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Conserved domains on  [gi|56759154|gb|AAW27717|]
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SJCHGC05921 protein [Schistosoma japonicum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 14-139 2.12e-47

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


:

Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 149.59  E-value: 2.12e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154  14 IEYSNVFNLIDDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVLHRYGLVPAGE 93
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWG-LLRVAIIHRVGRLPPGE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56759154  94 ISVAIAVSSPHRKDSLEAVKFLIDSIKSCLPIWKKEIYEDGtSTWK 139
Cdd:cd00756  80 AIVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG-EEWV 124
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 14-139 2.12e-47

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 149.59  E-value: 2.12e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154  14 IEYSNVFNLIDDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVLHRYGLVPAGE 93
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWG-LLRVAIIHRVGRLPPGE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56759154  94 ISVAIAVSSPHRKDSLEAVKFLIDSIKSCLPIWKKEIYEDGtSTWK 139
Cdd:cd00756  80 AIVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG-EEWV 124
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 6-144 3.47e-43

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 139.54  E-value: 3.47e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154   6 YIKISIEPIEYSNVFNLI--DDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVL 83
Cdd:COG0314   3 RVRVTEEPFDLAAELAALraSDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWG-LLDVAVI 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56759154  84 HRYGLVPAGEISVAIAVSSPHRKDSLEAVKFLIDSIKSCLPIWKKEIYEDGtSTWKQNNEC 144
Cdd:COG0314  82 HRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARSS 141
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 25-134 5.20e-43

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 138.28  E-value: 5.20e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154   25 DSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWpSLIHVIVLHRYGLVPAGEISVAIAVSSPH 104
Cdd:PLN02390   1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRW-SLHKIAVAHRLGPVPVGETSVFVAVSSVH 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 56759154  105 RKDSLEAVKFLIDSIKSCLPIWKKEIYEDG 134
Cdd:PLN02390  80 RADALDACKFLIDELKASVPIWKKEVYDDG 109
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 9-121 8.53e-37

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 122.56  E-value: 8.53e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154     9 ISIEPIEYSNVFNLIDDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVLHRYGL 88
Cdd:pfam02391   1 ITEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWP-LLDVAIVHRVGR 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 56759154    89 VPAGEISVAIAVSSPHRKDSLEAVKFLIDSIKS 121
Cdd:pfam02391  80 LPVGEAIVLVAVSSPHRAEAFEACEYLIDELKA 112
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 14-139 2.12e-47

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 149.59  E-value: 2.12e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154  14 IEYSNVFNLIDDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVLHRYGLVPAGE 93
Cdd:cd00756   1 FDLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWG-LLRVAIIHRVGRLPPGE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 56759154  94 ISVAIAVSSPHRKDSLEAVKFLIDSIKSCLPIWKKEIYEDGtSTWK 139
Cdd:cd00756  80 AIVLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGG-EEWV 124
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 6-144 3.47e-43

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 139.54  E-value: 3.47e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154   6 YIKISIEPIEYSNVFNLI--DDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVL 83
Cdd:COG0314   3 RVRVTEEPFDLAAELAALraSDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWG-LLDVAVI 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56759154  84 HRYGLVPAGEISVAIAVSSPHRKDSLEAVKFLIDSIKSCLPIWKKEIYEDGtSTWKQNNEC 144
Cdd:COG0314  82 HRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG-EEWVEARSS 141
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 25-134 5.20e-43

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 138.28  E-value: 5.20e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154   25 DSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWpSLIHVIVLHRYGLVPAGEISVAIAVSSPH 104
Cdd:PLN02390   1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRW-SLHKIAVAHRLGPVPVGETSVFVAVSSVH 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 56759154  105 RKDSLEAVKFLIDSIKSCLPIWKKEIYEDG 134
Cdd:PLN02390  80 RADALDACKFLIDELKASVPIWKKEVYDDG 109
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 9-121 8.53e-37

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 122.56  E-value: 8.53e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154     9 ISIEPIEYSNVFNLIDDSSIGAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVLHRYGL 88
Cdd:pfam02391   1 ITEEPLDVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWP-LLDVAIVHRVGR 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 56759154    89 VPAGEISVAIAVSSPHRKDSLEAVKFLIDSIKS 121
Cdd:pfam02391  80 LPVGEAIVLVAVSSPHRAEAFEACEYLIDELKA 112
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
29-134 1.07e-17

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 74.78  E-value: 1.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154   29 GAVATFFGITRKYDKERIVQALNYECYLKMAYLELERIVNNSYKLWPsLIHVIVLHRYG-LVPAGEIsVAIAVSSPHRKD 107
Cdd:PRK10678  29 GAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWP-LGRVTVIHRVGeLWPGDEI-VFVGVTSAHRSS 106

                         90       100
                 ....*....|....*....|....*..
gi 56759154  108 SLEAVKFLIDSIKSCLPIWKKEIYEDG 134
Cdd:PRK10678 107 AFEAGQFIMDYLKTRAPFWKREATPEG 133
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 29-146 4.34e-16

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 72.72  E-value: 4.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56759154   29 GAVATFFGITRKYD--KERIVQALNYECYLKMAYLELERIvNNSYKLWPSLIHVIVLHRYGLVPAGEISVAIAVSSPHRK 106
Cdd:PRK14493 160 GAIATFTGRVRAKEdaDDEPTEYLEFEKYDGVADERMAAI-REELKQRDGVFEVLLHHRTGVIEAGEDIVFVVVLAGHRQ 238

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 56759154  107 DSLEAVKFLIDSIKSCLPIWKKEIYEDGTstwkqnnecFW 146
Cdd:PRK14493 239 EAFRAVSDGIDRLKDEVPIFKKEVTVDEE---------FW 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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