|
Name |
Accession |
Description |
Interval |
E-value |
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
13-1148 |
0e+00 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 1688.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAADPSASVWVSANAGSGKTHVLTERVIRLLLEGTDPSKILCLTYTKAAAAVMQNRVFMRLSEWAVLPDEALAERL 92
Cdd:TIGR02784 1 ARQAQAADPAASAWVSANAGSGKTHVLTQRVIRLLLAGTEPSKILCLTYTKAAAAEMQNRVFKRLGEWAVLDDADLRARL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 93 EKLERRRPGAARLATARRLFARALETPGGLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDLMQAALVGEARRTLLETAY 172
Cdd:TIGR02784 81 EALEGKRPDAAKLAEARRLFARALETPGGLKIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLEEARRALLAGPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 173 GGGDpALAAAFADVLQAAGETGLQSLLDEAVGRRNGLQLYLAELGvGTHRMEALHRAFGFEPDAREDDLLADLWPVPEFS 252
Cdd:TIGR02784 161 APDD-ALADALATVLEAAGETGLEALLAEIVARRDALMAFLDEAG-GEGAEARLRRALGLAPGDTAEDLLEAVWPLPGLP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 253 DDALDLILSIPKGASRAQDFALQLKRLEKASGLPD---KIAVLRAAFLKSTGEPKSGSYVCSAAVKKLLPEFEEEFDTAA 329
Cdd:TIGR02784 239 RLALALIAALLKSGGGSKDAAAALSQLREAAAEPDpvaRLDLLLGAFLTSKGEPKSASFVIKKAIQKSLPDLAEALEDAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 330 ARVEMGLDRLKELRLVRLNLAALTLIDNLLQRYHDLKCRRGLLDFEDLITRTVALLARNGAGQWVQYKLDRGIDHILVDE 409
Cdd:TIGR02784 319 SRVEALRERLRALRMAQRTLAALRLAARLLQRYARLKKARGLLDFNDLIERTVALLARPGAGAWVHYKLDRGIDHILVDE 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 410 AQDTSPDQWQVIRMLSEEFFSGLGQRN-VQRTLFAVGDEKQSIYSFQGAVPDDFAEQGRAISIQASNAELKFERVSLNFS 488
Cdd:TIGR02784 399 AQDTSPEQWDIIQALAEEFFSGEGARSgVERTIFAVGDEKQSIYSFQGADPERFAEERREFSRKVRAVGRKFEDLSLNYS 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 489 FRSTPDVLQAVDEVFARPEANRGLSG---ATVHSAIRDKEPGEIEIWDMLTPEMVEEPDDWRVPVDQLA--APAVRLAEQ 563
Cdd:TIGR02784 479 FRSTPDVLAAVDLVFADPENARGLSAdsdAPVHEAFRDDLPGRVDLWDLISKEEGEEPEDWTDPVDELGerAPEVRLAER 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 564 IAATIRYWLDRGEPIPGQNRKIAPRDIMVLVRKRDQFMPALSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFVLQPS 643
Cdd:TIGR02784 559 IAAEIRAWLDRGTPIPGRGRAVRPGDILVLVRKRDAFFSALIRALKRRGIPVAGADRLKLTSHIAVKDLMALGRFVLQPE 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 644 DDLSLAALLKSPLFGWDDDRLFTLAYPRGAGdTLFEYLYRASrhdAELAQIHKLLSRWRNMADTMPVFEFYARVLGADGA 723
Cdd:TIGR02784 639 DDLSLAALLKSPLFGLDEDDLFRLAAGRSGG-SLWAALRRRE---AEFAATLAVLRDWLSLADFLTPFEFYARLLGRDGG 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 724 RRKLLARLGPEAGDIIDEFQNYALSAERAGLPGLQAFLETLEAAAPEIKRELDQGRDEVRIMTVHAAKGLEGAVVFLVDP 803
Cdd:TIGR02784 715 RRKLLARLGAEAEDILDEFLSQALAYERTGLPGLQAFLSWLEADDPEIKREMDQARDEVRVMTVHGAKGLEAPVVFLVDT 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 804 GSAVWTGSRAPKLIPYDFQGDgppvKGFLWQPNSSCQTGFTAAEIEKLKNRAEEEYRRLLYVGMTRAEDRLIICGYRGTR 883
Cdd:TIGR02784 795 GSKPFASQRAPLLLATGGSGG----KAPLWRPASAFDPSLSAAARERLKERAEDEYRRLLYVAMTRAEDRLIVCGYRGKR 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 884 ESGE-TWHRLVEDALAAKSETFV--HPVTGVAARRYRKTPRSFIEINEEDQAGAT-SLPPLPHDYRQPMEAEPGLPRPLA 959
Cdd:TIGR02784 871 ESPKdSWHALVKRALAAAGIAWQepHPAQGKAEWRLRFTRRDWDPVGLPVEAAQTdTLEALPDWLRAPAPAEPALPRPLA 950
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 960 PSGASALIEADEEPPLDLSSpvlqPGTGAPAFALRRGTAIHMLLQYLPDVAPEKREHLAADYLARIAADWPDAERLKAWQ 1039
Cdd:TIGR02784 951 PSGLGGAIDSALPGEAVRSS----LGTQAPAFALLRGTLLHRLLQHLPDLPPEEREDAARRYLARSAADWPEAEREALLA 1026
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1040 SVHAILDDPRFGPVFAEGSRGEVAVMGMIDIGGRDHAVSGQIDRISVDESRVLIVDYKTNRPPPKTLEAVPSAYRAQLAL 1119
Cdd:TIGR02784 1027 AVLAVLDDPRLAPVFAPGSRAEVAIMGTLKEGGQQLAVSGQIDRLAVDRDRVLIVDYKTNRPVPATAEEVPPAYLRQLAL 1106
|
1130 1140
....*....|....*....|....*....
gi 23348986 1120 YRELLRPLYPGRVVEAALLFTEGPFLLLV 1148
Cdd:TIGR02784 1107 YRALLRPLYPGRAVEAALLWTEAPKLMPL 1135
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
8-1148 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 666.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 8 PPETIDAQARAADP-SASVWVSANAGSGKTHVLTERVIRLLLE-GTDPSKILCLTYTKAAAAVMQNRVFMRLSEWAVLPD 85
Cdd:COG1074 3 EPPWTDAQRRALDPlGGSVLVEASAGSGKTYTLVARYLRLLLErGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLED 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 86 ealaerleklerrrPGAARLATARRLFARALETPGGLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDlMQAALVGEARR 165
Cdd:COG1074 83 --------------PDLEELARARRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDD-AEALLLEEAVD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 166 TLLETAYGGGDPALAAAFADVLqaagetglqslldeavgrrnglqlylaelgvgthrmealhrafgfepdAREDDLLADL 245
Cdd:COG1074 148 DLLREAYAPLDALALARLLDAF------------------------------------------------GRDDDSLEEL 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 246 wpvpefsddaldlilsipkgasraqdfalqLKRLEKASGLPDKIAVLRAAFlkstgepksgsyvcsaavkKLLPEFEEEF 325
Cdd:COG1074 180 ------------------------------LLALYKLRSRPDWLEELAELD-------------------EALEALREAL 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 326 DTAAARVEMGLDRLKElRLVRLNLAALTLIDNLLQRYHDLKCRRGLLDFEDLITRTVALLARNGAgQWVQYKLDRGIDHI 405
Cdd:COG1074 211 LKAKEALAALREALAA-AAAPLLAALLRLLAAVLARYERRKRERGLLDFDDLLHRALRLLRDEDA-PWVAERLRERYRHI 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 406 LVDEAQDTSPDQWQVIRMLSEEFFSglgqrnVQRTLFAVGDEKQSIYSFQGAVPDDFAEQGRAISiqasnAELKFERVSL 485
Cdd:COG1074 289 LVDEFQDTSPLQWEILRRLAGEALA------DGRTLFLVGDPKQSIYRFRGADPELFLEARRALE-----GRVDGERLTL 357
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 486 NFSFRSTPDVLQAVDEVFARPEANRglSGATVHSAIRDKEPGE---IEIWDMltpemveEPDDWRVpvdqlAAPAVRLAE 562
Cdd:COG1074 358 TTNFRSTPEVVDAVNALFAQLMGAG--FGEIPYEPVEALRPGAypaVELWPL-------EPDDVSE-----EDAREREAR 423
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 563 QIAATIRYWLDRGEPIPGQNRKIAPRDIMVLVRKRDQFmPALSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFVLQP 642
Cdd:COG1074 424 AVAARIRRLLAEGTTVEGGGRPVRPGDIAVLVRTRSEA-AAIARALKAAGIPVAASDRLSLFESPEVRDLLALLRALLNP 502
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 643 SDDLSLAALLKSPLFGWDDDRLFTLAYPRGaGDTLFEYLYRASRHDAELAQihklLSRWRNMADTMPVFEFYARVLGADG 722
Cdd:COG1074 503 EDDLALAAVLRSPLFGLSDEDLAALAADRK-GESLWEALRAYERLARALER----LRALRELARRLGLAELLERLLEETG 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 723 ARRKLLARLGPE----AGDIIDEFQNYALSAERAGLPGLQAFLETLEA----AAPEIKRELDQGRDEVRIMTVHAAKGLE 794
Cdd:COG1074 578 LLERLLALPGGErrlaNLLHLDELLQLALEYEQTGGPGLAGFLRWLERliedGGDEEKRRLESDADAVRIMTIHKSKGLE 657
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 795 GAVVFLvdpgsavwtgsrapklipydfqgdgppvkgflwqpnsscqtgftAAEIEKLKNRAEEEYRRLLYVGMTRAEDRL 874
Cdd:COG1074 658 FPVVFL--------------------------------------------PALRERARAEELAEELRLLYVALTRARDRL 693
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 875 IICGYRGTRES--GETWHRlvedalaaksetfvhpvtgvaarryrktprsfieineedqagatslpplphdyrqpmeaep 952
Cdd:COG1074 694 VLSGAVKKKDAekESSWLA------------------------------------------------------------- 712
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 953 glprplapsgasalieadeeppldlsspvlqpgtgapafalRRGTAIHMLLQYLPDVAPEKREHLAADYLARIAADWPDA 1032
Cdd:COG1074 713 -----------------------------------------RRGTLVHRLLEHLDFSAPAELRAALARLLARGGLDEEEA 751
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1033 ERLKAWqsVHAILDDPRFGPVF-AEGSRGEVAVMGMIDIGGRDHAVSGQIDRISVDESRVLIVDYKTNRPPPKTLEAVPS 1111
Cdd:COG1074 752 EALAEA--LLAFLATPLLAELFaAAEVLREVPFLLPDLYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLGPDDEEYLPE 829
|
1130 1140 1150
....*....|....*....|....*....|....*..
