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Conserved domains on  [gi|551620653|gb|ABA80611|]
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lyso-ornithine lipid acyltransferase [Cereibacter sphaeroides 2.4.1]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 48-272 3.65e-39

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 135.91  E-value: 3.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  48 RPLCGLARPVTPFITQGVCRGALAILGLRVVTEGR---PMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPG 122
Cdd:COG0204    2 RSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLenlPADGPVLIVANHQSWLDILLLLAAlpRPVRFVAKKELFKIPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 123 IGWLARATGTVFINR-RGSEALVQQRLFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTVT 201
Cdd:COG0204   82 LGWLLRALGAIPVDRsKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVP----IVPVAID 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551620653 202 YSaperedpRFYGWWGDMdfgshlvkllaaPRQGRVRITFHTPVPADGFAG--RKGLAARCEALVREAFPPEP 272
Cdd:COG0204  158 GT-------ERALPKGFL------------PRPGKVTVRIGPPIDPSDLEGedRRELAERLRAAIEALLAELR 211
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 48-272 3.65e-39

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 135.91  E-value: 3.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  48 RPLCGLARPVTPFITQGVCRGALAILGLRVVTEGR---PMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPG 122
Cdd:COG0204    2 RSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLenlPADGPVLIVANHQSWLDILLLLAAlpRPVRFVAKKELFKIPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 123 IGWLARATGTVFINR-RGSEALVQQRLFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTVT 201
Cdd:COG0204   82 LGWLLRALGAIPVDRsKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVP----IVPVAID 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551620653 202 YSaperedpRFYGWWGDMdfgshlvkllaaPRQGRVRITFHTPVPADGFAG--RKGLAARCEALVREAFPPEP 272
Cdd:COG0204  158 GT-------ERALPKGFL------------PRPGKVTVRIGPPIDPSDLEGedRRELAERLRAAIEALLAELR 211
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 66-259 7.31e-31

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 113.52  E-value: 7.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  66 CRGALAILGLRVVTEGR---PMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPGIGWLARATGTVFINRRGS 140
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLenlPPKGPVIIVANHQSYLDPLVLGAAlpRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 141 EALVQQ-RLFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTVTysaperedprfyGWWGDM 219
Cdd:cd07989   81 RSAREAlREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVP----IVPVAIS------------GTWGSL 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 551620653 220 DFGSHLvkllaaPRQGRVRITFHTPVPADGFAGRKGLAAR 259
Cdd:cd07989  145 PKGKKL------PRPGRVTVRIGEPIPPEGLELAEEDRKE 178
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 90-203 1.24e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 92.42  E-value: 1.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653    90 VVANHGSWLDIFTLNAV-----QRVYFVSKSEVAGWPGIGWLARATGTVFInRRGSEALVQQRLFE--ERLRAGHRLLFF 162
Cdd:smart00563   3 VVANHQSFLDPLVLSALlprklGRVRFVAKKELFYVPLLGWLLRLLGAIFI-DRSNGRKARAALREavELLKEGEWLLIF 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 551620653   163 PEGTSTDTLRVLPFKStlFAAFFthGLEHALHIQPVTVTYS 203
Cdd:smart00563  82 PEGTRSRPGKLLPFKK--GAARL--ALEAGVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 80-200 6.06e-20

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 83.10  E-value: 6.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653   80 EGRPMQVPGAVVANHGSWLDIFTLNAV-----QRVYFVSKSEVAGWPGIGWLARATGTVFINR--RGSEALVQQRLfEER 152
Cdd:pfam01553   8 ENLPRGGPAIVVANHQSYLDVLLLSLAlykrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRknRKDAAGTLEYL-VEL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 551620653  153 LRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFfthgLEHALHIQPVTV 200
Cdd:pfam01553  87 LREGKLVVIFPEGTRSREGELLPFKKGAFRLA----IEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 74-200 8.73e-19

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 80.08  E-value: 8.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653   74 GLRVV---TEGRPMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPGIGWLARATGTVFINRRGSEALVQ-QR 147
Cdd:TIGR00530   1 GLKVEvvgPENLPAKSPVLVVANHQSNLDPLTLSAAfpPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATaLK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 551620653  148 LFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTV 200
Cdd:TIGR00530  81 AAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVP----ILPVVL 129
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 76-182 4.99e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 57.82  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  76 RVVTEGR----PMQVPGAVVANHGSWLDIFTLNAVQRVY-FVSKSEVAGWPGIGWLARATGTVFINRRGSEALVQQ-RLF 149
Cdd:PLN02901  36 KIEVEGLenlpSPDEPAVYVSNHQSFLDIYTLFHLGRPFkFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLEClKRC 115

                         90       100       110
                 ....*....|....*....|....*....|...
gi 551620653 150 EERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFA 182
Cdd:PLN02901 116 MELLKKGASVFFFPEGTRSKDGKLAAFKKGAFS 148
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 48-272 3.65e-39

