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Conserved domains on  [gi|599127323|gb|AAS64758|]
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uncharacterized protein Dmel_CG9826, isoform C [Drosophila melanogaster]

Protein Classification

SLC17 family MFS transporter( domain architecture ID 13022888)

SLC17 (solute carrier 17) family major facilitator superfamily (MFS) transporter is involved in the transport of organic anions

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0016020|GO:0055085|GO:0015711
PubMed:  23506876|26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 18-439 2.59e-143

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 416.63  E-value: 2.59e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  18 SFLLFLGLTVMHIARLNVSVAIVAMTNAATTNPN-------------FPEFEWTEKQKSYILSSFYWGYILTLFPGSFLC 84
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNnntstdkdtlpveAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  85 RRYGAKVVLFVASCGTAVLSLMTPWCiTWGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCG 164
Cdd:cd17318   81 EKYGAKRVLGYSILITALLTLLTPLA-ARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 165 TVLAMFISGMIAKgAMGWPGISYVSGSLCAAWCFLWLIFasnnatesrfvgeaeckyiesslehnedfhgrtipipwrai 244
Cdd:cd17318  160 TVIAMPLSGFLCE-SLGWPSIFYIFGGLGLLWCLLWFFL----------------------------------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 245 wtSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVRK 324
Cdd:cd17318  198 --VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRK 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 325 LFNTLSFWIPAAALIGIGFLSeENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIA 404
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLG-SNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIV 354

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 599127323 405 GEIVADKHNRGQWQIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17318  355 GAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 18-439 2.59e-143

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 416.63  E-value: 2.59e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  18 SFLLFLGLTVMHIARLNVSVAIVAMTNAATTNPN-------------FPEFEWTEKQKSYILSSFYWGYILTLFPGSFLC 84
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNnntstdkdtlpveAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  85 RRYGAKVVLFVASCGTAVLSLMTPWCiTWGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCG 164
Cdd:cd17318   81 EKYGAKRVLGYSILITALLTLLTPLA-ARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 165 TVLAMFISGMIAKgAMGWPGISYVSGSLCAAWCFLWLIFasnnatesrfvgeaeckyiesslehnedfhgrtipipwrai 244
Cdd:cd17318  160 TVIAMPLSGFLCE-SLGWPSIFYIFGGLGLLWCLLWFFL----------------------------------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 245 wtSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVRK 324
Cdd:cd17318  198 --VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRK 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 325 LFNTLSFWIPAAALIGIGFLSeENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIA 404
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLG-SNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIV 354

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 599127323 405 GEIVADKHNRGQWQIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17318  355 GAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 14-450 7.66e-73

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 238.10  E-value: 7.66e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   14 RHLQSFLLFLGLTVMHIARLNVSVAIVAM---------TNAATTNPNF----PEFEWTEKQKSYILSSFYWGYILTLFPG 80
Cdd:TIGR00894  17 RLFLSFLLHICNVIIIAQRICLSLTMVAMvnkenstdlACLSAENELDniknPNFKWSGALQGLILSSHFYGQIIIQIPV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   81 SFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGG-WQVFCaiRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYT 159
Cdd:TIGR00894  97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIaLVVFC--RVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTS 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  160 GTDCGTVLAMFISGMIAKGAMGWPGISYVSGSLCAAWCFLWLIFASNNATESRFVGEAECKYIESSLEhnEDFHGRTIPI 239
Cdd:TIGR00894 175 GFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQ--GQKGSTRQSL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  240 PWRAIWTSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSL 319
Cdd:TIGR00894 253 PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  320 TAVRKLFNTLSFWIPAAALIGIGFLSeENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPIL 399
Cdd:TIGR00894 333 TAARKIFNGIGGLGPGIFAYALPYLS-AAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLI 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 599127323  400 TPLIAGEIVADKhNRGQWQIVFGLAAVIFFVGNVVFIIWGTAKAQPWDADD 450
Cdd:TIGR00894 412 ASTLAGNILSQD-SKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEE 461
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-439 1.10e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.51  E-value: 1.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  19 FLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASC 98
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQA---------DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  99 GTAVLSLMTPWCitwGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkG 178
Cdd:COG2271   84 LWGLATLLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL-A 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 179 AMGWPGISYVSGSLCAAWCFLwlifasnnatesrfvgeaeckyiesslehnedfhgrtipipwraiwtsvPFLALLVTRC 258
Cdd:COG2271  160 AFGWRAAFLILGLPGLLLALL-------------------------------------------------RFWLLALAYF 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 259 AETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLtavrklfnTLSFWIPAAAL 338
Cdd:COG2271  191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL--------AIGLLLAALAL 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 339 IGIGFLSeeNKNLAIVLMTV-SVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVAdkhnRGQW 417
Cdd:COG2271  263 LLLALLP--SPALAIALLFLaGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD----ATGY 336

