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Conserved domains on  [gi|17945482|gb|AAL48794|]
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RE22146p [Drosophila melanogaster]

Protein Classification

18S rRNA (guanine-N(7))-methyltransferase family protein( domain architecture ID 18602768)

18S rRNA (guanine-N(7))-methyltransferase family protein is a class I SAM-dependent methyltransferase, similar to Saccharomyces cerevisiae 18S rRNA (guanine(1575)-N(7))-methyltransferase that specifically methylates the N(7) position of guanine 1575 (m7G1575) in 18S rRNA

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:0008757|GO:1904047|GO:0032259
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 202-272 6.35e-20

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


:

Pssm-ID: 432656  Cd Length: 81  Bit Score: 81.52  E-value: 6.35e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17945482   202 LMTGG-SAELPQALG-----SPEEERRVNYIKKRDACREARGKA--PKKSRDWILAKKERRRRQGLETRPDTKYTARKR 272
Cdd:pfam12589   1 LFVGGvQQQLPKGLGedgeeCSEEQNTVKYERRRRPRKKRKKKGkkAVKGREWILRKKERRRRRGKDVPPDSKYTGRKR 79
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 35-126 3.30e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.79  E-value: 3.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  35 EMAERALELLALPDDDEsrlILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVER----EVAGDVILGDMgEGMPFK 110
Cdd:COG2226   9 DGREALLAALGLRPGAR---VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDA-EDLPFP 84

                        90
                ....*....|....*.
gi 17945482 111 PGTFDGAISISALQWL 126
Cdd:COG2226  85 DGSFDLVISSFVLHHL 100
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 202-272 6.35e-20

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 81.52  E-value: 6.35e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17945482   202 LMTGG-SAELPQALG-----SPEEERRVNYIKKRDACREARGKA--PKKSRDWILAKKERRRRQGLETRPDTKYTARKR 272
Cdd:pfam12589   1 LFVGGvQQQLPKGLGedgeeCSEEQNTVKYERRRRPRKKRKKKGkkAVKGREWILRKKERRRRRGKDVPPDSKYTGRKR 79
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 35-126 3.30e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.79  E-value: 3.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  35 EMAERALELLALPDDDEsrlILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVER----EVAGDVILGDMgEGMPFK 110
Cdd:COG2226   9 DGREALLAALGLRPGAR---VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDA-EDLPFP 84

                        90
                ....*....|....*.
gi 17945482 111 PGTFDGAISISALQWL 126
Cdd:COG2226  85 DGSFDLVISSFVLHHL 100
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-151 6.00e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.05  E-value: 6.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    55 ILDIGCGSG-LSGSVLEDSEHMWIGIDISKSMLDIAVER----EVAGDVILGDMgEGMPFKPGTFDGAISISALQWLcna 129
Cdd:pfam13649   1 VLDLGCGTGrLTLALARRGGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL--- 76

                          90       100
                  ....*....|....*....|..
gi 17945482   130 dksyhnPHKRLLKFFTTLFSCL 151
Cdd:pfam13649  77 ------PDPDLEAALREIARVL 92
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 40-228 8.56e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 68.40  E-value: 8.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  40 ALELLALPDDDESRLILDIGCGSGLSGSVLEDSEHMW-IGIDISKSMLDIAVER-EVAG----DVILGDMGEGMPFKPGT 113
Cdd:COG0500  15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRvIGIDLSPEAIALARARaAKAGlgnvEFLVADLAELDPLPAES 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482 114 FDGAISISALQWLcnadksyhnPHKRLLKFFTTLFSCLTRTARAVFQFYPENSDQIEMVTSQAMKAGFYGGLVVDYPNsA 193
Cdd:COG0500  95 FDLVVAFGVLHHL---------PPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLRLL-A 164

                       170       180       190
                ....*....|....*....|....*....|....*
gi 17945482 194 KAKKYYLVLMTGGSAELPQALGSPEEERRVNYIKK 228
Cdd:COG0500 165 LELYLRALLAAAATEDLRSDALLESANALEYLLSK 199
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 31-126 4.92e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 61.15  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    31 EIQVEMAERALELLALPDDDESRLILDIGCGSGLSGSVLEDS---EHmWIGIDISKSMLDIAVEREVAG-DVILGDMgEG 106
Cdd:TIGR02072  14 KIQREMAKRLLALLKEKGIFIPASVLDIGCGTGYLTRALLKRfpqAE-FIALDISAGMLAQAKTKLSENvQFICGDA-EK 91