gi 23348986 1112 AYRAQLALYRELLRPLYPGRVVEAALLFTEGPFLLLV 1148
Cdd:COG1074 830 RYRLQLALYALALERLLPGRPVRAGLYFTDRGRLVEI 866
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
29-1139 |
5.09e-49 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 189.41 E-value: 5.09e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 29 ANAGSGKTHVLTERVIRLLLEGTDPSKILCLTYTKAAAAVMQNRVFMRL------SEWAVLpdEALAERL----EKLERR 98
Cdd:PRK13909 5 ASAGSGKTFALSVRFLALLFKGANPSEILALTFTKKAANEMKERIIDTLlnlekeKEESEL--NELEEKLglskEELLNK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 99 RPgaarlatarRLFARALETPggLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDLmqaalvgearrtlletaygggdpa 178
Cdd:PRK13909 83 RD---------KVYQEFLNSE--LKISTIDAFFQKILRKFCLNLGLSPDFSIKEDT------------------------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 179 LAAAFADVLQAAGETGLQSLLDEAVGRRNGLQLYLAELgvgthrMEALHRAFGfEPDAREDDLLADLWPVPEFSDDALDL 258
Cdd:PRK13909 128 KEELNEKFLSALSKEELLELLAFIKQCESKKNNSFFEL------LEKLYEKNN-ELKLFEKAKNPIEFDEEKFLEELRSL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 259 ---ILSIPKGASRAQDFAlqlkrlekasglpdKIAVLRAAFLKS-TGEPKSGSYvcsAAVKKL-LPEFEEEFDtaaarve 333
Cdd:PRK13909 201 kqqIQSIETASKNAKKAF--------------KKEDFEELLNSSkTWLEKESEY---RYFKKLyNEELDAEFE------- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 334 mgldRLKELrLVRLNLA----ALTLIDNLLQRY----HDLKCRRGLLDFEDLITRTVALLAR-NGAGQWVQYKLDRGIDH 404
Cdd:PRK13909 257 ----ELKNA-LKRYYDAkenyKLSKLFKLLQLYkeakNELNKKKNALDFDDISKKVYELLGEeEIDKDFLYFRLDSKISH 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 405 ILVDEAQDTSPDQWQVIRMLSEEFFSGLGQrNVQRTLFAVGDEKQSIYSFQGavpddfaeqgraisiqaSNAELkFERVS 484
Cdd:PRK13909 332 ILIDEFQDTSVLQYKILLPLIDEIKSGEGQ-KKFRSFFYVGDVKQSIYRFRG-----------------GKKEL-FDKVS 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 485 ---------LNFSFRSTPDVLQAVDEVFArpEANRGLSGAtvhSAIRDKEPGEIEIwdmltPEMVEEPDDwrvpvdqlaa 555
Cdd:PRK13909 393 kdfkqkvdnLDTNYRSAPLIVDFVNEVFK--KKYKNYKTQ---YAEQHKSGGYVEV-----VEVADESEE---------- 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 556 pavrLAEQIAATIRYWLDRGepipgqnrkIAPRDIMVLVRKRDqfmpalsralknlsvpvagaDRLQLTSHIaiqdlmal 635
Cdd:PRK13909 453 ----LLEQLLQEIQFLLEKG---------IDPDDIAILCWTND--------------------DALEIKEFL-------- 491
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 636 grfvlqpSDDLSLAALLKSPLfgwdddRLFTLAYPRGAGDTLfEYLYRASRHDAElaQIHKLLSrwrnmADTMPVFEFYA 715
Cdd:PRK13909 492 -------QEQFGIKAVTESSA------KLINQPEVKALIEAL-KYCLFGEEIYKH--NVLKLLG-----KEPDKIPSFLP 550
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 716 RVLGADGARRKLLARLGPEAGDIIdEFQNYALSAERaglpgLQAFLETLEAAAPEIKRELDQGrdeVRIMTVHAAKGLEG 795
Cdd:PRK13909 551 KEESVAEFVKKLIEELKLYDENLL-KFLELASGYED-----IEEFLFKLEPCDKEIASEESKG---VQIMTVHKSKGLEF 621
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 796 AVVFLVDPGSAvwTGSRAPKLIpYDFQGDGppvkgfLWQ--PNSSCQTGFT---AAEIEKLKNRAEEEYRRLLYVGMTRA 870
Cdd:PRK13909 622 EHVIVCDRLGK--PNSDSSNLL-FEYDGIE------LWQiyYRIKGRENFDkdyARALEKEKALKYEEEINVLYVAFTRA 692
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 871 EDRLIICgyrgtresgetwhrlvedalaAKSETFVHPVTGVAArryrkTPRSFIEINEEDQAGATSLPPLPHdyrqpmea 950
Cdd:PRK13909 693 KNSLIVV---------------------KKDESSGSMFEILDL-----KPLERGEIEIKEPKISPKKESLIT-------- 738
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 951 ePGLPRPLAPSGASALIEADEEPPLDLSspvlqpgtgapafALRRGTAIHMLLQYLPDVAPEKREHLAADYLARIAA--D 1028
Cdd:PRK13909 739 -SVKLKPHGYQEQVKEIEEEPKEDNDLE-------------AIYFGIALHYCLEMLYAFKIENLEVLKNLLKNRYGHflD 804
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1029 WPDAERLKawQSVHAILDDPRFGPVFAEGS-RGEVAVMgmidiggRDHAVSgQIDRISVDESRVLIVDYKTNRPppktle 1107
Cdd:PRK13909 805 ESDLEDLE--KRLELLINNKEFQALLKDGKlLKEQALL-------FNGELK-QIDLLLEKDEEICVIDYKSSKK------ 868
|
1130 1140 1150
....*....|....*....|....*....|..