                        410       420
                 ....*....|....*....|..
gi 599127323 418 QIVFGLAAVIFFVGNVVFIIWG 439
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
37-401 6.35e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.80  E-value: 6.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   37 VAIVAMTNAATTNPNFP-----EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCI 111
Cdd:pfam07690   4 AAFLAALGRSLLGPALPlllaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  112 TWGgwqVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkGAMGWPGISYVSGS 191
Cdd:pfam07690  84 SLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  192 LCAAWCFLWLIFASnnatesrfvgeaeckYIESSLEHNEDFHGRTIPIPWRAIWTSVPFLALLVTrCAETYGLSTLQAEI 271
Cdd:pfam07690 160 LSLLAAVLLLLPRP---------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  272 PSYMNgVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVrklfntlsfwIPAAALIGIGFLSEENKNL 351
Cdd:pfam07690 224 PLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL----------LLILAALGLLLLSLTLSSL 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 599127323  352 AIVLMTVSVGVNSGATIGSSLNSIDLS--PNHAGILIGLSNTVANVIPILTP 401
Cdd:pfam07690 293 WLLLALLLLGFGFGLVFPALNALVSDLapKEERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 74-190 6.02e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 45.34  E-value: 6.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  74 ILTLFPGSF----LCRRYGAKVVLFVASCGTAVLSLMTpwCITWGGWQVFcAIRILQGLFQGVIFPCVTEHLAMWSPPEE 149
Cdd:PRK11551  60 ILGLLPGALlggrLADRIGRKRILIVSVALFGLFSLAT--AQAWDFPSLL-VARLLTGVGLGGALPNLIALTSEAVGPRL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 599127323 150 RNRLGAFSYTGTDCGTVLAMFIsGMIAKGAMGWPGISYVSG 190
Cdd:PRK11551 137 RGTAVSLMYCGVPFGGALASVI-GVLAAGDAAWRHIFYVGG 176
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 18-439 2.59e-143

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 416.63  E-value: 2.59e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  18 SFLLFLGLTVMHIARLNVSVAIVAMTNAATTNPN-------------FPEFEWTEKQKSYILSSFYWGYILTLFPGSFLC 84
Cdd:cd17318    1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNnntstdkdtlpveAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  85 RRYGAKVVLFVASCGTAVLSLMTPWCiTWGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCG 164
Cdd:cd17318   81 EKYGAKRVLGYSILITALLTLLTPLA-ARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 165 TVLAMFISGMIAKgAMGWPGISYVSGSLCAAWCFLWLIFasnnatesrfvgeaeckyiesslehnedfhgrtipipwrai 244
Cdd:cd17318  160 TVIAMPLSGFLCE-SLGWPSIFYIFGGLGLLWCLLWFFL----------------------------------------- 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 245 wtSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVRK 324
Cdd:cd17318  198 --VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRK 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 325 LFNTLSFWIPAAALIGIGFLSeENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIA 404
Cdd:cd17318  276 LFTSIGFLGPGVFLIALGYLG-SNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIV 354

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 599127323 405 GEIVADKHNRGQWQIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17318  355 GAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 19-439 3.00e-77

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 246.31  E-value: 3.00e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  19 FLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASC 98
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAK---------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVA 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  99 GTAVLSLMTPWCITWGGWqVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFI-SGMIAK 177
Cdd:cd17380   73 LWSLATLLTPLLAYSSLP-LLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIgPLLLEY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 178 GamGWPGISYVSGSLCAAWCFLWLIFASnnatesrfvgeaeckyiesslehnedfhgrtipipwraiwtsvPFLALLVTR 257
Cdd:cd17380  152 Y--GWPSVFYFFGLLGLLWALVWLIYLP-------------------------------------------PVWAIIVAH 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 258 CAETYGLSTLQAEIPSYMNGVLnMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKIlSLTAVRKLFNTLSFWIPAAA 337
Cdd:cd17380  187 FCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALF 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 338 LIGIGFLSeeNKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVaDKHnrGQW 417
Cdd:cd17380  265 LLLLSHTD--SFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL-EAT--GSW 339

                        410       420
                 ....*....|....*....|..
gi 599127323 418 QIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17380  340 SLVFVLAAVVNLVGAVVFLLFG 361
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 14-450 7.66e-73

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 238.10  E-value: 7.66e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   14 RHLQSFLLFLGLTVMHIARLNVSVAIVAM---------TNAATTNPNF----PEFEWTEKQKSYILSSFYWGYILTLFPG 80
Cdd:TIGR00894  17 RLFLSFLLHICNVIIIAQRICLSLTMVAMvnkenstdlACLSAENELDniknPNFKWSGALQGLILSSHFYGQIIIQIPV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   81 SFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGG-WQVFCaiRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYT 159
Cdd:TIGR00894  97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIaLVVFC--RVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTS 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  160 GTDCGTVLAMFISGMIAKGAMGWPGISYVSGSLCAAWCFLWLIFASNNATESRFVGEAECKYIESSLEhnEDFHGRTIPI 239
Cdd:TIGR00894 175 GFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQ--GQKGSTRQSL 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  240 PWRAIWTSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSL 319
Cdd:TIGR00894 253 PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSL 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  320 TAVRKLFNTLSFWIPAAALIGIGFLSeENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPIL 399
Cdd:TIGR00894 333 TAARKIFNGIGGLGPGIFAYALPYLS-AAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLI 411

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 599127323  400 TPLIAGEIVADKhNRGQWQIVFGLAAVIFFVGNVVFIIWGTAKAQPWDADD 450
Cdd:TIGR00894 412 ASTLAGNILSQD-SKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEE 461
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 18-439 1.79e-72

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 235.06  E-value: 1.79e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  18 SFLLFLGLTVMHIARLNVSVAIVAMTNAATT---------------------NPNFPEFEWTEKQKSYILSSFYWGYILT 76
Cdd:cd17381    2 ALLAFFGFFVVYALRVNLSVALVDMVNSNSTlpsnnssnacpehssspsvehNETGKKYDWDAETQGWILGSFFYGYIIT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  77 LFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWG-GWQVfcAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGA 155
Cdd:cd17381   82 QIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGaGYLI--AVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 156 FSYTGTDCGTVLAMFISGMIAKgAMGWPGISYVSGSLCAAWCFLWlifasnnatesrfvgeaeckyiesslehnedfhgr 235
Cdd:cd17381  160 ISYAGAQLGTVVSLPLSGLICY-YLDWTYVFYIFGAVGLLWFFLW----------------------------------- 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 236 tipipwraIWTSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKK 315
Cdd:cd17381  204 --------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 316 ILSLTAVRKLFNTLSFWIPAAALIGIGFlSEENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANV 395
Cdd:cd17381  276 NFSTVCVRKIFTLIGMIGPAVFLLAAGF-TGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATI 354

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 599127323 396 IPILTPLIAGEIVADkHNRGQWQIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17381  355 PGMVGPVIAKSLTHN-NTVEEWQTVFYISAAINVFGAIFFTIFG 397
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 18-439 7.02e-60

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 201.41  E-value: 7.02e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  18 SFLLFLGLTVMHIARLNVSVAIVAMTN------AATTNPNFPEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKV 91
Cdd:cd17382    1 AIMAGLGFCISFGIRCNLGVAIVRMVNnftdayGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  92 VLFVASCGTAVLSLMTPWCITwGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFI 171
Cdd:cd17382   81 VFGLAIFVTSTLNMLIPIAAR-VHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 172 SGMIAKgAMGWPGISYVSGSLCAAWCFLWlifasnnatesrfvgeaeckyiesslehnedfhgrtipipwraIWTSVPFL 251
Cdd:cd17382  160 SGILVQ-YVGWSSPFYVYGVFGIIWYMFW-------------------------------------------MLVSMPVY 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 252 ALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVRKLFNTLSF 331
Cdd:cd17382  196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 332 WIPAAALIGIGFLSeeNKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVADK 411
Cdd:cd17382  276 GMEATFLLVVAFSH--SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHK 353

                        410       420
                 ....*....|....*....|....*...
gi 599127323 412 hNRGQWQIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17382  354 -TREEWQYVFLIASLVHFFGVIFYAIFA 380
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 14-437 1.21e-31

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 124.61  E-value: 1.21e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  14 RHLQSFLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVL 93
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMK---------DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  94 FVASCGTAVLSLMTPWCitwGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISG 173
Cdd:cd17319   72 AVSMLLWSLFTALTGFA---TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 174 MIAkGAMGWPGISYVSGSLCAAWCFLWLIFASNnatesrfvgeaeckyiesslehnedfhgrtipipwraiwtsvpFLAL 253
Cdd:cd17319  149 WLL-LLFGWRWAFIIEGLLGLLLAVLWWFYLRQ-------------------------------------------VWGL 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 254 LVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKilsltavRKLFNTLSFWI 333
Cdd:cd17319  185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVIIIGLLL 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 334 PAAALIGIGFLseENKNLAIVLMTVS-VGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVADKH 412
Cdd:cd17319  258 AAVGLLLAYLT--TSPVVAVILLSLAgFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335

                        410       420
                 ....*....|....*....|....*
gi 599127323 413 NrgqWQIVFGLAAVIFFVGNVVFII 437
Cdd:cd17319  336 S---YTAAFLFLAAVALLAALLVLL 357
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
19-439 1.10e-28