                          90       100
                  ....*....|....*....|
gi 17945482   107 MPFKPGTFDGAISISALQWL 126
Cdd:TIGR02072  92 LPLEDSSFDLIVSNLALQWC 111
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-142 3.10e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  55 ILDIGCGSGLSGSVLEDSE-HMWIGIDISKSMLDIAVEREVAG-----DVILGDMGEGMPFKPGTFDGAISISALQWLCN 128
Cdd:cd02440   2 VLDLGCGTGALALALASGPgARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHLVE 81

                        90
                ....*....|....
gi 17945482 129 ADKSYHNPHKRLLK 142
Cdd:cd02440  82 DLARFLEEARRLLK 95
PRK08317 PRK08317
hypothetical protein; Provisional
 38-142 8.62e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 57.64  E-value: 8.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   38 ERALELLALPDDDesrLILDIGCGSG-----LSGSVLEDSEhmWIGIDISKSMLDIAVEREVAG----DVILGDmGEGMP 108
Cdd:PRK08317   9 ARTFELLAVQPGD---RVLDVGCGPGndareLARRVGPEGR--VVGIDRSEAMLALAKERAAGLgpnvEFVRGD-ADGLP 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17945482  109 FKPGTFDGAISISALQWLCNADKSYHNPHkRLLK 142
Cdd:PRK08317  83 FPDGSFDAVRSDRVLQHLEDPARALAEIA-RVLR 115
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 202-272 6.35e-20

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 81.52  E-value: 6.35e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17945482   202 LMTGG-SAELPQALG-----SPEEERRVNYIKKRDACREARGKA--PKKSRDWILAKKERRRRQGLETRPDTKYTARKR 272
Cdd:pfam12589   1 LFVGGvQQQLPKGLGedgeeCSEEQNTVKYERRRRPRKKRKKKGkkAVKGREWILRKKERRRRRGKDVPPDSKYTGRKR 79
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 35-126 3.30e-15

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 70.79  E-value: 3.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  35 EMAERALELLALPDDDEsrlILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVER----EVAGDVILGDMgEGMPFK 110
Cdd:COG2226   9 DGREALLAALGLRPGAR---VLDLGCGTGRLALALAERGARVTGVDISPEMLELARERaaeaGLNVEFVVGDA-EDLPFP 84

                        90
                ....*....|....*.
gi 17945482 111 PGTFDGAISISALQWL 126
Cdd:COG2226  85 DGSFDLVISSFVLHHL 100
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-151 6.00e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.05  E-value: 6.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    55 ILDIGCGSG-LSGSVLEDSEHMWIGIDISKSMLDIAVER----EVAGDVILGDMgEGMPFKPGTFDGAISISALQWLcna 129
Cdd:pfam13649   1 VLDLGCGTGrLTLALARRGGARVTGVDLSPEMLERARERaaeaGLNVEFVQGDA-EDLPFPDGSFDLVVSSGVLHHL--- 76

                          90       100
                  ....*....|....*....|..
gi 17945482   130 dksyhnPHKRLLKFFTTLFSCL 151
Cdd:pfam13649  77 ------PDPDLEAALREIARVL 92
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 40-228 8.56e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 68.40  E-value: 8.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  40 ALELLALPDDDESRLILDIGCGSGLSGSVLEDSEHMW-IGIDISKSMLDIAVER-EVAG----DVILGDMGEGMPFKPGT 113
Cdd:COG0500  15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFGGRvIGIDLSPEAIALARARaAKAGlgnvEFLVADLAELDPLPAES 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482 114 FDGAISISALQWLcnadksyhnPHKRLLKFFTTLFSCLTRTARAVFQFYPENSDQIEMVTSQAMKAGFYGGLVVDYPNsA 193
Cdd:COG0500  95 FDLVVAFGVLHHL---------PPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLLLLRLL-A 164

                       170       180       190
                ....*....|....*....|....*....|....*
gi 17945482 194 KAKKYYLVLMTGGSAELPQALGSPEEERRVNYIKK 228
Cdd:COG0500 165 LELYLRALLAAAATEDLRSDALLESANALEYLLSK 199
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
35-126 1.59e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 67.33  E-value: 1.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  35 EMAERALELLAlpdDDESRLILDIGCGSGLSGSVLED-SEHMwIGIDISKSMLDIAVEREVAGDVILGDMGEgMPFKPGT 113
Cdd:COG4976  33 LLAEELLARLP---PGPFGRVLDLGCGTGLLGEALRPrGYRL-TGVDLSEEMLAKAREKGVYDRLLVADLAD-LAEPDGR 107

