NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17380608|gb|AAL36067|]
View 

AT3g61540/F2A19_140 [Arabidopsis thaliana]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 120-263 7.75e-09

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member pfam00561:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 245  Bit Score: 56.36  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608   120 LLYLQGGPGfegprpseaSGWIQR------ACEEFRVVLLDQRGTGLSTPLTCSSmlqfksakeladylvHFRADNIVKD 193
Cdd:pfam00561   3 VLLLHGLPG---------SSDLWRklapalARDGFRVIALDLRGFGKSSRPKAQD---------------DYRTDDLAED 58

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608   194 AEFIRVRLvpKADPWTILGQSFGGFCALTYLSFAPEGLKQVLITGGIPPIGKACTADDVYEAGFEQVARQ 263
Cdd:pfam00561  59 LEYILEAL--GLEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDG 126
 
Name Accession Description Interval E-value
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 120-263 7.75e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 56.36  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608   120 LLYLQGGPGfegprpseaSGWIQR------ACEEFRVVLLDQRGTGLSTPLTCSSmlqfksakeladylvHFRADNIVKD 193
Cdd:pfam00561   3 VLLLHGLPG---------SSDLWRklapalARDGFRVIALDLRGFGKSSRPKAQD---------------DYRTDDLAED 58

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608   194 AEFIRVRLvpKADPWTILGQSFGGFCALTYLSFAPEGLKQVLITGGIPPIGKACTADDVYEAGFEQVARQ 263
Cdd:pfam00561  59 LEYILEAL--GLEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDG 126
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 140-229 3.73e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 41.91  E-value: 3.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608 140 WIQRACEEFRVVLLDQRGTGLSTPLTCSSmlqfkSAKELADYLVHFRAdnivkdaefirvRLvpKADPWTILGQSFGGFC 219
Cdd:COG0596  42 LIPALAAGYRVIAPDLRGHGRSDKPAGGY-----TLDDLADDLAALLD------------AL--GLERVVLVGHSMGGMV 102

                        90
                ....*....|
gi 17380608 220 ALTYLSFAPE 229
Cdd:COG0596 103 ALELAARHPE 112
 
Name Accession Description Interval E-value
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 120-263 7.75e-09

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 56.36  E-value: 7.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608   120 LLYLQGGPGfegprpseaSGWIQR------ACEEFRVVLLDQRGTGLSTPLTCSSmlqfksakeladylvHFRADNIVKD 193
Cdd:pfam00561   3 VLLLHGLPG---------SSDLWRklapalARDGFRVIALDLRGFGKSSRPKAQD---------------DYRTDDLAED 58

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608   194 AEFIRVRLvpKADPWTILGQSFGGFCALTYLSFAPEGLKQVLITGGIPPIGKACTADDVYEAGFEQVARQ 263
Cdd:pfam00561  59 LEYILEAL--GLEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDG 126
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 140-229 3.73e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 41.91  E-value: 3.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608 140 WIQRACEEFRVVLLDQRGTGLSTPLTCSSmlqfkSAKELADYLVHFRAdnivkdaefirvRLvpKADPWTILGQSFGGFC 219
Cdd:COG0596  42 LIPALAAGYRVIAPDLRGHGRSDKPAGGY-----TLDDLADDLAALLD------------AL--GLERVVLVGHSMGGMV 102

                        90
                ....*....|
gi 17380608 220 ALTYLSFAPE 229
Cdd:COG0596 103 ALELAARHPE 112
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
148-238 3.06e-03

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 39.21  E-value: 3.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17380608 148 FRVVLLDQRGTGLSTPLtcssmlqfksakelADYLVHFraDNIVKD-AEFIRVRLVPKADPWTILGQSFGGFCALTYLSF 226
Cdd:COG2267  56 YAVLAFDLRGHGRSDGP--------------RGHVDSF--DDYVDDlRAALDALRARPGLPVVLLGHSMGGLIALLYAAR 119

                        90
                ....*....|..
gi 17380608 227 APEGLKQVLITG 238
Cdd:COG2267 120 YPDRVAGLVLLA 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH