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Conserved domains on  [gi|48869523|gb|AAT47409|]
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small t antigen [Betapolyomavirus hominis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-151 7.32e-77

Small T antigen; Reviewed


:

Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 226.09  E-value: 7.32e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48869523    7 REESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPDFGTWSSSE----- 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSEeedvp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48869523   82 ---VCADFPLCPDTLYCKDWPICSKKPSVHCPCMLCQLRLRHLNRKFLRKEPLVWIDCYCIDCFTQWFGLDLT 151
Cdd:PHA03102  81 sgyVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRLKQKLRPEPLVWGECYCYKCFRQWFGLDIT 153
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-151 7.32e-77

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 226.09  E-value: 7.32e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48869523    7 REESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPDFGTWSSSE----- 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSEeedvp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48869523   82 ---VCADFPLCPDTLYCKDWPICSKKPSVHCPCMLCQLRLRHLNRKFLRKEPLVWIDCYCIDCFTQWFGLDLT 151
Cdd:PHA03102  81 sgyVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRLKQKLRPEPLVWGECYCYKCFRQWFGLDIT 153
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 83-172 4.77e-44

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 140.99  E-value: 4.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48869523    83 CADFPLCPDTLYCKDWPICSKKPSVHCPCMLCQLRLRHLNR-KFLRKEPLVWIDCYCIDCFTQWFGLDLTEETLQWWVQI 161
Cdd:pfam02380   3 GATFGDKYDALYCKDWPTCLKNVSSNCNCILCLLRKQHKNRkKFLRKPPLVWGECYCYDCYRQWFGLPLTEETLFLWAQI 82

                          90
                  ....*....|.
gi 48869523   162 IGETPFRDLKL 172
Cdd:pfam02380  83 IANTPFRDLKL 93
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 3.07e-11

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 55.70  E-value: 3.07e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48869523     11 MELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD-----EDKMKRMNTLYKKMEQDVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 2.40e-05

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 40.22  E-value: 2.40e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 48869523  12 ELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD----EDKMKRMNTLYK 60
Cdd:cd06257   1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-59 3.79e-05

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 40.47  E-value: 3.79e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 48869523  15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGG-----DEDKMKRMNTLY 59
Cdd:COG2214   9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLNEAY 56
 
Name Accession Description Interval E-value
PHA03102 PHA03102
Small T antigen; Reviewed
 7-151 7.32e-77

Small T antigen; Reviewed


Pssm-ID: 222986 [Multi-domain]  Cd Length: 153  Bit Score: 226.09  E-value: 7.32e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48869523    7 REESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPDFGTWSSSE----- 81
Cdd:PHA03102   1 REESKELMDLLGLPRSAWGNLPLMRKAYLRKCLEFHPDKGGDEEKMKELNTLYKKFRESVKSLRDLDGEEDSSSEeedvp 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48869523   82 ---VCADFPLCPDTLYCKDWPICSKKPSVHCPCMLCQLRLRHLNRKFLRKEPLVWIDCYCIDCFTQWFGLDLT 151
Cdd:PHA03102  81 sgyVGATFGDRVNALYCKDWDTCLKNLSSLCKCIFCLLRKQHRLKQKLRPEPLVWGECYCYKCFRQWFGLDIT 153
Papo_T_antigen pfam02380
T-antigen specific domain; This domain represents a conserved region in papovavirus small and ...
 83-172 4.77e-44

T-antigen specific domain; This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.


Pssm-ID: 367062  Cd Length: 93  Bit Score: 140.99  E-value: 4.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48869523    83 CADFPLCPDTLYCKDWPICSKKPSVHCPCMLCQLRLRHLNR-KFLRKEPLVWIDCYCIDCFTQWFGLDLTEETLQWWVQI 161
Cdd:pfam02380   3 GATFGDKYDALYCKDWPTCLKNVSSNCNCILCLLRKQHKNRkKFLRKPPLVWGECYCYDCYRQWFGLPLTEETLFLWAQI 82

                          90
                  ....*....|.
gi 48869523   162 IGETPFRDLKL 172
Cdd:pfam02380  83 IANTPFRDLKL 93
PHA02624 PHA02624
large T antigen; Provisional
 1-82 3.24e-42

large T antigen; Provisional


Pssm-ID: 222912 [Multi-domain]  Cd Length: 647  Bit Score: 148.59  E-value: 3.24e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48869523    1 MDKVLNREESMELMDLLGLERAAWGNLPLMRKAYLRKCKEFHPDKGGDEDKMKRMNTLYKKMEQDVKVAHQPdFGTWSSS 80
Cdd:PHA02624   1 MDKTLSREESKELMDLLGLPMAAWGNLPLMRKAYLRKCKEYHPDKGGDEEKMKRLNSLYKKLQEGVKSARQS-FGTQDSS 79


                 ..
gi 48869523   81 EV 82
Cdd:PHA02624  80 EI 81
DnaJ smart00271
DnaJ molecular chaperone homology domain;
11-67 3.07e-11

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 55.70  E-value: 3.07e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48869523     11 MELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD-----EDKMKRMNTLYKKMEQDVK 67
Cdd:smart00271   1 TDYYEILGVPRDA--SLDEIKKAYRKLALKYHPDKNPGdkeeaEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 12-60 2.40e-05

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 40.22  E-value: 2.40e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 48869523  12 ELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD----EDKMKRMNTLYK 60
Cdd:cd06257   1 DYYDILGVPPDA--SDEEIKKAYRKLALKYHPDKNPDdpeaEEKFKEINEAYE 51
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
15-59 3.79e-05

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 40.47  E-value: 3.79e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 48869523  15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGG-----DEDKMKRMNTLY 59
Cdd:COG2214   9 AVLGVPPDA--SLEEIRQAYRRLAKLLHPDRGGelkalAEELFQRLNEAY 56
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
11-55 1.37e-04

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 38.62  E-value: 1.37e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 48869523  11 MELMD---LLGLERAAwgNLPLMRKAYLRKCKEFHPDK--GGDEDKMKRM 55
Cdd:COG1076   1 MQLDDafeLLGLPPDA--DDAELKRAYRKLQREHHPDRlaAGLPEEEQRL 48
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 15-59 4.52e-04

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 36.68  E-value: 4.52e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 48869523    15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKG----GDEDKMKRMNTLY 59
Cdd:pfam00226   4 EILGVSPDA--SDEEIKKAYRKLALKYHPDKNpgdpEAEEKFKEINEAY 50
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 15-59 4.89e-04

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 38.53  E-value: 4.89e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 48869523  15 DLLGLERAAwgNLPLMRKAYLRKCKEFHPDKGGD----EDKMKRMNTLY 59
Cdd:COG0484   4 EILGVSRDA--SAEEIKKAYRKLAKKYHPDRNPGdpeaEEKFKEINEAY 50
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 10-75 2.17e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 37.69  E-value: 2.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48869523   10 SMELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDK---GGDEDKMKRMNTLYKKMEQDVKVAHQPDFG 75
Cdd:PRK14300   2 SQDYYQILGVSKTA--SQADLKKAYLKLAKQYHPDTtdaKDAEKKFKEINAAYDVLKDEQKRAAYDRFG 68
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 11-76 3.95e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 36.79  E-value: 3.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48869523   11 MELMDLLGLERAAwgNLPLMRKAYLRKCKEFHPDKG---GDEDKMKRMNTLYKKMEQDVKVAHQPDFGT 76
Cdd:PRK14292   2 MDYYELLGVSRTA--SADEIKSAYRKLALKYHPDRNkekGAAEKFAQINEAYAVLSDAEKRAHYDRFGT 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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