                        90
                ....*....|...
gi 17945482 114 FDGAISISALQWL 126
Cdd:COG4976 108 FDLIVAADVLTYL 120
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 33-161 3.74e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 62.64  E-value: 3.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  33 QVEMAERALELLALPDDDEsrlILDIGCGSGlsgsvlEDSEHM-------WIGIDISKSMLDIAVER-EVAG-----DVI 99
Cdd:COG2230  36 QEAKLDLILRKLGLKPGMR---VLDIGCGWG------GLALYLarrygvrVTGVTLSPEQLEYARERaAEAGladrvEVR 106

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17945482 100 LGDMGEgmPFKPGTFDGAISISALQWLcnadksyhnPHKRLLKFFTTLFSCLTRTARAVFQF 161
Cdd:COG2230 107 LADYRD--LPADGQFDAIVSIGMFEHV---------GPENYPAYFAKVARLLKPGGRLLLHT 157
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
51-161 1.09e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 59.84  E-value: 1.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  51 ESRLILDIGCGSGLSGSVLED--SEHMWIGIDISKSMLDIAVEREVAGDVILGDMGEGMPfkPGTFDGAISISALQWLcn 128
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDP--PEPFDLVVSNAALHWL-- 76

                        90       100       110
                ....*....|....*....|....*....|...
gi 17945482 129 adksyhnphKRLLKFFTTLFSCLTRTARAVFQF 161
Cdd:COG4106  77 ---------PDHAALLARLAAALAPGGVLAVQV 100
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 56-142 1.44e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.60  E-value: 1.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    56 LDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVER--EVAGDVILGDMgEGMPFKPGTFDGAISISALQWLcnadksy 133
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKapREGLTFVVGDA-EDLPFPDNSFDLVLSSEVLHHV------- 72

                          90
                  ....*....|....*
gi 17945482   134 HNPHK------RLLK 142
Cdd:pfam08241  73 EDPERalreiaRVLK 87
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 31-126 4.92e-11

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 61.15  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    31 EIQVEMAERALELLALPDDDESRLILDIGCGSGLSGSVLEDS---EHmWIGIDISKSMLDIAVEREVAG-DVILGDMgEG 106
Cdd:TIGR02072  14 KIQREMAKRLLALLKEKGIFIPASVLDIGCGTGYLTRALLKRfpqAE-FIALDISAGMLAQAKTKLSENvQFICGDA-EK 91

                          90       100
                  ....*....|....*....|
gi 17945482   107 MPFKPGTFDGAISISALQWL 126
Cdd:TIGR02072  92 LPLEDSSFDLIVSNLALQWC 111
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 38-126 1.03e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 58.11  E-value: 1.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  38 ERALELLALPDDDESRLILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVER--EVAGDVILGDMgEGMPFKPGTFD 115
Cdd:COG2227  11 DRRLAALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERaaELNVDFVQGDL-EDLPLEDGSFD 89

                        90
                ....*....|.
gi 17945482 116 GAISISALQWL 126
Cdd:COG2227  90 LVICSEVLEHL 100
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 55-142 3.10e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 56.28  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  55 ILDIGCGSGLSGSVLEDSE-HMWIGIDISKSMLDIAVEREVAG-----DVILGDMGEGMPFKPGTFDGAISISALQWLCN 128
Cdd:cd02440   2 VLDLGCGTGALALALASGPgARVTGVDISPVALELARKAAAALladnvEVLKGDAEELPPEADESFDVIISDPPLHHLVE 81

                        90
                ....*....|....
gi 17945482 129 ADKSYHNPHKRLLK 142
Cdd:cd02440  82 DLARFLEEARRLLK 95
PRK08317 PRK08317
hypothetical protein; Provisional
 38-142 8.62e-10

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 57.64  E-value: 8.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   38 ERALELLALPDDDesrLILDIGCGSG-----LSGSVLEDSEhmWIGIDISKSMLDIAVEREVAG----DVILGDmGEGMP 108
Cdd:PRK08317   9 ARTFELLAVQPGD---RVLDVGCGPGndareLARRVGPEGR--VVGIDRSEAMLALAKERAAGLgpnvEFVRGD-ADGLP 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 17945482  109 FKPGTFDGAISISALQWLCNADKSYHNPHkRLLK 142
Cdd:PRK08317  83 FPDGSFDAVRSDRVLQHLEDPARALAEIA-RVLR 115
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 31-128 9.26e-09

