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Conserved domains on  [gi|62823685|gb|AAY15457|]
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CD7 antigen [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10542315)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets, similar to Homo sapiens T-cell antigen CD7 and voltage-gated sodium channel beta3 subunit Ig Domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 31-128 2.13e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 2.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685    31 QSPHCTTVPVGASVNITCSTS------GGLRGIYLRQLGPQPQDIIYY--EDGVVPTTDRRFRGRIDFsgSQDNLTITMH 102
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmseaSTSVYWYRQPPGKGPTFLIAYysNGSEEGVKKGRFSGRGDP--SNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 62823685   103 RLQLSD----TCQAIT-EVNVYGSGTLVLVT 128
Cdd:pfam07686  79 NLTLSDsgtyTCAVIPsGEGVFGKGTRLTVL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 31-128 2.13e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 2.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685    31 QSPHCTTVPVGASVNITCSTS------GGLRGIYLRQLGPQPQDIIYY--EDGVVPTTDRRFRGRIDFsgSQDNLTITMH 102
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmseaSTSVYWYRQPPGKGPTFLIAYysNGSEEGVKKGRFSGRGDP--SNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 62823685   103 RLQLSD----TCQAIT-EVNVYGSGTLVLVT 128
Cdd:pfam07686  79 NLTLSDsgtyTCAVIPsGEGVFGKGTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 29-127 3.76e-08

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 50.03  E-value: 3.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685  29 VQQSPHCTTVPVGASVNITCSTSGGLRGIYL---RQ-LGPQPQDIIYYeDGVVPTTDRRFRGRIDFSGSQDNL-TITMHR 103
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIywyRQkPGQGPEFLIYL-SSSKGKTKGGVPGRFSGSRDGTSSfSLTISN 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 62823685 104 LQLSDT----CQAITEVNVY----GSGTLVLV 127
Cdd:cd00099  80 LQPEDSgtyyCAVSESGGTDkltfGSGTRLTV 111
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 36-127 8.41e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 8.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685     36 TTVPVGASVNITCSTSGGlrgiylrqlgPQPQDIIYYEDGVVPTTDRRFRGridfSGSQDNLTITMHRLQLSD----TCQ 111
Cdd:smart00410   4 VTVKEGESVTLSCEASGS----------PPPEVTWYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDsgtyTCA 69

                           90
                   ....*....|....*.
gi 62823685    112 AITEVNVYGSGTLVLV 127
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 31-128 2.13e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.31  E-value: 2.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685    31 QSPHCTTVPVGASVNITCSTS------GGLRGIYLRQLGPQPQDIIYY--EDGVVPTTDRRFRGRIDFsgSQDNLTITMH 102
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmseaSTSVYWYRQPPGKGPTFLIAYysNGSEEGVKKGRFSGRGDP--SNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 62823685   103 RLQLSD----TCQAIT-EVNVYGSGTLVLVT 128
Cdd:pfam07686  79 NLTLSDsgtyTCAVIPsGEGVFGKGTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 29-127 3.76e-08

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 50.03  E-value: 3.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685  29 VQQSPHCTTVPVGASVNITCSTSGGLRGIYL---RQ-LGPQPQDIIYYeDGVVPTTDRRFRGRIDFSGSQDNL-TITMHR 103
Cdd:cd00099   1 VTQSPRSLSVQEGESVTLSCEVSSSFSSTYIywyRQkPGQGPEFLIYL-SSSKGKTKGGVPGRFSGSRDGTSSfSLTISN 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 62823685 104 LQLSDT----CQAITEVNVY----GSGTLVLV 127
Cdd:cd00099  80 LQPEDSgtyyCAVSESGGTDkltfGSGTRLTV 111
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 29-128 4.33e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 44.18  E-value: 4.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685  29 VQQSPHCTTVPVGASVNITC--STSGglrGIYL---RQL-GPQPQDIIYYEDGVVPTTDRRFRGRIDFSGSQDNLTITmh 102
Cdd:cd04983   1 VTQSPQSLSVQEGENVTLNCnySTST---FYYLfwyRQYpGQGPQFLIYISSDSGNKKKGRFSATLDKSRKSSSLHIS-- 75

                        90       100       110
                ....*....|....*....|....*....|....
gi 62823685 103 RLQLSDT----C----QAITEVNVYGSGTLVLVT 128
Cdd:cd04983  76 AAQLSDSavyfCalseSGGTGKLTFGKGTRLTVE 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 36-127 8.41e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.88  E-value: 8.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685     36 TTVPVGASVNITCSTSGGlrgiylrqlgPQPQDIIYYEDGVVPTTDRRFRGridfSGSQDNLTITMHRLQLSD----TCQ 111
Cdd:smart00410   4 VTVKEGESVTLSCEASGS----------PPPEVTWYKQGGKLLAESGRFSV----SRSGSTSTLTISNVTPEDsgtyTCA 69

                           90
                   ....*....|....*.
gi 62823685    112 AITEVNVYGSGTLVLV 127
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 28-127 3.36e-05

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 41.61  E-value: 3.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62823685  28 EVQQSPHCTTVPVGASVNITCSTSGGLRGIYL----RQLGPQPQDIIYYEDGVVPTTDRRFRGridfSGSQDNLTITMHR 103
Cdd:cd04980   2 VMTQSPASLSVSPGERVTISCKASQSISSNYLawyqQKPGQAPKLLIYYASTLHSGVPSRFSG----SGSGTDFTLTISS 77

                        90       100
                ....*....|....*....|....*....
gi 62823685 104 LQLSDT----CQAI-TEVNVYGSGTLVLV 127
Cdd:cd04980  78 VEPEDAavyyCQQGyTFPYTFGGGTKLEI 106
IGv smart00406
Immunoglobulin V-Type;
43-109 1.15e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 39.67  E-value: 1.15e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62823685     43 SVNITCSTSGGLRGIY----LRQ-LGPQPQDIIYYEDGVVPTTDRRFRGRIDFSG--SQDNLTITMHRLQLSDT 109
Cdd:smart00406   1 SVTLSCKFSGSTFSSYyvswVRQpPGKGLEWLGYIGSNGSSYYQESYKGRFTISKdtSKNDVSLTISNLRVEDT 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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