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Conserved domains on  [gi|41387501|gb|AAS01608|]
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EML5 [Rattus norvegicus]

Protein Classification

HELP and WD40 domain-containing protein( domain architecture ID 13687862)

HELP and WD40 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
720-1140 5.26e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.28  E-value: 5.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  720 QRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIV 799
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  800 LWDWKKGEKLSVARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRRAGGGLIgrkgyvgtlgkndtmmcavygwtee 876
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLL------------------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  877 mafsgtstgdvciwrdvflvKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDdsferclktyaikradlapgskgll 954
Cdd:COG2319  198 --------------------RTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWD------------------------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  955 lednpsiraislghghilvgTKNGEILEVdksgpvtllVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCML 1034
Cdd:COG2319  233 --------------------LATGKLLRT---------LTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1035 AVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPgSGKYLAVASHDSFVDIYNVTS 1114
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                        410       420
                 ....*....|....*....|....*.
gi 41387501 1115 SKRVGVCKGATSYITHIDWDSRGKLL 1140
Cdd:COG2319  362 GELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 1.66e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   58 RGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  218 GDIYVW--KGINLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETeqgykglSVRSVCWR 292
Cdd:COG2319  184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  293 --GDHILVGTQDSEI--FEIvvhERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MDE 367
Cdd:COG2319  256 pdGRLLASGSADGTVrlWDL---ATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTG 331

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387501  368 PIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 2-49 5.73e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 5.73e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 41387501      2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 672-715 4.69e-17

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 76.82  E-value: 4.69e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 41387501    672 APGNSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-592 4.84e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 4.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  321 QGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIAR-CNMDEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMT 399
Cdd:cd00200    6 KGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  400 EVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrYKKVGECVGSLSFITHLDWSSDSKYLQT--NDGSGKrlL 477
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASssQDGTIK--L 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  478 YKMPGGKEVTS----KEEVKGMHW---------------------ASWTCVAGLEVNGIWpkysdindINSVDGNYVGQV 532
Cdd:cd00200  162 WDLRTGKCVATltghTGEVNSVAFspdgekllssssdgtiklwdlSTGKCLGTLRGHENG--------VNSVAFSPDGYL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  533 LVTADDYGVVKLFRypcLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWK 592
Cdd:cd00200  234 LASGSEDGTIRVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 1363-1410 2.31e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 69.50  E-value: 2.31e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 41387501   1363 KKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1410
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
1407-1556 3.87e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 3.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1407 LHNVATGTQSF-YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSVHIWDAVNKQTLSILRcSHSKGVCSVSF 1485
Cdd:COG2319  188 LWDLATGKLLRtLTGHTGAVRSVAFSPDGKLL---ASG----SAD-----GTVRLWDLATGKLLRTLT-GHSGSVRSVAF 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41387501 1486 SATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqFVSVGI-KHVKFWTLAGRALL 1556
Cdd:COG2319  255 SPDGRLLASGSAD--GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDdGTVRLWDLATGKLL 323
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
720-1140 5.26e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.28  E-value: 5.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  720 QRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIV 799
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  800 LWDWKKGEKLSVARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRRAGGGLIgrkgyvgtlgkndtmmcavygwtee 876
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLL------------------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  877 mafsgtstgdvciwrdvflvKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDdsferclktyaikradlapgskgll 954
Cdd:COG2319  198 --------------------RTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWD------------------------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  955 lednpsiraislghghilvgTKNGEILEVdksgpvtllVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCML 1034
Cdd:COG2319  233 --------------------LATGKLLRT---------LTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1035 AVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPgSGKYLAVASHDSFVDIYNVTS 1114
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                        410       420
                 ....*....|....*....|....*.
gi 41387501 1115 SKRVGVCKGATSYITHIDWDSRGKLL 1140
Cdd:COG2319  362 GELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1063 7.23e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.84  E-value: 7.23e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  725 GHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIVLWDWK 804
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  805 KGEKLSVARGSKDKIFVVKMNPYvpDKLITAGIKH--MKFWRRAGGGLIGRkgyvgTLGKNDTMMCAVYGWTEEMAFSGT 882
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  883 STGDVCIW--RDVFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDDSFERCLKTYaikradlapgskgllledn 958
Cdd:cd00200  155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTL------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  959 psiraislghghilvgtkngeilevdksgpvtllvQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRK 1038
Cdd:cd00200  216 -----------------------------------RGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        330       340
                 ....*....|....*....|....*
gi 41387501 1039 LKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 1.66e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   58 RGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  218 GDIYVW--KGINLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETeqgykglSVRSVCWR 292
Cdd:COG2319  184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  293 --GDHILVGTQDSEI--FEIvvhERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MDE 367
Cdd:COG2319  256 pdGRLLASGSADGTVrlWDL---ATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTG 331

