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Conserved domains on  [gi|62702310|gb|AAX93234|]
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unknown, partial [Homo sapiens]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 11240944)

enoyl-CoA hydratase/isomerase family protein plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate; similar to Homo sapiens 3-hydroxyisobutyryl-CoA hydrolase and Cereibacter sphaeroides Enoyl-CoA hydratase

CATH:  3.90.226.10
EC:  3.1.2.-
Gene Ontology:  GO:0016790
PubMed:  18470480|11263873
SCOP:  4004188

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-230 8.06e-134

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


:

Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 379.89  E-value: 8.06e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310     1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:pfam16113 103 GVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLPGELGLYLALTGARLNGADALAAGLATHYVPSARLPALE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    81 EDLLALKSPSKENIASVLENYHTESKidrDKSFILEEHMDKINSCFSANTVEEIIENLQQ--DGSSFALEQLKVINKMSP 158
Cdd:pfam16113 183 EALAALDWSDPADVDAVLAEFAEESD---PPPSPLAAHREAIDRCFSADTVEEIIAALEAeaDGDEWAAETLKTLRKRSP 259

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62702310   159 TSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHF 230
Cdd:pfam16113 260 TSLKVTLRQLRRGRKLSLAECLRMEYRLALRCLRRPDFVEGVRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
 
Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-230 8.06e-134

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 379.89  E-value: 8.06e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310     1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:pfam16113 103 GVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLPGELGLYLALTGARLNGADALAAGLATHYVPSARLPALE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    81 EDLLALKSPSKENIASVLENYHTESKidrDKSFILEEHMDKINSCFSANTVEEIIENLQQ--DGSSFALEQLKVINKMSP 158
Cdd:pfam16113 183 EALAALDWSDPADVDAVLAEFAEESD---PPPSPLAAHREAIDRCFSADTVEEIIAALEAeaDGDEWAAETLKTLRKRSP 259

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62702310   159 TSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHF 230
Cdd:pfam16113 260 TSLKVTLRQLRRGRKLSLAECLRMEYRLALRCLRRPDFVEGVRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 1-232 5.30e-99

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 291.72  E-value: 5.30e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:PRK05617 115 GVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPGALGTYLALTGARISAADALYAGLADHFVPSADLPALL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   81 EDLLALKSPSKE-NIASVLENYHTESKIDRdksfiLEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPT 159
Cdd:PRK05617 195 DALISLRWDSGAdVVDAALAAFATPAPASE-----LAAQRAWIDECFAGDTVEDIIAALEADGGEFAAKTADTLRSRSPT 269

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62702310  160 SLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKS 232
Cdd:PRK05617 270 SLKVTLEQLRRARGLTLEECLRRELRLALAMLRSPDFVEGVRAVLIDKDRNPKWSPATLEDVTPEDVEAFFAP 342
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-76 5.97e-20

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 84.15  E-value: 5.97e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62702310   1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKL 76
Cdd:cd06558 108 GLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGpARARELLLTGRRISAEEALELGLVDEVVPDEEL 184
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-204 1.81e-17

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 78.67  E-value: 1.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLamL 79
Cdd:COG1024 107 GLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGlARAKELLLTGRRIDAEEALELGLVNRVVPDDEL--L 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310  80 EEdllalkspskeniasvlenyhteskidrdksfileehmdkinscfsantveeiienlqqdgssfALEQLKVINKMSPT 159
Cdd:COG1024 185 AA----------------------------------------------------------------ALALAARLAAGPPL 200

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 62702310 160 SLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVL 204
Cdd:COG1024 201 ALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFL 245
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 1-72 8.12e-04

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 40.21  E-value: 8.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62702310     1 GVGLSVHGQFRVATE--KCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYF-LALTGFRLKGRDVYRAGIATHFVD 72
Cdd:TIGR02441 123 GLELALACHYRIATKdrKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALdMMLTGKKIRADRAKKMGIVDQLVD 197
 
Name Accession Description Interval E-value
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-230 8.06e-134

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 379.89  E-value: 8.06e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310     1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:pfam16113 103 GVGLSVHGSFRVVTERTRFAMPETAIGLFPDVGGSYFLSRLPGELGLYLALTGARLNGADALAAGLATHYVPSARLPALE 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    81 EDLLALKSPSKENIASVLENYHTESKidrDKSFILEEHMDKINSCFSANTVEEIIENLQQ--DGSSFALEQLKVINKMSP 158
Cdd:pfam16113 183 EALAALDWSDPADVDAVLAEFAEESD---PPPSPLAAHREAIDRCFSADTVEEIIAALEAeaDGDEWAAETLKTLRKRSP 259

