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Conserved domains on  [gi|78059255|gb|ABB18004|]
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glucose-6-phosphate isomerase, partial [Aggregatibacter segnis]

Protein Classification

glucose-6-phosphate isomerase( domain architecture ID 1000311)

glucose-6-phosphate isomerase (GPI) catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate

CATH:  1.10.1390.10|3.40.50.10490
EC:  5.3.1.9
Gene Ontology:  GO:0097367|GO:0004347|GO:0006096|GO:0006094|GO:0051156
PubMed:  6115414
SCOP:  4000799

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pgi super family cl30093
glucose-6-phosphate isomerase; Reviewed
 2-131 3.27e-97

glucose-6-phosphate isomerase; Reviewed


The actual alignment was detected with superfamily member PRK00179:

Pssm-ID: 234679  Cd Length: 548  Bit Score: 289.00  E-value: 3.27e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    2 FCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:PRK00179 128 FAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALRPYaDPGLRVHFVSNVDGAHLAETLKKLDPETTLFIVASK 207

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 78059255   81 TFTTQETMTNALSARDWFLAAAKDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:PRK00179 208 TFTTQETLTNAHSARDWFLAAGGDEAAVAKHFVAVSTNAEAVAEFGIDPDN 258
 
Name Accession Description Interval E-value
pgi PRK00179
glucose-6-phosphate isomerase; Reviewed
 2-131 3.27e-97

glucose-6-phosphate isomerase; Reviewed


Pssm-ID: 234679  Cd Length: 548  Bit Score: 289.00  E-value: 3.27e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    2 FCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:PRK00179 128 FAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALRPYaDPGLRVHFVSNVDGAHLAETLKKLDPETTLFIVASK 207

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 78059255   81 TFTTQETMTNALSARDWFLAAAKDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:PRK00179 208 TFTTQETLTNAHSARDWFLAAGGDEAAVAKHFVAVSTNAEAVAEFGIDPDN 258
PGI pfam00342
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ...
 1-131 1.70e-81

Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.


Pssm-ID: 395271  Cd Length: 487  Bit Score: 247.00  E-value: 1.70e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255     1 SFCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVAS 79
Cdd:pfam00342  78 SFSERVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALKPYsGRDLDVHFVSNVDGTHIAEVLKKLNPETTLFIVAS 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 78059255    80 KTFTTQETMTNALSARDWFLAAAKDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:pfam00342 158 KTFTTAETMTNAESAKEWLLKALKDDSAVAKHFIALSTNAEKVEEFGIDTKN 209
Pgi COG0166
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ...
 2-130 1.71e-67

Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439936  Cd Length: 484  Bit Score: 210.77  E-value: 1.71e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255   2 FCERVIsgewkgyTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:COG0166  95 FAEKVR-------TGKRITDVVNIGIGGSDLGPRAVIEALKPYfRDGPRVHFVSNVDPDYLAELLAGLDPETTLFIVISK 167

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 78059255  81 TFTTQETMTNALSARDWFLAAAKDpaHVAKHFAALSTNAKAVADFGIDTN 130
Cdd:COG0166 168 SGTTQETLTNARVAREWLEKAGGE--DAAKHFVAVTDNAGALRAFGIDEG 215
SIS_PGI_1 cd05015
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ...
 1-128 1.13e-57

Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.


Pssm-ID: 240146  Cd Length: 158  Bit Score: 175.79  E-value: 1.13e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255   1 SFCERVISGewkgytgKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVAS 79
Cdd:cd05015   9 EFAEKVRSG-------KKITDVVVIGIGGSDLGPRAVYEALKPYfKGGLRLHFVSNVDPDDLAELLKKLDPETTLFIVIS 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 78059255  80 KTFTTQETMTNALSARDWFLAAAKDpaHVAKHFAALSTNAKAVAD-FGID 128
Cdd:cd05015  82 KSGTTLETLANARLAREWLEEAGGD--DLAKHFVAITDNGSGLLKkAGIE 129
 
Name Accession Description Interval E-value
pgi PRK00179
glucose-6-phosphate isomerase; Reviewed
 2-131 3.27e-97

glucose-6-phosphate isomerase; Reviewed


Pssm-ID: 234679  Cd Length: 548  Bit Score: 289.00  E-value: 3.27e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    2 FCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:PRK00179 128 FAEAVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALRPYaDPGLRVHFVSNVDGAHLAETLKKLDPETTLFIVASK 207

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 78059255   81 TFTTQETMTNALSARDWFLAAAKDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:PRK00179 208 TFTTQETLTNAHSARDWFLAAGGDEAAVAKHFVAVSTNAEAVAEFGIDPDN 258
PGI pfam00342
Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of ...
 1-131 1.70e-81

Phosphoglucose isomerase; Phosphoglucose isomerase catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.


