|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
483-793 |
3.24e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 97.70 E-value: 3.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 483 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 562
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 563 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 637
Cdd:COG4886 83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 638 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 717
Cdd:COG4886 148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74054090 718 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 793
Cdd:COG4886 217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
898-1040 |
2.23e-16 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 76.98 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 898 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 977
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74054090 978 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1040
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
591-792 |
3.91e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.81 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 591 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 660
Cdd:cd21340 4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 661 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 740
Cdd:cd21340 72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 74054090 741 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 792
Cdd:cd21340 131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
81-460 |
1.19e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 81 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 158
Cdd:COG4886 72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 159 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 236
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 237 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 315
Cdd:COG4886 204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 316 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 395
Cdd:COG4886 261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74054090 396 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 460
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
301-790 |
4.32e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.18 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 301 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 377
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 378 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 433
Cdd:PLN00113 188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 434 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 513
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 514 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 590
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 591 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 653
Cdd:PLN00113 374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 654 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 728
Cdd:PLN00113 449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74054090 729 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 790
Cdd:PLN00113 519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
898-1042 |
4.89e-11 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 62.38 E-value: 4.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 898 YDAYISYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 973
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 974 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1032
Cdd:pfam01582 76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150
|
170
....*....|
gi 74054090 1033 WQTLRNVVLT 1042
Cdd:pfam01582 151 WKKIAYDISN 160
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
658-718 |
2.26e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.45 E-value: 2.26e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74054090 658 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 718
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
83-615 |
8.68e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 8.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 161
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 162 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 240
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 241 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 306
Cdd:PLN00113 211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 307 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 386
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 387 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 447
Cdd:PLN00113 363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 448 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 527
Cdd:PLN00113 440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 528 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 604
Cdd:PLN00113 504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570
|
570
....*....|....
gi 74054090 605 KVL---NLSHNNIY 615
Cdd:PLN00113 571 ESLvqvNISHNHLH 584
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
305-367 |
1.55e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.55e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74054090 305 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 367
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
130-339 |
1.66e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.25 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 130 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 205
Cdd:cd21340 10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 206 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 272
Cdd:cd21340 80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 273 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 339
Cdd:cd21340 129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
760-847 |
1.32e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 52.78 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 760 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 839
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....*...
gi 74054090 840 CVSDVTAV 847
Cdd:TIGR00864 78 SGCDEEYV 85
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
790-835 |
5.88e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 5.88e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 74054090 790 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 835