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 54.76  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   31 EIQVEMAERALELLAlpdDDESRLILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVEREVAGDVILGDMgEGMPFK 110
Cdd:PRK10258  25 ELQRQSADALLAMLP---QRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDI-ESLPLA 100

                         90
                 ....*....|....*...
gi 17945482  111 PGTFDGAISISALQWlCN 128
Cdd:PRK10258 101 TATFDLAWSNLAVQW-CG 117
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 55-121 3.51e-06

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 47.07  E-value: 3.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17945482   55 ILDIGCGSG-----LSGSVLEdSEHMWiGIDISKSMLDIAVER----EVAGDV--ILGDmGEGMPFKPGTFDgAISIS 121
Cdd:PRK00216  55 VLDLACGTGdlaiaLAKAVGK-TGEVV-GLDFSEGMLAVGREKlrdlGLSGNVefVQGD-AEALPFPDNSFD-AVTIA 128
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 56-140 3.99e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    56 LDIGCGSGLSGSVLEDSEHMW--IGIDISKSMLDIAVER--------EVAGDVILGDMGEGmpfKPGTFDGAISISALQW 125
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARERlaalgllnAVRVELFQLDLGEL---DPGSFDVVVASNVLHH 77

                          90
                  ....*....|....*
gi 17945482   126 LCNADKSYHNPHKRL 140
Cdd:pfam08242  78 LADPRAVLRNIRRLL 92
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 15-165 1.39e-05

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 45.17  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    15 YNDDEAKKYSTNTrIIEIQVEMAERALELLalPDDDESRL-ILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVERE 93
Cdd:TIGR02021  21 YGSGDPVSRVRQT-VREGRAAMRRKLLDWL--PKDPLKGKrVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNRA 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17945482    94 VAGDVI------LGDMGEgmpfKPGTFDGAISISALqwlcnadksYHNPHKRLLKFFTTLFScLTRtARAVFQFYPEN 165
Cdd:TIGR02021  98 QGRDVAgnvefeVNDLLS----LCGEFDIVVCMDVL---------IHYPASDMAKALGHLAS-LTK-ERVIFTFAPKT 160
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 55-147 7.58e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.02  E-value: 7.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    55 ILDIGCGSG-----LSGSVLEDSEHmwIGIDISKSMLDIAveREVAGD-------VILGDMGE-GMPFKPGTFDGAISIS 121
Cdd:pfam13847   7 VLDLGCGTGhlsfeLAEELGPNAEV--VGIDISEEAIEKA--RENAQKlgfdnveFEQGDIEElPELLEDDKFDVVISNC 82

                          90       100
                  ....*....|....*....|....*.
gi 17945482   122 ALQWLCNADKSYHNPhKRLLKFFTTL 147
Cdd:pfam13847  83 VLNHIPDPDKVLQEI-LRVLKPGGRL 107
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 36-122 7.98e-05

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 42.98  E-value: 7.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   36 MAERALELLALPDDDESRLILDIGCGSG-----LSGSVLEDSEHMWIGIDISKSMLDIAVERE------VAGdvilgdmG 104
Cdd:PRK11088  70 LRDAVANLLAERLDEKATALLDIGCGEGyythaLADALPEITTMQLFGLDISKVAIKYAAKRYpqvtfcVAS-------S 142

                         90
                 ....*....|....*...
gi 17945482  105 EGMPFKPGTFDGAISISA 122
Cdd:PRK11088 143 HRLPFADQSLDAIIRIYA 160
N6_N4_Mtase pfam01555
DNA methylase; Members of this family are DNA methylases. The family contains both N-4 ...
 22-91 1.59e-04

DNA methylase; Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.


Pssm-ID: 396230 [Multi-domain]  Cd Length: 221  Bit Score: 42.00  E-value: 1.59e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17945482    22 KYSTNTRIIEIQ--VEMAERALELLALPDDdesrLILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVE 91
Cdd:pfam01555 154 KESGGNGKHPTQkpEALLERLILASTNPGD----IVLDPFAGSGTTGAAAKELGRNFIGIEIEEEYVEIAKE 221
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 42-125 1.82e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 41.98  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   42 ELLALPDDDESRLILDIGCGSGLSGSVLEDSehmW-----IGIDISKSMLDIAVEREVagDVILGDMGEGMPfKPGTfDG 116
Cdd:PRK14103  20 DLLARVGAERARRVVDLGCGPGNLTRYLARR---WpgaviEALDSSPEMVAAARERGV--DARTGDVRDWKP-KPDT-DV 92


