYGT 349
Cdd:PRK11091 492 EEGKGS 497
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 239-349 3.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 36.88  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 239 LVKNSLRAVQERFVDSDRVAPPIRiivADGiEDVTIKVSDEGGGIARSGLPRIFTYLYSTArnpleedvdlgiadvpvTM 318
Cdd:cd16915   8 LIDNALDALAATGAPNKQVEVFLR---DEG-DDLVIEVRDTGPGIAPELRDKVFERGVSTK-----------------GQ 66

                        90       100       110
                ....*....|....*....|....*....|.
gi 14334688 319 AGYGYGLPISRLYARYFGGDLQIISMEGYGT 349
Cdd:cd16915  67 GERGIGLALVRQSVERLGGSITVESEPGGGT 97
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 215-343 3.29e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 39.28  E-value: 3.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 215 INIYGDPsfTFPYVPTHLHLMMYELVKNSLRAVQErfvdsdrvAPPIRIIVADGIEDVTIKVSDEGGGIARsgLPRIFTY 294
Cdd:COG4192 529 LHIPDDL--MVQGDQVLLEQVLVNLLVNALDAVAT--------QPQISVDLLSNAENLRVAISDNGNGWPL--VDKLFTP 596

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 14334688 295 LYSTarnpleEDVDLGIadvpvtmagygyGLPISRLYARYFGGDLQIIS 343
Cdd:COG4192 597 FTTT------KEVGLGL------------GLSICRSIMQQFGGDLYLAS 627
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 211-349 4.22e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 38.94  E-value: 4.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688 211 SAPEINIYGDPSftfpyvptHLHLMMYELVKNSLRAVqerfvdsdrvapP----IRIIVADGIEDVTIKVSDEGGGIARS 286
Cdd:COG5805 383 LDEDPFIYCDEN--------QIKQVFINLIKNAIEAM------------PnggtITIHTEEEDNSVIIRVIDEGIGIPEE 442

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14334688 287 GLPRIFTYLYSTARNpleedvdlgiadvpvtmaGYGYGLPISRLYARYFGGDLQIISMEGYGT 349
Cdd:COG5805 443 RLKKLGEPFFTTKEK------------------GTGLGLMVSYKIIENHNGTIDIDSKVGKGT 487
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
271-357 8.06e-03

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 38.03  E-value: 8.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14334688  271 DVTIKVSDEGGGIARSGLPRIFTYLYSTARnpleedvdlgiadvpvtmAGYGYGLPISRLYARYFGGDLQIISMEGYGTD 350
Cdd:PRK11360 533 QVAVSIEDNGCGIDPELLKKIFDPFFTTKA------------------KGTGLGLALSQRIINAHGGDIEVESEPGVGTT 594


                 ....*..
gi 14334688  351 AYLHLSR 357
Cdd:PRK11360 595 FTLYLPI 601
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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