Cdd:smart00082 1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
483-793 |
3.24e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 97.70 E-value: 3.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 483 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 562
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 563 DN----ASALTELSDLEVLDLSYNshyfriagvthhlEFIQNFTNLKVLNLSHNNIYTLTDK-YNLesKSLVELVFSGNR 637
Cdd:COG4886 83 SLlllgLTDLGDLTNLTELDLSGN-------------EELSNLTNLESLDLSGNQLTDLPEElANL--TNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 638 LDILWNDddnryisiFKGLKNLTRLDLSLNRLKHIPNEaFLNLPaSLTELHINDNMLKFFNWTlLQQFPRLELLDLRGNK 717
Cdd:COG4886 148 LTDLPEP--------LGNLTNLKSLDLSNNQLTDLPEE-LGNLT-NLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74054090 718 LLFLTDSLSDFTsSLRTLLLSHNRISHLPSgfLSEVSSLKHLDLSSNLLKTINKSAletkTTTKLSMLELHGNPFE 793
Cdd:COG4886 217 LTDLPEPLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLT 285
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
898-1040 |
2.23e-16 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 76.98 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 898 YDAYISYdtkdaSVTDWVINELRYHLEESRDKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTA 977
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74054090 978 FYLALQRLMDENMDVIIFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEglFWQTLRNVV 1040
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWKKALYAV 137
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
502-790 |
1.03e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 74.58 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 502 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 581
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSN 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 582 NshyfRIAGVTHHLEfiqNFTNLKVLNLSHNNIYTLTDKYNlESKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 661
Cdd:COG4886 192 N----QITDLPEPLG---NLTNLEELDLSGNQLTDLPEPLA-NLTNLETLDLSNNQL---------TDLPELGNLTNLEE 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 662 LDLSLNRLKHIPNEAFLnlpASLTELHINDNMLKFFNWTLLQ--QFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH 739
Cdd:COG4886 255 LDLSNNQLTDLPPLANL---TNLKTLDLSNNQLTDLKLKELEllLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 74054090 740 NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 790
Cdd:COG4886 332 GLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
591-792 |
3.91e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 69.81 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 591 VTH------HLEFIQNF---TNLKVLNLSHNNIYTLTdkyNLES-KSLVELVFSGNRLDILWNdddnryisiFKGLKNLT 660
Cdd:cd21340 4 ITHlylndkNITKIDNLslcKNLKVLYLYDNKITKIE---NLEFlTNLTHLYLQNNQIEKIEN---------LENLVNLK 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 661 RLDLSLNRLKHIPNeafLNLPASLTELHINDnmlkffnwtllQQFPRlelldlrGNKLLFLTDSLSDFTSSLRTLLLSHN 740
Cdd:cd21340 72 KLYLGGNRISVVEG---LENLTNLEELHIEN-----------QRLPP-------GEKLTFDPRSLAALSNSLRVLNISGN 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 74054090 741 RISHLpsGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPF 792
Cdd:cd21340 131 NIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
81-460 |
1.19e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 68.04 E-value: 1.19e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 81 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITD--GAFLNLKNLRELLLEDNQLPQI 158
Cdd:COG4886 72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDL 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 159 PSGLPE--SLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgVFETLTNlellslsfnslshvpp 236
Cdd:COG4886 152 PEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN----------QITD-LPEPLGN---------------- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 237 klPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF-AFQNLTQLRYLNLSST 315
Cdd:COG4886 204 --LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN--------------------QLTDLpELGNLTNLEELDLSNN 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 316 SLRKINAAwfKNMPHLKVLDLEFNYlvgeiasgafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY 395
Cdd:COG4886 261 QLTDLPPL--ANLTNLKTLDLSNNQ----------LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74054090 396 VFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYA 460
Cdd:COG4886 329 LLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLL 393
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
502-787 |
1.57e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.65 E-value: 1.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 502 KALDLSLNSIFFIgPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYLDLTNNRLDfDNASALTELSDLEVLDLSY 581
Cdd:COG4886 139 KELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSG 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 582 NshyfriaGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLdilwndddnRYISIFKGLKNLTR 661
Cdd:COG4886 215 N-------QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNL--TNLEELDLSNNQL---------TDLPPLANLTNLKT 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 662 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNR 741
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 74054090 742 ISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLEL 787
Cdd:COG4886 357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
122-451 |
1.75e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 67.65 E-value: 1.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 122 NGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 201
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 202 NKVCEKTNIEDgvFETLTNLELLSLSFNSlshvPPKLPSSLRKLFLSNTQIKYISEEdFKGLINLTLLDLSGNcprcfna 281
Cdd:COG4886 81 LLSLLLLGLTD--LGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNN------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 282 pfpcvpcdggaSINIDRFAFQNLTQLRYLNLSSTSLRKINaAWFKNMPHLKVLDLEFNYLvGEIasGAFLTMLPRLEILD 361
Cdd:COG4886 147 -----------QLTDLPEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELD 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 362 LSFNYIKgsypqhiNISRNFSKLLSLRALHLRGYVFQELREddfqpLMQLPNLSTINLGINFIKQIDFklFQNFSNLEII 441
Cdd:COG4886 212 LSGNQLT-------DLPEPLANLTNLETLDLSNNQLTDLPE-----LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTL 277
|
330
....*....|
gi 74054090 442 YLSENRISPL 451
Cdd:COG4886 278 DLSNNQLTDL 287