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62702310   159 TSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHF 230
Cdd:pfam16113 260 TSLKVTLRQLRRGRKLSLAECLRMEYRLALRCLRRPDFVEGVRALLIDKDRNPKWSPATLEEVTDEMVDAYF 331
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 1-232 5.30e-99

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 291.72  E-value: 5.30e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:PRK05617 115 GVGISAHGSHRIVTERTKMAMPETGIGFFPDVGGTYFLSRAPGALGTYLALTGARISAADALYAGLADHFVPSADLPALL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   81 EDLLALKSPSKE-NIASVLENYHTESKIDRdksfiLEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPT 159
Cdd:PRK05617 195 DALISLRWDSGAdVVDAALAAFATPAPASE-----LAAQRAWIDECFAGDTVEDIIAALEADGGEFAAKTADTLRSRSPT 269

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62702310  160 SLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKS 232
Cdd:PRK05617 270 SLKVTLEQLRRARGLTLEECLRRELRLALAMLRSPDFVEGVRAVLIDKDRNPKWSPATLEDVTPEDVEAFFAP 342
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 1-231 9.14e-76

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 233.92  E-value: 9.14e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:PLN02874 120 GAGLMVPMKFRVVTEKTVFATPEASVGFHTDCGFSYILSRLPGHLGEYLALTGARLNGKEMVACGLATHFVPSEKLPELE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   81 EDLLALKSPSKENIASVLENYHTESKIDRDKsfILEEhMDKINSCFSANTVEEIIENLQ----QDGSSFALEQLKVINKM 156
Cdd:PLN02874 200 KRLLNLNSGDESAVQEAIEEFSKDVQADEDS--ILNK-QSWINECFSKDTVEEIIKAFEseasKTGNEWIKETLKGLRRS 276

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62702310  157 SPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRG---HDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFK 231
Cdd:PLN02874 277 SPTGLKITLRSIREGRKQSLAECLKKEFRLTMNILRStvsDDVYEGIRALVIDKDNAPKWNPSTLDEVTDEKVDLVFQ 354
PLN02851 PLN02851
3-hydroxyisobutyryl-CoA hydrolase-like protein
 1-237 1.62e-59

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178443 [Multi-domain]  Cd Length: 407  Bit Score: 192.89  E-value: 1.62e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:PLN02851 153 GAGISIPGMFRVVTDKTVFAHPEVQMGFHPDAGASYYLSRLPGYLGEYLALTGQKLNGVEMIACGLATHYCLNARLPLIE 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   81 EDLLALKSPSKENIASVLENYHteSKIDRDKSFILEEhMDKINSCFSANTVEEIIENLQQDGSS----FALEQLKVINKM 156
Cdd:PLN02851 233 ERLGKLLTDDPAVIEDSLAQYG--DLVYPDKSSVLHK-IETIDKCFGHDTVEEIIEALENEAASsydeWCKKALKKIKEA 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310  157 SPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMR---GHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSL 233
Cdd:PLN02851 310 SPLSLKVTLQSIREGRFQTLDQCLAREYRISLCGVSkwvSGDFCEGVRARLVDKDFAPKWDPPSLGEVSKDMVDCYFTPL 389


                 ....
gi 62702310  234 GSSD 237
Cdd:PLN02851 390 DESE 393
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 1-233 3.16e-59

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 191.47  E-value: 3.16e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:PLN02988 120 GAGVSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGFFGEYVGLTGARLDGAEMLACGLATHFVPSTRLTALE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   81 EDLLALKSPSKENIASVLENYHTESKIDRDKSFileEHMDKINSCFSANTVEEIIENLQ----QDGSSFALEQLKVINKM 156
Cdd:PLN02988 200 ADLCRIGSNDPTFASTILDAYTQHPRLKPQSAY---HRLDVIDRCFSRRTVEEIISALEreatQEADGWISATIQALKKA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310  157 SPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGH---DFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSL 233
Cdd:PLN02988 277 SPASLKISLRSIREGRLQGVGQCLIREYRMVCHVMKGEiskDFVEGCRAILVDKDKNPKWEPRRLEDMKDSMVEQYFERV 356
PLN02157 PLN02157
3-hydroxyisobutyryl-CoA hydrolase-like protein
 1-237 1.59e-52

