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Conserved domains on  [gi|31322628|gb|AAO64429|]
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FEM1C [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-284 1.93e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.25  E-value: 1.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQcsasievgGSVNFDGET 80
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA--------AGADINAKD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  81 IEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
Cdd:COG0666  85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Cdd:COG0666 165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31322628 240 SKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNII 284
Cdd:COG0666 245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-564 2.21e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 2.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 478 RGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
Cdd:COG0666 116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182


                ....*..
gi 31322628 558 NLHKQTA 564
Cdd:COG0666 183 DNDGETP 189
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-284 1.93e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.25  E-value: 1.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQcsasievgGSVNFDGET 80
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA--------AGADINAKD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  81 IEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
Cdd:COG0666  85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Cdd:COG0666 165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31322628 240 SKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNII 284
Cdd:COG0666 245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-178 2.98e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.25  E-value: 2.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    87 LWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHkADLEVSNrHGHTCLMISCYKGHKEIAQ 166
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 31322628   167 YLLEKGADVNRK 178
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-233 2.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 78.55  E-value: 2.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   85 PPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGH-----LEIVKYLVEHKADLEVSNRHGHTCLM--ISC 157
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLyaISK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  158 YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGS--LDIMKMLLMYCAKM-----------------EKDGYGMTPL 218
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDInaknrvnyllsygvpinIKDVYGFTPL 196

                        170
                 ....*....|....*
gi 31322628  219 LSASVTGHTNIVDFL 233
Cdd:PHA03100 197 HYAVYNNNPEFVKYL 211
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-564 2.21e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 2.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 478 RGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
Cdd:COG0666 116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182


                ....*..
gi 31322628 558 NLHKQTA 564
Cdd:COG0666 183 DNDGETP 189
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 1.34e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 57.72  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   5 TAVFNAARDGKLRLLTKLLASKSKEevssLISEKTNGATPLLMAARYGHLDMVEFLLEqcsasiEVGGSVN--FDGETIE 82
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCD----LFQRGALGETALHVAALYDNLEAAVVLME------AAPELVNepMTSDLYQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR---------------AACFdGHLEIVKYLVEHKADLEVSNR 147
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFFRPgpknliyygehplsfAACV-GNEEIVRLLIEHGADIRAQDS 167


                ....*...
gi 31322628 148 HGHTCLMI 155
Cdd:cd22192 168 LGNTVLHI 175
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 480-552 2.39e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 2.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31322628  480 KNNFSPLHLAVDknttcvgrypvckFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
Cdd:PHA03100 190 VYGFTPLHYAVY-------------NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
480-558 3.28e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 3.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31322628   480 KNNFSPLHLAvdknttcvgrypvCKFPSLQVTAILIECgADVNVRDsDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
Cdd:pfam12796  28 KNGRTALHLA-------------AKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-176 6.89e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 6.89e-05
                           10        20
                   ....*....|....*....|....*....
gi 31322628    148 HGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 527-556 7.13e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 7.13e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 31322628    527 DDNSPLHIAALNNHPDIMNLLIKSGAHFDA 556
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-284 1.93e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 146.25  E-value: 1.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   1 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQcsasievgGSVNFDGET 80
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA--------AGADINAKD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  81 IEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKG 160
Cdd:COG0666  85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 161 HKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQT 239
Cdd:COG0666 165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31322628 240 SKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNII 284
Cdd:COG0666 245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-233 3.99e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 131.61  E-value: 3.99e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  34 LISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTT 113
Cdd:COG0666   5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 114 LTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESG 193
Cdd:COG0666  85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 31322628 194 SLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:COG0666 165 NLEIVKLLLEAGADVNaRDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-178 2.98e-21

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 88.25  E-value: 2.98e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    87 LWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHkADLEVSNrHGHTCLMISCYKGHKEIAQ 166
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 31322628   167 YLLEKGADVNRK 178
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
120-204 1.64e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.55  E-value: 1.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   120 LRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKgADVNRKSvKGNTALHDCAESGSLDIMK 199
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*
gi 31322628   200 MLLMY 204
Cdd:pfam12796  79 LLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-236 2.05e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   153 LMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDgYGMTPLLSASVTGHTNIVDF 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  ....
gi 31322628   233 LTHH 236
Cdd:pfam12796  80 LLEK 83
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-233 2.55e-15

