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Conserved domains on  [gi|38350535|gb|AAR18380|]
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T-cell receptor alpha chain V domain 3, partial [Anas platyrhynchos]

Protein Classification

T-cell receptor alpha chain V region( domain architecture ID 10141821)

T-cell receptor alpha chain V (variable) region participates in the antigen recognition of an alpha-beta T cell antigen-specific receptor essential to the immune response; it is present on the cell surface of T lymphocytes to recognize peptide-major histocompatibility (pMH) complexes displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 23-132 5.59e-44

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


:

Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 140.10  E-value: 5.59e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  23 VVQFAQETAIQVGHNATLHCNFSTSTiSPYILWYQQHLTQSPQFLLQVSKFKPHVHSERISSVLSMENSQVLLHVQDAKL 102
Cdd:cd04983   1 VTQSPQSLSVQEGENVTLNCNYSTST-FYYLFWYRQYPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSLHISAAQL 79

                        90       100       110
                ....*....|....*....|....*....|
gi 38350535 103 QDSAVYLCALSPSSGSlNKPTFGSGTRLSV 132
Cdd:cd04983  80 SDSAVYFCALSESGGT-GKLTFGKGTRLTV 108
 
Name Accession Description Interval E-value
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 23-132 5.59e-44

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 140.10  E-value: 5.59e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  23 VVQFAQETAIQVGHNATLHCNFSTSTiSPYILWYQQHLTQSPQFLLQVSKFKPHVHSERISSVLSMENSQVLLHVQDAKL 102
Cdd:cd04983   1 VTQSPQSLSVQEGENVTLNCNYSTST-FYYLFWYRQYPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSLHISAAQL 79

                        90       100       110
                ....*....|....*....|....*....|
gi 38350535 103 QDSAVYLCALSPSSGSlNKPTFGSGTRLSV 132
Cdd:cd04983  80 SDSAVYFCALSESGGT-GKLTFGKGTRLTV 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 33-133 4.49e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 66.71  E-value: 4.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535    33 QVGHNATLHCNFSTSTISP--YILWYQQHLTQSPQFLLQVSKFK--PHVHSERISSVLSMENSQVLLHVQDAKLQDSAVY 108
Cdd:pfam07686   9 ALGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNGseEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|....*
gi 38350535   109 LCALSPSsgslNKPTFGSGTRLSVL 133
Cdd:pfam07686  89 TCAVIPS----GEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 28-132 5.62e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 5.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535     28 QETAIQVGHNATLHCNFSTSTiSPYILWYQQHLtqspqfllqvskfKPHVHSERISsvLSMENSQVLLHVQDAKLQDSAV 107
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSP-PPEVTWYKQGG-------------KLLAESGRFS--VSRSGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|....*
gi 38350535    108 YLCALSPSSGSLNkptfgSGTRLSV 132
Cdd:smart00410  66 YTCAATNSSGSAS-----SGTTLTV 85
 
Name Accession Description Interval E-value
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 23-132 5.59e-44

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 140.10  E-value: 5.59e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  23 VVQFAQETAIQVGHNATLHCNFSTSTiSPYILWYQQHLTQSPQFLLQVSKFKPHVHSERISSVLSMENSQVLLHVQDAKL 102
Cdd:cd04983   1 VTQSPQSLSVQEGENVTLNCNYSTST-FYYLFWYRQYPGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSLHISAAQL 79

                        90       100       110
                ....*....|....*....|....*....|
gi 38350535 103 QDSAVYLCALSPSSGSlNKPTFGSGTRLSV 132
Cdd:cd04983  80 SDSAVYFCALSESGGT-GKLTFGKGTRLTV 108
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 23-132 5.82e-29

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 102.03  E-value: 5.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  23 VVQFAQETAIQVGHNATLHCNFSTSTISPYILWYQQHLTQSPQFLLQVSKFKPHV---HSERISSVLSmENSQVLLHVQD 99
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIYWYRQKPGQGPEFLIYLSSSKGKTkggVPGRFSGSRD-GTSSFSLTISN 79

                        90       100       110
                ....*....|....*....|....*....|...
gi 38350535 100 AKLQDSAVYLCALSpSSGSLNKPTFGSGTRLSV 132
Cdd:cd00099  80 LQPEDSGTYYCAVS-ESGGTDKLTFGSGTRLTV 111
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 23-134 2.32e-16