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 177817 [Multi-domain]  Cd Length: 401  Bit Score: 174.87  E-value: 1.59e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLE 80
Cdd:PLN02157 148 GTGVSIPGTFRVATDRTIFATPETIIGFHPDAGASFNLSHLPGRLGEYLGLTGLKLSGAEMLACGLATHYIRSEEIPVME 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   81 EDLLALKSPSKENIASVLENYhteSKIDRDKSFILEEHMDKINSCFSANTVEEIIENLQQDGS----SFALEQLKVINKM 156
Cdd:PLN02157 228 EQLKKLLTDDPSVVESCLEKC---AEVAHPEKTGVIRRIDLLEKCFSHDTVEEIIDSLEIEAGrrkdTWCITTLRRLKES 304

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310  157 SPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRG---HDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSL 233
Cdd:PLN02157 305 SPLSLKVALRSIREGRLQTLDQCLIREYRMSLQGLIGpmsGNFCEGVRARLIDKDEAPKWDPPSLEKVSEDMVDDYFCAL 384


                 ....
gi 62702310  234 GSSD 237
Cdd:PLN02157 385 TPTE 388
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 1-76 5.97e-20

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 84.15  E-value: 5.97e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62702310   1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKL 76
Cdd:cd06558 108 GLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGpARARELLLTGRRISAEEALELGLVDEVVPDEEL 184
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 1-204 1.81e-17

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 78.67  E-value: 1.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLamL 79
Cdd:COG1024 107 GLELALACDLRIAAEDARFGLPEVRLGLIPGGGGTQRLPRLVGlARAKELLLTGRRIDAEEALELGLVNRVVPDDEL--L 184

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310  80 EEdllalkspskeniasvlenyhteskidrdksfileehmdkinscfsantveeiienlqqdgssfALEQLKVINKMSPT 159
Cdd:COG1024 185 AA----------------------------------------------------------------ALALAARLAAGPPL 200

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 62702310 160 SLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVL 204
Cdd:COG1024 201 ALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFL 245
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 1-204 1.90e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 62.19  E-value: 1.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSV--HGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLqgkLGYF----LALTGFRLKGRDVYRAGIATHFVDSE 74
Cdd:PRK06688 109 GVGVSLalACDLVYASESAKFSLPFAKLGLCPDAGGSALLPRL---IGRAraaeMLLLGEPLSAEEALRIGLVNRVVPAA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   75 KLAmleedllalkspskeniasvlenyhteskidrdksfileehmdkinscfsantveeiienlqqdgsSFALEQLKVIN 154
Cdd:PRK06688 186 ELD------------------------------------------------------------------AEADAQAAKLA 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 62702310  155 KMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVL 204
Cdd:PRK06688 200 AGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPDFREGATAFI 249
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 1-99 8.21e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 45.50  E-value: 8.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGK-LGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAML 79
Cdd:PRK07657 112 GLELALACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVgRAKELIYTGRRISAQEAKEIGLVEFVVPAHLLEEK 191

                         90       100
                 ....*....|....*....|....*...
gi 62702310   80 EEDL---LALKSP-----SKENIASVLE 99
Cdd:PRK07657 192 AIEIaekIASNGPiavrqAKEAISNGIQ 219
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
1-89 1.36e-05

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 45.07  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLfpdVGGGYFLPRLQGK-LGYFLALTGFRLKGRDVYRAGIATHFVDSEKL--- 76
Cdd:PRK06495 112 GLGLVASCDIIVASENAVFGLPEIDVGL---AGGGKHAMRLFGHsLTRRMMLTGYRVPAAELYRRGVIEACLPPEELmpe 188

                         90
                 ....*....|...
gi 62702310   77 AMLEEDLLALKSP 89
Cdd:PRK06495 189 AMEIAREIASKSP 201
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
1-95 5.59e-05

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 43.20  E-value: 5.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLaML 79
Cdd:PRK05809 112 GCELSMACDIRIASEKAKFGQPEVGLGITPGFGGTQRLARIVGpGKAKELIYTGDMINAEEALRIGLVNKVVEPEKL-ME 190

                         90
                 ....*....|....*.
gi 62702310   80 EEDLLALKSPSKENIA 95
Cdd:PRK05809 191 EAKALANKIAANAPIA 206
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 1-76 1.44e-04