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 78.55  E-value: 2.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   85 PPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGH-----LEIVKYLVEHKADLEVSNRHGHTCLM--ISC 157
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLyaISK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  158 YKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGS--LDIMKMLLMYCAKM-----------------EKDGYGMTPL 218
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDInaknrvnyllsygvpinIKDVYGFTPL 196

                        170
                 ....*....|....*
gi 31322628  219 LSASVTGHTNIVDFL 233
Cdd:PHA03100 197 HYAVYNNNPEFVKYL 211
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-146 9.96e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 69.76  E-value: 9.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    45 LLMAARYGHLDMVEFLLEQcsasievggSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASvnNTTLTNSTPLRAAC 124
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN---------GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|..
gi 31322628   125 FDGHLEIVKYLVEHKADLEVSN 146
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-564 2.21e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 71.14  E-value: 2.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 478 RGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
Cdd:COG0666 116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182


                ....*..
gi 31322628 558 NLHKQTA 564
Cdd:COG0666 183 DNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-579 5.08e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.98  E-value: 5.08e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 478 RGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
Cdd:COG0666 149 QDNDGNTPLHLAAANG-------------NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                        90       100
                ....*....|....*....|....*
gi 31322628 558 NLHKQTASDLLDEK---EIAKNLIQ 579
Cdd:COG0666 216 DNDGKTALDLAAENgnlEIVKLLLE 240
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 40-202 5.29e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.23  E-value: 5.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   40 NGATPLLMAA--RYGHLDMVEFLLEQCSasievggsvNFDGETIEGAPPLWAASAAGH--LKVVQSLLNHGASVNNTTlt 115
Cdd:PHA03100 105 NGITPLLYAIskKSNSYSIVEYLLDNGA---------NVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKN-- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  116 nstplraacfdghleIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSL 195
Cdd:PHA03100 174 ---------------RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238


                 ....*..
gi 31322628  196 DIMKMLL 202
Cdd:PHA03100 239 EIFKLLL 245
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 43-242 2.02e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   43 TPLLMAARYGHLDMVEFLLEQcsaSIEVGGSVNFDgetiegAPPLWAASAAGH-----LKVVQSLLNHGASVNNTTLTNS 117
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDN---GADINSSTKNN------STPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  118 TPLRAACFD--GHLEIVKYLVEHKADLEVSNRHGHTCLMI--SCYKGHKEIAQYLLEKGADVNRKS-------------- 179
Cdd:PHA03100 108 TPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNrvnyllsygvpini 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31322628  180 --VKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKT 242
Cdd:PHA03100 188 kdVYGFTPLHYAVYNNNPEFVKYLLDLGANPNlVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 82-236 3.89e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.45  E-value: 3.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   82 EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV----------------- 144
Cdd:PHA02874  34 ETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSIlpipciekdmiktildc 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  145 ------SNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTP 217
Cdd:PHA02874 114 gidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANvKDNNGESP 193

                        170
                 ....*....|....*....
gi 31322628  218 LLSASVTGHTNIVDFLTHH 236
Cdd:PHA02874 194 LHNAAEYGDYACIKLLIDH 212
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-284 1.18e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.91  E-value: 1.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   25 SKSKEEVSSLISEKTN--------GATPLLMAARYGHLDMVEFLleqcsasIEVGGSVNFDGETIEGapPLWAASAAGHL 96
Cdd:PHA02874  11 SGDIEAIEKIIKNKGNcinisvdeTTTPLIDAIRSGDAKIVELF-------IKHGADINHINTKIPH--PLLTAIKIGAH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   97 KVVQSLLNHGA-----------------------SVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCL 153
Cdd:PHA02874  82 DIIKLLIDNGVdtsilpipciekdmiktildcgiDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  154 MISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK-MEKDGYGMTPLLSAsVTGHTNIVDF 232
Cdd:PHA02874 162 HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHiMNKCKNGFTPLHNA-IIHNRSAIEL 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 31322628  233 LTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNII 284
Cdd:PHA02874 241 LINNASINDQDIDGSTPLHHAINPPCDIDIIDILLYHKADISIKDNKGENPI 292
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-110 2.09e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 2.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    10 AARDGKLRLLTKLLASKSKEEVSSlisekTNGATPLLMAARYGHLDMVEFLLEQCSASIEVggsvnfDGETiegapPLWA 89
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQD-----KNGRTALHLAAKNGHLEIVKLLLEHADVNLKD------NGRT-----ALHY 67

                          90       100
                  ....*....|....*....|.
gi 31322628    90 ASAAGHLKVVQSLLNHGASVN 110
Cdd:pfam12796  68 AARSGHLEIVKLLLEKGADIN 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
475-564 4.21e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.20  E-value: 4.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 475 LHPRGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHF 554
Cdd:COG0666  80 INAKDDGGNTLLHAAARNG-------------DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADV 146

                        90
                ....*....|
gi 31322628 555 DATNLHKQTA 564
Cdd:COG0666 147 NAQDNDGNTP 156
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 4-248 9.87e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 64.24  E-value: 9.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    4 KTAVFNAARDGKLRLLTKLLASKSKEEVsslisEKTNGATPLLMAARYGHLDMVEFLLE--------------QCSASIE 69
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNF-----EIYDGISPIKLAMKFRDSEAIKLLMKhgaipdvkypdiesELHDAVE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   70 VGGSV---------NFDGETI--EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEH 138
Cdd:PHA02875  78 EGDVKaveelldlgKFADDVFykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  139 KADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSLDIMKMLLmycaKMEKDGYGMTP 217
Cdd:PHA02875 158 KACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFI----KRGADCNIMFM 233

                        250       260       270
                 ....*....|....*....|....*....|.
gi 31322628  218 LLSASVTghtnIVDFLTHHAQTSKTERINAL 248
Cdd:PHA02875 234 IEGEECT----ILDMICNMCTNLESEAIDAL 260
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 7-179 1.26e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.50  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    7 VFNAARDGKLRLLTKLLASKSKEEVSSlisekTNGATPLLMAARYGHLDMVEFLLEQ-CSASIEvggsvnfdgeTIEGAP 85
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGD-----SKGRTPLHIAASKGYEDCVLVLLKHaCNVHIR----------DANGNT 593

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   86 PLWAASAAGHLKVVQsLLNHGASVNNTTlTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIA 165
Cdd:PLN03192 594 ALWNAISAKHHKIFR-ILYHFASISDPH-AAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMV 671

                        170
                 ....*....|....
gi 31322628  166 QYLLEKGADVNRKS 179
Cdd:PLN03192 672 RLLIMNGADVDKAN 685
PHA03095 PHA03095
ankyrin-like protein; Provisional
 16-233 3.44e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 3.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   16 LRLLTKLLASKSKEEVSSLI-------SEKTNGATPLLMAARYGH-LDMVEFLLEqCSASIEVGGSVnfdgetieGAPPL 87
Cdd:PHA03095  51 LHLYLHYSSEKVKDIVRLLLeagadvnAPERCGFTPLHLYLYNATtLDVIKLLIK-AGADVNAKDKV--------GRTPL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   88 --WAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLraACF----DGHLEIVKYLVEHKADL-EVSNRhGHTCLMISC--Y 158
Cdd:PHA03095 122 hvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrNANVELLRLLIDAGADVyAVDDR-FRSLLHHHLqsF 198

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31322628  159 KGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKM--LLMYCAKM-EKDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:PHA03095 199 KPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISInARNRYGQTPLHYAAVFNNPRACRRL 276
Ank_4 pfam13637
Ankyrin repeats (many copies);
116-169 4.83e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 4.83e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31322628   116 NSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLL 169
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-221 1.69e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.28  E-value: 1.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISC-YKGH 161
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKD 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31322628  162 KEIAQYLLEKGADVNRKS-VKGNTALHDCAESGslDIMKMLLMYCAKMEK-DGYGMTPLLSA 221
Cdd:PHA02878 248 YDILKLLLEHGVDVNAKSyILGLTALHSSIKSE--RKLKLLLEYGADINSlNSYKLTPLSSA 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 96-264 1.86e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.42  E-value: 1.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   96 LKVVQSLLNHGASVNNTTLTNSTPL----RAACFDGhLEIVKYLVEHKADLEVSNRHGHTCLMisCYKGHK---EIAQYL 168
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPLhlylHYSSEKV-KDIVRLLLEAGADVNAPERCGFTPLH--LYLYNAttlDVIKLL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  169 LEKGADVNRKSVKGNTALHDCAESGSLD--IMKMLLMYCAKME-KDGYGMTP-----------------LLSASVTGHTN 228
Cdd:PHA03095 104 IKAGADVNAKDKVGRTPLHVYLSGFNINpkVIRLLLRKGADVNaLDLYGMTPlavllksrnanvellrlLIDAGADVYAV 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 31322628  229 IVDFLT---HHAQTSKT-ERINAlELLGATFVDKKRDLLG 264
Cdd:PHA03095 184 DDRFRSllhHHLQSFKPrARIVR-ELIRAGCDPAATDMLG 222
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 17-245 4.31e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 59.31  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   17 RLLTKLLaskskEEVSSLISEKTNGATPLLMAARYGhldmveFLLEQCSASIEVGGSVNfDGETIEGAPPLWAASAAGHL 96
Cdd:PHA02876 288 RLVPKLL-----ERGADVNAKNIKGETPLYLMAKNG------YDTENIRTLIMLGADVN-AADRLYITPLHQASTLDRNK 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   97 KVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIA-QYLLEKGADV 175
Cdd:PHA02876 356 DIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSvKTLIDRGANV 435

