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Conserved domains on  [gi|81175330|gb|ABB59012|]
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sublingual parotid tongue-2 salivary protein [Mus musculus]

Protein Classification

jacalin family lectin( domain architecture ID 5034)

jacalin family lectin is a sugar-binding protein containing a jacalin domain

Gene Ontology:  GO:0030246
PubMed:  28737678|15329359
SCOP:  4002758

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Jacalin_like super family cl03205
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
 28-158 4.56e-22

Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.


The actual alignment was detected with superfamily member cd09611:

Pssm-ID: 446042 [Multi-domain]  Cd Length: 128  Bit Score: 85.84  E-value: 4.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175330  28 GPEVGKHSCTSAPEGKNIISIRVFLQGRSIVGIQLTYNDNEDgQVYGSTAGKVMVARLSKEEHIIGVEGTYNPsALTQII 107
Cdd:cd09611   1 GSGGGKYFSDVGEGGGPITGIRVSVGNNYIKGIQVRYGSNWS-DVYGGRGGNEQEIVLEPGESITKVSGSYKI-YLHGLV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 81175330 108 FTTNQPRQLMVGYHVGNYQYSSYPdDPSLVLKGACVSWRAGGIKSILFLWG 158
Cdd:cd09611  79 FTTNKGRYLSFGKLRGRSFNATPP-PSNYVLRGISGRYGGLGIKSIGFHWG 128
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 28-158 4.56e-22

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 85.84  E-value: 4.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175330  28 GPEVGKHSCTSAPEGKNIISIRVFLQGRSIVGIQLTYNDNEDgQVYGSTAGKVMVARLSKEEHIIGVEGTYNPsALTQII 107
Cdd:cd09611   1 GSGGGKYFSDVGEGGGPITGIRVSVGNNYIKGIQVRYGSNWS-DVYGGRGGNEQEIVLEPGESITKVSGSYKI-YLHGLV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 81175330 108 FTTNQPRQLMVGYHVGNYQYSSYPdDPSLVLKGACVSWRAGGIKSILFLWG 158
Cdd:cd09611  79 FTTNKGRYLSFGKLRGRSFNATPP-PSNYVLRGISGRYGGLGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 46-114 3.43e-07

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 46.84  E-value: 3.43e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81175330     46 ISIRVFLQGRS-IVGIQLTYNDN--EDGQVYGSTAGKVMVARLSKEEHIIGVEGTYNPSA-LTQIIFTTNQPR 114
Cdd:smart00915  12 VRKIYVGQGGEgIKSIQFDYDKGgkVWGDEHGGKGGTGEEILLYPGEYITSVEGTYDKSGvITSLTFKTNKGR 84
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 54-111 3.65e-03

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 35.72  E-value: 3.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81175330    54 GRSIVGIQL---TYnDNEDGQVYGSTAGKvMVARLSKE-------EHIIGVEGTYNPS------ALTQIIFTTN 111
Cdd:pfam01419  18 GQGGDGITYikfEY-VKGGGKVEGDEHGK-KGLLGPEEfeidypdEYITSVEGTYDKVfgsdseVITSLTFKTN 89
 
Name Accession Description Interval E-value
Jacalin_ZG16_like cd09611
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
 28-158 4.56e-22

Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.


Pssm-ID: 187707 [Multi-domain]  Cd Length: 128  Bit Score: 85.84  E-value: 4.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175330  28 GPEVGKHSCTSAPEGKNIISIRVFLQGRSIVGIQLTYNDNEDgQVYGSTAGKVMVARLSKEEHIIGVEGTYNPsALTQII 107
Cdd:cd09611   1 GSGGGKYFSDVGEGGGPITGIRVSVGNNYIKGIQVRYGSNWS-DVYGGRGGNEQEIVLEPGESITKVSGSYKI-YLHGLV 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 81175330 108 FTTNQPRQLMVGYHVGNYQYSSYPdDPSLVLKGACVSWRAGGIKSILFLWG 158
Cdd:cd09611  79 FTTNKGRYLSFGKLRGRSFNATPP-PSNYVLRGISGRYGGLGIKSIGFHWG 128
Jacalin smart00915
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
 46-114 3.43e-07

Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.


Pssm-ID: 214909 [Multi-domain]  Cd Length: 128  Bit Score: 46.84  E-value: 3.43e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 81175330     46 ISIRVFLQGRS-IVGIQLTYNDN--EDGQVYGSTAGKVMVARLSKEEHIIGVEGTYNPSA-LTQIIFTTNQPR 114
Cdd:smart00915  12 VRKIYVGQGGEgIKSIQFDYDKGgkVWGDEHGGKGGTGEEILLYPGEYITSVEGTYDKSGvITSLTFKTNKGR 84
Jacalin cd09612
Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains ...
 37-112 1.19e-03

Jacalin-like plant lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. The family was initially named after an abundant protein found in the jackfruit seed. Jacalin specifically binds to the alpha-O-glycoside of the disaccharide Gal-beta1-3-GalNAc, and has proven useful in the study of O-linked glycoproteins. Jacalin-like lectins in this family may occur in various oligomerization states.


Pssm-ID: 187708 [Multi-domain]  Cd Length: 130  Bit Score: 37.16  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81175330  37 TSAPEGknIISIRVFLQGRSIVGIQLTYNDNEDGQVY----GSTAGKVMVARLSKEEHIIGVEGTYNPS----ALTQIIF 108
Cdd:cd09612   7 GVFPDG--LRKITVRSGENGIDSIKFEYDKDGQHVVGpwhgGGGGTPEEIVLDYPDEYITSVSGTYGPVsgsnVITSLTF 84


                ....
gi 81175330 109 TTNQ 112
Cdd:cd09612  85 KTNK 88
Jacalin pfam01419
Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 ...
 54-111 3.65e-03

Jacalin-like lectin domain; Proteins containing this domain are lectins. It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein.


Pssm-ID: 396138 [Multi-domain]  Cd Length: 134  Bit Score: 35.72  E-value: 3.65e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81175330    54 GRSIVGIQL---TYnDNEDGQVYGSTAGKvMVARLSKE-------EHIIGVEGTYNPS------ALTQIIFTTN 111
Cdd:pfam01419  18 GQGGDGITYikfEY-VKGGGKVEGDEHGK-KGLLGPEEfeidypdEYITSVEGTYDKVfgsdseVITSLTFKTN 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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