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Conserved domains on  [gi|21554426|gb|AAM63527|]
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biotin carboxyl carrier protein precursor-like protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 1-255 2.01e-133

biotin carboxyl carrier protein of acetyl-CoA carboxylase


:

Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 377.26  E-value: 2.01e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426    1 MASLSVPCVKICALNRRVGSLPGISTQRWQPQPNgISFPSD-VSQNHSAFWRLRATTNEV-----------------VSN 62
Cdd:PLN02983   1 MASLSVPCAKTAAAAANVGSRLSRSSFRLQPKPN-ISFPSKgPNPKRSAVPKVKAQLNEVavdgssnsaksddpkseVAP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426   63 STPMTNGGyMNGKAKTNVPEPAELSEFMAKVSGLLKLVDSKDIVELELKQLDCEIVIRKKEALQQAVPPAPVYHSMPP-- 140
Cdd:PLN02983  80 SEPKDEPP-SNSSSKPNLPDEESISEFMTQVSSLVKLVDSRDIVELQLKQLDCELVIRKKEALPQPPPPAPVVMMQPPpp 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  141 -VMADFSMPPAQPVALPPSPTPTSTPATAKPTSAPSSSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAM 219
Cdd:PLN02983 159 hAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAM 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 21554426  220 KLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP 255
Cdd:PLN02983 239 KLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIEP 274
 
Name Accession Description Interval E-value
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 1-255 2.01e-133

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 377.26  E-value: 2.01e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426    1 MASLSVPCVKICALNRRVGSLPGISTQRWQPQPNgISFPSD-VSQNHSAFWRLRATTNEV-----------------VSN 62
Cdd:PLN02983   1 MASLSVPCAKTAAAAANVGSRLSRSSFRLQPKPN-ISFPSKgPNPKRSAVPKVKAQLNEVavdgssnsaksddpkseVAP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426   63 STPMTNGGyMNGKAKTNVPEPAELSEFMAKVSGLLKLVDSKDIVELELKQLDCEIVIRKKEALQQAVPPAPVYHSMPP-- 140
Cdd:PLN02983  80 SEPKDEPP-SNSSSKPNLPDEESISEFMTQVSSLVKLVDSRDIVELQLKQLDCELVIRKKEALPQPPPPAPVVMMQPPpp 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  141 -VMADFSMPPAQPVALPPSPTPTSTPATAKPTSAPSSSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAM 219
Cdd:PLN02983 159 hAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAM 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 21554426  220 KLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP 255
Cdd:PLN02983 239 KLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIEP 274
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 96-253 1.52e-46

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 151.59  E-value: 1.52e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  96 LLKLVDSKDIVELELKQLDCEIVIRKKEALQQAVPPAPVyhsmppvmadfsmpPAQPVAlppsptptsTPATAKPTSAPS 175
Cdd:COG0511   1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPA--------------AAAPAA---------AAPAAAAAAAAA 57

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21554426 176 SSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:COG0511  58 SGGGAVKSPMVGTFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVI 135
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 92-253 6.55e-41

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 138.05  E-value: 6.55e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426    92 KVSGLLKLVDSKDIVELELKQLDCEIVIRKKEAL--QQAVPPApvyHSMPPVMADFSMPPAQPVALPPSptptstpatak 169
Cdd:TIGR00531   5 EIKELIKLVEESGITELELKEEEFSVRLSKAAAAasFSVVQQA---AAPVPAQVPAQSSAAVPAPAPAA----------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426   170 PTSAPSSSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTP 249
Cdd:TIGR00531  71 PAPAADIKGHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEP 150


                  ....
gi 21554426   250 LFVI 253
Cdd:TIGR00531 151 LIVI 154
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 181-253 9.58e-25

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 93.25  E-value: 9.58e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21554426 181 LKSPMAGTFYRspgpgepPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:cd06850   2 VTAPMPGTVVK-------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 179-253 1.29e-24

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 93.05  E-value: 1.29e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21554426   179 PPLKSPMAGTFYRSPGpgEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:pfam00364   1 TEIKSPMIGESVREGV--VEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 1-255 2.01e-133