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.51  E-value: 1.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  19 FLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASC 98
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQA---------DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  99 GTAVLSLMTPWCitwGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkG 178
Cdd:COG2271   84 LWGLATLLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL-A 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 179 AMGWPGISYVSGSLCAAWCFLwlifasnnatesrfvgeaeckyiesslehnedfhgrtipipwraiwtsvPFLALLVTRC 258
Cdd:COG2271  160 AFGWRAAFLILGLPGLLLALL-------------------------------------------------RFWLLALAYF 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 259 AETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLtavrklfnTLSFWIPAAAL 338
Cdd:COG2271  191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL--------AIGLLLAALAL 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 339 IGIGFLSeeNKNLAIVLMTV-SVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVAdkhnRGQW 417
Cdd:COG2271  263 LLLALLP--SPALAIALLFLaGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD----ATGY 336

                        410       420
                 ....*....|....*....|..
gi 599127323 418 QIVFGLAAVIFFVGNVVFIIWG 439
Cdd:COG2271  337 QAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
37-401 6.35e-23

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 99.80  E-value: 6.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   37 VAIVAMTNAATTNPNFP-----EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCI 111
Cdd:pfam07690   4 AAFLAALGRSLLGPALPlllaeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  112 TWGgwqVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkGAMGWPGISYVSGS 191
Cdd:pfam07690  84 SLW---LLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  192 LCAAWCFLWLIFASnnatesrfvgeaeckYIESSLEHNEDFHGRTIPIPWRAIWTSVPFLALLVTrCAETYGLSTLQAEI 271
Cdd:pfam07690 160 LSLLAAVLLLLPRP---------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  272 PSYMNgVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVrklfntlsfwIPAAALIGIGFLSEENKNL 351
Cdd:pfam07690 224 PLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALL----------LLILAALGLLLLSLTLSSL 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 599127323  352 AIVLMTVSVGVNSGATIGSSLNSIDLS--PNHAGILIGLSNTVANVIPILTP 401
Cdd:pfam07690 293 WLLLALLLLGFGFGLVFPALNALVSDLapKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 54-436 1.77e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 92.87  E-value: 1.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  54 EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWcitWGGWQVFCAIRILQGLFQGVI 133
Cdd:cd06174   25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF---APSFWLLLLGRFLLGLGSGLI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 134 FPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAKGAM-GWPGISYVSGSLCAAWCFLWLIFASNNATESR 212
Cdd:cd06174  102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 213 FVGEAECKyiesslehnedfhgRTIPIPWRAIWTSVPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSL 292
Cdd:cd06174  182 AKNEEASS--------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 293 PFLAMWLLSYVYLIAADVLLKKKILSLTAVrklfntlsfwIPAAALIGIGFLSEENKNLAIVLMTVSVGVNSGATIGSSL 372
Cdd:cd06174  248 FGLAGALGSLLLGLLSDRLIGRKPLLLIGL----------LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 599127323 373 NSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVADKHNrgqWQIVFGLAAVIFFVGNVVFI 436
Cdd:cd06174  318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG---LTGAFLVLAVLLLLAAILLL 378
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-437 9.93e-18

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 84.93  E-value: 9.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  19 FLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASC 98
Cdd:COG2223    8 LLATLAFFLAFGVWYLWSVLAPPLAE---------EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  99 GTAVLSLMTPWCITWGgwqVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkG 178
Cdd:COG2223   79 LLGIGLLLLALAVSYW---LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI-A 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 179 AMGWPGISYVSGSLCAAWCFLWLIFASNNATESRFVGEAECKyiesslehnedfhgrtipiPWRAIWTSVPFLALLVTRC 258
Cdd:COG2223  155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR-------------------DQLEALRDPRFWLLSLLYF 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 259 AETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILsltavrklfnTLSFWIPAAAL 338
Cdd:COG2223  216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL----------LIVFALMALGL 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 339 IGIGFLSeENKNLAIVLMTVsVGVNSGATIGS--SLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVAdkhNRGQ 416
Cdd:COG2223  286 LLLALAL-GSLWLFLVLFLL-LGLALGGGNGAvfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGS 360

                        410       420
                 ....*....|....*....|.
gi 599127323 417 WQIVFGLAAVIFFVGNVVFII 437
Cdd:COG2223  361 YTAAFLVFAVLALVALVLTLL 381
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-395 1.37e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.09  E-value: 1.37e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  14 RHLQSFLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVL 93
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAA---------DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  94 FVASCGTAVLSLMtpwCITWGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISG 173
Cdd:COG2814   79 LLGLLLFALGSLL---CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 174 MIAkGAMGWPGISYVSGSLCAAwCFLWLIFAsnnatesrfvgeaeckyiessLEHNEDFHGRTIPIPWRAIWTSVPFLAL 253
Cdd:COG2814  156 LLA-DLFGWRWVFLVNAVLALL-ALLLLLRL---------------------LPESRPAARARLRGSLRELLRRPRLLLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 254 LVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILsltavrklfnTLSFWI 333
Cdd:COG2814  213 LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL----------LIGLLL 282

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 599127323 334 PAAALIGIGFLSeENKNLAIVLMTVSVGVNSGATIGSSLNSIDLSPNHAGILIGLSNTVANV 395
Cdd:COG2814  283 LALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 61-430 9.60e-15