gi 23348986 1108 aVPSAYRAQLALYRELLRPLYPGRVVEAALLF 1139
Cdd:PRK13909 869 -YQEEHKAQVSHYKEAIKEILPKKKVEAYIVY 899
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
13-462 |
4.97e-34 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 131.98 E-value: 4.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAADPSAS-VWVSANAGSGKTHVLTERVIRLLLE-GTDPSKILCLTYTKAAAAVMQNRVfmrlsewavlpdealAE 90
Cdd:pfam00580 3 PEQRKAVTHLGGpLLVLAGAGSGKTRVLTERIAYLILEgGIDPEEILAVTFTNKAAREMKERI---------------LK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 91 RLEKLERRrpgaarlatarrlfaraletpgGLKIQTIHAFCEAILHQFPLEANIAGHFemmddlmqaalvgearrtllet 170
Cdd:pfam00580 68 LLGKAELS----------------------ELNISTFHSFCLRILRKYANRIGLLPNF---------------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 171 aygggdpalaaafadvlqaagetglqSLLDEavgrrnglqlylaelgvgthrmealhrafgfepdareDDLLADLwpvpe 250
Cdd:pfam00580 104 --------------------------SILDE-------------------------------------LDQLALL----- 115
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 251 fSDDALDLILSIPKGASRAQDFALQLKRLeKASGLpdkiavlraaflkstgepksgsyvcsaAVKKLLPEFEEEFDTAAA 330
Cdd:pfam00580 116 -KELLEKDRLNLDPKLLRKLELKELISKA-KNRLL---------------------------SPEELQQGAADPRDKLAA 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 331 rvemgldrlkelrlvrlnlaaltlidNLLQRYHDLKCRRGLLDFEDLITRTVALLARNgagQWVQYKLDRGIDHILVDEA 410
Cdd:pfam00580 167 --------------------------EFYQEYQERLKENNALDFDDLLLLTLELLRSD---PELLEAYRERFKYILVDEF 217
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 23348986 411 QDTSPDQWQVIRMLSeeffsglgqrNVQRTLFAVGDEKQSIYSFQGAVPDDF 462
Cdd:pfam00580 218 QDTNPIQYRLLKLLA----------GGHENLFLVGDPDQSIYGFRGADIENI 259
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
325-462 |
4.45e-20 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 89.11 E-value: 4.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 325 FDTAAARvEMgLDRLKELrLVRLNLAALT------LIDNLLQRYhdlkcrrglLDFEDLITRTVALLARN-GAGQWVQYK 397
Cdd:cd17932 52 FTNKAAK-EM-RERLRKL-LGEQLASGVWigtfhsFALRILRRY---------GDFDDLLLYALELLEENpDVREKLQSR 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23348986 398 ldrgIDHILVDEAQDTSPDQWQVIRMLSEEffsglgqrnvQRTLFAVGDEKQSIYSFQGAVPDDF 462
Cdd:cd17932 120 ----FRYILVDEYQDTNPLQYELLKLLAGD----------GKNLFVVGDDDQSIYGFRGADPENI 170
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
13-1148 |
0e+00 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 1688.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAADPSASVWVSANAGSGKTHVLTERVIRLLLEGTDPSKILCLTYTKAAAAVMQNRVFMRLSEWAVLPDEALAERL 92
Cdd:TIGR02784 1 ARQAQAADPAASAWVSANAGSGKTHVLTQRVIRLLLAGTEPSKILCLTYTKAAAAEMQNRVFKRLGEWAVLDDADLRARL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 93 EKLERRRPGAARLATARRLFARALETPGGLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDLMQAALVGEARRTLLETAY 172
Cdd:TIGR02784 81 EALEGKRPDAAKLAEARRLFARALETPGGLKIQTIHAFCEALLHQFPLEANVAGHFSVIDDRAAATLLEEARRALLAGPA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 173 GGGDpALAAAFADVLQAAGETGLQSLLDEAVGRRNGLQLYLAELGvGTHRMEALHRAFGFEPDAREDDLLADLWPVPEFS 252
Cdd:TIGR02784 161 APDD-ALADALATVLEAAGETGLEALLAEIVARRDALMAFLDEAG-GEGAEARLRRALGLAPGDTAEDLLEAVWPLPGLP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 253 DDALDLILSIPKGASRAQDFALQLKRLEKASGLPD---KIAVLRAAFLKSTGEPKSGSYVCSAAVKKLLPEFEEEFDTAA 329
Cdd:TIGR02784 239 RLALALIAALLKSGGGSKDAAAALSQLREAAAEPDpvaRLDLLLGAFLTSKGEPKSASFVIKKAIQKSLPDLAEALEDAA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 330 ARVEMGLDRLKELRLVRLNLAALTLIDNLLQRYHDLKCRRGLLDFEDLITRTVALLARNGAGQWVQYKLDRGIDHILVDE 409
Cdd:TIGR02784 319 SRVEALRERLRALRMAQRTLAALRLAARLLQRYARLKKARGLLDFNDLIERTVALLARPGAGAWVHYKLDRGIDHILVDE 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 410 AQDTSPDQWQVIRMLSEEFFSGLGQRN-VQRTLFAVGDEKQSIYSFQGAVPDDFAEQGRAISIQASNAELKFERVSLNFS 488
Cdd:TIGR02784 399 AQDTSPEQWDIIQALAEEFFSGEGARSgVERTIFAVGDEKQSIYSFQGADPERFAEERREFSRKVRAVGRKFEDLSLNYS 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 489 FRSTPDVLQAVDEVFARPEANRGLSG---ATVHSAIRDKEPGEIEIWDMLTPEMVEEPDDWRVPVDQLA--APAVRLAEQ 563
Cdd:TIGR02784 479 FRSTPDVLAAVDLVFADPENARGLSAdsdAPVHEAFRDDLPGRVDLWDLISKEEGEEPEDWTDPVDELGerAPEVRLAER 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 564 IAATIRYWLDRGEPIPGQNRKIAPRDIMVLVRKRDQFMPALSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFVLQPS 643
Cdd:TIGR02784 559 IAAEIRAWLDRGTPIPGRGRAVRPGDILVLVRKRDAFFSALIRALKRRGIPVAGADRLKLTSHIAVKDLMALGRFVLQPE 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 644 DDLSLAALLKSPLFGWDDDRLFTLAYPRGAGdTLFEYLYRASrhdAELAQIHKLLSRWRNMADTMPVFEFYARVLGADGA 723
Cdd:TIGR02784 639 DDLSLAALLKSPLFGLDEDDLFRLAAGRSGG-SLWAALRRRE---AEFAATLAVLRDWLSLADFLTPFEFYARLLGRDGG 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 724 RRKLLARLGPEAGDIIDEFQNYALSAERAGLPGLQAFLETLEAAAPEIKRELDQGRDEVRIMTVHAAKGLEGAVVFLVDP 803
Cdd:TIGR02784 715 RRKLLARLGAEAEDILDEFLSQALAYERTGLPGLQAFLSWLEADDPEIKREMDQARDEVRVMTVHGAKGLEAPVVFLVDT 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 804 GSAVWTGSRAPKLIPYDFQGDgppvKGFLWQPNSSCQTGFTAAEIEKLKNRAEEEYRRLLYVGMTRAEDRLIICGYRGTR 883
Cdd:TIGR02784 795 GSKPFASQRAPLLLATGGSGG----KAPLWRPASAFDPSLSAAARERLKERAEDEYRRLLYVAMTRAEDRLIVCGYRGKR 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 884 ESGE-TWHRLVEDALAAKSETFV--HPVTGVAARRYRKTPRSFIEINEEDQAGAT-SLPPLPHDYRQPMEAEPGLPRPLA 959
Cdd:TIGR02784 871 ESPKdSWHALVKRALAAAGIAWQepHPAQGKAEWRLRFTRRDWDPVGLPVEAAQTdTLEALPDWLRAPAPAEPALPRPLA 950
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 960 PSGASALIEADEEPPLDLSSpvlqPGTGAPAFALRRGTAIHMLLQYLPDVAPEKREHLAADYLARIAADWPDAERLKAWQ 1039
Cdd:TIGR02784 951 PSGLGGAIDSALPGEAVRSS----LGTQAPAFALLRGTLLHRLLQHLPDLPPEEREDAARRYLARSAADWPEAEREALLA 1026
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1040 SVHAILDDPRFGPVFAEGSRGEVAVMGMIDIGGRDHAVSGQIDRISVDESRVLIVDYKTNRPPPKTLEAVPSAYRAQLAL 1119
Cdd:TIGR02784 1027 AVLAVLDDPRLAPVFAPGSRAEVAIMGTLKEGGQQLAVSGQIDRLAVDRDRVLIVDYKTNRPVPATAEEVPPAYLRQLAL 1106
|
1130 1140
....*....|....*....|....*....
gi 23348986 1120 YRELLRPLYPGRVVEAALLFTEGPFLLLV 1148
Cdd:TIGR02784 1107 YRALLRPLYPGRAVEAALLWTEAPKLMPL 1135
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
8-1148 |
0e+00 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 666.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 8 PPETIDAQARAADP-SASVWVSANAGSGKTHVLTERVIRLLLE-GTDPSKILCLTYTKAAAAVMQNRVFMRLSEWAVLPD 85
Cdd:COG1074 3 EPPWTDAQRRALDPlGGSVLVEASAGSGKTYTLVARYLRLLLErGLDPEEILVVTFTRAAAAEMRERIRERLAEAADLED 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 86 ealaerleklerrrPGAARLATARRLFARALETPGGLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDlMQAALVGEARR 165
Cdd:COG1074 83 --------------PDLEELARARRRLARALENLDRAAISTIHSFCQRLLREFAFEAGLDPNFELLDD-AEALLLEEAVD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 166 TLLETAYGGGDPALAAAFADVLqaagetglqslldeavgrrnglqlylaelgvgthrmealhrafgfepdAREDDLLADL 245
Cdd:COG1074 148 DLLREAYAPLDALALARLLDAF------------------------------------------------GRDDDSLEEL 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 246 wpvpefsddaldlilsipkgasraqdfalqLKRLEKASGLPDKIAVLRAAFlkstgepksgsyvcsaavkKLLPEFEEEF 325
Cdd:COG1074 180 ------------------------------LLALYKLRSRPDWLEELAELD-------------------EALEALREAL 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 326 DTAAARVEMGLDRLKElRLVRLNLAALTLIDNLLQRYHDLKCRRGLLDFEDLITRTVALLARNGAgQWVQYKLDRGIDHI 405
Cdd:COG1074 211 LKAKEALAALREALAA-AAAPLLAALLRLLAAVLARYERRKRERGLLDFDDLLHRALRLLRDEDA-PWVAERLRERYRHI 288
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 406 LVDEAQDTSPDQWQVIRMLSEEFFSglgqrnVQRTLFAVGDEKQSIYSFQGAVPDDFAEQGRAISiqasnAELKFERVSL 485
Cdd:COG1074 289 LVDEFQDTSPLQWEILRRLAGEALA------DGRTLFLVGDPKQSIYRFRGADPELFLEARRALE-----GRVDGERLTL 357
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 486 NFSFRSTPDVLQAVDEVFARPEANRglSGATVHSAIRDKEPGE---IEIWDMltpemveEPDDWRVpvdqlAAPAVRLAE 562
Cdd:COG1074 358 TTNFRSTPEVVDAVNALFAQLMGAG--FGEIPYEPVEALRPGAypaVELWPL-------EPDDVSE-----EDAREREAR 423
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 563 QIAATIRYWLDRGEPIPGQNRKIAPRDIMVLVRKRDQFmPALSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFVLQP 642
Cdd:COG1074 424 AVAARIRRLLAEGTTVEGGGRPVRPGDIAVLVRTRSEA-AAIARALKAAGIPVAASDRLSLFESPEVRDLLALLRALLNP 502
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 643 SDDLSLAALLKSPLFGWDDDRLFTLAYPRGaGDTLFEYLYRASRHDAELAQihklLSRWRNMADTMPVFEFYARVLGADG 722
Cdd:COG1074 503 EDDLALAAVLRSPLFGLSDEDLAALAADRK-GESLWEALRAYERLARALER----LRALRELARRLGLAELLERLLEETG 577
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 723 ARRKLLARLGPE----AGDIIDEFQNYALSAERAGLPGLQAFLETLEA----AAPEIKRELDQGRDEVRIMTVHAAKGLE 794
Cdd:COG1074 578 LLERLLALPGGErrlaNLLHLDELLQLALEYEQTGGPGLAGFLRWLERliedGGDEEKRRLESDADAVRIMTIHKSKGLE 657
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 795 GAVVFLvdpgsavwtgsrapklipydfqgdgppvkgflwqpnsscqtgftAAEIEKLKNRAEEEYRRLLYVGMTRAEDRL 874
Cdd:COG1074 658 FPVVFL--------------------------------------------PALRERARAEELAEELRLLYVALTRARDRL 693
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 875 IICGYRGTRES--GETWHRlvedalaaksetfvhpvtgvaarryrktprsfieineedqagatslpplphdyrqpmeaep 952
Cdd:COG1074 694 VLSGAVKKKDAekESSWLA------------------------------------------------------------- 712
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 953 glprplapsgasalieadeeppldlsspvlqpgtgapafalRRGTAIHMLLQYLPDVAPEKREHLAADYLARIAADWPDA 1032
Cdd:COG1074 713 -----------------------------------------RRGTLVHRLLEHLDFSAPAELRAALARLLARGGLDEEEA 751
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1033 ERLKAWqsVHAILDDPRFGPVF-AEGSRGEVAVMGMIDIGGRDHAVSGQIDRISVDESRVLIVDYKTNRPPPKTLEAVPS 1111
Cdd:COG1074 752 EALAEA--LLAFLATPLLAELFaAAEVLREVPFLLPDLYRGLGGLLKGRIDLVFEDDGRVYIVDYKTNRLGPDDEEYLPE 829
|
1130 1140 1150
....*....|....*....|....*....|....*..