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387501  368 PIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-353 4.40e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 4.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   57 YRGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKdVHTHGIACLAFDLDGQRLVSVGLDskNAVCVWD 136
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  137 WKRGKMLSMAPGHTDRIFDISWDlyqPNK--LVSCGV-KHIKFWSLcgNALTPKRGVFGKTGDlqtILCLACARDE-LTY 212
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFS---PDGriLSSSSRdKTIKVWDV--ETGKCLTTLRGHTDW---VNSVAFSPDGtFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  213 SGALNGDIYVW--KGINLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDlreteqgYKGLSVR 287
Cdd:cd00200  152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLR-------GHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  288 SVCW--RGDHILVGTQDS--EIFEIVVHERNKPFlimQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:cd00200  224 SVAFspDGYLLASGSEDGtiRVWDLRTGECVQTL---SGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 2-49 5.73e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 5.73e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 41387501      2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 672-715 4.69e-17

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 76.82  E-value: 4.69e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 41387501    672 APGNSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-592 4.84e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 4.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  321 QGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIAR-CNMDEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMT 399
Cdd:cd00200    6 KGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  400 EVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrYKKVGECVGSLSFITHLDWSSDSKYLQT--NDGSGKrlL 477
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASssQDGTIK--L 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  478 YKMPGGKEVTS----KEEVKGMHW---------------------ASWTCVAGLEVNGIWpkysdindINSVDGNYVGQV 532
Cdd:cd00200  162 WDLRTGKCVATltghTGEVNSVAFspdgekllssssdgtiklwdlSTGKCLGTLRGHENG--------VNSVAFSPDGYL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  533 LVTADDYGVVKLFRypcLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWK 592
Cdd:cd00200  234 LASGSEDGTIRVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 1363-1410 2.31e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 69.50  E-value: 2.31e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 41387501   1363 KKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1410
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
1407-1556 3.87e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 3.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1407 LHNVATGTQSF-YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSVHIWDAVNKQTLSILRcSHSKGVCSVSF 1485
Cdd:COG2319  188 LWDLATGKLLRtLTGHTGAVRSVAFSPDGKLL---ASG----SAD-----GTVRLWDLATGKLLRTLT-GHSGSVRSVAF 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41387501 1486 SATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqFVSVGI-KHVKFWTLAGRALL 1556
Cdd:COG2319  255 SPDGRLLASGSAD--GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDdGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1406-1548 4.31e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1406 ILHNVATGTQSF-YQEHNDDILCLTVNQHPKFInivatgqVGDSADMSatapsVHIWDAVNKQTLSILRcSHSKGVCSVS 1484
Cdd:cd00200  118 KVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFV-------ASSSQDGT-----IKLWDLRTGKCVATLT-GHTGEVNSVA 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41387501 1485 FSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFW 1548
Cdd:cd00200  185 FSPDGEKLLSSSSD--GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 760-802 3.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 41387501     760 TIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIVLWD 802
Cdd:smart00320    1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-353 1.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41387501    314 NKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:pfam00400    1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 315-353 1.92e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.92e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41387501     315 KPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
720-757 5.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 5.92e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41387501    720 QRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWD 757
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASG--SDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 1080-1140 6.48e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 6.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387501  1080 HRKDViSDIQFSPGSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLL 1140
Cdd:PTZ00421  124 HTKKV-GIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLL 183
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
720-1140 5.26e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 139.28  E-value: 5.26e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  720 QRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIV 799
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  800 LWDWKKGEKLSVARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRRAGGGLIgrkgyvgtlgkndtmmcavygwtee 876
Cdd:COG2319  146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLL------------------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  877 mafsgtstgdvciwrdvflvKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDdsferclktyaikradlapgskgll 954
Cdd:COG2319  198 --------------------RTLTGHTGAVRSVAFSPDGklLASGSADGTVRLWD------------------------- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  955 lednpsiraislghghilvgTKNGEILEVdksgpvtllVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCML 1034
Cdd:COG2319  233 --------------------LATGKLLRT---------LTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1035 AVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPgSGKYLAVASHDSFVDIYNVTS 1114
Cdd:COG2319  283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT 361