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 75.75  E-value: 9.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  61 QKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGGwqvFCAIRILQGLFQGVIFPCVTEH 140
Cdd:cd17327   42 QYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGG---LIALRFFLGLFESGVFPGFILY 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 141 LAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAK-----GAMGWPGISYVSG---SLCAAWCFLWLifaSNNATESR 212
Cdd:cd17327  119 LGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgGLAGWRWLFIIEGlitIIIGLVIFFWL---PDNPSKAW 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 213 FVGEAECKYIESSLEHNEDFHGRTiPIPWRAIWTSV--PFLALlvtrcaetYGLSTLQAEIPSYMNGVLNMEIQSNAVFS 290
Cdd:cd17327  196 FLTEEEKELAVERLRANQTGKGDQ-KFKWKQIKEAFkdPRTWL--------LFLFFFCSQITNNGISNFLPLILKSLGFY 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 291 SLPFLAM----WLLSYVYLIAADVLLKKkilslTAVRKLFNTLSFWIPAAALIGIGFLSEENKNLAIVLMTVSVGVNSGA 366
Cdd:cd17327  267 SLQTNLLsvpiGALGAVSLLIAALLSDR-----FKKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFP 341

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 599127323 367 TIGSSLNSIDLSPNHAGILIGLSNTVANVIPILTPLIAGEIVADKHNRGqWQIVFGLAAVIFFV 430
Cdd:cd17327  342 ILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQIFRAGDAPRYIPG-NIALLVCACVSIVL 404
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 37-438 3.17e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.07  E-value: 3.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  37 VAIVAMTNAATTNPNFP----EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCIT 112
Cdd:cd17325    4 ALFLDMLGYGIIIPILPlyaeSLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 113 wggWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkGAMGWPGISYVSGSL 192
Cdd:cd17325   84 ---YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA-DALGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 193 C--AAWCFLWLIFASNNATESRFVgeaeckyiesslehnedfHGRTIPIPWRAIWTSVPFLALLVTRCAETYGLSTLQAE 270
Cdd:cd17325  160 AllALVLALLLLPEPRPPPNKRAV------------------SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 271 IPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILsltavrklfnTLSFWIPAAALIGIGFLSeenkN 350
Cdd:cd17325  222 LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI----------LIGLLLSAVALLLLPLAT----S 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 351 LAIVLMTVSVGVNSGATIGSSLNSI--DLSPN-HAGILIGLSNTVANVIPILTPLIAGEIVAdkhnRGQWQIVFGLAAVI 427
Cdd:cd17325  288 FWLLLLLLALLGLGLGLVFPATLALlaDIVPPeGRGTAMGLFNTAFSLGMVLGPLLGGFLYD----AFGFATPFLAAAAL 363

                        410
                 ....*....|.
gi 599127323 428 FFVGNVVFIIW 438
Cdd:cd17325  364 LLLAAVLFLLL 374
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 22-206 9.68e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 66.63  E-value: 9.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   22 FLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTA 101
Cdd:TIGR00881   1 FIGYAAYYLVRKNFALAMPYLVE---------EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  102 VLSLMTPWCIT-WggwqVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAKGAM 180
Cdd:TIGR00881  72 IVNLFFGFSTSlW----VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY 147

                         170       180
                  ....*....|....*....|....*.
gi 599127323  181 GWPGISYVSGSLCAAWCFLWLIFASN 206
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVSLICFLLLRD 173
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 14-202 7.50e-08

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 54.20  E-value: 7.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  14 RHLQSFLLFLGLTVMHIARLNVSVAIVAMTNaattnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVL 93
Cdd:cd17312    1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE---------EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFM 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  94 FVASCGTAVLSLMTPWCITWggWQvFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISG 173
Cdd:cd17312   72 SAGLLLSALANIFMGFSTSL--WF-FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAA 148

                        170       180       190
                 ....*....|....*....|....*....|..
gi 599127323 174 MIAkGAMGWPGISYVSGSLC---AAWCFLWLI 202
Cdd:cd17312  149 SLA-SYYGWRAAFLVPGIVGlvvAIILFFFLR 179
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 61-203 1.66e-07

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 53.42  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  61 QKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGGWQVFCAIRILQGLFQGVIFPCVTEH 140
Cdd:cd17357   50 LWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMY 129

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 599127323 141 LAMWSPPEERNRLGAFSYTGTDCGTVLAMFISgmiAKGAMG----WPGISYVSGSLCAAWCFLWLIF 203
Cdd:cd17357  130 LQEISPSELRGALGSLTQIGVTLGILLGQVFG---LPSVLGtetlWPYLLFFPGIPALLQLAALPFF 193
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 18-203 2.23e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.51  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  18 SFLLFLGLTVmhiarlnVSVAIVAMtnAATTNPNFPEFEWtekqksyILSSFYWGYILTLFPGSFLCRRYGAKVVLFVas 97
Cdd:COG0477   23 TFLEGLDFTI-------VNVALPSI--AADLGASSAQLGW-------IVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI-- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  98 cGTAVLSLMTPWCITWGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAk 177
Cdd:COG0477   85 -GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV- 162