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31322628  176 NRKSVKGNTALH-DCAESGSLDIMKMLLMYCAKMEK-DGYGMTPLLSAsvTGHTNIVDFLTHHAQTSKTERI 245
Cdd:PHA02876 436 NSKNKDLSTPLHyACKKNCKLDVIEMLLDNGADVNAiNIQNQYPLLIA--LEYHGIVNILLHYGAELRDSRV 505
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 5-236 7.00e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 58.44  E-value: 7.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628    5 TAVFNAARDGKLRLLTKLLasKSKEEVSSLiseKTNGATPLLMAARYGHLDMVEFLL----------------EQCSASI 68
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFI--KHGADINHI---NTKIPHPLLTAIKIGAHDIIKLLIdngvdtsilpipciekDMIKTIL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   69 EVGGSVNFdgETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRH 148
Cdd:PHA02874 112 DCGIDVNI--KDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNN 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  149 GHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDcAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSA-SVTGHT 227
Cdd:PHA02874 190 GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHN-AIIHNRSAIELLINNASINDQDIDGSTPLHHAiNPPCDI 268


                 ....*....
gi 31322628  228 NIVDFLTHH 236
Cdd:PHA02874 269 DIIDILLYH 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-233 1.07e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 1.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADV 175
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31322628 176 NRKSVKGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNaRDKDGETPLHLAAYNGNLEIVKLL 139
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-155 1.34e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 57.72  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   5 TAVFNAARDGKLRLLTKLLASKSKEevssLISEKTNGATPLLMAARYGHLDMVEFLLEqcsasiEVGGSVN--FDGETIE 82
Cdd:cd22192  19 SPLLLAAKENDVQAIKKLLKCPSCD----LFQRGALGETALHVAALYDNLEAAVVLME------AAPELVNepMTSDLYQ 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  83 GAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLR---------------AACFdGHLEIVKYLVEHKADLEVSNR 147
Cdd:cd22192  89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFFRPgpknliyygehplsfAACV-GNEEIVRLLIEHGADIRAQDS 167


                ....*...
gi 31322628 148 HGHTCLMI 155
Cdd:cd22192 168 LGNTVLHI 175
PHA02798 PHA02798
ankyrin-like protein; Provisional
 96-202 1.74e-08

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 57.15  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   96 LKVVQSLLNHGASVNNTTLTNSTPLraaC--------FDGHLEIVKYLVEHKADLEVSNRHGHT---CLMISCYKGHKEI 164
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPL---CtilsnikdYKHMLDIVKILIENGADINKKNSDGETplyCLLSNGYINNLEI 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 31322628  165 AQYLLEKGADVNRKSVKGNTALHDCAESG---SLDIMKMLL 202
Cdd:PHA02798 128 LLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLL 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
149-202 2.33e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 2.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31322628   149 GHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLL 202
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 480-552 2.39e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 2.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31322628  480 KNNFSPLHLAVDknttcvgrypvckFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGA 552
Cdd:PHA03100 190 VYGFTPLHYAVY-------------NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-578 2.41e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.73  E-value: 2.41e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 478 RGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDAT 557
Cdd:COG0666 182 RDNDGETPLHLAAENG-------------HLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                        90       100
                ....*....|....*....|.
gi 31322628 558 NLHKQTASDLLDEKEIAKNLI 578
Cdd:COG0666 249 DKDGLTALLLAAAAGAALIVK 269
Ank_4 pfam13637
Ankyrin repeats (many copies);
85-136 2.70e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.35  E-value: 2.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 31322628    85 PPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV 136
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 66-304 2.17e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 2.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   66 ASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVS 145
Cdd:PHA02876 161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKN 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  146 NrhghTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLD--IMKMLLMYCAKMEKDGYGMTPLLSASV 223
Cdd:PHA02876 241 D----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrlVPKLLERGADVNAKNIKGETPLYLMAK 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  224 TGH--TNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMR-YSDRTNIISKPVPQTLIMA---YD 297
Cdd:PHA02876 317 NGYdtENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARdYCDKTPIHYAAVRNNVVIIntlLD 396