                        410       420
                 ....*....|....*....|....*.
gi 41387501 1115 SKRVGVCKGATSYITHIDWDSRGKLL 1140
Cdd:COG2319  362 GELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 725-1063 7.23e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.84  E-value: 7.23e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  725 GHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIVLWDWK 804
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  805 KGEKLSVARGSKDKIFVVKMNPYvpDKLITAGIKH--MKFWRRAGGGLIGRkgyvgTLGKNDTMMCAVYGWTEEMAFSGT 882
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVETGKCLTT-----LRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  883 STGDVCIW--RDVFLVKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDDSFERCLKTYaikradlapgskgllledn 958
Cdd:cd00200  155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTL------------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  959 psiraislghghilvgtkngeilevdksgpvtllvQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRK 1038
Cdd:cd00200  216 -----------------------------------RGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        330       340
                 ....*....|....*....|....*
gi 41387501 1039 LKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 1.66e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.96  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   58 RGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  218 GDIYVW--KGINLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETeqgykglSVRSVCWR 292
Cdd:COG2319  184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  293 --GDHILVGTQDSEI--FEIvvhERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MDE 367
Cdd:COG2319  256 pdGRLLASGSADGTVrlWDL---ATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTG 331

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387501  368 PIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
719-1063 8.02e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 8.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  719 TQRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTI 798
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASG--SADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  799 VLWDWKKGEKLSVARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRRAGGGLIGrkgyvgTLGKNDtmmcavyGWTE 875
Cdd:COG2319  187 RLWDLATGKLLRTLTGHTGAVRSVAFSP---DgkLLASGSAdGTVRLWDLATGKLLR------TLTGHS-------GSVR 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  876 EMAFS--------GTSTGDVCIWrDV---FLVKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDDSFERCLKTYaik 942
Cdd:COG2319  251 SVAFSpdgrllasGSADGTVRLW-DLatgELLRTLTGHSGGVNSVAFSPDGklLASGSDDGTVRLWDLATGKLLRTL--- 326

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  943 radlapgskglllednpsiraislghghilvgtkngeilevdksgpvtllvQGHmEGEVWGLATHPYLPICATVSDDKTL 1022
Cdd:COG2319  327 ---------------------------------------------------TGH-TGAVRSVAFSPDGKTLASGSDDGTV 354

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 41387501 1023 RIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 1063
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
52-354 2.16e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 2.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   52 HRQKFYRGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKDvHTHGIACLAFDLDGQRLVSVGLDskNA 131
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  132 VCVWDWKRGKMLSMAPGHTDRIFDISWDlyqPN--KLVSCGV-KHIKFWSLcgnaltpKRGVFGKT--GDLQTILCLACA 206
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSAdGTVRLWDL-------ATGKLLRTltGHSGSVRSVAFS 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  207 RDELT-YSGALNGDIYVW--KGINLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIdlreteQG 280
Cdd:COG2319  256 PDGRLlASGSADGTVRLWdlATGELLRTLTG-HSGGVNSVAFSPDGklLASGSDDGTVRLWDLaTGKLLRTL------TG 328