gi 23348986 1112 AYRAQLALYRELLRPLYPGRVVEAALLFTEGPFLLLV 1148
Cdd:COG1074 830 RYRLQLALYALALERLLPGRPVRAGLYFTDRGRLVEI 866
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
13-888 |
4.39e-72 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 255.63 E-value: 4.39e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAAD-PSASVWVSANAGSGKTHVLTERVIRLLLE-GTDPSKILCLTYTKAAAAVMQNRVfmrlsewavlpdealae 90
Cdd:COG0210 9 PEQRAAVEhPEGPLLVLAGAGSGKTRVLTHRIAYLIAEgGVDPEQILAVTFTNKAAREMRERI----------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 91 rleklerrrpgAARLAtarrlfaralETPGGLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDLMQAALVGEArrtllet 170
Cdd:COG0210 72 -----------EALLG----------RLARGLWVGTFHSLALRILRRHAELLGLPPNFTILDGDDQLRLIKEL------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 171 aygggdpalaaafadvlqaagetglqslldeavgrrnglqlyLAELGVGTHRMEAlhrafgfepdareddlladlwpvpe 250
Cdd:COG0210 124 ------------------------------------------LKELGLDEKRFPP------------------------- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 251 fsDDALDLIlsipkgaSRAqdfalqlkrleKASGL-PDKIAVLRAaflkstgepksgsyvcsaavkkllpefEEEFDTAA 329
Cdd:COG0210 137 --RELLSLI-------SRA-----------KNEGLtPEELAELLA---------------------------ADPEWRAA 169
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 330 ARVemgldrlkelrlvrlnlaaltlidnlLQRYHDLKCRRGLLDFEDLITRTVALLARNgagQWVQYKLDRGIDHILVDE 409
Cdd:COG0210 170 AEL--------------------------YEAYQERLRANNALDFDDLLLLAVRLLEEN---PEVLEKYQNRFRYILVDE 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 410 AQDTSPDQWQVIRMLSEEffsglgqrnvQRTLFAVGDEKQSIYSFQGAVPD---DFAEQgraisiqASNAELkferVSLN 486
Cdd:COG0210 221 YQDTNPAQYELLRLLAGD----------GRNLCVVGDDDQSIYGFRGADPEnilRFEKD-------FPDAKV----IKLE 279
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 487 FSFRSTPDVLQAVDEVFARpeaNRGLSGATVHSairDKEPGE-IEIWDMLTPEmvEEpddwrvpvdqlaapavrlAEQIA 565
Cdd:COG0210 280 QNYRSTQNILDAANAVIAN---NPGRLGKNLWT---DNGEGEkVRLYVAPDEE--EE------------------ARFVA 333
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 566 ATIRYWLDRGepipgqnrkIAPRDIMVLVRKRDQfMPALSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFVLQPSDD 645
Cdd:COG0210 334 DEIRELHEEG---------VPLSDIAVLYRTNAQ-SRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLANPDDD 403
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 646 LSLAALLKSPLFGWDDDRLFTLA-YPRGAGDTLFEYLYRASRHD-------AELAQIHKLLSRWRNMADTMPVFEFYARV 717
Cdd:COG0210 404 VALLRILNVPRRGIGAATLERLReAAREEGISLLEALRDLGELAglsgraaKALRRFAELLEALRAAAERLPLEELLEAL 483
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 718 LGADGARRKLLARLGPEAG---DIIDEFQNYALS-AERAGLPGLQAFLETLEAAAPEIKRELDQgrDEVRIMTVHAAKGL 793
Cdd:COG0210 484 LDESGYEEELREEAGEEAErrlENLEELVDAAARfEERNPGASLEAFLEELALLSDLDAADEDE--DAVTLMTLHAAKGL 561
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 794 EGAVVFLVDpgsavwtgsrapkLIPYDFqgdgppvkgflwqPNSSCQTgfTAAEIEklknraEEeyRRLLYVGMTRAEDR 873
Cdd:COG0210 562 EFPVVFLVG-------------LEEGLF-------------PHQRSLD--DEEELE------EE--RRLFYVAITRARER 605
|
890
....*....|....*
gi 23348986 874 LIICGYRGTRESGET 888
Cdd:COG0210 606 LYLTYAASRRLWGET 620
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
13-1142 |
2.39e-69 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 254.63 E-value: 2.39e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAADPSA-SVWVSANAGSGKTHVLTERVIRLLLEGTDPSKILCLTYTKAAAAVMQNRvfmrlsewavlpdeaLAER 91
Cdd:TIGR02785 4 DEQWQAIYTRGqDILVSASAGSGKTAVLVERIIRKITRGVDVDRLLVVTFTNAAAREMKER---------------IAEA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 92 LEKLERRRPGAARLATARRLFARAletpgglKIQTIHAFCEAILHQFPLEANIAGHFEMMDDLMQAALVGEARRTLLETA 171
Cdd:TIGR02785 69 LEKELVQEPNSKHLRRQLALLNTA-------NISTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVFEEE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 172 YGGGDPA----LAAAFADvlqAAGETGLQSLLdeavgrrngLQLYlaELGVGTHRMEA----LHRAFGFEPDAREDD--- 240
Cdd:TIGR02785 142 YYKEDKEaffeLVDNFSG---DRSDDGLRDLI---------LQLY--DFSRSTPNPEKwlnnLAEAYEVKEKFTIESlkl 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 241 ---LLADLWPVPEFS----DDALDLILSIPKGASRAQDF---ALQLKRLEKASGLPDKIAVLR---AAFLKSTGEPKSGS 307
Cdd:TIGR02785 208 qqqIKELLKNELEGLqeklQRALELFMAEDGLAPRLENFqldLQNIDELIQESLAQADWNELRkavAAFKFKNLKAAKGD 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 308 YVCSAA----------VKKLLPEFEEEFDTAAArvEMGLDRLKELRLVRLNLAALTLidNLLQRYHDLKCRRGLLDFEDL 377
Cdd:TIGR02785 288 EEDADLleeadklreeAKKQLEKLKTDYFTRSE--EDHLRIMQEMKPVVKTLVQLVK--DFIERFGAEKREKNILDFSDL 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 378 ITRTVALL-ARNGAGQWVQYKLDRGIDHILVDEAQDTSPDQWQVIRMLSeeffSGLGQRNvqrTLFAVGDEKQSIYSFQG 456
Cdd:TIGR02785 364 EHYALQILtNENESPSEAAEFYREKFHEVLVDEYQDTNLVQESILQLVK----RGPEEEG---NLFMVGDVKQSIYRFRQ 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 457 AVPDDFAEQGRAISiQASNAELKfeRVSLNFSFRSTPDVLQAVDEVFAR-----------PEANRGLSGATVHSAIRDKE 525
Cdd:TIGR02785 437 ADPLLFLEKYHRFA-QEGEEHGK--RIDLAENFRSRAEVLDTTNFLFKQlmdeevgeidyDEEAQLKFGAAKYPENPDNK 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 526 PgEIEIWDMLTPEMVEEP--DDWRVPVDQLAAPAVRLAEQIAATIRYWLDRGEPIPGQNRKIAPRDIMVLVRKRDQfMPA 603
Cdd:TIGR02785 514 T-EELLYEKLLIEEAEEEeiDEEAEILDKAQQEATMVAERIKALIKEGFKVYDKKTGTYRPVTYRDIVILTRSRGW-NLQ 591
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 604 LSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFVLQPSDDLSLAALLKSPLFGWDDDRlftLAYPRGAGDT-----LF 678