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 135.91  E-value: 3.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  48 RPLCGLARPVTPFITQGVCRGALAILGLRVVTEGR---PMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPG 122
Cdd:COG0204    2 RSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLenlPADGPVLIVANHQSWLDILLLLAAlpRPVRFVAKKELFKIPL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 123 IGWLARATGTVFINR-RGSEALVQQRLFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTVT 201
Cdd:COG0204   82 LGWLLRALGAIPVDRsKRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVP----IVPVAID 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551620653 202 YSaperedpRFYGWWGDMdfgshlvkllaaPRQGRVRITFHTPVPADGFAG--RKGLAARCEALVREAFPPEP 272
Cdd:COG0204  158 GT-------ERALPKGFL------------PRPGKVTVRIGPPIDPSDLEGedRRELAERLRAAIEALLAELR 211
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 66-259 7.31e-31

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 113.52  E-value: 7.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  66 CRGALAILGLRVVTEGR---PMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPGIGWLARATGTVFINRRGS 140
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLenlPPKGPVIIVANHQSYLDPLVLGAAlpRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 141 EALVQQ-RLFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTVTysaperedprfyGWWGDM 219
Cdd:cd07989   81 RSAREAlREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVP----IVPVAIS------------GTWGSL 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 551620653 220 DFGSHLvkllaaPRQGRVRITFHTPVPADGFAGRKGLAAR 259
Cdd:cd07989  145 PKGKKL------PRPGRVTVRIGEPIPPEGLELAEEDRKE 178
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 90-203 1.24e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 92.42  E-value: 1.24e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653    90 VVANHGSWLDIFTLNAV-----QRVYFVSKSEVAGWPGIGWLARATGTVFInRRGSEALVQQRLFE--ERLRAGHRLLFF 162
Cdd:smart00563   3 VVANHQSFLDPLVLSALlprklGRVRFVAKKELFYVPLLGWLLRLLGAIFI-DRSNGRKARAALREavELLKEGEWLLIF 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 551620653   163 PEGTSTDTLRVLPFKStlFAAFFthGLEHALHIQPVTVTYS 203
Cdd:smart00563  82 PEGTRSRPGKLLPFKK--GAARL--ALEAGVPIVPVAIRGT 118
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 66-241 2.31e-22

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 91.90  E-value: 2.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  66 CRGALAILGLRVVT-EGR--PMQVPGAVVANHGSWLDIFTLnAVQRVY-FVSKSEVAGWPGIGWLARATGTVFINRrgSE 141
Cdd:cd07991    1 ARVLLFAFGFYVIKvHGKpdPPEAPRIIVANHTSFIDPLIL-FSDLFPsIVAKKELGKLPFIGTILRALGCIFVDR--SE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 142 ALVQQRLFEERLRAGHR-----LLFFPEGTSTDTLRVLPFKSTLFAAFFThglehalhIQPVTVTYsaPEREDPRFYGWW 216
Cdd:cd07991   78 PKDRKKVVEEIKERATDpnwppILIFPEGTTTNGKALIMFKKGAFEPGVP--------VQPVAIRY--PNKFVDAFWNSS 147

                        170       180
                 ....*....|....*....|....*
gi 551620653 217 GDMdFGSHLVKLLAAPRqGRVRITF 241
Cdd:cd07991  148 GYS-SLMYLFRLLTQPA-NVLEVEF 170
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 80-200 6.06e-20

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 83.10  E-value: 6.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653   80 EGRPMQVPGAVVANHGSWLDIFTLNAV-----QRVYFVSKSEVAGWPGIGWLARATGTVFINR--RGSEALVQQRLfEER 152
Cdd:pfam01553   8 ENLPRGGPAIVVANHQSYLDVLLLSLAlykrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRknRKDAAGTLEYL-VEL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 551620653  153 LRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFfthgLEHALHIQPVTV 200
Cdd:pfam01553  87 LREGKLVVIFPEGTRSREGELLPFKKGAFRLA----IEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 74-200 8.73e-19

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 80.08  E-value: 8.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653   74 GLRVV---TEGRPMQVPGAVVANHGSWLDIFTLNAV--QRVYFVSKSEVAGWPGIGWLARATGTVFINRRGSEALVQ-QR 147
Cdd:TIGR00530   1 GLKVEvvgPENLPAKSPVLVVANHQSNLDPLTLSAAfpPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATaLK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 551620653  148 LFEERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFAAFFTHGLEhalhIQPVTV 200
Cdd:TIGR00530  81 AAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVP----ILPVVL 129
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 76-207 3.60e-15

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 72.29  E-value: 3.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  76 RVVTEGR---PMQVPGAVVANH-GSWLDIFTLNAV--QRVYFVSKSEVAGWPGIGWLARATGTVFINRR------GSEAL 143
Cdd:cd07992   15 RITVVGRenvPKDGPVIFLGNHpNALIDPLLLAATlrRPVRFLAKADLFKNPLIGWLLESFGAIPVYRPkdlargGIGKI 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 144 VQQRLFE---ERLRAGHRLLFFPEGTSTDTLRVLPFKsTLFAAFFTHGLEHA---LHIQPVTVTYSAPER 207
Cdd:cd07992   95 SNAAVFDavgEALKAGGAIGIFPEGGSHDRPRLLPLK-AGAARMALEALEAGqkdVKIVPVGLNYEDKSR 163
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 76-182 4.99e-10