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
103-559 |
3.24e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 66.50 E-value: 3.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 103 GLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQlpqiPSGLPESLTELSLIQNNIYNITKE 182
Cdd:COG4886 56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELSNLTNLESLDLSGNQLTDLPEE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 183 gISRLINLKNLYLAWNcyfnkvcektNIEDgvfetltnlellslsfnslshVPPKLPS--SLRKLFLSNTQIKYISEEdF 260
Cdd:COG4886 132 -LANLTNLKELDLSNN----------QLTD---------------------LPEPLGNltNLKSLDLSNNQLTDLPEE-L 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 261 KGLINLTLLDLSGNcprcfnapfpcvpcdggasiNIDRF--AFQNLTQLRYLNLSSTSLRKINAAwFKNMPHLKVLDLEF 338
Cdd:COG4886 179 GNLTNLKELDLSNN--------------------QITDLpePLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 339 NylvgEIASGAFLTMLPRLEILDLSFNYIKgsypqhinisrnfskllslralhlrgyvfqelredDFQPLMQLPNLSTIN 418
Cdd:COG4886 238 N----QLTDLPELGNLTNLEELDLSNNQLT-----------------------------------DLPPLANLTNLKTLD 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 419 LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYhftrpLIKPQCA 498
Cdd:COG4886 279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL-----LALLTLL 353
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74054090 499 AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNR 559
Cdd:COG4886 354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
301-790 |
4.32e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 67.18 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 301 FQNLTQLRYLNLSSTSLRKINAAWFknMPHLKVLDLEFNYLVGEIAS--GAFltmlPRLEILDLSFNYIKGSYPQHI-NI 377
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLSGEIPNdiGSF----SSLKVLDLGGNVLVGKIPNSLtNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 378 SRnfSKLLSLRALHLRGYVFQELReddfqplmQLPNLSTINLGINFIK-QIDFKL-----------------------FQ 433
Cdd:PLN00113 188 TS--LEFLTLASNQLVGQIPRELG--------QMKSLKWIYLGYNNLSgEIPYEIggltslnhldlvynnltgpipssLG 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 434 NFSNLEIIYLSENRISPLVkdtrqsyansssfqrhirkrrstdfefdPHSNFYhfTRPLIkpqcaaygkALDLSLNSIFF 513
Cdd:PLN00113 258 NLKNLQYLFLYQNKLSGPI----------------------------PPSIFS--LQKLI---------SLDLSDNSLSG 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 514 IGPNQFENLPDIACLNLSANSnaqvLSGT---EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAg 590
Cdd:PLN00113 299 EIPELVIQLQNLEILHLFSNN----FTGKipvALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 591 vthhlEFIQNFTNLKVLNLSHNNI-----YTLTDKYNLESKSLVELVFSG------------NRLDILWNDDDNRYISIF 653
Cdd:PLN00113 374 -----EGLCSSGNLFKLILFSNSLegeipKSLGACRSLRRVRLQDNSFSGelpseftklplvYFLDISNNNLQGRINSRK 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 654 KGLKNLTRLDLSLNRLkhipneaFLNLPAS-----LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKllfLTDSLSDF 728
Cdd:PLN00113 449 WDMPSLQMLSLARNKF-------FGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENK---LSGEIPDE 518
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74054090 729 TSSLRTLL---LSHNRIS-HLPSGFlSEVSSLKHLDLSSNLLK---TINKSALETKTTTKLSMLELHGN 790
Cdd:PLN00113 519 LSSCKKLVsldLSHNQLSgQIPASF-SEMPVLSQLDLSQNQLSgeiPKNLGNVESLVQVNISHNHLHGS 586
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
898-1042 |
4.89e-11 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 62.38 E-value: 4.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 898 YDAYISYDTKDasVTDWVINELRYHLeesRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKS-WN--- 973
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKEL---KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 974 FKTAFYLALQRLMdenmdVIIFILLEPVLQHSQYL---------RLRQRICKSSILQWP------------DNPKAEGLF 1032
Cdd:pfam01582 76 LVKILECALDLGQ-----KVIPIFYEVDPSDVRKQtgsfgkafkKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKF 150
|
170
....*....|
gi 74054090 1033 WQTLRNVVLT 1042
Cdd:pfam01582 151 WKKIAYDISN 160
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
68-274 |
6.32e-11 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 65.73 E-value: 6.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 68 SNRRLQEVPQTVG--KYVTELDLSDNFITHItNESFQGLQNLTKINLNHNpnvqhqngnpgiqsnglNITD--GAFLNLK 143
Cdd:COG4886 121 SGNQLTDLPEELAnlTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN-----------------QLTDlpEELGNLT 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 144 NLRELLLEDNQLPQIPSGL--PESLTELSLIQNNIYNITKEgISRLINLKNLYLAWNcyfnkvcektNIEDgvFETLTNL 221
Cdd:COG4886 183 NLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNN----------QLTD--LPELGNL 249
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 74054090 222 ellslsfnslshvppklpSSLRKLFLSNTQIKYISEEdfKGLINLTLLDLSGN 274
Cdd:COG4886 250 ------------------TNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNN 282
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
327-792 |
4.55e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 64.10 E-value: 4.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 327 NMPHLKVLDLEFNYLVGEIASGAFltMLPRLEILDLSFNYIKGSYPQHInisrnFSKLLSLRALHLRGYVFQelredDFQ 406
Cdd:PLN00113 67 NSSRVVSIDLSGKNISGKISSAIF--RLPYIQTINLSNNQLSGPIPDDI-----FTTSSSLRYLNLSNNNFT-----GSI 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 407 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENrisPLVKDTRQSYANSSSFQ--------------RHIRKR 472
Cdd:PLN00113 135 PRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGN---VLVGKIPNSLTNLTSLEfltlasnqlvgqipRELGQM 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 473 RSTDFEFDPHSNFYHFTrPLIKPQCAAYGKaLDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSaIPHVKY 552
Cdd:PLN00113 212 KSLKWIYLGYNNLSGEI-PYEIGGLTSLNH-LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS-LQKLIS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 553 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQ-------NFT-----------NLKVLNLSHNNI 614
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQvlqlwsnKFSgeipknlgkhnNLTVLDLSTNNL 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 615 YTLTDKYNLESKSLVELVFSGNRLDilwndddnryISIFKGL---KNLTRLDLSLNRLKHIPNEAFLNLPAsLTELHIND 691
Cdd:PLN00113 369 TGEIPEGLCSSGNLFKLILFSNSLE----------GEIPKSLgacRSLRRVRLQDNSFSGELPSEFTKLPL-VYFLDISN 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 692 NMLKFFNWTLLQQFPRLELLDLRGNKLLfltDSLSDFTSS--LRTLLLSHNRISH-LPSGFLSeVSSLKHLDLSSNLLKT 768
Cdd:PLN00113 438 NNLQGRINSRKWDMPSLQMLSLARNKFF---GGLPDSFGSkrLENLDLSRNQFSGaVPRKLGS-LSELMQLKLSENKLSG 513
|
490 500
....*....|....*....|....