                        170       180
                 ....*....|....*....|....*.
gi 599127323 178 GAMGWPGISYVSGSLCAAWCFLWLIF 203
Cdd:COG0477  163 AALGWRWIFLINAPLGLLALVLRLRL 188
Sugar_tr pfam00083
Sugar (and other) transporter;
60-199 3.98e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.11  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   60 KQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGGWQVFCAIRILQGLFQGVIFPCVTE 139
Cdd:pfam00083  46 VLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPM 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 599127323  140 HLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAK--GAMGWP---GISYVSGSL-CAAWCFL 199
Cdd:pfam00083 126 YISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKtsNSDGWRiplGLQLVPALLlIIGLLFL 191
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 74-190 6.02e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 45.34  E-value: 6.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  74 ILTLFPGSF----LCRRYGAKVVLFVASCGTAVLSLMTpwCITWGGWQVFcAIRILQGLFQGVIFPCVTEHLAMWSPPEE 149
Cdd:PRK11551  60 ILGLLPGALlggrLADRIGRKRILIVSVALFGLFSLAT--AQAWDFPSLL-VARLLTGVGLGGALPNLIALTSEAVGPRL 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 599127323 150 RNRLGAFSYTGTDCGTVLAMFIsGMIAKGAMGWPGISYVSG 190
Cdd:PRK11551 137 RGTAVSLMYCGVPFGGALASVI-GVLAAGDAAWRHIFYVGG 176
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
54-431 1.70e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  54 EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWcitWGGWQVFCAIRILQGLFQGVI 133
Cdd:COG0738   37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGLGLL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 134 FPCVTEHLAMWSPPEERNRL----GAFSytgtdCGTVLAMFISGMIAKGAMG--WPGISYVSGSLCAAWcFLWLIFASNN 207
Cdd:COG0738  114 DVAANPYVAALGPETAASRLnllhAFFS-----LGALLGPLLGGLLILLGLSlsWHLPYLILAVLLLLL-ALLFLRSKLP 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 208 ATEsrfvgeaeckyiESSLEHNEDFHGRTIPIPWRAIWTSVpfLALLVTRCAETyGLSTLqaeIPSYMNGVLNMEIQSNA 287
Cdd:COG0738  188 EIE------------EEEEEAAGSAASLKSLLKNPRLLLGG--LAIFLYVGAEG-AIGDW---LPLYLKDVLGLSEATAA 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 288 VFSSLPFLAMwLLSYvylIAADVLLKK----KILSLTAVrklfntlsfwipAAALIGIGFLSEENKNLAIV-LMTVSVGV 362
Cdd:COG0738  250 LGLSLFWGGM-TIGR---FLGGFLLKRfgpvRLLRLSAL------------LAAVGLLLALLAPGPWLALIgLALVGLGL 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 363 NSGATIGSSLnSIDLSPNHAGILIGLSNTVANVIPILTPLIAGeIVADKHN-RGQWQIVFGLAAVIFFVG 431
Cdd:COG0738  314 SLMFPTIFSL-ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIG-FLADAFGlRAAFLVPLVCYLLILLLA 381
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
93-359 1.74e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  93 LFVASCGTAVLSLMTPWCITWGGWQ---VFCAIRILQGLFQGVIFPCVTEHLAMWSP-PEERNRLGAFSYTGTDCGTVLA 168
Cdd:COG2211   84 ILIGAIPLALSFVLLFTAPDLSPTGkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLA 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 169 MFISGMIAKGAMGWPGISY-VSGSLCAAWCFLWLIFASNNATESRFVGEAECKYIESslehnedfhgrtipipWRAIWTS 247
Cdd:COG2211  164 SVLPPPLVAAFGGDAALGYrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES----------------LKALLKN 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 248 VPFLALLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILsltavrklfn 327
Cdd:COG2211  228 RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAF---------- 297

                        250       260       270
                 ....*....|....*....|....*....|..
gi 599127323 328 TLSFWIPAAALIGIGFLSEENKNLAIVLMTVS 359
Cdd:COG2211  298 IIGLLLAALGLLLLFFLGPGNLWLLLVLAALA 329
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 66-203 1.97e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 43.85  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323   66 LSSFYWGYIltlfpgsflCRRYGAKVVLFVASCGTAVLSLMTPWCITwggWQVFCAIRILQGLFQGVIFPCVTEHLAMWS 145
Cdd:TIGR00898 142 LGSFVFGYL---------SDRFGRKKVLLLSTLVTAVSGVLTAFSPN---YTVFLVFRLLVGMGIGGIWVQAVVLNTEFL 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 599127323  146 PPEERNRLGAFSYTGTDCGTVLAMFISGMIakgaMGWPGISYVSGSLCAAWCFLWLIF 203
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLVAYFI----PDWRWLQLAVSLPTFLFFLLSWFV 263
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 57-217 2.62e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 43.06  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  57 WTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGGWqvfCAIRILQGLFQGVIFPC 136
Cdd:cd06180   31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAAL---LALRFLAGAASAFVFVF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 137 VTEHLAMWSPPEERNRLGAFSYtgtdCGTVLAMFISGMIA----KGAMGWPGISYVSG---SLCAAWCFLWLIFASNNAT 209
Cdd:cd06180  108 GSNLVLHHATAAGRGHLIGLLF----AGVGLGIALSGLLVpaglGGGLSWRAGWLALAllsAVLLLLSFLLLRRGPSAPT 183