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 377.26  E-value: 2.01e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426    1 MASLSVPCVKICALNRRVGSLPGISTQRWQPQPNgISFPSD-VSQNHSAFWRLRATTNEV-----------------VSN 62
Cdd:PLN02983   1 MASLSVPCAKTAAAAANVGSRLSRSSFRLQPKPN-ISFPSKgPNPKRSAVPKVKAQLNEVavdgssnsaksddpkseVAP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426   63 STPMTNGGyMNGKAKTNVPEPAELSEFMAKVSGLLKLVDSKDIVELELKQLDCEIVIRKKEALQQAVPPAPVYHSMPP-- 140
Cdd:PLN02983  80 SEPKDEPP-SNSSSKPNLPDEESISEFMTQVSSLVKLVDSRDIVELQLKQLDCELVIRKKEALPQPPPPAPVVMMQPPpp 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  141 -VMADFSMPPAQPVALPPSPTPTSTPATAKPTSAPSSSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAM 219
Cdd:PLN02983 159 hAMPPASPPAAQPAPSAPASSPPPTPASPPPAKAPKSSHPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIEAM 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 21554426  220 KLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP 255
Cdd:PLN02983 239 KLMNEIEADQSGTIVEILAEDGKPVSVDTPLFVIEP 274
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 96-253 1.52e-46

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 151.59  E-value: 1.52e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  96 LLKLVDSKDIVELELKQLDCEIVIRKKEALQQAVPPAPVyhsmppvmadfsmpPAQPVAlppsptptsTPATAKPTSAPS 175
Cdd:COG0511   1 LIELLEESGLTELEVEEGEYKVRIKRGGAAAAAPVAAPA--------------AAAPAA---------AAPAAAAAAAAA 57

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21554426 176 SSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:COG0511  58 SGGGAVKSPMVGTFYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVI 135
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 92-253 6.55e-41

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 138.05  E-value: 6.55e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426    92 KVSGLLKLVDSKDIVELELKQLDCEIVIRKKEAL--QQAVPPApvyHSMPPVMADFSMPPAQPVALPPSptptstpatak 169
Cdd:TIGR00531   5 EIKELIKLVEESGITELELKEEEFSVRLSKAAAAasFSVVQQA---AAPVPAQVPAQSSAAVPAPAPAA----------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426   170 PTSAPSSSHPPLKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTP 249
Cdd:TIGR00531  71 PAPAADIKGHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEP 150


                  ....
gi 21554426   250 LFVI 253
Cdd:TIGR00531 151 LIVI 154
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 170-255 1.74e-25

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 104.54  E-value: 1.74e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  170 PTSAPSSSHP-PLKSPMAGTFYRSpgpgeppFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDT 248
Cdd:PRK09282 513 VGGRPRASAPgAVTSPMPGTVVKV-------KVKEGDKVKAGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGD 585


                 ....*..
gi 21554426  249 PLFVIAP 255
Cdd:PRK09282 586 VLMEIEP 592
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 181-253 9.58e-25

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 93.25  E-value: 9.58e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21554426 181 LKSPMAGTFYRspgpgepPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:cd06850   2 VTAPMPGTVVK-------VLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 179-253 1.29e-24

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 93.05  E-value: 1.29e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21554426   179 PPLKSPMAGTFYRSPGpgEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:pfam00364   1 TEIKSPMIGESVREGV--VEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
181-254 4.42e-22

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 86.61  E-value: 4.42e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21554426  181 LKSPMAGTFYRSPGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIA 254
Cdd:PRK07051   6 IVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARIE 79
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 186-253 1.19e-13

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 64.39  E-value: 1.19e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21554426 186 AGTFYRSpgpgeppFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:cd06663  13 DGTVVKW-------LKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLVKI 73
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 200-254 2.25e-13

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 63.55  E-value: 2.25e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21554426 200 FVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIA 254
Cdd:COG0508  23 LVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVIA 77
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 200-253 3.41e-13

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 62.81  E-value: 3.41e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 21554426 200 FVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:cd06849  21 LVKEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEEGDTVPVGQVIAVI 74
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
170-254 7.16e-13

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 67.65  E-value: 7.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  170 PTSAPSSSHPPLKSPMAGTFYRSpgpgeppFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTP 249
Cdd:PRK14040 516 AAAPAAAAGEPVTAPLAGNIFKV-------IVTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIAVKEGDAVAVGDT 588


                 ....*
gi 21554426  250 LFVIA 254
Cdd:PRK14040 589 LLTLA 593
PRK11856 PRK11856
branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed
 200-254 7.82e-10

branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed


Pssm-ID: 237001 [Multi-domain]  Cd Length: 411  Bit Score: 58.26  E-value: 7.82e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21554426  200 FVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIA 254
Cdd:PRK11856  23 LVKVGDTVKEGQPLAEVETDKATVEIPSPVAGTVAKLLVEEGDVVPVGSVIAVIE 77
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 183-253 8.50e-10

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 58.55  E-value: 8.50e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21554426  183 SPMAGTFYRspgpgepPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:COG1038 1081 APMPGTVVK-------VLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 148-254 7.28e-09

