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Conserved domains on  [gi|62822296|gb|AAY14845|]
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unknown [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142358)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-425 1.04e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.04e-05
                          10        20
                  ....*....|....*....|....
gi 62822296   402 NLKRHQRVHTGEKPYKCPLCPYAC 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 2.51e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.51e-05
                          10        20
                  ....*....|....*....|....*.
gi 62822296   192 NLTRHTRTHTGEKPYRCPHCPFACSS 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-487 3.02e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.02e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62822296 414 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQS--MNLKRHMLRHTGEKPFRCATCAYTTGHWDNY 487
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 1.70e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 62822296   374 HLARHMKTHSGEKPFRCARCPYASAH 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 2.62e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 62822296   164 HLKRHMQTHSGEKPFRCGRCPYASAQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-425 1.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.04e-05
                          10        20
                  ....*....|....*....|....
gi 62822296   402 NLKRHQRVHTGEKPYKCPLCPYAC 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 2.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.51e-05
                          10        20
                  ....*....|....*....|....*.
gi 62822296   192 NLTRHTRTHTGEKPYRCPHCPFACSS 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-487 3.02e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.02e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62822296 414 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQS--MNLKRHMLRHTGEKPFRCATCAYTTGHWDNY 487
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-450 1.27e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822296 372 PNHLARHMKTHSG-EKPFRCARCPYASAHLDNLKRHQR--VHTGE--KPYKCP--LCPYACGNLANLKRHGRIHSGDKPF 444
Cdd:COG5048 273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352


                ....*.
gi 62822296 445 RCSLCN 450
Cdd:COG5048 353 KEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-481 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....
gi 62822296   458 NLKRHMLRHTGEKPFRCATCAYTT 481
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 1.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 62822296   374 HLARHMKTHSGEKPFRCARCPYASAH 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 2.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 62822296   164 HLKRHMQTHSGEKPFRCGRCPYASAQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-425 1.04e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.36  E-value: 1.04e-05
                          10        20
                  ....*....|....*....|....
gi 62822296   402 NLKRHQRVHTGEKPYKCPLCPYAC 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
192-217 2.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.51e-05
                          10        20
                  ....*....|....*....|....*.
gi 62822296   192 NLTRHTRTHTGEKPYRCPHCPFACSS 217
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
414-487 3.02e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.02e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62822296 414 KPYKCPLCPYACGNLANLKRHGRIHSGDKPFRCSLCNYSCNQS--MNLKRHMLRHTGEKPFRCATCAYTTGHWDNY 487
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-450 1.27e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822296 372 PNHLARHMKTHSG-EKPFRCARCPYASAHLDNLKRHQR--VHTGE--KPYKCP--LCPYACGNLANLKRHGRIHSGDKPF 444
Cdd:COG5048 273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPA 352


                ....*.
gi 62822296 445 RCSLCN 450
Cdd:COG5048 353 KEKLLN 358
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-481 1.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.33e-04
                          10        20
                  ....*....|....*....|....
gi 62822296   458 NLKRHMLRHTGEKPFRCATCAYTT 481
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-399 1.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 62822296   374 HLARHMKTHSGEKPFRCARCPYASAH 399
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
164-189 2.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.62e-04
                          10        20
                  ....*....|....*....|....*.
gi 62822296   164 HLKRHMQTHSGEKPFRCGRCPYASAQ 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-228 4.62e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 4.62e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62822296 176 KPFRCGRCPYASAQLVNLTRHTRTHTGEKPYRCPHCPFAC--SSLGNLRRHQRTH 228
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKsfSRPLELSRHLRTH 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-477 7.98e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 7.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822296 356 SDKGFAC--SLCPFATHYPNHLARHMKTHSGEKPFRC--ARCPYASAHLDNLKRHQRV--HTGEKPYKCPLCPYACGNLA 429
Cdd:COG5048 318 SLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRN 397

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62822296 430 NLKRHGRI-----HSGDKP--FRCSLCNYSCNQSMNLKRHMLRHTGEKPFRCATC 477
Cdd:COG5048 398 FKRDSNLSlhiitHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
356-458 9.58e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62822296 356 SDKGFACSLCPFATHYPNHLARHMKTHSGEKPFRCARCPYASAH--LDNLKRHQRVHTGEKPYKCPlcpyACGNLANLKr 433
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNS----KSLPLSNSK- 104

                        90       100
                ....*....|....*....|....*
gi 62822296 434 hgriHSGDKPFRCSLCNYSCNQSMN 458
Cdd:COG5048 105 ----ASSSSLSSSSSNSNDNNLLSS 125
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
444-468 1.65e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 35.99  E-value: 1.65e-03
                          10        20
                  ....*....|....*....|....*
gi 62822296   444 FRCSLCNYSCNQSMNLKRHMLRHTG 468
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
430-455 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 62822296   430 NLKRHGRIHSGDKPFRCSLCNYSCNQ 455
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 206-228 3.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|...
gi 62822296   206 YRCPHCPFACSSLGNLRRHQRTH 228
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
388-412 8.66e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 34.06  E-value: 8.66e-03
                          10        20
                  ....*....|....*....|....*
gi 62822296   388 FRCARCPYASAHLDNLKRHQRVHTG 412
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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