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Conserved domains on  [gi|15421803|gb|AAK97542|]
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sodium/phosphate type I cotransporter, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0114euk super family cl31037
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-148 4.63e-60

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


The actual alignment was detected with superfamily member TIGR00894:

Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 191.88  E-value: 4.63e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803     1 MENQCLPKKVPGFCSFRYGLAILLHFCNIAIMAQRVCLNLTMVAMVNNTGSPHLSNESVVEMLDNVKNPVYSWSPDIQGL 80
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15421803    81 ILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQGTV 148
Cdd:TIGR00894  81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSV 148
 
Name Accession Description Interval E-value
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-148 4.63e-60

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 191.88  E-value: 4.63e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803     1 MENQCLPKKVPGFCSFRYGLAILLHFCNIAIMAQRVCLNLTMVAMVNNTGSPHLSNESVVEMLDNVKNPVYSWSPDIQGL 80
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15421803    81 ILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQGTV 148
Cdd:TIGR00894  81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSV 148
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 21-148 1.11e-35

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 126.58  E-value: 1.11e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803  21 AILLHFCNIAIMAQRVCLNLTMVAMVNNTGSPHLSNESVVEMLDNVKNPVYSWSPDIQGLILSSVFFGMVVVQAPVGYLS 100
Cdd:cd17318   1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15421803 101 GIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQGTV 148
Cdd:cd17318  81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVT 128
MFS_1 pfam07690
Major Facilitator Superfamily;
71-148 8.55e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 35.09  E-value: 8.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15421803    71 YSWSPDIQGLILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVgaALVIVCRVLQGIAQGTV 148
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--WLLLVLRVLQGLGAGAL 102
 
Name Accession Description Interval E-value
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-148 4.63e-60

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 191.88  E-value: 4.63e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803     1 MENQCLPKKVPGFCSFRYGLAILLHFCNIAIMAQRVCLNLTMVAMVNNTGSPHLSNESVVEMLDNVKNPVYSWSPDIQGL 80
Cdd:TIGR00894   1 MENVFASTKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFKWSGALQGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15421803    81 ILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQGTV 148
Cdd:TIGR00894  81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSV 148
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 21-148 1.11e-35

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 126.58  E-value: 1.11e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803  21 AILLHFCNIAIMAQRVCLNLTMVAMVNNTGSPHLSNESVVEMLDNVKNPVYSWSPDIQGLILSSVFFGMVVVQAPVGYLS 100
Cdd:cd17318   1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15421803 101 GIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQGTV 148
Cdd:cd17318  81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVT 128
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 20-146 1.97e-18

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 80.21  E-value: 1.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803  20 LAILLHFCNIAIMAQRVCLNLTMVAMVNNTGSPHLSNESVV--------EMLDNVKNPVYSWSPDIQGLILSSVFFGMVV 91
Cdd:cd17381   1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNAcpehssspSVEHNETGKKYDWDAETQGWILGSFFYGYII 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15421803  92 VQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQG 146
Cdd:cd17381  81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEG 135
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 35-146 4.40e-13

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 65.05  E-value: 4.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15421803  35 RVCLNLTMVAMVNNTGSPhlsnesvVEMLDNVKNPVYSWSPDIQGLILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLF 114
Cdd:cd17382  15 RCNLGVAIVRMVNNFTDA-------YGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIF 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 15421803 115 LSSLMSLLIPPAAQVGAALVIVCRVLQGIAQG 146
Cdd:cd17382  88 VTSTLNMLIPIAARVHYGCVIFVRILQGLVEG 119
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 71-146 8.98e-08

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 49.86  E-value: 8.98e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15421803  71 YSWSPDIQGLILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVGAALVIVCRVLQGIAQG 146
Cdd:cd17380  29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEG 104
MFS_1 pfam07690
Major Facilitator Superfamily;
71-148 8.55e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 35.09  E-value: 8.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15421803    71 YSWSPDIQGLILSSVFFGMVVVQAPVGYLSGIYPMKRIIGSSLFLSSLMSLLIPPAAQVgaALVIVCRVLQGIAQGTV 148
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--WLLLVLRVLQGLGAGAL 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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