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Conserved domains on  [gi|30582817|gb|AAP35635|]
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claudin 4 [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology:  GO:0016020
PubMed:  19706201

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin super family cl21598
PMP-22/EMP/MP20/Claudin family;
4-170 8.96e-25

PMP-22/EMP/MP20/Claudin family;


The actual alignment was detected with superfamily member pfam00822:

Pssm-ID: 473919  Cd Length: 162  Bit Score: 95.13  E-value: 8.96e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30582817     4 MGLQVMGIALAVLGWLAVMLCCALP-MWRVTAFIGsnivtsQTIWEGLWMNCVVQS-TGQMQCKVydslLALPQDLQAAR 81
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKV----LELNDALQAVQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30582817    82 ALVIISIIVAALGVLLSVVGGKCTNCLEDEsakaktmIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASgQKREMG 161
Cdd:pfam00822  71 ALMILSIILGIISLIVFFFQLFTMRKGGRF-------KLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPN-RKYSFG 142


                  ....*....
gi 30582817   162 ASLYVGWAA 170
Cdd:pfam00822 143 YSFILGWVA 151
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
4-170 8.96e-25

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 95.13  E-value: 8.96e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30582817     4 MGLQVMGIALAVLGWLAVMLCCALP-MWRVTAFIGsnivtsQTIWEGLWMNCVVQS-TGQMQCKVydslLALPQDLQAAR 81
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKV----LELNDALQAVQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30582817    82 ALVIISIIVAALGVLLSVVGGKCTNCLEDEsakaktmIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASgQKREMG 161
Cdd:pfam00822  71 ALMILSIILGIISLIVFFFQLFTMRKGGRF-------KLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPN-RKYSFG 142


                  ....*....
gi 30582817   162 ASLYVGWAA 170
Cdd:pfam00822 143 YSFILGWVA 151
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
4-170 8.96e-25

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 95.13  E-value: 8.96e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30582817     4 MGLQVMGIALAVLGWLAVMLCCALP-MWRVTAFIGsnivtsQTIWEGLWMNCVVQS-TGQMQCKVydslLALPQDLQAAR 81
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPdQWKVSRYVG------AAASAGLWRNCTTQScTGQISCKV----LELNDALQAVQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30582817    82 ALVIISIIVAALGVLLSVVGGKCTNCLEDEsakaktmIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASgQKREMG 161
Cdd:pfam00822  71 ALMILSIILGIISLIVFFFQLFTMRKGGRF-------KLAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPN-RKYSFG 142


                  ....*....
gi 30582817   162 ASLYVGWAA 170
Cdd:pfam00822 143 YSFILGWVA 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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