Cdd:TIGR02785 592 IMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPLVAVLRSPIVGFDENE---LALIRLENKDssyyeAV 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 679 EYLYRASRHDAELAQihKL------LSRWRNMADTMPVFEF------------YARVLGADGARRKLLARLGPEAgdiiD 740
Cdd:TIGR02785 669 KDYVKAGLIEDELYE--KLntfldsLQKWREFARTHSVSELiwkiyndtgyydYVGGLPGGKQRQANLYALYERA----R 742
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 741 EFqnyalsaERAGLPGLQAFL----ETLEA----AAPeikRELDQGRDEVRIMTVHAAKGLEGAVVFLVDPGSAVWTG-S 811
Cdd:TIGR02785 743 QY-------ESTSFKGLFQFIrfieRMQERqkdlASA---VAVGEAENAVRLMTIHKSKGLEFPVVFVLGMGKQFNKQdL 812
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 812 RAPKLIPYDFqgdGPPVKGFLWQPNSSCQTGFTAAEIEKLKNRAEEEYRRLLYVGMTRAEDRLIICG-----------YR 880
Cdd:TIGR02785 813 NSSYLLDRQL---GLGIKYIDPQERLSYPSLPKVAIKQKMKRELLSEEMRVLYVALTRAKEKLILVGsvkdekkelkkWL 889
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 881 GTRESGEtWHRLVEDALAAKSE-TFVHPVtgVAARRYRKTPRSFIEINEEDQAGATSLP--------------------- 938
Cdd:TIGR02785 890 AALAQSD-WLLPENDRLQARNYlDWIGPA--LARHRDIKLLGDDAGVSIHDELTKDPANfavevidsydllaeeleermd 966
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 939 ---------------PLPHDYRQ----------PMEAEPGLPRPLAPSGASALIEADEEPPLDLSSPVLQPGTGA---PA 990
Cdd:TIGR02785 967 ekseqlealadknqsTGDKEFREklreqlsydyPHQAATETPAKQSVSEIKRIFEDEDEGSERAPVKQSRGKSISlerPK 1046
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 991 F--------ALRRGTAIHMLLQYLPDVAPEKREHLAAdYLARI---------AADWPDAERLKAW-QSVHA--ILDDP-- 1048
Cdd:TIGR02785 1047 FltktkgltAAEIGTATHLVMQHIDLSKDPSEEELQQ-TIDRLvkkellteeQAEKIDIDKIVAFfDTPLGkqILKAKev 1125
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1049 -RFGPVFAEGSRGEVAVMGMIDIGGRDHAVSGQIDRISVDESRVLIVDYKTNRPPPKTLEAVPS----AYRAQLALYREL 1123
Cdd:TIGR02785 1126 lRREPFFSMLISAEIYFDAHDEADEEDILVQGIIDGYYETEDGLYLFDYKTDHVEGHGFEGAINqlkeRYRGQLQLYEKA 1205
|
1290
....*....|....*....
gi 23348986 1124 LRPLYPGRVVEAALLFTEG 1142
Cdd:TIGR02785 1206 LEEIYKKKVKGKYLYLLDG 1224
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
29-1139 |
5.09e-49 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 189.41 E-value: 5.09e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 29 ANAGSGKTHVLTERVIRLLLEGTDPSKILCLTYTKAAAAVMQNRVFMRL------SEWAVLpdEALAERL----EKLERR 98
Cdd:PRK13909 5 ASAGSGKTFALSVRFLALLFKGANPSEILALTFTKKAANEMKERIIDTLlnlekeKEESEL--NELEEKLglskEELLNK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 99 RPgaarlatarRLFARALETPggLKIQTIHAFCEAILHQFPLEANIAGHFEMMDDLmqaalvgearrtlletaygggdpa 178
Cdd:PRK13909 83 RD---------KVYQEFLNSE--LKISTIDAFFQKILRKFCLNLGLSPDFSIKEDT------------------------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 179 LAAAFADVLQAAGETGLQSLLDEAVGRRNGLQLYLAELgvgthrMEALHRAFGfEPDAREDDLLADLWPVPEFSDDALDL 258
Cdd:PRK13909 128 KEELNEKFLSALSKEELLELLAFIKQCESKKNNSFFEL------LEKLYEKNN-ELKLFEKAKNPIEFDEEKFLEELRSL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 259 ---ILSIPKGASRAQDFAlqlkrlekasglpdKIAVLRAAFLKS-TGEPKSGSYvcsAAVKKL-LPEFEEEFDtaaarve 333
Cdd:PRK13909 201 kqqIQSIETASKNAKKAF--------------KKEDFEELLNSSkTWLEKESEY---RYFKKLyNEELDAEFE------- 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 334 mgldRLKELrLVRLNLA----ALTLIDNLLQRY----HDLKCRRGLLDFEDLITRTVALLAR-NGAGQWVQYKLDRGIDH 404
Cdd:PRK13909 257 ----ELKNA-LKRYYDAkenyKLSKLFKLLQLYkeakNELNKKKNALDFDDISKKVYELLGEeEIDKDFLYFRLDSKISH 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 405 ILVDEAQDTSPDQWQVIRMLSEEFFSGLGQrNVQRTLFAVGDEKQSIYSFQGavpddfaeqgraisiqaSNAELkFERVS 484
Cdd:PRK13909 332 ILIDEFQDTSVLQYKILLPLIDEIKSGEGQ-KKFRSFFYVGDVKQSIYRFRG-----------------GKKEL-FDKVS 392
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 485 ---------LNFSFRSTPDVLQAVDEVFArpEANRGLSGAtvhSAIRDKEPGEIEIwdmltPEMVEEPDDwrvpvdqlaa 555
Cdd:PRK13909 393 kdfkqkvdnLDTNYRSAPLIVDFVNEVFK--KKYKNYKTQ---YAEQHKSGGYVEV-----VEVADESEE---------- 452
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 556 pavrLAEQIAATIRYWLDRGepipgqnrkIAPRDIMVLVRKRDqfmpalsralknlsvpvagaDRLQLTSHIaiqdlmal 635
Cdd:PRK13909 453 ----LLEQLLQEIQFLLEKG---------IDPDDIAILCWTND--------------------DALEIKEFL-------- 491
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 636 grfvlqpSDDLSLAALLKSPLfgwdddRLFTLAYPRGAGDTLfEYLYRASRHDAElaQIHKLLSrwrnmADTMPVFEFYA 715
Cdd:PRK13909 492 -------QEQFGIKAVTESSA------KLINQPEVKALIEAL-KYCLFGEEIYKH--NVLKLLG-----KEPDKIPSFLP 550
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 716 RVLGADGARRKLLARLGPEAGDIIdEFQNYALSAERaglpgLQAFLETLEAAAPEIKRELDQGrdeVRIMTVHAAKGLEG 795
Cdd:PRK13909 551 KEESVAEFVKKLIEELKLYDENLL-KFLELASGYED-----IEEFLFKLEPCDKEIASEESKG---VQIMTVHKSKGLEF 621
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 796 AVVFLVDPGSAvwTGSRAPKLIpYDFQGDGppvkgfLWQ--PNSSCQTGFT---AAEIEKLKNRAEEEYRRLLYVGMTRA 870
Cdd:PRK13909 622 EHVIVCDRLGK--PNSDSSNLL-FEYDGIE------LWQiyYRIKGRENFDkdyARALEKEKALKYEEEINVLYVAFTRA 692
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 871 EDRLIICgyrgtresgetwhrlvedalaAKSETFVHPVTGVAArryrkTPRSFIEINEEDQAGATSLPPLPHdyrqpmea 950
Cdd:PRK13909 693 KNSLIVV---------------------KKDESSGSMFEILDL-----KPLERGEIEIKEPKISPKKESLIT-------- 738
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 951 ePGLPRPLAPSGASALIEADEEPPLDLSspvlqpgtgapafALRRGTAIHMLLQYLPDVAPEKREHLAADYLARIAA--D 1028
Cdd:PRK13909 739 -SVKLKPHGYQEQVKEIEEEPKEDNDLE-------------AIYFGIALHYCLEMLYAFKIENLEVLKNLLKNRYGHflD 804
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1029 WPDAERLKawQSVHAILDDPRFGPVFAEGS-RGEVAVMgmidiggRDHAVSgQIDRISVDESRVLIVDYKTNRPppktle 1107
Cdd:PRK13909 805 ESDLEDLE--KRLELLINNKEFQALLKDGKlLKEQALL-------FNGELK-QIDLLLEKDEEICVIDYKSSKK------ 868
|
1130 1140 1150
....*....|....*....|....*....|..