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41387501  281 YKGlSVRSVCWR--GDHILVGTQDSEI--FEIvvhERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSL 354
Cdd:COG2319  329 HTG-AVRSVAFSpdGKTLASGSDDGTVrlWDL---ATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-353 4.40e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 121.67  E-value: 4.40e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   57 YRGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKdVHTHGIACLAFDLDGQRLVSVGLDskNAVCVWD 136
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  137 WKRGKMLSMAPGHTDRIFDISWDlyqPNK--LVSCGV-KHIKFWSLcgNALTPKRGVFGKTGDlqtILCLACARDE-LTY 212
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFS---PDGriLSSSSRdKTIKVWDV--ETGKCLTTLRGHTDW---VNSVAFSPDGtFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  213 SGALNGDIYVW--KGINLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDlreteqgYKGLSVR 287
Cdd:cd00200  152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLR-------GHENGVN 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  288 SVCW--RGDHILVGTQDS--EIFEIVVHERNKPFlimQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:cd00200  224 SVAFspDGYLLASGSEDGtiRVWDLRTGECVQTL---SGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
260-802 3.87e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 3.87e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  260 RLWDLTFKPITVIDLRETEQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVHERNKPFLIMQGHcEGELWALAVHPTKPL 339
Cdd:COG2319   14 ADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  340 AVTGSDDRSVRIWSLVDHALIARCNM-DEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIKDRKEAIHELKYSP 418
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  419 DGTYLAVGCNDSSVDIYGVAQrykkvGECVGSL----SFITHLDWSSDSKYLQT--NDGSGKrlLYKMPGGKEVTSKEEv 492
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLAT-----GKLLRTLtghtGAVRSVAFSPDGKLLASgsADGTVR--LWDLATGKLLRTLTG- 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  493 kgmHWASWTCVAglevngiWpkysdindinSVDGnyvgQVLVTADDYGVVKLFRypcLRKGAKFRKYIGHSAHVTNVRWS 572
Cdd:COG2319  245 ---HSGSVRSVA-------F----------SPDG----RLLASGSADGTVRLWD---LATGELLRTLTGHSGGVNSVAFS 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  573 HDYQWVISiGGADHSVFQWkfiperklkdalhiapqesltesnsdesdsdlsdvpeldseieqetqltyhrqvykedlpq 652
Cdd:COG2319  298 PDGKLLAS-GSDDGTVRLW------------------------------------------------------------- 315

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  653 lkeqckekqksatskrrERAPGNSIRLHfihgyrgydcrsnlfytqigeivyhvaavgviynrqqntqrfyLGHDDDILC 732
Cdd:COG2319  316 -----------------DLATGKLLRTL-------------------------------------------TGHTGAVRS 335

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  733 LAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIVLWD 802
Cdd:COG2319  336 VAFSPDGKTLASG--SDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSAD--GTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
251-591 5.13e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 5.13e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  251 ATGGRDGCIRLWDLTFKPITVIDLRETEqgykglSVRSVCWR--GDHILVGTQDSEI--FEIvvhERNKPFLIMQGHcEG 326
Cdd:COG2319   94 ASASADGTVRLWDLATGLLLRTLTGHTG------AVRSVAFSpdGKTLASGSADGTVrlWDL---ATGKLLRTLTGH-SG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  327 ELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MDEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIK 405
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  406 DRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrykkvGECVGSL----SFITHLDWSSDSKYLQTNDGSGKRLLYKMP 481
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLtghsGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  482 GGKEVTSkeeVKGmHWASWTCVAglevngiwpkYSDindinsvdgnyVGQVLVTADDYGVVKLFRypcLRKGAKFRKYIG 561
Cdd:COG2319  319 TGKLLRT---LTG-HTGAVRSVA----------FSP-----------DGKTLASGSDDGTVRLWD---LATGELLRTLTG 370