                 ....*...
gi 599127323 210 ESRFVGEA 217
Cdd:cd06180  184 EASAAESA 191
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 54-182 2.98e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.95  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  54 EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWggwQVFCAIRILQGLFQGVI 133
Cdd:cd17315   28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNV---WVLIVGRFLLGLGVGLA 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 599127323 134 FPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAKGAMGW 182
Cdd:cd17315  105 SVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGW 153
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 54-203 3.09e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.92  E-value: 3.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  54 EFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWGgwqVFCAIRILQGLFQGVI 133
Cdd:cd17324   28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA---LLLLARALAGLAHGGF 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 134 FPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkGAMGWPGISYVSGSLCAAwCFLWLIF 203
Cdd:cd17324  105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLG-QLLGWRAAFLAIAVLALL-AALLLWR 172
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 76-203 1.83e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  76 TLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWcitWGGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNR-LG 154
Cdd:cd17474  251 SLFVGRLLKKRFGARRILVIGLLLYALSLLLLGF---VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTaSS 327

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 599127323 155 AFSYTGTdCGTVLAMFISGMIAkGAMGWPGISYVSGSLCAAWCFLWLIF 203
Cdd:cd17474  328 LYNFVRF-LGQAVGPLLFGLLL-EIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 65-211 2.35e-03

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 40.40  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  65 ILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCIT-WggwqVFCAIRILQGLFQGVIFPCVTEHLAM 143
Cdd:cd17343   43 ITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSvW----VFSILWFLNGLAQGLGWPPCAKILRK 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599127323 144 WSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAKgAMGWPGISYVSGSLCAAWCFLWLIFASNNATES 211
Cdd:cd17343  119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLAL-SYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDV 185
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 74-439 2.49e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  74 ILTLFPGSFLCRRYGAKVVLFVASCGTAVLSlmtpwciTWGGW----QVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEE 149
Cdd:cd17473   49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGG-------VAGLFldslYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 150 RNRLGAFSYTGTDCGTVLAMFISGMIAkgAMGW--PGISYVSGSLCA--AWCFLWlifasnnatESRFVGEAECKYIESS 225
Cdd:cd17473  122 RAKMLGLQSAAMSLGGVVFLLLGGALA--EIGWraPFLVYLLALPVLilVLLFLP---------EPARKSKSAASPGAAT 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 226 LEhnedfhgrtiPIPWRAIWtsVPFLALLVTRCAetygLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYL 305
Cdd:cd17473  191 AA----------ALPWKRVL--PIYFLAFLAMLL----FYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFG 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 306 IAADVLLKKKILsltavrklfnTLSFWIPAAALIGIGFLSEenkNLAIVLMTVSVGVNSGATIGSSLNSI--DLSPNHAG 383
Cdd:cd17473  255 RLKRRLGKRRLL----------AIGFALMALGFLLLALASG---LWVVLLGAILAGLGFGLLLPTLNSWAmsLVPPELRG 321

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 599127323 384 ILIGLSNTVANVIPILTPLIAGEIVADKHNRgqwQIVFGLAAVIFFVGNVVFIIWG 439
Cdd:cd17473  322 RAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL---SGAFLILGVLALVLAIVLLLLR 374
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 70-205 2.86e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  70 YWGYILTLFPGSF---------LCRRYGAKVV----LFVASCGTAVLSLMT-PWCITWGGwqvfcairILQGLFQGVIFP 135
Cdd:cd17489  228 NAGLFFTVYAIALllsrpfsgkLSDRKGPKTViipgLLLLALGLLLLSFAGsPWMLLLAA--------VLYGLGFGLLFP 299