                 ....*..
gi 31322628  298 YAKEVNS 304
Cdd:PHA02876 397 YGADIEA 403
PHA03095 PHA03095
ankyrin-like protein; Provisional
 483-568 2.77e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 53.49  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  483 FSPLHLAVDKNTTcvgrypvckfpsLQVTAILIECGADVNVRDSDDNSPLHI--AALNNHPDIMNLLIKSGAHFDATNLH 560
Cdd:PHA03095  84 FTPLHLYLYNATT------------LDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLY 151


                 ....*...
gi 31322628  561 KQTASDLL 568
Cdd:PHA03095 152 GMTPLAVL 159
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 86-207 9.58e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.80  E-value: 9.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   86 PLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGH-------------TC 152
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAikdafnnrnveifKI 119

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31322628  153 LMISCYKGHK------------------EIAQYLLEKGADVNRKSV-KGNTALHDCAESGSLDIMKMLLMYCAK 207
Cdd:PHA02878 120 ILTNRYKNIQtidlvyidkkskddiieaEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGAN 193
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 97-221 1.29e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.42  E-value: 1.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   97 KVVQSLLNHGASVNNTTL-TNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADV 175
Cdd:PHA02878 148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 31322628  176 NRKSVKGNTALHDCAES-GSLDIMKMLLMYCAKMEKDGY--GMTPLLSA 221
Cdd:PHA02878 228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYilGLTALHSS 276
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 455-588 1.51e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  455 VPCtLEQDHFKkqTIYRF-LKLHPRGKNNFSPLHLAVDKNttcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLH 533
Cdd:PHA02874  99 IPC-IEKDMIK--TILDCgIDVNIKDAELKTFLHYAIKKG-------------DLESIKMLFEYGADVNIEDDNGCYPIH 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 31322628  534 IAALNNHPDIMNLLIKSGAHFDATNLHKQT----ASDLLDEKEIaKNLIQPINHTTLQC 588
Cdd:PHA02874 163 IAIKHNFFDIIKLLLEKGAYANVKDNNGESplhnAAEYGDYACI-KLLIDHGNHIMNKC 220
Ank_5 pfam13857
Ankyrin repeats (many copies);
135-187 2.40e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.03  E-value: 2.40e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 31322628   135 LVEHK-ADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALH 187
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 132-205 2.73e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 2.73e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31322628  132 VKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYC 205
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
Ank_2 pfam12796
Ankyrin repeats (3 copies);
480-558 3.28e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 3.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31322628   480 KNNFSPLHLAvdknttcvgrypvCKFPSLQVTAILIECgADVNVRDsDDNSPLHIAALNNHPDIMNLLIKSGAHFDATN 558
Cdd:pfam12796  28 KNGRTALHLA-------------AKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 91-169 3.75e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.90  E-value: 3.75e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31322628   91 SAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLL 169
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
Ank_4 pfam13637
Ankyrin repeats (many copies);
503-548 4.01e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 4.01e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 31322628   503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLI 548
Cdd:pfam13637   9 AASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02798 PHA02798
ankyrin-like protein; Provisional
 96-187 4.06e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 49.83  E-value: 4.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   96 LKVVQSLLNHGASVNNTTLTNSTPLRAACFDGH---LEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHK---EIAQYLL 169
Cdd:PHA02798  89 LDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLL 168