                        330       340       350
                 ....*....|....*....|....*....|
gi 41387501  562 HSAHVTNVRWSHDYQWVISiGGADHSVFQW 591
Cdd:COG2319  371 HTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
318-847 3.74e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 3.74e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  318 LIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MDEPIRCAAVNADGVHLALGMKDGSLTVLRVR 396
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  397 DMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrykkvGECVGSLS----FITHLDWSSDSKYLQTNDGS 472
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-----GKLLRTLTghsgAVTSVAFSPDGKLLASGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  473 GKRLLYKMPGGKEVTSkeeVKGmHWASWTCVAglevngiWpkysdindinSVDgnyvGQVLVTADDYGVVKLFRypcLRK 552
Cdd:COG2319  184 GTVRLWDLATGKLLRT---LTG-HTGAVRSVA-------F----------SPD----GKLLASGSADGTVRLWD---LAT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  553 GAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWKfiperklkdalhiapqesltesnsdesdsdlsdvpeldse 632
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLAS-GSADGTVRLWD---------------------------------------- 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  633 ieqetqltyhrqvykedlpqlkeqckekqksatskrrerapgnsirlhfihgyrgydcrsnlfyTQIGEIVyhvaavgvi 712
Cdd:COG2319  275 ----------------------------------------------------------------LATGELL--------- 281

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  713 ynrqqntqRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASVGI 792
Cdd:COG2319  282 --------RTLTGHSGGVNSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSD 350

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 41387501  793 DdsHTIVLWDWKKGEKLSVARGSKDKIFVVKmnpYVPD--KLITAGI-KHMKFWRRAG 847
Cdd:COG2319  351 D--GTVRLWDLATGELLRTLTGHTGAVTSVA---FSPDgrTLASGSAdGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
895-1266 3.40e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.30  E-value: 3.40e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWDdsferclktyaikradLAPGSKGLLLEDNPS-IRAISLGH-GH 970
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGrlLASASADGTVRLWD----------------LATGLLLRTLTGHTGaVRSVAFSPdGK 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  971 ILV-GTKNGEILEVD-KSGPVTLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRC 1045
Cdd:COG2319  134 TLAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1046 CCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGAT 1125
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHS 288

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1126 SYITHIDWDSRGKLLqvntgakeqlffeAPRGKKQTIpsveveKIsWATWTSVLglccegIWPIIGEVTDVTASCLTSDK 1205
Cdd:COG2319  289 GGVNSVAFSPDGKLL-------------ASGSDDGTV------RL-WDLATGKL------LRTLTGHTGAVRSVAFSPDG 342

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387501 1206 MVLATGDDLGFVKLFRypaKGKFGKFKKYVAHSTHVTNVRWTYDDSMLVTlGGADMSLMVW 1266
Cdd:COG2319  343 KTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 712-929 2.79e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 2.79e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  712 IYNRQQNTQRFYL-GHDDDILCLAIHPLKDYVATGqvGRDPSIHVWDTETIKPLSILKGyHQYGICAVDFSADGKRLASV 790
Cdd:cd00200   77 LWDLETGECVRTLtGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  791 GIDdsHTIVLWDWKKGEKLSVARGSKDKIFVVKmnpYVPD--KLITAGI-KHMKFWRRAGGGLIgrkgyvGTL-GKNDTM 866
Cdd:cd00200  154 SQD--GTIKLWDLRTGKCVATLTGHTGEVNSVA---FSPDgeKLLSSSSdGTIKLWDLSTGKCL------GTLrGHENGV 222