gi 74054090 769 INKSalETKTTTKLSMLELHGNPF 792
Cdd:PLN00113 514 EIPD--ELSSCKKLVSLDLSHNQL 535
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
901-1012 |
1.38e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 56.94 E-value: 1.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 901 YISYDTKDASVTDWVINELryhleESRDKNVLLclEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYL 980
Cdd:pfam13676 2 FISYAGEDRAWAEWLADAL-----EAAGYRVWL--DRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
|
90 100 110
....*....|....*....|....*....|....*..
gi 74054090 981 ALQRLMDENmdVIIFILLE-----PVLQHSQYLRLRQ 1012
Cdd:pfam13676 75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
658-718 |
2.26e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.45 E-value: 2.26e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74054090 658 NLTRLDLSLNRLKHIPNEAFLNLPaSLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 718
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
83-615 |
8.68e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 8.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiQSNGlNITDGAFLNLKNLRELLLEDNQLP-QIPSG 161
Cdd:PLN00113 71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNN------------QLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 162 LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKV-CEKTNIEDGVFETLTNLELLSlsfnslsHVPPKLPS 240
Cdd:PLN00113 138 SIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIpNSLTNLTSLEFLTLASNQLVG-------QIPRELGQ 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 241 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNcprcfNAPFPCVPCDGGASINIDRFAFQN------------LTQ 306
Cdd:PLN00113 211 mkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYN-----NLTGPIPSSLGNLKNLQYLFLYQNklsgpippsifsLQK 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 307 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINISRNFSkLLS 386
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLT-VLD 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 387 LRALHLRGYV---------------FQELREDDFQP-LMQLPNLSTINLGINfikQIDFKLFQNFSNLEIIY---LSENR 447
Cdd:PLN00113 363 LSTNNLTGEIpeglcssgnlfklilFSNSLEGEIPKsLGACRSLRRVRLQDN---SFSGELPSEFTKLPLVYfldISNNN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 448 ISPLVKDTRQsyaNSSSFQRHIRKRRStdfefdphsnfyhFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIAC 527
Cdd:PLN00113 440 LQGRINSRKW---DMPSLQMLSLARNK-------------FFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQ 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 528 LNLSANSnaqvLSG---TEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNshyfRIAGvthhlEFIQNFTNL 604
Cdd:PLN00113 504 LKLSENK----LSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QLSG-----EIPKNLGNV 570
|
570
....*....|....
gi 74054090 605 KVL---NLSHNNIY 615
Cdd:PLN00113 571 ESLvqvNISHNHLH 584
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
234-740 |
2.19e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.64 E-value: 2.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 234 VPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS 313
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 314 STSLRKINAAWFKNMPHLKVLDLEFNylvgeiasgAFLTMLPRLEILDLSFNYIKgsypqhiNISRNFSKLLSLRALHLR 393
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLT-------DLPEELANLTNLKELDLS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 394 GYVFQELREddfqPLMQLPNLSTINLGINFIKQIDfKLFQNFSNLEIIYLSENRISPLvkdtrqsyansssfqrhirkrr 473
Cdd:COG4886 145 NNQLTDLPE----PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL---------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 474 stdfefdphsnfyhftrplikpqcaaygkaldlslnsiffigPNQFENLPDIACLNLSANSNAQVlsGTEFSAIPHVKYL 553
Cdd:COG4886 198 ------------------------------------------PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETL 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 554 DLTNNRLDfdNASALTELSDLEVLDLSYNshyfRIAgvthHLEFIQNFTNLKVLNLSHNNIYTLtdkyNLESKSLVELVF 633
Cdd:COG4886 234 DLSNNQLT--DLPELGNLTNLEELDLSNN----QLT----DLPPLANLTNLKTLDLSNNQLTDL----KLKELELLLGLN 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 634 SGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDL 713
Cdd:COG4886 300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATL 379
|
490 500
....*....|....*....|....*..