gi 23348986 1108 aVPSAYRAQLALYRELLRPLYPGRVVEAALLF 1139
Cdd:PRK13909 869 -YQEEHKAQVSHYKEAIKEILPKKKVEAYIVY 899
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
13-462 |
4.97e-34 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 131.98 E-value: 4.97e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAADPSAS-VWVSANAGSGKTHVLTERVIRLLLE-GTDPSKILCLTYTKAAAAVMQNRVfmrlsewavlpdealAE 90
Cdd:pfam00580 3 PEQRKAVTHLGGpLLVLAGAGSGKTRVLTERIAYLILEgGIDPEEILAVTFTNKAAREMKERI---------------LK 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 91 RLEKLERRrpgaarlatarrlfaraletpgGLKIQTIHAFCEAILHQFPLEANIAGHFemmddlmqaalvgearrtllet 170
Cdd:pfam00580 68 LLGKAELS----------------------ELNISTFHSFCLRILRKYANRIGLLPNF---------------------- 103
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 171 aygggdpalaaafadvlqaagetglqSLLDEavgrrnglqlylaelgvgthrmealhrafgfepdareDDLLADLwpvpe 250
Cdd:pfam00580 104 --------------------------SILDE-------------------------------------LDQLALL----- 115
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 251 fSDDALDLILSIPKGASRAQDFALQLKRLeKASGLpdkiavlraaflkstgepksgsyvcsaAVKKLLPEFEEEFDTAAA 330
Cdd:pfam00580 116 -KELLEKDRLNLDPKLLRKLELKELISKA-KNRLL---------------------------SPEELQQGAADPRDKLAA 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 331 rvemgldrlkelrlvrlnlaaltlidNLLQRYHDLKCRRGLLDFEDLITRTVALLARNgagQWVQYKLDRGIDHILVDEA 410
Cdd:pfam00580 167 --------------------------EFYQEYQERLKENNALDFDDLLLLTLELLRSD---PELLEAYRERFKYILVDEF 217
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 23348986 411 QDTSPDQWQVIRMLSeeffsglgqrNVQRTLFAVGDEKQSIYSFQGAVPDDF 462
Cdd:pfam00580 218 QDTNPIQYRLLKLLA----------GGHENLFLVGDPDQSIYGFRGADIENI 259
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
325-462 |
4.45e-20 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 89.11 E-value: 4.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 325 FDTAAARvEMgLDRLKELrLVRLNLAALT------LIDNLLQRYhdlkcrrglLDFEDLITRTVALLARN-GAGQWVQYK 397
Cdd:cd17932 52 FTNKAAK-EM-RERLRKL-LGEQLASGVWigtfhsFALRILRRY---------GDFDDLLLYALELLEENpDVREKLQSR 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23348986 398 ldrgIDHILVDEAQDTSPDQWQVIRMLSEEffsglgqrnvQRTLFAVGDEKQSIYSFQGAVPDDF 462
Cdd:cd17932 120 ----FRYILVDEYQDTNPLQYELLKLLAGD----------GKNLFVVGDDDQSIYGFRGADPENI 170
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
314-1136 |
5.06e-19 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 93.27 E-value: 5.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 314 VKKLLPEFEEE---FDTAAAR---VEMGLDRLKELRLVRLNLAAL-TLIDNLLQRYHDL---------KCRRGLLDFEDL 377
Cdd:COG3857 90 LRKILEEHKDElkvFARAADKpgfIEQLAELITELKRYGITPEDLeEAAELLKEKLRDLaliyeayeeKLAGRYIDSEDL 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 378 ITrtvALLARNGAGQWVQYKldrgidHILVDEAQDTSPDQWQVIRMLSEEFfsglgqRNVQRTLFAVGDEkQSIYSFQGA 457
Cdd:COG3857 170 LR---LLAEKLEKSEFLEGA------EIYIDGFTDFTPQELELLEALLKKA------KEVTITLTLDPDE-LDLFSATGE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 458 VPDDFAEQGRAISIQasnaelkfervslnFSFRSTPDVLQAVDEVFARPEanrglsgatvhsairDKEPGEIEIWDMLTP 537
Cdd:COG3857 234 TYERLLELAKENGVE--------------VEFKKSPELAHLERNLFAYPP---------------EEEPEGIEIIEAANR 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 538 EmvEEpddwrvpvdqlaapavrlAEQIAATIRYWLdrgepipgQNRKIAPRDIMVLVRKRDQFMPALSRALKNLSVPVAG 617
Cdd:COG3857 285 R--AE------------------VEAVAREIRRLV--------REEGYRYRDIAVVVRDLEAYAPLIERVFAEYGIPYFI 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 618 ADRLQLTSHIAIQDLMALGRFVLQPSDDLSLAALLKSPLFGWDD----DRL--FTLAYPRGAGDTLFEYLYRASRHDAEL 691
Cdd:COG3857 337 DEKRPLSHHPLVELILSLLELVRSNFRYEDVFRLLKTGLLRPLSreeiDRLenYVLAYGIRGRRWLERYLEEEEELTDEE 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 692 AQIHKLLSRWRNMADTmPVFEFYARVLGADGAR------RKLLARLG-----------PEAGDIIDEFQNY-ALSA---- 749
Cdd:COG3857 417 EEDLERLNELRDRLLE-PLLPLRERLKKAKTVRewaealYEFLEELGvpekleewreaEEAGDLEEAREHEqAWNAliel 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 750 --ERAGLPG-----LQAFLETLEAAAPEIK-RELDQGRDEVRIMTVHAAKGLEGAVVFLVDPGSAVWtgsraPKLIPYDf 821
Cdd:COG3857 496 ldELVEVLGdeklsLEEFLRILESGLEELTfGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVF-----PARPRED- 569
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 822 qgdgppvkGFLwqpnsscqtgfTAAEIEKLKN----------RAEEEYRRLLYVGMTRAEDRLIICgYRGTRESGET--W 889
Cdd:COG3857 570 --------GLL-----------SDEERERLNElglelpptsrERLLEERFLFYRALTRASERLYLS-YPLADEEGKAllP 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 890 HRLVEDalaaksetFVHPVTGVAARRYRKTPRSFIEINEEdqagatSLPPLPHDYRQPMEAEP--GLPRPLAPSGASAL- 966
Cdd:COG3857 630 SPLIDR--------LRELFPELEERSLLEEELEYIGTPES------ALSELAAALRQLELAPLwwDVYKWLLKLSVSRLe 695
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 967 --------------IEADEEPPLDLSSPVlqpgtgapafalrRGTAIHMLLQYL-----------PDVAPEKREHLAADY 1021
Cdd:COG3857 696 tyaacpfqfflrygLKLKEREEYELDAPD-------------RGTLFHAVLERFykelkeegldwADLSDEELEELLEEA 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1022 LARIAADWPDA------------ERLKAW--QSVHAILDDPRFG---PVFAE---GSRGEVAVMGMIDIGGRDHAVSGQI 1081
Cdd:COG3857 763 VEELAPELQNGillssaryryllERLKRLlkRARRWLEEEARRSgfePVALElsfGPEGGLPPLELELPNGRKIRLRGRI 842
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*...
gi 23348986 1082 DRI---SVDESRVLIVDYKTNRPPPKtLEAVPSAYRAQLALYRELLRPLYPGRVVEAA 1136
Cdd:COG3857 843 DRIdrlESDGRYLRIIDYKSGSKKFD-LDDVYYGLALQLPLYLDAALENLEGKEAEPA 899
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
13-159 |
2.71e-16 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 78.33 E-value: 2.71e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 13 DAQARAAD-PSASVWVSANAGSGKTHVLTERVIRLLLEG-TDPSKILCLTYTKAAAAVMQNRVFMRLSEWAVlpdealae 90
Cdd:cd17932 2 PEQREAVThPDGPLLVLAGAGSGKTRVLTHRIAYLILEGgVPPERILAVTFTNKAAKEMRERLRKLLGEQLA-------- 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23348986 91 rleklerrrpgaarlatarrlfaraletpGGLKIQTIHAFCEAILHQFpleaniaGHFemmDDLMQAAL 159
Cdd:cd17932 74 -----------------------------SGVWIGTFHSFALRILRRY-------GDF---DDLLLYAL 103
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
561-881 |
3.50e-16 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 82.07 E-value: 3.50e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 561 AEQIAATIRYWLDRGEPIpgqnrkiapRDIMVLVR-KRDQFmpALSRALKNLSVPVAGADRLQLTSHIAIQDLMALGRFV 639
Cdd:pfam13361 58 AEWIALEIKKLVARDEKY---------NDIAVLTRsNSDAD--LIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLI 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 640 LQPSDDLSLAALLKSPLFGWDDDRLFTLAYPRGAGDTL--------FEYLYRASRH-------------------DAELA 692
Cdd:pfam13361 127 ANKHDSISLKRILNGPKRGIGNATLERIREYKKRGLRLsdfinpdtLTYGDPFVIAleqdnivvfdvettgldttEDEII 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 693 QI---------------HKLLSRWRNMADTMPVFEFYARVLGADG-----ARRKLLARLG--PEAGDIIDEFQNYALSAE 750
Cdd:pfam13361 207 QIaaiklnkkgvviesfERFLRLKKPVGDSLQVHGFSDEFLQENGetpaeALRDFLEKLEnlRELYSILREYDDIEETPE 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 751 RAGlpGLQAFLETLEAAAPEIKRELDQGRdeVRIMTVHAAKGLEGAVVFLVDpgsavwtgsrapklipydfqgdgppvkg 830
Cdd:pfam13361 287 PED--ALRNFLEIATLSNSELEGSDIKER--IPIMTIHQAKGLEFDTVFLAG---------------------------- 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 23348986 831 flwqpnssCQTG-FTAAEIEKLKNRAEEEyRRLLYVGMTRAEDRLIICGYRG 881
Cdd:pfam13361 335 --------LEEGiFPSYRSIKDEGNLEEE-RRLFYVAITRAKKRLYISYSKS 377
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
360-891 |
1.69e-15 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 81.46 E-value: 1.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 360 QRYHDLkCRR-GLLDFEDLITRTVALLaRNGAGQWVQYKldRGIDHILVDEAQDTSPDQWQVIRMLSEEffsglgqrnvQ 438
Cdd:PRK11773 175 QAYQEA-CDRaGLVDFAELLLRAHELW-LNKPHILQHYQ--ERFTHILVDEFQDTNAIQYAWIRLLAGD----------T 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 439 RTLFAVGDEKQSIYSFQGA-------VPDDFAeqgraisiqasNAELkferVSLNFSFRSTPDVLQAVDEVFARpeaNRG 511
Cdd:PRK11773 241 GKVMIVGDDDQSIYGWRGAqveniqrFLNDFP-----------GAET----IRLEQNYRSTANILKAANALIAN---NNG 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 512 LSGATVHSAIRDKEPgeIEIWDMLTpEMVEepddwrvpvdqlaapavrlAEQIAATIRYWLDRGEpipgqnrkiAPRDIM 591
Cdd:PRK11773 303 RLGKELWTDGGDGEP--ISLYCAFN-ELDE-------------------ARFVVERIKTWQDNGG---------ALSDCA 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 592 VLVRKRDQfmpalSRAL------KNLSVPVAGA----DRLQltshiaIQDLMALGRFVLQPSDDLSLAALLKSPLFGWDD 661
Cdd:PRK11773 352 ILYRSNAQ-----SRVLeeallqAGIPYRIYGGmrffERQE------IKDALAYLRLIANRNDDAAFERVVNTPTRGIGD 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 662 DRLFTL-AYPRGAGDTLFEYLYR-------ASRHDAELAQIHKLLSRWRNMADTMPVFEFYARVLGADGarrkLLARLGP 733
Cdd:PRK11773 421 RTLDVVrQTARDRQLTLWQACRAllqekvlAGRAASALQRFIELIDALAQETADMPLHEQTDRVIKDSG----LRAMYEQ 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 734 EAGD-----------IIDEFQNYALSAERAGLPGLQAFLE--TLEAAapeiKRELDQGRDEVRIMTVHAAKGLEGAVVFL 800
Cdd:PRK11773 497 EKGEkgqarienleeLVTATRQFSYPDEDEDLTPLQAFLShaALEAG----EGQADAHEDAVQLMTLHSAKGLEFPLVFI 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 801 VdpgsAVWTGsrapkLIPYDFQGDGPpvkgflwqpnsscqtgftaaeieklkNRAEEEyRRLLYVGMTRAEDRLIICgYR 880
Cdd:PRK11773 573 V----GMEEG-----LFPSQMSLEEG--------------------------GRLEEE-RRLAYVGITRAMQKLTLT-YA 615
|
570
....*....|...
