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Conserved domains on  [gi|55832768|gb|AAV66897|]
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truncated HERC6 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-308 3.10e-62

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 200.97  E-value: 3.10e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768  27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETlIVDlVSCGKEHSLAVCHKGRVFAWGAGSEGQ 106
Cdd:COG5184   2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN-VVA-VAAGGDHTCALKADGTVWCWGNNSYGQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 107 LGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVR-SLEGIplAQ 185
Cdd:COG5184  80 LGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDaGLSGV--VA 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 186 VAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265
Cdd:COG5184 154 IAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKSDGTVWCWGSNSS 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 55832768 266 GQLGYSPTPEKRGPQLVERIDGlVSQIDCGRLRGC---SSQTHFCW 308
Cdd:COG5184 229 GQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCalkSDGTVWCW 273
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-308 3.10e-62

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 200.97  E-value: 3.10e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768  27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETlIVDlVSCGKEHSLAVCHKGRVFAWGAGSEGQ 106
Cdd:COG5184   2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN-VVA-VAAGGDHTCALKADGTVWCWGNNSYGQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 107 LGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVR-SLEGIplAQ 185
Cdd:COG5184  80 LGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDaGLSGV--VA 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 186 VAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265
Cdd:COG5184 154 IAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKSDGTVWCWGSNSS 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 55832768 266 GQLGYSPTPEKRGPQLVERIDGlVSQIDCGRLRGC---SSQTHFCW 308
Cdd:COG5184 229 GQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCalkSDGTVWCW 273
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
93-143 7.59e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 67.54  E-value: 7.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55832768    93 KGRVFAWGAGSEGQLGIGEFKEiSFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 27-308 3.10e-62

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 200.97  E-value: 3.10e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768  27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETlIVDlVSCGKEHSLAVCHKGRVFAWGAGSEGQ 106
Cdd:COG5184   2 QVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN-VVA-VAAGGDHTCALKADGTVWCWGNNSYGQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 107 LGIGEfKEISFTPKKIMTLNDIKiiQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGkEFPSQASPQRVR-SLEGIplAQ 185
Cdd:COG5184  80 LGDGT-TTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDG-TTTNRLTPVQVDaGLSGV--VA 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 186 VAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALKnlGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265
Cdd:COG5184 154 IAAGGYHTCALKSDGTVWCWGANSYGQL---GDGTTTDRPTPVQVGGLS--GVVAVAAGGDHSCALKSDGTVWCWGSNSS 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 55832768 266 GQLGYSPTPEKRGPQLVERIDGlVSQIDCGRLRGC---SSQTHFCW 308
Cdd:COG5184 229 GQLGDGTTTDRATPVQVAGLTG-VVAIAAGGSHTCalkSDGTVWCW 273
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-308 8.79e-60

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 194.81  E-value: 8.79e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768   3 FCWGADSR-ELQRRRTAGSPGAELL-------QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALET 74
Cdd:COG5184  20 WCWGDNSYgQLGDGTTTDRSTPVRVpglsnvvAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768  75 liVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEiSFTPKKImTLNDIKIIQVSCGHYHSLALSKDSQVFSWGK 154
Cdd:COG5184 100 --VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTN-RLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGA 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 155 NSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALK 234
Cdd:COG5184 176 NSYGQLGDG-TTTDRPTPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGSNSSGQL---GDGTTTDRATPVQVAGLT 249

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55832768 235 NlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGlVSQIDCGRLRGC---SSQTHFCW 308
Cdd:COG5184 250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG-VVAVAAGSSHTCallTDGTVWCW 323
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 3-280 4.44e-57

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 187.88  E-value: 4.44e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768   3 FCWGADSR-ELQRRRTAGSP-------GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALET 74
Cdd:COG5184  70 WCWGNNSYgQLGDGTTTDRTtpvkvpgLTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLS 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768  75 LIVDlVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISfTPKKIMTLNDIkiIQVSCGHYHSLALSKDSQVFSWGK 154
Cdd:COG5184 150 GVVA-IAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRP-TPVQVGGLSGV--VAVAAGGDHSCALKSDGTVWCWGS 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 155 NSHGQLGLGkEFPSQASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSAGQLalsGRNVPVQSNKPLSVGALK 234
Cdd:COG5184 226 NSSGQLGDG-TTTDRATPVQVAGLTGV--VAIAAGGSHTCALKSDGTVWCWGDNSYGQL---GDGTTTDRSTPVKVPGLS 299

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 55832768 235 NlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQ 280
Cdd:COG5184 300 G--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 131-308 1.42e-35

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 131.64  E-value: 1.42e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 131 IQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSqASPQRVRSLEGIplAQVAAGGAHSFALSLCGTSFGWGSNSA 210
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDR-STPVRVPGLSNV--VAVAAGGDHTCALKADGTVWCWGNNSY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55832768 211 GQLalsGRNVPVQSNKPLSVGALKNlgVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVS 290
Cdd:COG5184  78 GQL---GDGTTTDRTTPVKVPGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVV 152

                       170       180
                ....*....|....*....|.
gi 55832768 291 QIDCGRLRGC---SSQTHFCW 308
Cdd:COG5184 153 AIAAGGYHTCalkSDGTVWCW 173
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
93-143 7.59e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 67.54  E-value: 7.59e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55832768    93 KGRVFAWGAGSEGQLGIGEFKEiSFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
146-196 1.19e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 1.19e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 55832768   146 DSQVFSWGKNSHGQLGLGKEFpSQASPQRVRSLEGIPLAQVAAGGAHSFAL 196
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTE-NVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
130-159 1.16e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 50.12  E-value: 1.16e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 55832768   130 IIQVSCGHYHSLALSKDSQVFSWGKNSHGQ 159
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
238-267 5.49e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.19  E-value: 5.49e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 55832768   238 VVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
203-251 6.48e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.59  E-value: 6.48e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 55832768   203 FGWGSNSAGQLalsGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVL 251
Cdd:pfam00415   5 YTWGRNDYGQL---GLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
41-90 4.36e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 43.27  E-value: 4.36e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 55832768    41 NHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
254-295 1.61e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 41.73  E-value: 1.61e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 55832768   254 DGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCG 295
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNkVVQVACG 43
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
27-54 9.69e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 38.94  E-value: 9.69e-05
                          10        20
                  ....*....|....*....|....*...
gi 55832768    27 QAASGERHSLLLLTNHRVLSCGDNSRGQ 54
Cdd:pfam13540   3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
77-106 3.61e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 37.40  E-value: 3.61e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 55832768    77 VDLVSCGKEHSLAVCHKGRVFAWGAGSEGQ 106
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
184-212 5.24e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 36.63  E-value: 5.24e-04
                          10        20
                  ....*....|....*....|....*....
gi 55832768   184 AQVAAGGAHSFALSLCGTSFGWGSNSAGQ 212
Cdd:pfam13540   2 VSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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