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 69.86  E-value: 2.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  23 VVQFAQETAIQVGHNATLHCNFSTSTISPYILWYQQHLTQSPQFLLQVSKFKPHVHSERISSVLSMENSQVLLHVQDAKL 102
Cdd:cd07706   2 VTQAQPDVSVQVGEEVTLNCRYETSWTNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQL 81

                        90       100       110
                ....*....|....*....|....*....|..
gi 38350535 103 QDSAVYLCALSpSSGSLNKPTFGSGTRLSVLP 134
Cdd:cd07706  82 EDSAKYFCALS-LPYDTDKLIFGKGTRLTVEP 112
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 23-132 2.85e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 66.92  E-value: 2.85e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  23 VVQFAQETAIQVGHNATLHCNFSTStiSPYILWYQQHLTQSPQFLL----QVSKFKPHVHSERiSSVLSMENSQVLLHVQ 98
Cdd:cd05899   1 VTQSPRYLIKRRGQSVTLRCSQKSG--HDNMYWYRQDPGKGLQLLFysygGGLNEEGDLPGDR-FSASRPSLTRSSLTIK 77

                        90       100       110
                ....*....|....*....|....*....|....
gi 38350535  99 DAKLQDSAVYLCALSPSSGSlNKPTFGSGTRLSV 132
Cdd:cd05899  78 SAEPEDSAVYLCASSLGGGA-DEAYFGPGTRLTV 110
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 33-133 4.49e-15

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 66.71  E-value: 4.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535    33 QVGHNATLHCNFSTSTISP--YILWYQQHLTQSPQFLLQVSKFK--PHVHSERISSVLSMENSQVLLHVQDAKLQDSAVY 108
Cdd:pfam07686   9 ALGGSVTLPCTYSSSMSEAstSVYWYRQPPGKGPTFLIAYYSNGseEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGTY 88

                          90       100
                  ....*....|....*....|....*
gi 38350535   109 LCALSPSsgslNKPTFGSGTRLSVL 133
Cdd:pfam07686  89 TCAVIPS----GEGVFGKGTRLTVL 109
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 33-132 2.12e-14

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 65.08  E-value: 2.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  33 QVGHNATLHCNFSTSTISP-YILWYQQHLTQSPQFLLQVSKFKPHVH-----SERISSVLSMENSQVLLHVQDAKLQDSA 106
Cdd:cd04982  11 EESKSVTISCKVSGIDFSTtYIHWYRQKPGQALERLLYVSSTSAVRKdsgktKNKFEARKDVGKSTSTLTITNLEKEDSA 90

                        90       100
                ....*....|....*....|....*.
gi 38350535 107 VYLCALSPSSGSLNKPTFGSGTRLSV 132
Cdd:cd04982  91 TYYCAYWESGSGYYIKVFGSGTKLIV 116
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 34-132 1.06e-11

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 57.86  E-value: 1.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  34 VGHNATLHCNFSTSTISP-YILWYQQHLTQSPQFLLQVSKFKPHVHSERISSvlSMENSQVLLHVQDAKLQDSAVYLCAL 112
Cdd:cd04984  12 PGETVTITCTGSSGNISGnYVNWYQQKPGSAPRYLIYEDKHRPSGIPDRFSG--SKSGNTASLTISGAQTEDEADYYCQV 89

                        90       100
                ....*....|....*....|
gi 38350535 113 SPSSGSLnkptFGSGTRLSV 132
Cdd:cd04984  90 WDSNSYV----FGGGTKLTV 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 28-132 5.62e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 52.89  E-value: 5.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535     28 QETAIQVGHNATLHCNFSTSTiSPYILWYQQHLtqspqfllqvskfKPHVHSERISsvLSMENSQVLLHVQDAKLQDSAV 107
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSP-PPEVTWYKQGG-------------KLLAESGRFS--VSRSGSTSTLTISNVTPEDSGT 65

                           90       100
                   ....*....|....*....|....*
gi 38350535    108 YLCALSPSSGSLNkptfgSGTRLSV 132
Cdd:smart00410  66 YTCAATNSSGSAS-----SGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
37-111 3.32e-09

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.46  E-value: 3.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535     37 NATLHCNFSTSTISPYIL-WYQQHLTQSPQFLLQVSKFKPHVHSE----RISSVLSMENSQVLLHVQDAKLQDSAVYLCA 111
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVsWVRQPPGKGLEWLGYIGSNGSSYYQEsykgRFTISKDTSKNDVSLTISNLRVEDTGTYYCA 80
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 33-132 4.60e-09