                         90
                 ....*....|....*....
gi 31322628  170 EKGADVNRKSVK-GNTALH 187
Cdd:PHA02798 169 EKGVDINTHNNKeKYDTLH 187
Ank_2 pfam12796
Ankyrin repeats (3 copies);
503-549 4.52e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.11  E-value: 4.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 31322628   503 CKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK 549
Cdd:pfam12796   5 AKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 40-210 6.96e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 49.10  E-value: 6.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   40 NGATPLLMAARYGHLDMVEFLLeQCSASIEVGGSvnfdgetiEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTP 119
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELL-KAKLDPDIGDS--------KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA 594

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  120 LRAACFDGHLEIVKYLVEHKAdleVSNRH-GHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIM 198
Cdd:PLN03192 595 LWNAISAKHHKIFRILYHFAS---ISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMV 671

                        170
                 ....*....|..
gi 31322628  199 KMLLMYCAKMEK 210
Cdd:PLN03192 672 RLLIMNGADVDK 683
Ank_5 pfam13857
Ankyrin repeats (many copies);
514-567 1.15e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 31322628   514 LIECG-ADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDL 567
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 87-233 1.43e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.33  E-value: 1.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   87 LWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQ 166
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31322628  167 YLLEKGADVNRKSvkGNTALHDCAESGSLDIMKMLLMYCAKME-KDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:PLN03192 609 ILYHFASISDPHA--AGDLLCTAAKRNDLTAMKELLKQGLNVDsEDHQGATALQVAMAEDHVDMVRLL 674
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 513-570 3.22e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 3.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 31322628  513 ILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDE 570
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE 157
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 480-579 3.48e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  480 KNNFSPLHLAVDK--NTTCVgrypvckfpsLQVTAILIECGADVNVRDSDDNSPLHIAALN--NHPDIMNLLIKSGAHFD 555
Cdd:PHA03100  66 KNNSTPLHYLSNIkyNLTDV----------KEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVN 135

                         90       100
                 ....*....|....*....|....*....
gi 31322628  556 AT-----NLHKQTASDLLDEKEIAKNLIQ 579
Cdd:PHA03100 136 IKnsdgeNLLHLYLESNKIDLKILKLLID 164
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
508-579 4.76e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.72  E-value: 4.76e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31322628 508 LQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLL---DEKEIAKNLIQ 579
Cdd:COG0666  67 LLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAaynGNLEIVKLLLE 141
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-176 6.89e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 6.89e-05
                           10        20
                   ....*....|....*....|....*....
gi 31322628    148 HGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
182-233 7.05e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 7.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31322628   182 GNTALHDCAESGSLDIMKMLLMYCAKM-EKDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVLKLL 53
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 484-556 7.47e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 7.47e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31322628  484 SPLHLAvdknttcvgrypvCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIK-SGAHFDA 556
Cdd:PTZ00322 117 TPLHIA-------------CANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhSQCHFEL 177
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 148-178 1.57e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 1.57e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 31322628   148 HGHTCLMISCYK-GHKEIAQYLLEKGADVNRK 178
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNAR 32
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 513-559 2.00e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 2.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 31322628  513 ILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNL 559
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNK 223
Ank_5 pfam13857
Ankyrin repeats (many copies);
102-151 2.30e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 2.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 31322628   102 LLNHG-ASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHT 151
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLT 51
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 73-138 5.62e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 5.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31322628   73 SVNFDGETiegapPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEH 138
Cdd:PTZ00322 110 CRDYDGRT-----PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
5-61 6.33e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 6.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31322628     5 TAVFNAARDGKLRLLTKLLASKSKEEVSSLisektNGATPLLMAARYGHLDMVEFLL 61
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDG-----NGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 164-568 6.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 42.74  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  164 IAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMekdgygmtpllsasvtghtNIVdflthhaqtskte 243
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADV-------------------NII------------- 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  244 RINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEE-----LEGLIADPDEM 318
Cdd:PHA02876 208 ALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDckntpLHHASQAPSLS 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  319 RMQALLIR-------ERILGpshpDTSYYIRYRGAVyaDSGNFKRCINLwkyALDMQQSNLDPLSPM-TASSLLSFAELF 390
Cdd:PHA02876 288 RLVPKLLErgadvnaKNIKG----ETPLYLMAKNGY--DTENIRTLIML---GADVNAADRLYITPLhQASTLDRNKDIV 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  391 SFMLQdrakglLGTTVTFDDL-------MGILCKSVLEIERAIKQTqcpADPLQLNKALSIILHLICllekvpCTLEQDH 463
Cdd:PHA02876 359 ITLLE------LGANVNARDYcdktpihYAAVRNNVVIINTLLDYG---ADIEALSQKIGTALHFAL------CGTNPYM 423