gi 74054090 714 RGNKLLFLTDSLSDFTSSLRTLLLSHN 740
Cdd:COG4886 380 LTLALLLLTLLLLLLTTTAGVLLLTLA 406
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
504-719 |
2.87e-08 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 56.59 E-value: 2.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 504 LDLSLNSIFFIGPNQFENLPDIACL-NLSANSNAQVLSGTEFSA------IPHVKYLDLTNNRLD----FDNASALTELS 572
Cdd:cd00116 86 LDLSDNALGPDGCGVLESLLRSSSLqELKLNNNGLGDRGLRLLAkglkdlPPALEKLVLGRNRLEgascEALAKALRANR 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 573 DLEVLDLSYNShyFRIAGVTHHLEFIQNFTNLKVLNLSHNniyTLTDKynlESKSLVElvfsgnrldilwndddnryisI 652
Cdd:cd00116 166 DLKELNLANNG--IGDAGIRALAEGLKANCNLEVLDLNNN---GLTDE---GASALAE---------------------T 216
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74054090 653 FKGLKNLTRLDLSLNRLKHIP----NEAFLNLPASLTELHINDNMLKFFNW----TLLQQFPRLELLDLRGNKLL 719
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGaaalASALLSPNISLLTLSLSCNDITDDGAkdlaEVLAEKESLLELDLRGNKFG 291
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
238-694 |
9.68e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 56.39 E-value: 9.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 238 LPSSLRKLFLSNTqikyiseeDFKGLI------NLTLLDLSGN-----CPRCFNAPFPCVPCDGGASINIDRF--AFQNL 304
Cdd:PLN00113 116 TSSSLRYLNLSNN--------NFTGSIprgsipNLETLDLSNNmlsgeIPNDIGSFSSLKVLDLGGNVLVGKIpnSLTNL 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 305 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGafLTMLPRLEILDLSFNYIKGSYPQHINisrNFSKL 384
Cdd:PLN00113 188 TSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYE--IGGLTSLNHLDLVYNNLTGPIPSSLG---NLKNL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 385 LSLralhlrgYVFQELREDDFQP-LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYAN-- 461
Cdd:PLN00113 263 QYL-------FLYQNKLSGPIPPsIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRlq 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 462 -----SSSFQRHIRKrrstdfEFDPHSNFyhftrplikpqcaaygKALDLSLNS------------------IFFIGPNQ 518
Cdd:PLN00113 336 vlqlwSNKFSGEIPK------NLGKHNNL----------------TVLDLSTNNltgeipeglcssgnlfklILFSNSLE 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 519 FENLPDI-AC-----LNLSANSNAQVLSgTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFriagvt 592
Cdd:PLN00113 394 GEIPKSLgACrslrrVRLQDNSFSGELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFG------ 466
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 593 hhlEFIQNF--TNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDdnryisiFKGLKNLTRLDLSLNRLK 670
Cdd:PLN00113 467 ---GLPDSFgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDE-------LSSCKKLVSLDLSHNQLS 536
|
490 500
....*....|....*....|....*
gi 74054090 671 -HIPnEAFLNLPAsLTELHINDNML 694
Cdd:PLN00113 537 gQIP-ASFSEMPV-LSQLDLSQNQL 559
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
305-367 |
1.55e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.55e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74054090 305 TQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYI 367
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSG-LPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
130-339 |
1.66e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 53.25 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 130 NGLNITD-GAFLNLKNLRELLLEDNQLPQIP--SGLPeSLTELSLiQNNiyNITK-EGISRLINLKNLYLAWNCyfnkvc 205
Cdd:cd21340 10 NDKNITKiDNLSLCKNLKVLYLYDNKITKIEnlEFLT-NLTHLYL-QNN--QIEKiENLENLVNLKKLYLGGNR------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 206 ektnIEdgVFETLTNlellslsfnslshvppklPSSLRKLFLSNTQ-------------IKYISEedfkgliNLTLLDLS 272
Cdd:cd21340 80 ----IS--VVEGLEN------------------LTNLEELHIENQRlppgekltfdprsLAALSN-------SLRVLNIS 128
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 273 GNcprcfnapfpcvpcdggasiNIDRFA-FQNLTQLRYLNLSSTSLRKIN--AAWFKNMPHLKVLDLEFN 339
Cdd:cd21340 129 GN--------------------NIDSLEpLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
730-792 |
1.97e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 1.97e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74054090 730 SSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALEtkTTTKLSMLELHGNPF 792
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
706-766 |