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 41.96  E-value: 1.44e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62702310     1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGK-LGYFLALTGFRLKGRDVYRAGIATHFVDSEKL 76
Cdd:pfam00378 103 GCELALACDIIIAADNASFGLNETKLGIIPGAGGTDRLPRIIGHsKAMEMLLLGRRISAQEALKWGLVDKVVPEDQL 179
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 1-74 1.83e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 41.58  E-value: 1.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKL-GYFLALTGFRLKGRDVYRAGIATHFVDSE 74
Cdd:PRK08138 113 GCELAMHADIIVAGESASFGQPEIKVGLMPGAGGTQRLVRAVGKFkAMRMALTGCMVPAPEALAIGLVSEVVEDE 187
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 1-66 2.48e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 41.30  E-value: 2.48e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGI 66
Cdd:PRK06072 104 CIGIALSTDFKFASRDVKFVTAFQRLGLASDTGVAYFLLKLTGQRFYEILVLGGEFTAEEAERWGL 169
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 1-72 8.12e-04

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 40.21  E-value: 8.12e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62702310     1 GVGLSVHGQFRVATE--KCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYF-LALTGFRLKGRDVYRAGIATHFVD 72
Cdd:TIGR02441 123 GLELALACHYRIATKdrKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALdMMLTGKKIRADRAKKMGIVDQLVD 197
PLN02600 PLN02600
enoyl-CoA hydratase
 1-71 1.30e-03

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 39.02  E-value: 1.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGK-LGYFLALTGFRLKGRDVYRAGIATHFV 71
Cdd:PLN02600 103 GLELALSCDLRICGEEAVFGLPETGLAIIPGAGGTQRLPRLVGRsRAKELIFTGRRIGAREAASMGLVNYCV 174
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 12-99 1.61e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 38.87  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   12 VATEKCLFAMPETAIGLFPDVGGGYFLPR---LQGKLGYFlaLTGFRLKGRDVYRAGIATHFV-DSEKLAMLE---EDLL 84
Cdd:PRK06494 120 VAAENATFALPEPRVGLAALAGGLHRLPRqigLKRAMGMI--LTGRRVTAREGLELGFVNEVVpAGELLAAAErwaDDIL 197

                         90       100
                 ....*....|....*....|
gi 62702310   85 ALkSP-----SKENIASVLE 99
Cdd:PRK06494 198 AC-SPlsiraSKQAVYRGLE 216
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 11-99 1.64e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 38.85  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310   11 RVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKL-GYFLALTGFRLKGRDVYRAGIATHFVDSEKLamLEEDL-----L 84
Cdd:PRK07658 119 RFATESAKLGLPELNLGLIPGFAGTQRLPRYVGKAkALEMMLTSEPITGAEALKWGLVNGVFPEETL--LDDAKklakkI 196

                         90
                 ....*....|....*
gi 62702310   85 ALKSPskENIASVLE 99
Cdd:PRK07658 197 AGKSP--ATTRAVLE 209
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
12-53 1.89e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 38.59  E-value: 1.89e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 62702310   12 VATEKCLFAMPETAIGLFPDVGGGYFLPRLQG-KLGYFLALTG 53
Cdd:PRK05980 126 IASERALFAKPEIRLGMPPTFGGTQRLPRLAGrKRALELLLTG 168
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 26-77 2.40e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 38.36  E-value: 2.40e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 62702310   26 IGLFPDVGGGYFLPRLQGK---LGyfLALTGFRLKGRDVYRAGIATHFVDSEKLA 77
Cdd:PRK08140 139 IGLVPDSGGTWFLPRLVGMaraLG--LALLGEKLSAEQAEQWGLIWRVVDDAALA 191
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
1-76 5.78e-03

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 36.98  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62702310    1 GVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRlqgKLGYFLA----LTGFRLKGRDVYRAGIATHFVDSEKL 76
Cdd:PRK03580 109 GFELALAADFIVCADNASFALPEAKLGIVPDSGGVLRLPK---RLPPAIAnemvMTGRRMDAEEALRWGIVNRVVPQAEL 185
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
10-43 8.63e-03

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 37.15  E-value: 8.63e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 62702310   10 FRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQG 43
Cdd:PRK11730 126 YRVASPDARIGLPETKLGIMPGFGGTVRLPRLIG 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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