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 51.02  E-value: 4.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  33 QVGHNATLHCN-----FSTSTISPYiLWYQQHltqSPQFLLQVSKFKPHVHSERISSVLSMENSQVLLHVQDAKLQDSAV 107
Cdd:cd16095  13 PAGKTLSLKCQtsgfqFNTSQLSWY-LWVPGH---APLWLTSLDHISTKVSEDRITSSREDTNSQIFLQIKGLGLRDSGQ 88

                        90       100
                ....*....|....*....|....*.
gi 38350535 108 YLCALSPSSG-SLNKPTFGSGTRLSV 132
Cdd:cd16095  89 YHCARRVGYGdDTDKLIFGPGTDVIV 114
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 31-132 5.02e-08

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 48.16  E-value: 5.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  31 AIQVGHNATLHCNFSTSTISPYILWYQQHLTQSPQFLL-QVSKFKPHVhSERISSvlSMENSQVLLHVQDAKLQDSAVYL 109
Cdd:cd04980  11 SVSPGERVTISCKASQSISSNYLAWYQQKPGQAPKLLIyYASTLHSGV-PSRFSG--SGSGTDFTLTISSVEPEDAAVYY 87

                        90       100
                ....*....|....*....|...
gi 38350535 110 CalspSSGSLNKPTFGSGTRLSV 132
Cdd:cd04980  88 C----QQGYTFPYTFGGGTKLEI 106
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 32-132 5.25e-08

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 48.21  E-value: 5.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  32 IQVGHNATLHCNFSTSTISPYILWYQQHLTQSP----QFLLQVSKFKPHVHSERISS-----VLSMENSQVLLHVQDAKL 102
Cdd:cd07700  10 VQTNQTVKMSCEAKTSPKNTRIYWLRQRQAPSKdshfEFLASWDPSKGIVYGEGVDQekliiLSDSDSSRYILSLMSVKP 89

                        90       100       110
                ....*....|....*....|....*....|
gi 38350535 103 QDSAVYLCALSPSSgslnKPTFGSGTRLSV 132
Cdd:cd07700  90 EDSGTYFCMTVGSP----ELIFGTGTKLSV 115
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 29-132 1.92e-04

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 38.80  E-value: 1.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  29 ETAIQVGHNATLHCNFSTSTISPYI---LWYQQHLTQSPQFLLQVSKFKPHVHSerISSVLSMENSQVLLHVQDAKLQDS 105
Cdd:cd20926   9 EIRTLEGSSAFLPCSFNASQGRLAIgsvTWFRDEVAPGKEVRNGTPEFRGRLAP--LASSRFLRDHQAELHIWDVRGHDA 86

                        90       100       110
                ....*....|....*....|....*....|
gi 38350535 106 AVYLC---ALSPSSGSlnkptfGSGTRLSV 132
Cdd:cd20926  87 GIYVCrveVLGLGVGT------GNGTRLVV 110
IgV_1_MRC-OX-2_like cd05846
First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; ...
 28-127 2.10e-03

First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins. MRC OX-2 is a membrane glycoprotein expressed in a variety of lymphoid and non-lymphoid cells in rats. It has a similar broad distribution pattern in humans. MRC OX-2 may regulate myeloid cell activity. The protein has an extracellular portion containing two Ig-like domains, a transmembrane portion, and a cytoplasmic portion.


Pssm-ID: 409433  Cd Length: 108  Bit Score: 35.78  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535  28 QETAIQVGHNATLHCNFSTSTISPYILWyQQHLTQSPQFLLQVSkfkpHVHSERI---------SSVLSMENSQVLLHvq 98
Cdd:cd05846   6 GDTRAVLGGNATLSCNLTLPEEVLQVTW-QKIKASSPENIVTYS----KKYGVKIqpsyvrrisFTSSGLNSTSITIW-- 78

                        90       100
                ....*....|....*....|....*....
gi 38350535  99 DAKLQDSAVYLCALSpssgslnkpTFGSG 127
Cdd:cd05846  79 NVTLEDEGCYKCLFN---------TFPDG 98
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 22-110 5.18e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.08  E-value: 5.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38350535    22 SVVQFAQETAIQVGHNATLHCNFSTSTiSPYILWYQQhltqspqfllqvSKFKPHVHSERISSVlsmeNSQVLLHVQDAK 101
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSP-PPTITWYKN------------GEPISSGSTRSRSLS----GSNSTLTISNVT 65


                  ....*....
gi 38350535   102 LQDSAVYLC 110
Cdd:pfam13927  66 RSDAGTYTC 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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