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41387501  867 MCAVYGWTEEMAFSGTSTGDVCIWRDVF--LVKTVKAHDGPVFSM--HALEKGFVTGGKDGVVALWD 929
Cdd:cd00200  223 NSVAFSPDGYLLASGSEDGTIRVWDLRTgeCVQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 895-1140 2.98e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 2.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  895 LVKTVKAHDGPVFSMHALEKG--FVTGGKDGVVALWD---DSFERCLKTYAIKRADLAPGSKGLLLednpsiraislghg 969
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYL-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  970 hiLVGTKNGEILEVD-KSGPVTLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCF 1048
Cdd:cd00200   67 --ASGSSDKTIRLWDlETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1049 SPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYI 1128
Cdd:cd00200  144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                        250
                 ....*....|..
gi 41387501 1129 THIDWDSRGKLL 1140
Cdd:cd00200  223 NSVAFSPDGYLL 234
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 2-49 5.73e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 5.73e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 41387501      2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
943-1552 7.38e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 7.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  943 RADLAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPVTLLVQGHmEGEVWGLATHPYLPICATVSDDKTL 1022
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1023 RIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPgSGKYLAVAS 1102
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1103 HDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLLqvntgakeqlffeaprgkkqtipsvevekiswatwtsvlglc 1182
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL------------------------------------------ 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1183 cegiwpiigevtdVTAScltSDKMV----LATGDDLGFVKlfrypakgkfgkfkkyvAHSTHVTNVRWTYDDSMLVTlGG 1258
Cdd:COG2319  220 -------------ASGS---ADGTVrlwdLATGKLLRTLT-----------------GHSGSVRSVAFSPDGRLLAS-GS 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1259 ADMSLMVWtseverhrekkncdseesDTDSeedggydsdvtreneisytiralstnirpmfgvkphlqqkepsvDERQGV 1338
Cdd:COG2319  266 ADGTVRLW------------------DLAT--------------------------------------------GELLRT 283

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1339 VRGSRPPVsrappqpeklqsnnvgkkkrpiedlvlelafgyrgrdcrNNVHYLNDGddiiyhtasvgilhnvatgtqsfy 1418
Cdd:COG2319  284 LTGHSGGV---------------------------------------NSVAFSPDG------------------------ 300

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1419 qehnddilcltvnqhpkfiNIVATGqvgdSADmsataPSVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLD 1498
Cdd:COG2319  301 -------------------KLLASG----SDD-----GTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDD 351

                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 41387501 1499 peHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqFVSVGI-KHVKFWTLAG 1552
Cdd:COG2319  352 --GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT-LASGSAdGTVRLWDLAT 403
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 672-715 4.69e-17

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 76.82  E-value: 4.69e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 41387501    672 APGNSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 321-592 4.84e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 4.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  321 QGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIAR-CNMDEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMT 399
Cdd:cd00200    6 KGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  400 EVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrYKKVGECVGSLSFITHLDWSSDSKYLQT--NDGSGKrlL 477
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASssQDGTIK--L 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  478 YKMPGGKEVTS----KEEVKGMHW---------------------ASWTCVAGLEVNGIWpkysdindINSVDGNYVGQV 532
Cdd:cd00200  162 WDLRTGKCVATltghTGEVNSVAFspdgekllssssdgtiklwdlSTGKCLGTLRGHENG--------VNSVAFSPDGYL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  533 LVTADDYGVVKLFRypcLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWK 592
Cdd:cd00200  234 LASGSEDGTIRVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
 1363-1410 2.31e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 69.50  E-value: 2.31e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 41387501   1363 KKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1410
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 COG2319
WD40 repeat [General function prediction only];
1407-1556 3.87e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 3.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1407 LHNVATGTQSF-YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSVHIWDAVNKQTLSILRcSHSKGVCSVSF 1485
Cdd:COG2319  188 LWDLATGKLLRtLTGHTGAVRSVAFSPDGKLL---ASG----SAD-----GTVRLWDLATGKLLRTLT-GHSGSVRSVAF 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41387501 1486 SATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTqFVSVGI-KHVKFWTLAGRALL 1556
Cdd:COG2319  255 SPDGRLLASGSAD--GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDdGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-178 3.87e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 3.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501   46 VYSPREHR-QKFYRGHSDDIISLALHPERVLVATGQVGKEpyICVWDSYTVQTVSVLKdVHTHGIACLAFDLDGQRLVSV 124
Cdd:cd00200  161 LWDLRTGKcVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT--IKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASG 237