Pssm-ID: 395271  Cd Length: 487  Bit Score: 247.00  E-value: 1.70e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255     1 SFCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVAS 79
Cdd:pfam00342  78 SFSERVRSGEWKGYTGKAITDVVNIGIGGSDLGPVMVTEALKPYsGRDLDVHFVSNVDGTHIAEVLKKLNPETTLFIVAS 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 78059255    80 KTFTTQETMTNALSARDWFLAAAKDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:pfam00342 158 KTFTTAETMTNAESAKEWLLKALKDDSAVAKHFIALSTNAEKVEEFGIDTKN 209
Pgi COG0166
Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate ...
 2-130 1.71e-67

Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Glucose-6-phosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439936  Cd Length: 484  Bit Score: 210.77  E-value: 1.71e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255   2 FCERVIsgewkgyTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:COG0166  95 FAEKVR-------TGKRITDVVNIGIGGSDLGPRAVIEALKPYfRDGPRVHFVSNVDPDYLAELLAGLDPETTLFIVISK 167

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 78059255  81 TFTTQETMTNALSARDWFLAAAKDpaHVAKHFAALSTNAKAVADFGIDTN 130
Cdd:COG0166 168 SGTTQETLTNARVAREWLEKAGGE--DAAKHFVAVTDNAGALRAFGIDEG 215
SIS_PGI_1 cd05015
Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification ...
 1-128 1.13e-57

Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF). Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.


Pssm-ID: 240146  Cd Length: 158  Bit Score: 175.79  E-value: 1.13e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255   1 SFCERVISGewkgytgKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVAS 79
Cdd:cd05015   9 EFAEKVRSG-------KKITDVVVIGIGGSDLGPRAVYEALKPYfKGGLRLHFVSNVDPDDLAELLKKLDPETTLFIVIS 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 78059255  80 KTFTTQETMTNALSARDWFLAAAKDpaHVAKHFAALSTNAKAVAD-FGID 128
Cdd:cd05015  82 KSGTTLETLANARLAREWLEEAGGD--DLAKHFVAITDNGSGLLKkAGIE 129
PLN02649 PLN02649
glucose-6-phosphate isomerase
 1-131 3.37e-57

glucose-6-phosphate isomerase


Pssm-ID: 215351 [Multi-domain]  Cd Length: 560  Bit Score: 186.01  E-value: 3.37e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    1 SFCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHL------TMHFVSNVDGTHIAETLKKVNPETTL 74
Cdd:PLN02649 129 AFSEDVRSGKWKGATGKRFTNVVSIGIGGSFLGPLFVHEALATDPEALksakgrKLRFLANVDPVDIARQIAQLDPETTL 208

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 78059255   75 ILVASKTFTTQETMTNALSARDWFLAAAkDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:PLN02649 209 VVVVSKTFTTAETMLNARTVRKWLRDAL-GGLAVAKHMVAVSTNLLLVNKFGIDPWN 264
PTZ00430 PTZ00430
glucose-6-phosphate isomerase; Provisional
 1-131 6.54e-40

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 185612  Cd Length: 552  Bit Score: 139.77  E-value: 6.54e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    1 SFCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHL------TMHFVSNVDGTHIAETLKKVNPETTL 74
Cdd:PTZ00430 124 KFSDKIRSGEILGSTGKKLKNVICIGIGGSYLGTEFVYEALRTYGEAReaskgrKLRFLANVDPIDVRRATEGLDPEETL 203

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 78059255   75 ILVASKTFTTQETMTNALSARDWFLAAAKDPAHVAKHFAALSTNAKAVADFGIDTNN 131
Cdd:PTZ00430 204 VVIISKTFTTAETMLNAKTVRQWLLDNIKSKEALSKHLCAVSTNLKLTSEFGIPDEN 260
pgi PRK14095
glucose-6-phosphate isomerase; Provisional
 2-114 2.72e-25