gi 23348986 881 GTRE--SGETWHR 891
Cdd:PRK11773 616 ESRRlyGKEVYHR 628
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
781-878 |
4.46e-14 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 70.72 E-value: 4.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 781 EVRIMTVHAAKGLEGAVVFLVDPGSavwtgsrapKLIPYDFQGDGPPvkgflwqpnsscqtgftaAEIEKLknraEEEyR 860
Cdd:cd18807 85 RVTLMTIHASKGLEFPVVFIVGLGE---------GFIPSDASYHAAK------------------EDEERL----EEE-R 132
|
90
....*....|....*...
gi 23348986 861 RLLYVGMTRAEDRLIICG 878
Cdd:cd18807 133 RLLYVALTRAKKELYLVG 150
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
366-870 |
1.37e-13 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 75.78 E-value: 1.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 366 KCRRGLLDFEDLITRTVALLARNGAGQWVQ-----YKLdrgidhILVDEAQDTSPDQWQVirmlseefFSGLGQRNVQRT 440
Cdd:PRK10876 343 KRRRGELGFDDLLSRLDSALQSEGGEALAAairtrYPV------AMIDEFQDTDPQQYRI--------FRRIYRHQPETA 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 441 LFAVGDEKQSIYSFQGAvpDDFAEQgRAISIQASnaelkfeRVSLNFSFRSTPDVLQAVDEVFARPEA------------ 508
Cdd:PRK10876 409 LLLIGDPKQAIYAFRGA--DIFTYM-KARSEVSA-------HYTLDTNWRSAPGMVNSVNKLFSQTDDpflfreipfipv 478
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 509 -----NRGLSgatvhSAIRDKEPGEIEIWdmLTP-EMVEEPDdwrvpVDQLaapavrLAEQIAATIRYWL---DRGEPIP 579
Cdd:PRK10876 479 kaagkNQALR-----FVVKGETQPAMKFW--LMEgEGVGVGD-----YQQT------MAQQCAAQIRDWLqagQRGEALL 540
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 580 GQNRKIAP---RDIMVLVRKRDQfmPALSR-ALKNLSVP-VAGADRLQLTSHIAIQDLMALGRFVLQPSDDLSLAALLKS 654
Cdd:PRK10876 541 MNGDDSRPvraSDITVLVRSRQE--AALIRdALTLLAIPsVYLSNRDSVFETLEAQEMLWLLQAVLAPERERTLRSALAT 618
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 655 PLFGWDDDRLFTLAYPRGAGDTLFEYL--YRAS-RHDAELAQIHKLLSRwRNMADTMpvfefyarvLGADGARRKL---- 727
Cdd:PRK10876 619 SMMGLDALDIDALNNDERAWDALVEEFdgYRQIwRKRGVLPMLRALMSA-RNIAENL---------LATAGGERRLtdil 688
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 728 -LARLGPEAGDIIDefQNYALS---AERAGLPGLQafletleAAAPEIKRELDqgRDEVRIMTVHAAKGLEGAVVFLvdp 803
Cdd:PRK10876 689 hIGELLQEASSQLD--SEHALVrwlAQQILEPDSQ-------ASSQQLRLESD--KHLVQIVTIHKSKGLEYPLVWL--- 754
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23348986 804 gsavwtgsrapklipydfqgdgPPVKGFLWQPNS------SCQTGFTAAEIEKLKNRAEEEyR-----RLLYVGMTRA 870
Cdd:PRK10876 755 ----------------------PFITNFRVQDQAfyhdrhSFEAVLDLNAAEESVALAEEE-RlaedlRLLYVALTRS 809
|
|
| Slr0479 |
COG2887 |
RecB family exonuclease [Replication, recombination and repair]; |
982-1139 |
1.61e-12 |
|
RecB family exonuclease [Replication, recombination and repair];
Pssm-ID: 442133 [Multi-domain] Cd Length: 248 Bit Score: 68.91 E-value: 1.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 982 LQPGTGAPAFALRRGTAIHMLLQ-----YLPDVAPEKREHLAADYLARIAADWPDAERLkAWQSVHAILD--------DP 1048
Cdd:COG2887 26 LRDPLEPPPDAADRGTLVHAVLErfyklPADELPAEELLALLEEAWAELGFEDPWAAAL-WLERAERLLEafleweraPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1049 RFGPVFAEgSRGEVAVMGMIDIGGRdhavsgqIDRISVDES-RVLIVDYKTNRPPPKTLEAvpsAYRAQLALYRELL-RP 1126
Cdd:COG2887 105 GLEPVAVE-VEFELELPGGVRLRGR-------IDRIDRLPDgRLVVVDYKTGKAPSTKDEA---GEDPQLALYALALeRG 173
|
170
....*....|...
gi 23348986 1127 LYPGRVVEAALLF 1139
Cdd:COG2887 174 FEGLVPAGARLVY 186
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
371-887 |
5.19e-12 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 70.25 E-value: 5.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 371 LLDFEDLITRTVALLARNgagQWVQYKLDRGIDHILVDEAQDTSPDQWQVIRMLseeffsgLGQRNvqrTLFAVGDEKQS 450
Cdd:PRK10919 180 VLDFDDLILLPTLLLQRN---EEVRERWQNKIRYLLVDEYQDTNTSQYELVKLL-------VGSRA---RFTVVGDDDQS 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 451 IYSFQGAVPDDFaeqgraISIQASNAELKFerVSLNFSFRSTPDVLQAVDEVFARpeaNRGLSGATVHSairdkEPGEIE 530
Cdd:PRK10919 247 IYSWRGARPQNL------VLLSQDFPALQV--IKLEQNYRSSGRILKAANILIAN---NPHVFEKRLFS-----ELGYGD 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 531 IWDMLTPEMvEEPDDWRVpvdqlaapavrLAEQIAATIRywldrgepipgqnRKIAPRDIMVLVRKRDQfmpalSRALKN 610
Cdd:PRK10919 311 ELKVLSANN-EEHEAERV-----------TGELIAHHFV-------------NKTQYKDYAILYRGNHQ-----SRVFEK 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 611 L----SVPVAGADRLQLTSHIAIQDLMALGRFVLQPSDDLSLAALLKSP-----------LFGWDDDR---LFTLAYPRG 672
Cdd:PRK10919 361 FlmqnRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDDSAFLRIVNTPkreigpatlqkLGEWAMTRnksLFTASFDMG 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 673 AGDTL----FEYLYRASRHDAELAQihkllsrwrnMADTMPVFEFYARVLGADGARRKLLARLGPEA------------- 735
Cdd:PRK10919 441 LSQTLsgrgYESLTRFTHWLAEIQR----------LAEREPVAAVRDLIHGIDYESWLYETSPSPKAaemrmknvnqlfs 510
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 736 -------GDIIDEFQNYALSAERAglpGLQAFLEtleaaapeiKRELDQGRDEVRIMTVHAAKGLEGAVVFLVdpgsavw 808
Cdd:PRK10919 511 wmtemleGSELDEPMTLTQVVTRF---TLRDMME---------RGESEEELDQVQLMTLHASKGLEFPYVYLV------- 571
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23348986 809 tgSRAPKLIPYDFQGDgppvkgflwqpnsscqtgftaaeieklKNRAEEEyRRLLYVGMTRAEDRLIICGYRGTRESGE 887
Cdd:PRK10919 572 --GMEEGLLPHQSSID---------------------------EDNIDEE-RRLAYVGITRAQKELTFTLCKERRQYGE 620
|
|
| PDDEXK_1 |
pfam12705 |
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease ... |
992-1145 |
2.54e-10 |
|
PD-(D/E)XK nuclease superfamily; Members of this family belong to the PD-(D/E)XK nuclease superfamily
Pssm-ID: 432731 [Multi-domain] Cd Length: 250 Bit Score: 62.17 E-value: 2.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 992 ALRRGTAIHMLLQYL---PDVAPEKREHLAADYLARIAADWPDAE----RLKAWQS-VHAILddPRFGPVFAEGSRGEVA 1063
Cdd:pfam12705 33 APDLGTLVHAALERFyrwGRLPEEDLEELLQALLEELWPELGLQSeilpRLPWLAGrLRRRL--ERMLRRLAEWLRARRG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 1064 VMGM---IDIGGRDHAVSGQIDRISVDES-RVLIVDYKTNRPPPKTLEAVpSAYRAQLALYRELLR--PLYPGRVVEAAL 1137
Cdd:pfam12705 111 FRPVaveLGFGGTTVRLVGRIDRVDLDGEgYLRIIDYKTGSAPPQSEDLD-LYEGLQLLLYLLALAagEKALGGPAGALY 189
|
....*...