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 41387501  125 GLDSKnaVCVWDWKRGKMLSMAPGHTDRIFDISWDlYQPNKLVSCGV-KHIKFWS 178
Cdd:cd00200  238 SEDGT--IRVWDLRTGECVQTLSGHTNSVTSLAWS-PDGKRLASGSAdGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1457-1556 4.06e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 4.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1457 SVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTq 1536
Cdd:COG2319  143 TVRLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL- 218

                         90       100
                 ....*....|....*....|.
gi 41387501 1537 FVSVGI-KHVKFWTLAGRALL 1556
Cdd:COG2319  219 LASGSAdGTVRLWDLATGKLL 239
WD40 COG2319
WD40 repeat [General function prediction only];
1428-1556 8.53e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 8.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1428 LTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWR 1507
Cdd:COG2319   72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 41387501 1508 WQEGAKIASRGGHNQRIFVAEFRPDSdTQFVSVGI-KHVKFWTLAGRALL 1556
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLL 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1406-1548 4.31e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 4.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1406 ILHNVATGTQSF-YQEHNDDILCLTVNQHPKFInivatgqVGDSADMSatapsVHIWDAVNKQTLSILRcSHSKGVCSVS 1484
Cdd:cd00200  118 KVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFV-------ASSSQDGT-----IKLWDLRTGKCVATLT-GHTGEVNSVA 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41387501 1485 FSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFW 1548
Cdd:cd00200  185 FSPDGEKLLSSSSD--GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1418-1556 2.05e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 2.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1418 YQEHNDDILCLTVNQHPKFInivatgqVGDSADMSatapsVHIWDAVNKQTLSILRCsHSKGVCSVSFSATGKLLLSVGL 1497
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRIL-------SSSSRDKT-----IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQ 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 41387501 1498 DpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFWTLAGRALL 1556
Cdd:cd00200  156 D--GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1418-1551 3.67e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 3.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1418 YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSVHIWDAVNKQTLSILrCSHSKGVCSVSFSATGKLLLSVGL 1497
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLL---ATG----SGD-----GTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSS 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 41387501 1498 DpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSdtQFVSVGIKH--VKFWTLA 1551
Cdd:cd00200   72 D--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVE 123
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1460-1548 9.51e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 9.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1460 IWDAVNKQTLSILRCsHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVS 1539
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRD--KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153


                 ....*....
gi 41387501 1540 VGIKHVKFW 1548
Cdd:cd00200  154 SQDGTIKLW 162
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1421-1533 4.41e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 4.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1421 HNDDILCLTVnqHPKFINIVATGqvGDSadmsatapSVHIWDAVNKQTLSILRcSHSKGVCSVSFSATGKLLLSVGLDpe 1500
Cdd:cd00200  176 HTGEVNSVAF--SPDGEKLLSSS--SDG--------TIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASGSED-- 240

                         90       100       110
                 ....*....|....*....|....*....|...
gi 41387501 1501 HTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDS 1533
Cdd:cd00200  241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDG 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 993-1507 2.00e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  993 VQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTL 1072
Cdd:cd00200    5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1073 EDLVSFHHRKDVISDIQFSPgSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSrgkllqvntgakeqlff 1152
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP----------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1153 eaprgkkqtipsvevekiswatwtsvlglccegiwpiigevtdvtascltsDKMVLATGDDLGFVKLFRypaKGKFGKFK 1232
Cdd:cd00200  146 ---------------------------------------------------DGTFVASSSQDGTIKLWD---LRTGKCVA 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1233 KYVAHSTHVTNVRWTYDDSMLVTlGGADMSLMVWtseverhrekkncdseesDTDSEEdggydsdvtreneisytirals 1312
Cdd:cd00200  172 TLTGHTGEVNSVAFSPDGEKLLS-SSSDGTIKLW------------------DLSTGK---------------------- 210