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 136 CVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIAKgAMGWPGIsYVSGSLCAAWCFLWLIFAS 205
Cdd:cd17489  300 ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE-LFGYRAM-FLLAAVVVLLALVLYIFLL 367
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 65-430 2.93e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.91  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  65 ILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWCITWggWQVFCAIrILQGLFQGVIFPCVTEHLAMW 144
Cdd:cd17475   36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY--PVLLVLL-FLVGAGYGSVQPGGGRAIMRW 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 145 SPPEERNRLGAFSYTGTDCGTVLAMFISGMIAkGAMGWPGISYVSGSLC--AAWCFLWLIFASNNATESRFVGEAECKYI 222
Cdd:cd17475  113 FPPRERGLAMGIRQTGVPLGGALAAALLPPLA-LHYGWRAAFVVAGLVSilAAVLFWLFYREPPAASAATESASTLLRSL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 223 ESSLeHNEDFhgrtipipWRAIWTSV-------PFLALLVTRCAETYGLSTLQAeipsymnGVLNMEIQSNAVFSSLpFL 295
Cdd:cd17475  192 KEVL-RNRDV--------WLIAIAGAllvapqfALLTFLLLFLHDHLGLSVVAA-------GALLAVAQLGGALGRI-GL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 296 AMWllsyvyliaADVLLKKKilsltavRKLFNTLSFWIPAAALIGIGFLSEENKNLAIVLMTVSVGVNSGATIGSSLNSI 375
Cdd:cd17475  255 GRV---------SDRVFGGR-------RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLV 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 599127323 376 DLS--PNHAGILIGLSNTVANVIPILTPLIAGEIVADKHN-RGQWQIVFGLAAVIFFV 430
Cdd:cd17475  319 AESagPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSyAPAWLALALLLVLAALL 376
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 33-195 4.37e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 4.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  33 LNVSVAIVAMTNAATtnpnfpEFEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPwcIT 112
Cdd:cd17321   10 LDVTIVNVALPTIAR------DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCA--LA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 113 WGGWQVFCAiRILQGLFQGVIFPCVTEHLAMWSPPEERNR-LGAFSyTGTDCGTVLAMFISGMIAkGAMGWPGISYVSGS 191
Cdd:cd17321   82 PSLAFLIAA-RALQGIGAAAIMPASLALIAATFPGERRGRaLGLWG-AVVGIGAALGPLLGGLLL-ELFGWRWIFLINVP 158


                 ....
gi 599127323 192 LCAA 195
Cdd:cd17321  159 IGLV 162
MFS_1 pfam07690
Major Facilitator Superfamily;
253-460 7.42e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 7.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  253 LLVTRCAETYGLSTLQAEIPSYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVrklfntlsfw 332
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLL---------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  333 ipaAALIGIGFLSEENKNLAIVLMTVSVGVNSGATIGSSLNSI-DLSP-NHAGILIGLSNTVANVIPILTPLIAGEIVAd 410
Cdd:pfam07690  71 ---LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIaDWFPpEERGRALGLVSAGFGLGAALGPLLGGLLAS- 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 599127323  411 khnRGQWQIVFGLAAVIFFVGNVVFIIWGTAKAQPWDADDFLKPKDTESA 460
Cdd:pfam07690 147 ---LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA 193
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 36-438 7.57e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  36 SVAIVAMTNAATTNPNFPE----FEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVV----LFVASCGtAVLSLMT 107
Cdd:cd17474    6 FATLLAVLGVSIVDPILPAiaeaLGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVllpgLLLFGIG-GLLCGLS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 108 PwcitwgGWQVFCAIRILQGLFQGVIFPCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLAMFISGMIakGAMGWPGISY 187
Cdd:cd17474   85 D------SFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRYPFF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 188 VSGSLCAAWCFLWLIFasnnatesrfvgeaeckyIESSLEHNEDFHGRTIPIPwRAIWTSVPFLALLVTRCAETYGLSTL 267
Cdd:cd17474  157 LLAALIPVAFLAILFL------------------LPEPKEKAKSSSATKLRDL-KKALRGRGLLTFLVSAFLYFFLYFAF 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 268 QAeipsYMNGVLNMEIQSNAVFSSLPFLAMWLLSYVYLIAADVLLKKKILSLTAVrklfnTLSFWIPAAALIGIGFLsee 347
Cdd:cd17474  218 LT----YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRIL-----VIGLLLYALSLLLLGFV--- 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323 348 nKNLAIVLMTVSVgvnSGATIGSSLNSID-----LSPNHA-GILIGLSNTVANVIPILTPLIAGEIVAdkhnRGQWQIVF 421
Cdd:cd17474  286 -PSLALLLIAIVL---FGLGLGLNLPLLTtlvteLAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLE----IFGLSAPF 357

                        410
                 ....*....|....*..
gi 599127323 422 GLAAVIFFVGNVVFIIW 438
Cdd:cd17474  358 LVGAAIALAAAVLLALL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
55-168 9.45e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.42  E-value: 9.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599127323  55 FEWTEKQKSYILSSFYWGYILTLFPGSFLCRRYGAKVVLFVASCGTAVLSLMTPWcitWGGWQVFCAIRILQGLFQGVIF 134
Cdd:COG2814  238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLF 314

                         90       100       110
                 ....*....|....*....|....*....|....
gi 599127323 135 PCVTEHLAMWSPPEERNRLGAFSYTGTDCGTVLA 168
Cdd:COG2814  315 PLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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