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  464 FKKQTIYRFLKLHPRGKNNFSPLHLAVDKNttcvgrypvCKfpsLQVTAILIECGADVNVRDSDDNSPLHIaALNNHpDI 543
Cdd:PHA02876 424 SVKTLIDRGANVNSKNKDLSTPLHYACKKN---------CK---LDVIEMLLDNGADVNAINIQNQYPLLI-ALEYH-GI 489

                        410       420
                 ....*....|....*....|....*.
gi 31322628  544 MNLLIKSGAHF-DATNLHKQTASDLL 568
Cdd:PHA02876 490 VNILLHYGAELrDSRVLHKSLNDNMF 515
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 484-563 6.70e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.56  E-value: 6.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  484 SPLHLAVDKnttcvgrypvckfPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQT 563
Cdd:PHA02878 170 TALHYATEN-------------KDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNT 236
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 527-556 7.13e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 7.13e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 31322628    527 DDNSPLHIAALNNHPDIMNLLIKSGAHFDA 556
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 40-200 7.41e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 7.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   40 NGATPLLMAARYGH--LDMVEFLLEQcSASIEVGGSVNF--------DGETIEGAPPLWAASAAGHLKVVQSLLNHGASV 109
Cdd:PHA03100 140 DGENLLHLYLESNKidLKILKLLIDK-GVDINAKNRVNYllsygvpiNIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANP 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  110 NNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV--------SNRHGHTCLMISCYKgHKEIAQYLLEKGADVNRKSVK 181
Cdd:PHA03100 219 NLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTiietllyfKDKDLNTITKIKMLK-KSIMYMFLLDPGFYKNRKLIE 297

                        170
                 ....*....|....*....
gi 31322628  182 GNTALHDCAESGSLDIMKM 200
Cdd:PHA03100 298 NSKSLKDVINECEKEIERM 316
Ank_4 pfam13637
Ankyrin repeats (many copies);
43-103 7.86e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 7.86e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31322628    43 TPLLMAARYGHLDMVEFLLEQcsasievggSVNFDGETIEGAPPLWAASAAGHLKVVQSLL 103
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK---------GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02741 PHA02741
hypothetical protein; Provisional
 121-201 8.45e-04

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 40.41  E-value: 8.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  121 RAACFDGHLEIVKYLVE--HKADLEVSNRHGHTCLMISCYKGHK----EIAQYLLEKGADVN-RKSVKGNTALHDCAESG 193
Cdd:PHA02741  30 RCGCFDIIARFTPFIRGdcHAAALNATDDAGQMCIHIAAEKHEAqlaaEIIDHLIELGADINaQEMLEGDTALHLAAHRR 109


                 ....*...
gi 31322628  194 SLDIMKML 201
Cdd:PHA02741 110 DHDLAEWL 117
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 140-239 8.56e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 42.44  E-value: 8.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628 140 ADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSvKGntalhdcaesgsldimkmlLMYCAKMEKDG--YGMTP 217
Cdd:cd22194 132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHA-KG-------------------VFFNPKYKHEGfyFGETP 191