2.59e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 2.59e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74054090 706 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLL 766
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
530-766 |
2.84e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.70 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 530 LSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHyfriaGVTHHLEFIQNftNLKVLNL 609
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYANSN-----QLTSIPATLPD--TIQEMEL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 610 SHNNIYTLTDKynLESkSLVELVFSGNRLDILWND--DDNRYISIFKglknltrldlslNRLKHIPNeaflNLPASLTEL 687
Cdd:PRK15370 249 SINRITELPER--LPS-ALQSLDLFHNKISCLPENlpEELRYLSVYD------------NSIRTLPA----HLPSGITHL 309
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74054090 688 HINDNMLKFFNWTLLqqfPRLELLDLRGNKLLFLTDSLSdftSSLRTLLLSHNRISHLPSGFlseVSSLKHLDLSSNLL 766
Cdd:PRK15370 310 NVQSNSLTALPETLP---PGLKTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPETL---PPTITTLDVSRNAL 379
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
83-155 |
3.06e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.29 E-value: 3.06e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74054090 83 VTELDLSDNFITHITNESFQGLQNLTKINLNHNpnvqhqngnpgiqsNGLNITDGAFLNLKNLRELLLEDNQL 155
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN--------------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
523-768 |
1.14e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 523 PDIACLNLSANSNAQVLSGTE-----FSAIPHVKYLDLTNNRLDFDNA---SALTELSDLEVLDLSYNSH-----YFRIA 589
Cdd:cd00116 51 PSLKELCLSLNETGRIPRGLQsllqgLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLgdrglRLLAK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 590 GVTHHLEfiqnftNLKVLNLSHNNIY--TLTDKYNLESK--SLVELVFSGNRLdilwNDDDNRYIS-IFKGLKNLTRLDL 664
Cdd:cd00116 131 GLKDLPP------ALEKLVLGRNRLEgaSCEALAKALRAnrDLKELNLANNGI----GDAGIRALAeGLKANCNLEVLDL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 665 SLNRLKHIPNEAF---LNLPASLTELHINDNmlkffnwtllqqfprleLLDLRGnkLLFLTDSLSDFTSSLRTLLLSHNR 741
Cdd:cd00116 201 NNNGLTDEGASALaetLASLKSLEVLNLGDN-----------------NLTDAG--AAALASALLSPNISLLTLSLSCND 261
|
250 260 270
....*....|....*....|....*....|.
gi 74054090 742 ISHLPSGFLSEV----SSLKHLDLSSNLLKT 768
Cdd:cd00116 262 ITDDGAKDLAEVlaekESLLELDLRGNKFGE 292
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
760-847 |
1.32e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 52.78 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 760 DLSSNLLKTINKSALETKTTtkLSMLELHGNPFECTCDIGDFRRWMDEHlNVKIPRLVDVICASPGDQRGKSIVSLELTT 839
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCN--LSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....*...
gi 74054090 840 CVSDVTAV 847
Cdd:TIGR00864 78 SGCDEEYV 85
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
529-742 |
1.63e-06 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 51.71 E-value: 1.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 529 NLSANSNAQVLSGTefsaiPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNL 604
Cdd:COG5238 222 DEGAEILAEALKGN-----KSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGN--QIGAEGAIALAKALQGNTTL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 605 KVLNLSHNNIytlTDK------YNLE-SKSLVELVFSGNRLDilwnddDNRYISIFKGLK---NLTRLDLSLNRLKHIPN 674
Cdd:COG5238 295 TSLDLSVNRI---GDEgaialaEGLQgNKTLHTLNLAYNGIG------AQGAIALAKALQentTLHSLDLSDNQIGDEGA 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 74054090 675 EAFLNLPASLTELHindnmlkffnwtllqqfprleLLDLRGNKL-----LFLTDSLSdfTSSLRTLLLSHNRI 742
Cdd:COG5238 366 IALAKYLEGNTTLR---------------------ELNLGKNNIgkqgaEALIDALQ--TNRLHTLILDGNLI 415
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
295-341 |
2.09e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.98 E-value: 2.09e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 74054090 295 NIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 341
Cdd:pfam13855 15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
657-769 |
3.14e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.24 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 657 KNLTRLDLSLNRLKHIPNeaflNLPASLTELHINDNMLKFFNWTLLQQfprLELLDLRGNKLLFLTDSLSdftSSLRTLL 736
Cdd:PRK15370 199 EQITTLILDNNELKSLPE----NLQGNIKTLYANSNQLTSIPATLPDT---IQEMELSINRITELPERLP---SALQSLD 268
|
90 100 110
....*....|....*....|....*....|...