                 ....*....
gi 17945482  117 AISISALQW 125
Cdd:PRK14103  93 VVSNAALQW 101
PLN02244 PLN02244
tocopherol O-methyltransferase
 33-115 2.25e-04

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 42.04  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   33 QVEMAERALELLALPDDDESRL--ILDIGCGSGlsGSvledSEHMW-------IGIDISKsmLDIAVEREVAGDVILGDM 103
Cdd:PLN02244  98 QIRMIEESLAWAGVPDDDEKRPkrIVDVGCGIG--GS----SRYLArkyganvKGITLSP--VQAARANALAAAQGLSDK 169

                         90
                 ....*....|....*....
gi 17945482  104 GE-------GMPFKPGTFD 115
Cdd:PLN02244 170 VSfqvadalNQPFEDGQFD 188
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 35-115 4.57e-04

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 40.90  E-value: 4.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482  35 EMAERALELLAlpdDDESRLILDIGCGSG---------LSGSVLedsehmwIGIDISKSMLDIA--------VEREVagD 97
Cdd:COG2890  99 ELVELALALLP---AGAPPRVLDLGTGSGaialalakeRPDARV-------TAVDISPDALAVArrnaerlgLEDRV--R 166

                        90
                ....*....|....*...
gi 17945482  98 VILGDMGEGMPfKPGTFD 115
Cdd:COG2890 167 FLQGDLFEPLP-GDGRFD 183
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
34-92 5.60e-04

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 40.29  E-value: 5.60e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17945482  34 VEMAERALELLALPDDdesrLILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVER 92
Cdd:COG0863 169 VELLERLILASSNPGD----IVLDPFAGSGTTLVAAERLGRRFIGIEIDPEYVEVARRR 223
PRK14968 PRK14968
putative methyltransferase; Provisional
 42-115 1.17e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.11  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   42 ELLA--LPDDDESRlILDIGCGSGLSGSVLEDSEHMWIGIDISKSMLDIAVE-------REVAGDVILGDMGEgmPFKPG 112
Cdd:PRK14968  13 FLLAenAVDKKGDR-VLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCnaklnniRNNGVEVIRSDLFE--PFRGD 89


                 ...
gi 17945482  113 TFD 115
Cdd:PRK14968  90 KFD 92
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-151 2.01e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.18  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482    37 AERALELLALPDDDESRlILDIGCGSGLSGSVLEDSEHMWIGIDISksmlDIAVEREVAGDVILGDMGEGMPFKPGTFDG 116
Cdd:pfam13489   9 LADLLLRLLPKLPSPGR-VLDFGCGTGIFLRLLRAQGFSVTGVDPS----PIAIERALLNVRFDQFDEQEAAVPAGKFDV 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 17945482   117 AISISALQWLcnadksyHNPHkrllKFFTTLFSCL 151
Cdd:pfam13489  84 IVAREVLEHV-------PDPP----ALLRQIAALL 107
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 37-151 2.25e-03

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 38.77  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   37 AER---ALELLALPDDDESRLILDIGCGSGLSGSVLEDSehmW-----IGIDISKSMLDIAVEREVAGDVILGDMGEgmp 108
Cdd:PRK01683  14 DERtrpARDLLARVPLENPRYVVDLGCGPGNSTELLVER---WpaariTGIDSSPAMLAEARSRLPDCQFVEADIAS--- 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 17945482  109 FKPGT-----FDGAIsisaLQWLCNadksyHnphkrlLKFFTTLFSCL 151
Cdd:PRK01683  88 WQPPQaldliFANAS----LQWLPD-----H------LELFPRLVSLL 120
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
33-122 9.40e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 36.34  E-value: 9.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17945482   33 QVEMAERALELLALPDDDEsrlILDIGCGSGLSGSVL-EDSEHMwIGIDISKSMLDIAVER-EVAG----DVILGDMGEG 106
Cdd:PRK00312  63 QPYMVARMTELLELKPGDR---VLEIGTGSGYQAAVLaHLVRRV-FSVERIKTLQWEAKRRlKQLGlhnvSVRHGDGWKG 138

                         90
                 ....*....|....*.
gi 17945482  107 MPFKpGTFDgAISISA 122
Cdd:PRK00312 139 WPAY-APFD-RILVTA 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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