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 237608  Cd Length: 533  Bit Score: 99.32  E-value: 2.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    2 FCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPY-KNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:PRK14095 134 FLKKVRSGEIKNSNGKKFTTVVQIGIGGSDLGPKALYLALKNYaKKDKRVHFISNVDPDDAAEVLSEIDLAKTLFIVVSK 213

                         90       100       110
                 ....*....|....*....|....*....|....
gi 78059255   81 TFTTQETMTNALSARDWFLAAAKDPahvAKHFAA 114
Cdd:PRK14095 214 SGTTLETAANEEFVRDALKKAGLDY---KKHFIA 244
pgi PRK14096
glucose-6-phosphate isomerase; Provisional
 1-109 1.23e-19

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 237609 [Multi-domain]  Cd Length: 528  Bit Score: 83.01  E-value: 1.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    1 SFCERVISGEWKGYTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHLTMHFVSNVDGTHIAETLKKVNPE--TTLILVA 78
Cdd:PRK14096  96 AFAAKVHSGTIKPPNGEKFTDVLWIGIGGSALGPQFVAEALQPNSDGLNIHFIDNTDPDGIDRVLAELGDRlaTTLVVVI 175

                         90       100       110
                 ....*....|....*....|....*....|...
gi 78059255   79 SKTFTTQETMTNALSARDWFLAAAKD-PAH-VA 109
Cdd:PRK14096 176 SKSGGTPETRNGMLEAKAAYEAAGLDfASHaVA 208
PRK00973 PRK00973
glucose-6-phosphate isomerase; Provisional
 20-112 3.82e-14

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 179193 [Multi-domain]  Cd Length: 446  Bit Score: 67.33  E-value: 3.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255   20 TDVINIGIGGSDLGPYMVTEALRP-YKNHLT--------MHFVSNVDGTHIAETLKKVNPETTLILVASKTFTTQETMTN 90
Cdd:PRK00973  72 DNVVVLGIGGSALGNLALHYALNPlNWNELSkeerngprVFVLDNVDPEKTASILDVIDLEKTLFNVISKSGNTAETLAN 151

                         90       100
                 ....*....|....*....|..
gi 78059255   91 ALSARDWFLAAAKDPahvAKHF 112
Cdd:PRK00973 152 YLIIRGILEKLGLDP---KKHL 170
PRK03868 PRK03868
glucose-6-phosphate isomerase; Provisional
 17-89 4.63e-13

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 235168  Cd Length: 410  Bit Score: 64.18  E-value: 4.63e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78059255   17 KAITDVINIGIGGSDLGPYMVTEALRPYK-NHLTMHFVSNVDGTHIAETLKKVNPETTLILVASKTFTTQETMT 89
Cdd:PRK03868  56 ESIKNIVVIGIGGSSLGVKAIYSFLKNEKnNKKELHFLENTDPISINKTLSKINLENTLFIVISKSGTTIETIS 129
PRK09533 PRK09533
bifunctional transaldolase/phosoglucose isomerase; Validated
 1-114 5.95e-09

bifunctional transaldolase/phosoglucose isomerase; Validated


Pssm-ID: 236551 [Multi-domain]  Cd Length: 948  Bit Score: 52.67  E-value: 5.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78059255    1 SFCERVisgewkgyTGKAITDVINIGIGGSDLGPYMVTEALRPYKNHLTMHFVSNVDGTHIAETLKKVNPETTLILVASK 80
Cdd:PRK09533 445 AFAEEV--------RAEGFTDAVVLGMGGSSLGPEVLAETFGQRDGFPKLHVLDSTDPAQVRALEAAVDLARTLFIVSSK 516

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 78059255   81 TFTTQETMtnalSARDWFLAAAKDP--AHVAKHFAA 114
Cdd:PRK09533 517 SGGTLEPN----IFKDYFFARVKEVlgAKAGRHFVA 548
pgi PRK14097
glucose-6-phosphate isomerase; Provisional
 20-86 6.24e-03

glucose-6-phosphate isomerase; Provisional


Pssm-ID: 184504  Cd Length: 448  Bit Score: 35.20  E-value: 6.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 78059255   20 TDVINIGIGGSDLGPYMVTEALR-PYKNHLT--------MHFVSN-VDGTHIAETLKKVNPETTLILVASKTFTTQE 86
Cdd:PRK14097  74 DVLVVIGIGGSYLGARAAIEFLNhSFYNLLPkeqrkapqIIFAGNsISSTYLADLLEYLKDKDFSINVISKSGTTTE 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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