gi 74054090 737 LSHNRISHLPSGFLSEvssLKHLDLSSNLLKTI 769
Cdd:PRK15370 269 LFHNKISCLPENLPEE---LRYLSVYDNSIRTL 298
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
547-764 |
3.34e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 50.43 E-value: 3.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 547 IPHVKYLDLTNNRLDFDNASALTEL----SDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTD--- 619
Cdd:cd00116 22 LLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvl 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 620 KYNLESKSLVELVFSGNRLDilwnDDDNRYISifKGLK----NLTRLDLSLNRLKHIPNEAFLN-LPA--SLTELHINDN 692
Cdd:cd00116 102 ESLLRSSSLQELKLNNNGLG----DRGLRLLA--KGLKdlppALEKLVLGRNRLEGASCEALAKaLRAnrDLKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 693 MLKFFNWTLLQQ----FPRLELLDLRGNKL-----LFLTDSLSDfTSSLRTLLLSHNRI-----SHLPSGFLSEVSSLKH 758
Cdd:cd00116 176 GIGDAGIRALAEglkaNCNLEVLDLNNNGLtdegaSALAETLAS-LKSLEVLNLGDNNLtdagaAALASALLSPNISLLT 254
|
....*.
gi 74054090 759 LDLSSN 764
Cdd:cd00116 255 LSLSCN 260
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
602-694 |
5.63e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.82 E-value: 5.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 602 TNLKVLNLSHNNIYTLTDkynleskslvelvfsgnrldilwndddnryiSIFKGLKNLTRLDLSLNRLKHIPNEAFLNLP 681
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDD-------------------------------GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
|
90
....*....|...
gi 74054090 682 aSLTELHINDNML 694
Cdd:pfam13855 50 -SLRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
790-835 |
5.88e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 5.88e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 74054090 790 NPFECTCDIGDFRRWMDEhlNVKIPRLVDVICASPGDQRGKSIVSL 835
Cdd:smart00082 1 NPFICDCELRWLLRWLQA--NEHLQDPVDLRCASPSSLRGPLLELL 44
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
548-614 |
3.33e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 3.33e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74054090 548 PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNShyfriagvthhLEFI-----QNFTNLKVLNLSHNNI 614
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL-----------LTTLspgafSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
84-199 |
3.75e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.93 E-value: 3.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 84 TELDLSDNFITHITNesFQGLQNLTKINLNHNPnvqhqngnpgIQS-NGLNitdgaflNLKNLRELLLEDNQL------- 155
Cdd:cd21340 49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNR----------ISVvEGLE-------NLTNLEELHIENQRLppgeklt 109
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 74054090 156 --PQIPSGLPESLTELSLIQNNIYNItkEGISRLINLKNLYLAWNC 199
Cdd:cd21340 110 fdPRSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
240-317 |
8.37e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 8.37e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74054090 240 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCfnapfpcvpcdggasinIDRFAFQNLTQLRYLNLSSTSL 317
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-----------------LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
141-284 |
2.81e-04 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 45.07 E-value: 2.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 141 NLK-NLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLknlylawNCYFNKV-CEKTNIEDGVfETL 218
Cdd:PRK15370 217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL-------DLFHNKIsCLPENLPEEL-RYL 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74054090 219 TnlellsLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEedfKGLINLTLLDLSGNCPRCFNAPFP 284
Cdd:PRK15370 289 S------VYDNSIRTLPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSLPASLP 345
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
579-791 |
2.93e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 44.27 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 579 LSYNSHYFRIAGVTHHLEFIQNftnLKVLNLSHNNIYTLTDKY---NLESK-SLVELVFSGNRLDilwNDDDN--RYISI 652
Cdd:cd00116 3 LSLKGELLKTERATELLPKLLC---LQVLRLEGNTLGEEAAKAlasALRPQpSLKELCLSLNETG---RIPRGlqSLLQG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 653 FKGLKNLTRLDLSLNRLKHIPNEAFLNL--PASLTELHINDNML-----KFFNWTLLQQFPRLELLDLRGNKL-LFLTDS 724
Cdd:cd00116 77 LTKGCGLQELDLSDNALGPDGCGVLESLlrSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLeGASCEA 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 74054090 725 LSD---FTSSLRTLLLSHNRISHlpSGF------LSEVSSLKHLDLSSNLLKTINKSALET--KTTTKLSMLELHGNP 791
Cdd:cd00116 157 LAKalrANRDLKELNLANNGIGD--AGIralaegLKANCNLEVLDLNNNGLTDEGASALAEtlASLKSLEVLNLGDNN 232
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
537-775 |
3.33e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 537 QVLSGTEFSAIPHVKYLDLTNNRLDFDN----ASALTELSDLEVLDLSYNshYFRIAGVTHHLEFIQNFTNLKVLNLSHN 612
Cdd:COG5238 169 AAISMAKALQNNSVETVYLGCNQIGDEGieelAEALTQNTTVTTLWLKRN--PIGDEGAEILAEALKGNKSLTTLDLSNN 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 613 NIytlTD-------KYNLESKSLVELVFSGNRLdilwndDDNRYISIFKGL---KNLTRLDLSLNRlkhIPNEAFLNL-- 680
Cdd:COG5238 247 QI---GDegvialaEALKNNTTVETLYLSGNQI------GAEGAIALAKALqgnTTLTSLDLSVNR---IGDEGAIALae 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 681 ----PASLTELHINDNMLKFFNWTLL----QQFPRLELLDLRGNKL-----LFLTDSLSDFTsSLRTLLLSHNRIShlPS 747
Cdd:COG5238 315 glqgNKTLHTLNLAYNGIGAQGAIALakalQENTTLHSLDLSDNQIgdegaIALAKYLEGNT-TLRELNLGKNNIG--KQ 391
|
250 260 270
....*....|....*....|....*....|...