gi 23348986 1138 LFTEGPFL 1145
Cdd:pfam12705 190 LRLDDPLK 197
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
403-615 |
6.08e-10 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 63.31 E-value: 6.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 403 DHILVDEAQDTSPDQWQVIRMLSeeffsglgqRNVQRTLFAVGDEKQSIYSFQgaVPDDFAEQGraiSIQASnaelkfer 482
Cdd:COG3972 290 DAILIDEAQDFEPEFLRLLYQLL---------KPPKKRLIWAYDEAQNIYGRK--IPSAGGIPA---GIGRD-------- 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 483 VSLNFSFRSTPDVLQAVDEVFARPEANRGLSGATVHSAIRDKEPGEIEIwdmltpEMVEEPDDWRVPVDQLAAPAVR--L 560
Cdd:COG3972 348 TILKKNYRNTRPILTFAHAFGMGLLRPPGLLQGDAEDYEVERPGDKVTL------IRPPEPAGRKGPLPEFKKYDDRaeE 421
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 561 AEQIAATIRYWLdrgepipgQNRKIAPRDIMVLV-----RKRDQfmPALSRALKNLSVPV 615
Cdd:COG3972 422 LEAIAEEIKKNL--------RDEGLRPSDIAVIYlgnneAKELG--DRLAAALERQGIDS 471
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
370-457 |
9.39e-10 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 63.05 E-value: 9.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 370 GLLDFEDLITRTVALLARngaGQWVQ-YKldrgidHILVDEAQDTSPDQWQVIrmlseeffSGLGQRNVQRTLFAVGDEK 448
Cdd:PRK11054 407 NAVDFSGLIHQAVNYLEK---GRFISpWK------HILVDEFQDISPQRAALL--------AALRKQNSQTTLFAVGDDW 469
|
....*....
gi 23348986 449 QSIYSFQGA 457
Cdd:PRK11054 470 QAIYRFSGA 478
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
322-576 |
6.02e-07 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 53.72 E-value: 6.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 322 EEEFDTAAARVEMGLDRLKELRLVRLNLAALTLIDNLLQRYHDL-KCRRGLL--DFEDLITRTVALlarnGAGQW----- 393
Cdd:COG3973 376 DEERDELRRELRRSKPVRAALNRLWPFLDPAELYRDLFSDPELLaRAAGWLSpeERALLLRPTREL----KKGRWtvadv 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 394 -----VQYKL-----DRGIDHILVDEAQDTSPDQWQVIRMLSEeffsglgqrnvQRTLFAVGDEKQSIYSFQGAvpDDFA 463
Cdd:COG3973 452 alldeLAELLggpdrTWTYGHVVVDEAQDLSPMQWRVLKRRFP-----------SASFTIVGDLAQAIHPYRGA--ESWE 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 464 EQGRAIsiqasnAELKFERVSLNFSFRSTPDVLQavdevFARPEANRGLSGATVHSAIRDkepgeieiwdmlTPEMVEEp 543
Cdd:COG3973 519 EVLEPL------GGDRARLVELTKSYRSTAEIME-----FANRVLRAAGPDLPPPESVRR------------HGEPPRV- 574
|
250 260 270
....*....|....*....|....*....|...
gi 23348986 544 ddwrVPVDQLAApavrLAEQIAATIRYWLDRGE 576
Cdd:COG3973 575 ----VRVPSEAE----LAAAVVEAVRELLAEGE 599
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
757-880 |
7.82e-06 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 50.22 E-value: 7.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 757 LQAFLETL----EAAAPEIKRELDQGRDEVRIMTVHAAKGLEGAVVFLVdpgsavwtgsrapklipydfqgdgppvkgfl 832
Cdd:COG3972 460 LAAALERQgidsYIAGARSDPNFFWKDGGVTISTIHRAKGLEAPVVIIV------------------------------- 508
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 23348986 833 wqpnsscqtgftaaEIEKL-KNRAEEEYRRLLYVGMTRAEDRLIICGYR 880
Cdd:COG3972 509 --------------GLDQLaKGESLERLRNLLYVAMTRARGWLVVSGSG 543
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
782-877 |
1.06e-05 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 43.72 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 782 VRIMTVHAAKGLEGAVVFLVDPgsaVWTGSRAPklipydfqgdgppvkgflwqpnsscqtgftaaeieklknraeEEYRR 861
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVFLVDP---DLTAHYHS------------------------------------------MLRRR 36
|
90
....*....|....*.
gi 23348986 862 LLYVGMTRAEDRLIIC 877
Cdd:pfam13538 37 LLYTAVTRARKKLVLV 52
|
|
| Cas4_I-A_I-B_I-C_I-D_II-B |
cd09637 |
CRISPR/Cas system-associated protein Cas4; CRISPR (Clustered Regularly Interspaced Short ... |
1077-1149 |
3.61e-05 |
|
CRISPR/Cas system-associated protein Cas4; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Cas4 is RecB-like nuclease with three-cysteine C-terminal cluster
Pssm-ID: 187768 [Multi-domain] Cd Length: 178 Bit Score: 45.50 E-value: 3.61e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23348986 1077 VSGQIDRISVDESRVLIVDYKTNRPPpktleAVPSAYRAQLALYRELLRPLYPGRVVEAALLFTEGPFLLLVP 1149
Cdd:cd09637 67 LKGVIDIVLKEDGELVPVEVKSGRAG-----SPREAHKLQLVAYAYLLEEMYGKRVARGYIVYLEGGKRLEVE 134
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
27-97 |
7.21e-05 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 43.75 E-value: 7.21e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23348986 27 VSANAGSGKTHVLTERVIRLLLEGTDPSKILCLTYTKAAAAVMQNRVFM------RLSEW-AVLPDEALAERLEKLER 97
Cdd:pfam13245 16 LTGGPGTGKTTTIRHIVALLVALGGVSFPILLAAPTGRAAKRLSERTGLpastihRLLGFdDLEAGGFLRDEEEPLDG 93
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
31-138 |
1.03e-03 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 43.28 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 31 AGSGKTHVLTERVIRLLLEGTDpSKILCLTYTKAAAAVMQNRVFMRLsewavlpdealaerleklerrrpgaarlatarr 110
Cdd:COG3972 182 AGSGKTVLLAAKAAYLALKHPG-WRILVTCFNRSLADHLRDLIPRFL--------------------------------- 227
|
90 100
....*....|....*....|....*...
gi 23348986 111 LFARALETPGGLKIQTIHAFCEAILHQF 138
Cdd:COG3972 228 RRFSNGEPEDNVKLIVFHAWGGKLLKQY 255
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
403-489 |
3.49e-03 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 38.62 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23348986 403 DHILVDEAQDTSPDQWQVIRMLSEEFfsglgQRnvqrtLFAVGDEKQSIYSFQGAVP-DDFAEQGraisiqasnaeLKFE 481
Cdd:cd17914 48 DNILVDEAAQILEPETSRLIDLALDQ-----GR-----VILVGDHDQLGPVWRGAVLaKICNEQS-----------LFTR 106
|
....*...
gi 23348986 482 RVSLNFSF 489
Cdd:cd17914 107 LVRLGVSL 114
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
27-71 |
9.52e-03 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 37.47 E-value: 9.52e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 23348986 27 VSANAGSGKTHVLTERVIRLL-LEGTDPSKILCLTYTKAAAAVMQN 71
Cdd:cd17914 4 IQGPPGTGKTRVLVKIVAALMqNKNGEPGRILLVTPTNKAAAQLDN 49
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|
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