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 57.82  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  76 RVVTEGR----PMQVPGAVVANHGSWLDIFTLNAVQRVY-FVSKSEVAGWPGIGWLARATGTVFINRRGSEALVQQ-RLF 149
Cdd:PLN02901  36 KIEVEGLenlpSPDEPAVYVSNHQSFLDIYTLFHLGRPFkFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLEClKRC 115

                         90       100       110
                 ....*....|....*....|....*....|...
gi 551620653 150 EERLRAGHRLLFFPEGTSTDTLRVLPFKSTLFA 182
Cdd:PLN02901 116 MELLKKGASVFFFPEGTRSKDGKLAAFKKGAFS 148
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 74-166 2.99e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 55.32  E-value: 2.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  74 GLRVVTEGRPMQVPGA---VVANHGSWLDIFTLNAV-------QRVYFVSKSEVAGWPGIGWLARATGTVFINRRGS--E 141
Cdd:cd07990    9 GVKVVVYGDEPKLPKEralIISNHRSEVDWLVLWMLadrfgrlGRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEkdE 88

                         90       100
                 ....*....|....*....|....*...
gi 551620653 142 ALVQQRLfeERLRAGHR---LLFFPEGT 166
Cdd:cd07990   89 KTIKRQL--KRLKDSPEpfwLLIFPEGT 114
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 121-252 7.65e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 51.42  E-value: 7.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653 121 PGIGWLARATGTVFINRRGSE-----ALVQQRLfEERLRAGHRLLFFPEGTSTDTLRVLPFK----STLFAAFFtHGLEH 191
Cdd:cd07993   62 PILGTLLRRLGAFFIRRSFGKdplyrAVLQEYV-QELLKNGQPLEFFIEGTRSRTGKLLPPKlgllSVVVEAYL-KGSVP 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 551620653 192 ALHIQPVTVTY-------------SAPEREDPRFYGWWGDM-DFGSHLvkllaaprqGRVRITFHTPVPADGFAG 252
Cdd:cd07993  140 DVLIVPVSISYdrvleeelyaeelLGPPKPKESLSGLLGASkILRENF---------GRIRVDFGEPISLREYLG 205
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 76-247 4.09e-07

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 51.08  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653   76 RVVTEGR---PMQVPGAVVANHGSWLDIFTLNAVQ--RVYFVSKSEVAGWPGIGWLARATGTVFINRRGSEALVQqrLFE 150
Cdd:PRK08633  428 RLRVEGReniPAKGGALLLGNHVSWIDWALLQAASprPIRFVMERSIYEKWYLKWFFKLFGVIPISSGGSKESLE--FIR 505

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  151 ERLRAGHRLLFFPEGTSTDTLRVLPFKStlfaaffthGLEHALHIQPVTVTysaPeredprFY--GWWGDMdFGSHLVKL 228
Cdd:PRK08633  506 KALDDGEVVCIFPEGAITRNGQLNEFKR---------GFELIVKGTDVPII---P------FYirGLWGSI-FSRASGKF 566

                         170       180
                  ....*....|....*....|..
gi 551620653  229 LAAPRQG---RVRITFHTPVPA 247
Cdd:PRK08633  567 LWRWPTRipyPVTVAFGKPMPA 588
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 72-208 2.85e-06

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 46.64  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  72 ILGLRVVTEGRPMQVPGA---VVANHGSWLDIFTLNAVQRVYF-------VSKSEVAGWPGIGWLaratGTVFINRRGSE 141
Cdd:cd06551    9 FGFVRLEVKGPPPPPGGGpvlFVSNHSSWWDGLILFLLLERGLrrdvyglMDEELLERYPFFTRL----GAFSVDRDSPR 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 551620653 142 ALVQ-----QRLFEERlraGHRLLFFPEGTSTD-TLRVLPFKSTLFAAffthGLEHALHIQPVTVTYSAPERE 208
Cdd:cd06551   85 SAAKslkyvARLLSKP---GSVVWIFPEGTRTRrDKRPLQFKPGVAHL----AEKAGVPIVPVALRYTFELFE 150
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 66-166 3.03e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 37.58  E-value: 3.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551620653  66 CRGALAILGLRVvtEGRPMQVPGAVV--ANHGS-WLDIFTLNAV----QRVYFVSKSEVAGWPgIGWLARATGTVFINRR 138
Cdd:cd07988    1 ARLLLRLSGWRI--EGEPPNKPKFVVigAPHTSnWDFVLGLLAAfalgLKISFLGKHSLFKPP-LGPFMRWLGGIPVDRS 77

                         90       100
                 ....*....|....*....|....*...
gi 551620653 139 GSEALVQQRLFEERLRAGHRLLFFPEGT 166
Cdd:cd07988   78 RAGGLVEQVVEEFRRREEFVLAIAPEGT 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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