                        90       100
                ....*....|....*....|..
gi 31322628 218 LLSASVTGHTNIVDFLTHHAQT 239
Cdd:cd22194 192 LALAACTNQPEIVQLLMEKEST 213
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 481-554 9.28e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.96  E-value: 9.28e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31322628  481 NNFSPLH--LAVDKNTtcvgrypvckfpSLQVTAILIECGADVNVRDSDDNSPLH--IAALNNHPDIMNLLIKSGAHF 554
Cdd:PHA02859  86 NNLSALHhyLSFNKNV------------EPEILKILIDSGSSITEEDEDGKNLLHmyMCNFNVRINVIKLLIDSGVSF 151
Ank_5 pfam13857
Ankyrin repeats (many copies);
168-218 1.10e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 1.10e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31322628   168 LLEKG-ADVNRKSVKGNTALHDCAESGSLDIMKMLLMY-CAKMEKDGYGMTPL 218
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYgVDLNLKDEEGLTAL 53
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 527-556 1.11e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 31322628   527 DDNSPLHIAALNNHPDIMNLLIKSGAHFDA 556
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 109-234 1.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.57  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  109 VNNTTLTNSTPLRAaCFDG---HLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHK----EIAQYLLEKGADVNRKSVK 181
Cdd:PHA02859  44 VNDCNDLYETPIFS-CLEKdkvNVEILKFLIENGADVNFKTRDNNLSALHHYLSFNKnvepEILKILIDSGSSITEEDED 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 31322628  182 GNTALHD--CAESGSLDIMKMLL-MYCAKMEKDGYGmTPLLSASVTGHTN--IVDFLT 234
Cdd:PHA02859 123 GKNLLHMymCNFNVRINVIKLLIdSGVSFLNKDFDN-NNILYSYILFHSDkkIFDFLT 179
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 514-580 1.30e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.78  E-value: 1.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31322628  514 LIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTAS----DLLDEKEIAKNLIQP 580
Cdd:PLN03192 641 LLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPtelrELLQKRELGHSITIV 711
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 148-176 1.70e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.70e-03
                          10        20
                  ....*....|....*....|....*....
gi 31322628   148 HGHTCLMISCYKGHKEIAQYLLEKGADVN 176
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 527-558 1.93e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 31322628   527 DDNSPLHIAAL-NNHPDIMNLLIKSGAHFDATN 558
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 168-303 2.33e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.01  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  168 LLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMY-CAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERIN 246
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHaCNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAG 623

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 31322628  247 ALELLGAtfvdkKRDLLGALK-YWKKAMNMRYSDRTNIISKPVPqtliMAYDYAKEVN 303
Cdd:PLN03192 624 DLLCTAA-----KRNDLTAMKeLLKQGLNVDSEDHQGATALQVA----MAEDHVDMVR 672
PHA03095 PHA03095
ankyrin-like protein; Provisional
 478-552 3.31e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 3.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31322628  478 RGKNNFSPLHLAVdkNTTCVgrypvckfPSLQVTAILIECGADVNVRDSDDNSPLHIAALN-NHPDIMNLLIKSGA 552
Cdd:PHA03095  43 RGEYGKTPLHLYL--HYSSE--------KVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNaTTLDVIKLLIKAGA 108
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 40-62 3.88e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|...
gi 31322628    40 NGATPLLMAARYGHLDMVEFLLE 62
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLE 23
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 118-147 5.17e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 5.17e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 31322628   118 TPL-RAACFDGHLEIVKYLVEHKADLEVSNR 147
Cdd:pfam00023   4 TPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 16-155 5.90e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 39.48  E-value: 5.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  16 LRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARY---GHLDMVEFLLEQCSASIEVGGSVN--FDGETIEGAPPLWAA 90
Cdd:cd21882   1 LEELLGLLECLRWYLTDSAYQRGATGKTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELVNapCTDEFYQGQTALHIA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628  91 SAAGHLKVVQSLLNHGASVN-------------NTTLTNSTPLRAACFDGHLEIVKYLVEHKAD---LEVSNRHGHTCLM 154
Cdd:cd21882  81 IENRNLNLVRLLVENGADVSaratgrffrkspgNLFYFGELPLSLAACTNQEEIVRLLLENGAQpaaLEAQDSLGNTVLH 160


                .
gi 31322628 155 I 155
Cdd:cd21882 161 A 161
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 165-238 7.96e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.11  E-value: 7.96e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31322628  165 AQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAK---MEKDgyGMTPLLSASVTGHTNIVDFLTHHAQ 238
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADptlLDKD--GKTPLELAEENGFREVVQLLSRHSQ 172
PHA03095 PHA03095
ankyrin-like protein; Provisional
 97-186 9.57e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.85  E-value: 9.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31322628   97 KVVQSLLNHGASVNNTTLTNSTPLRAA---CFDGHLEIVKYLvEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGA 173
Cdd:PHA03095 203 RIVRELIRAGCDPAATDMLGNTPLHSMatgSSCKRSLVLPLL-IAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281

                         90
                 ....*....|...
gi 31322628  174 DVNRKSVKGNTAL 186
Cdd:PHA03095 282 DINAVSSDGNTPL 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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