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 52.89  E-value: 7.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  148 PPAQPVALPPSPTPTSTPATAKPTSAP--SSSHPPLKSPMAGTFYRSpgpgeppFVKVGDKVQKGQIVCIIEAMKLMNEI 225
Cdd:PRK06549  29 APAQPASTPVPVPTEASPQVEAQAPQPaaAAGADAMPSPMPGTILKV-------LVAVGDQVTENQPLLILEAMKMENEI 101

                         90       100
                 ....*....|....*....|....*....
gi 21554426  226 EAEKSGTIMELLAEDGKPVSVDTPLFVIA 254
Cdd:PRK06549 102 VASSAGTVTAIHVTPGQVVNPGDGLITIG 130
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 183-255 8.22e-09

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 55.91  E-value: 8.22e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21554426   183 SPMAGTFYRspgpgepPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP 255
Cdd:PRK12999 1081 APMPGSVVT-------VLVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELEP 1146
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 148-250 1.23e-08

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 52.56  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  148 PPAQPVALPPSPTPTSTPATAKPTSAPSSSHPPlkSPMAGTFYRSPGPGE--PPFVKVGDKVQKGQIVCIIEAMKLMNEI 225
Cdd:PRK05641  47 AVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAP--ASAGENVVTAPMPGKilRILVREGQQVKVGQGLLILEAMKMENEI 124

                         90       100
                 ....*....|....*....|....*
gi 21554426  226 EAEKSGTIMELLAEDGKPVSVDTPL 250
Cdd:PRK05641 125 PAPKDGVVKKILVKEGDTVDTGQPL 149
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 181-241 1.57e-08

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 50.17  E-value: 1.57e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21554426  181 LKSPMAGTFYRSpgpgeppFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDG 241
Cdd:PRK08225   4 VYASMAGNVWKI-------VVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEG 57
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 201-255 1.46e-07

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 51.61  E-value: 1.46e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21554426  201 VKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP 255
Cdd:PTZ00144  66 KKVGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEIDT 120
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 202-254 3.24e-07

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 50.50  E-value: 3.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 21554426   202 KVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIA 254
Cdd:TIGR01347  23 KVGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGDTVESGQVLAILE 75
PRK05704 PRK05704
2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase;
200-255 1.15e-05

2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase;


Pssm-ID: 235571 [Multi-domain]  Cd Length: 407  Bit Score: 45.98  E-value: 1.15e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 21554426  200 FVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVIAP 255
Cdd:PRK05704  23 HKKPGDAVKRDEVLVEIETDKVVLEVPAPAAGVLSEILAEEGDTVTVGQVLGRIDE 78
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 193-245 1.64e-05

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 45.48  E-value: 1.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 21554426  193 PGPGEPPFVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVS 245
Cdd:PRK14042 533 PGSIIAIHVSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVT 585
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 148-253 3.59e-05

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 44.43  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21554426  148 PPAQPVALPPSPTPTSTPATAKPTSAPSSSHPPLKSPMAGTFyrspgpGEPP----FVKVGDKVQKGQIVCIIEAMKLMN 223
Cdd:PRK11855  89 AAAAPAAAAAAAPAPAAAAPAAAAAAAGGGVVEVKVPDIGEI------TEVEviewLVKVGDTVEEDQSLITVETDKATM 162

                         90       100       110
                 ....*....|....*....|....*....|
gi 21554426  224 EIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:PRK11855 163 EIPSPVAGVVKEIKVKVGDKVSVGSLLVVI 192
PRK11892 PRK11892
pyruvate dehydrogenase subunit beta; Provisional
 201-254 4.84e-04

pyruvate dehydrogenase subunit beta; Provisional


Pssm-ID: 237011 [Multi-domain]  Cd Length: 464  Bit Score: 41.06  E-value: 4.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 21554426  201 VKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDG-KPVSVDTPLFVIA 254
Cdd:PRK11892  24 KKEGDKVKSGDVIAEIETDKATMEVEAVDEGTLGKILVPEGtEGVKVNTPIAVLL 78
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 200-253 1.41e-03

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 39.42  E-value: 1.41e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 21554426  200 FVKVGDKVQKGQIVCIIEAMKLMNEIEAEKSGTIMELLAEDGKPVSVDTPLFVI 253
Cdd:PRK11855  22 LVKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVI 75
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 200-239 1.97e-03

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 38.99  E-value: 1.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 21554426  200 FVKVGDKVQKGQIVCIIEAMKLMNEIeAEKSGTIMELLAE 239
Cdd:PRK11578  76 SVAIGDKVKKDQLLGVIDPEQAENQI-KEVEATLMELRAQ 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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