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1313 tnirpmfgvkpHLQQkepsvderqgvvrgsrppvsrappqpeklqsnnvgkkkrpiedlvlelafgyrgrdcrnnvhyln 1392
Cdd:cd00200  211 -----------CLGT----------------------------------------------------------------- 214

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501 1393 dgddiiyhtasvgilhnvatgtqsfYQEHNDDILCLTVNQHPKFInivatgqVGDSADmsataPSVHIWDAVNKQTLSIL 1472
Cdd:cd00200  215 -------------------------LRGHENGVNSVAFSPDGYLL-------ASGSED-----GTIRVWDLRTGECVQTL 257

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 41387501 1473 RcSHSKGVCSVSFSATGKLLLSVGLDpeHTVTIWR 1507
Cdd:cd00200  258 S-GHTNSVTSLAWSPDGKRLASGSAD--GTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 760-802 3.64e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.64e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 41387501     760 TIKPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIVLWD 802
Cdd:smart00320    1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-353 1.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 41387501    314 NKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:pfam00400    1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 381-462 1.85e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501    381 LALGMKDGSLTVLRV-RDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVaqrYKkvGECVGSLS----FIT 455
Cdd:pfam12894   10 IALATEDGELLLHRLnWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDA---EN--GKIVHHFSagsdLIT 84


                   ....*..
gi 41387501    456 HLDWSSD 462
Cdd:pfam12894   85 CLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 315-353 1.92e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.92e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41387501     315 KPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 250-354 2.21e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.21  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41387501  250 FATGGRDGCIRLWDLTF--KPITVIDLRETeqGYKGLSVRSvcwRGDHILVGTQDSEIFEIvvHERN-KPFLIMQGHCEG 326
Cdd:cd22857  195 IVTGTGYHQVRLYDTRAqrRPVVSVDFGET--PIKAVAEDP---DGHTVYVGDTSGDLASI--DLRTgKLLGCFKGKCGG 267

                         90       100
                 ....*....|....*....|....*...
gi 41387501  327 ELWALAVHPTKPLAVTGSDDRSVRIWSL 354
Cdd:cd22857  268 SIRSIARHPELPLIASCGLDRYLRIWDT 295
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 994-1026 2.79e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.79e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 41387501     994 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 1026
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
720-757 5.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 5.92e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 41387501    720 QRFYLGHDDDILCLAIHPLKDYVATGqvGRDPSIHVWD 757
Cdd:pfam00400    4 LKTLEGHTGSVTSLAFSPDGKLLASG--SDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 1080-1140 6.48e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 6.48e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41387501  1080 HRKDViSDIQFSPGSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLL 1140
Cdd:PTZ00421  124 HTKKV-GIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLL 183
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-263 7.77e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 7.77e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 41387501     227 NLIRTIQGaHTAGIFSMNACEEG--FATGGRDGCIRLWD 263
Cdd:smart00320    3 ELLKTLKG-HTGPVTSVAFSPDGkyLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 725-757 8.09e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 8.09e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 41387501     725 GHDDDILCLAIHPLKDYVATGqvGRDPSIHVWD 757
Cdd:smart00320   10 GHTGPVTSVAFSPDGKYLASG--SDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
762-802 8.87e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 8.87e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 41387501    762 KPLSILKGyHQYGICAVDFSADGKRLASVGIDdsHTIVLWD 802
Cdd:pfam00400    2 KLLKTLEG-HTGSVTSLAFSPDGKLLASGSDD--GTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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