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Conserved domains on  [gi|37682566|gb|AAQ98250|]
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vpu protein [Human immunodeficiency virus 1]

Protein Classification

Vpu( domain architecture ID 10456474)

Vpu (viral protein U), a membrane protein of HIV-1, enhances virion budding by targeting host CD4 and tetherin/BST2 to proteasome degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vpu pfam00558
Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a ...
 11-83 8.04e-27

Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.


:

Pssm-ID: 109608  Cd Length: 81  Bit Score: 93.17  E-value: 8.04e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37682566   11 RIGVGALIVALIIAIVVWTIAYIEYKKWLRQRKIDRLIERIRERAEDSGNESDGDTEE-LATMV-DMEHLGLLDV 83
Cdd:pfam00558  6 IIGLIALIVALIINIVVWTIVYREYRKIKKQREILRLIKRIRERAEDSGNESNGDEEEeLADLVhSHGFDNPMFE 80
 
Name Accession Description Interval E-value
Vpu pfam00558
Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a ...
 11-83 8.04e-27

Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.


Pssm-ID: 109608  Cd Length: 81  Bit Score: 93.17  E-value: 8.04e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37682566   11 RIGVGALIVALIIAIVVWTIAYIEYKKWLRQRKIDRLIERIRERAEDSGNESDGDTEE-LATMV-DMEHLGLLDV 83
Cdd:pfam00558  6 IIGLIALIVALIINIVVWTIVYREYRKIKKQREILRLIKRIRERAEDSGNESNGDEEEeLADLVhSHGFDNPMFE 80
 
Name Accession Description Interval E-value
Vpu pfam00558
Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a ...
 11-83 8.04e-27

Vpu protein; The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing the release of viral particles from infected cells. The VPU protein binds specifically to CD4.


Pssm-ID: 109608  Cd Length: 81  Bit Score: 93.17  E-value: 8.04e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 37682566   11 RIGVGALIVALIIAIVVWTIAYIEYKKWLRQRKIDRLIERIRERAEDSGNESDGDTEE-LATMV-DMEHLGLLDV 83
Cdd:pfam00558  6 IIGLIALIVALIINIVVWTIVYREYRKIKKQREILRLIKRIRERAEDSGNESNGDEEEeLADLVhSHGFDNPMFE 80
SieB pfam14163
Super-infection exclusion protein B; This family includes superinfection exclusion proteins. ...
 12-52 1.92e-03

Super-infection exclusion protein B; This family includes superinfection exclusion proteins. These proteins prevent the growth of superinfecting phage which are insensitive to repression. It aborts lytic development of superinfecting phage.


Pssm-ID: 433755  Cd Length: 147  Bit Score: 34.58  E-value: 1.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 37682566    12 IGVGALI-VALIIAIVVWTIAYIEYKKWLRQRKIDRLIERIR 52
Cdd:pfam14163  35 IGLVFLIsIAYLLAIVIYKLVKEIKDRYAKKRRQKRVEEKLK 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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