gi 74054090 748 GFLSEVSSLKH-----LDLSSNLLKTINKSALE 775
Cdd:COG5238 392 GAEALIDALQTnrlhtLILDGNLIGAEAQQRLE 424
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
329-394 |
3.77e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 3.77e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74054090 329 PHLKVLDLEFNYLVGeIASGAFLTmLPRLEILDLSFNYIKGSYPQHinisrnFSKLLSLRALHLRG 394
Cdd:pfam13855 1 PNLRSLDLSNNRLTS-LDDGAFKG-LSNLKVLDLSNNLLTTLSPGA------FSGLPSLRYLDLSG 58
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
304-372 |
3.97e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 44.42 E-value: 3.97e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74054090 304 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAsgAFLTMLPRLEILDLSFNYIKGSYP 372
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP--ESLGQLTSLRILNLNGNSLSGRVP 507
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
504-560 |
4.96e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 4.96e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 74054090 504 LDLSLNSIFFIGPNQFENLPDIACLNLSaNSNAQVLSGTEFSAIPHVKYLDLTNNRL 560
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLS-NNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
528-582 |
5.48e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 5.48e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 74054090 528 LNLSANsNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 582
Cdd:pfam13855 6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
284-394 |
6.03e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 284 PCVPCD---GGASINIDRFAFQNLtqLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIaSGAFLTMlPRLEIL 360
Cdd:PLN03150 396 PCVPQQhpwSGADCQFDSTKGKWF--IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNI-PPSLGSI-TSLEVL 471
|
90 100 110
....*....|....*....|....*....|....
gi 74054090 361 DLSFNYIKGSYPQHInisrnfSKLLSLRALHLRG 394
Cdd:PLN03150 472 DLSYNSFNGSIPESL------GQLTSLRILNLNG 499
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
604-674 |
1.89e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 1.89e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74054090 604 LKVLNLSHNNIYTLTDKYNLesKSLVELVFSGNRLDilwndDDNRYISIFKGLKNLTRLDLSLNRLKHIPN 674
Cdd:cd21340 122 LRVLNISGNNIDSLEPLAPL--RNLEQLDASNNQIS-----DLEELLDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
41-193 |
2.30e-03 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 41.99 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 41 ELCAEENFSRSYPcdEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN------H 114
Cdd:PRK15370 224 TLYANSNQLTSIP--ATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYDNSirtlpaH 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 115 NPN-VQHQNgnpgIQSNGLNITDGAFLnlKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIY--------NITKEGIS 185
Cdd:PRK15370 302 LPSgITHLN----VQSNSLTALPETLP--PGLKTLEAGENALTSLPASLPPELQVLDVSKNQITvlpetlppTITTLDVS 375
|
170
....*....|.
gi 74054090 186 R--LINL-KNL 193
Cdd:PRK15370 376 RnaLTNLpENL 386
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
143-380 |
3.29e-03 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 41.61 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 143 KNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNItKEGISRliNLKNLYLAWNcyfnkvcEKTNIEDGVFETLtnlE 222
Cdd:PRK15370 178 NNKTELRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG--NIKTLYANSN-------QLTSIPATLPDTI---Q 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 223 LLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDlsgNCPRCFNAPFPcvpcdggasinidrfafq 302
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENLPEELRYLSVYD---NSIRTLPAHLP------------------ 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74054090 303 nlTQLRYLNLSSTSLRKINAAWfknMPHLKVLDLEFNYLVGEIASgafltMLPRLEILDLSFNYIK---GSYP---QHIN 376
Cdd:PRK15370 304 --SGITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPAS-----LPPELQVLDVSKNQITvlpETLPptiTTLD 373
|
....
gi 74054090 377 ISRN 380
Cdd:PRK15370 374 VSRN 377
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
541-612 |
4.79e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.95 E-value: 4.79e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 74054090 541 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAgvthhlEFIQNFTNLKVLNLSHN 612
Cdd:PLN03150 435 PNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP------ESLGQLTSLRILNLNGN 500
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
412-449 |
9.61e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 9.61e-03
10 20 30
....*....|....*....|....*....|....*...
gi 74054090 412 PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRIS 449
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
|
|
| |
