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Conserved domains on  [gi|110433411|gb|ABG74387|]
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DnaA, partial [Rickettsia sp. Bar29]

Protein Classification

chromosomal replication initiator protein DnaA( domain architecture ID 1903222)

chromosomal replication initiator protein DnaA plays a key role in the initiation and regulation of chromosomal replication

CATH:  3.30.300.180|1.10.1750.10
Gene Ontology:  GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275|GO:0006260|GO:0016887|GO:0005515
PubMed:  16753031|8110826
SCOP:  4002279|4005309

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
1-199 5.97e-86

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member TIGR00362:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 437  Bit Score: 260.15  E-value: 5.97e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411    1 PTNFVRDWIKSKYSMVILQLFQHYNNTIKSIEIITKELPgitqTVIALPTKTFADIGSSELNAENIFSTLDVRFTFDNFV 80
Cdd:TIGR00362  39 PNEFVKEWIEKNYLDLIEELLQELFGAEIEIEFTVGEDE----EELEPNSKKPEPAPPEAPAPPSSASGLNPKYTFDNFV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   81 VGAPNELAYAAARAVAESSGavSESNPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQFVKALRNKEVI 160
Cdd:TIGR00362 115 VGKSNRLAHAAALAVAENPG--KAYNPLFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKME 192

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 110433411  161 SFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:TIGR00362 193 EFKEKYRSVDLLLIDDIQFLAGKERTQEEFFHTFNALHE 231
 
Name Accession Description Interval E-value
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 1-199 5.97e-86

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 260.15  E-value: 5.97e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411    1 PTNFVRDWIKSKYSMVILQLFQHYNNTIKSIEIITKELPgitqTVIALPTKTFADIGSSELNAENIFSTLDVRFTFDNFV 80
Cdd:TIGR00362  39 PNEFVKEWIEKNYLDLIEELLQELFGAEIEIEFTVGEDE----EELEPNSKKPEPAPPEAPAPPSSASGLNPKYTFDNFV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   81 VGAPNELAYAAARAVAESSGavSESNPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQFVKALRNKEVI 160
Cdd:TIGR00362 115 VGKSNRLAHAAALAVAENPG--KAYNPLFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKME 192

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 110433411  161 SFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:TIGR00362 193 EFKEKYRSVDLLLIDDIQFLAGKERTQEEFFHTFNALHE 231
dnaA PRK00149
chromosomal replication initiator protein DnaA;
1-199 1.73e-77

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 237.34  E-value: 1.73e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   1 PTNFVRDWIKSKYSMVILQLFQhynntiksieiitkelpgitqtvialptktfadigsselnaenifstLDVRFTFDNFV 80
Cdd:PRK00149  44 PNRFVKDWIEKNYLDLIEEALQ-----------------------------------------------LNPKYTFDNFV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  81 VGAPNELAYaaaravaESSGAVSES-----NPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQFVKALR 155
Cdd:PRK00149  77 VGKSNRLAH-------AAALAVAENpgkayNPLFIYGGVGLGKTHLLHAIGNYILEKNPNAKVVYVTSEKFTNDFVNALR 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 110433411 156 NKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:PRK00149 150 NNTMEEFKEKYRSVDVLLIDDIQFLAGKERTQEEFFHTFNALHE 193
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
70-199 1.16e-70

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 216.60  E-value: 1.16e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  70 LDVRFTFDNFVVGAPNELAYaaaravaESSGAVSES-----NPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAE 144
Cdd:COG0593    1 LNPRYTFDNFVVGPSNRLAH-------AAALAVAEWpgkayNPLFLYGGVGLGKTHLLHAIGNEALENNPGARVVYLTAE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110433411 145 KFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:COG0593   74 EFTNDFINAIRNNTIEEFKEKYRSVDVLLIDDIQFLAGKEATQEEFFHTFNALRE 128
Bac_DnaA pfam00308
Bacterial dnaA protein;
70-199 8.29e-62

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 191.39  E-value: 8.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   70 LDVRFTFDNFVVGAPNELAYAAARAVAESSGAVSesNPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQ 149
Cdd:pfam00308   1 LNPRYTFENFVIGPSNRFAHAAALTVAKAPGKAY--NPLFIYGGVGLGKTHLLHAIGNYALQNAPNLRVVYLTAEEFLND 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 110433411  150 FVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:pfam00308  79 FVDAIRDNKTNQFKEKYRNVDVLLIDDIQFLAGKEGTQEEFFHTFNALHE 128
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 106-199 2.11e-14

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 67.17  E-value: 2.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411 106 NPLFLYGGVGLGKTHLMHAIGWYIKqnNPSRKVIYMSAEKFMYQFVKA----LRNKEVISFKEKFRSVDVLMIDDIQFI- 180
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELF--RPGAPFLYLNASDLLEGLVVAelfgHFLVRLLFELAEKAKPGVLFIDEIDSLs 97

                         90
                 ....*....|....*....
gi 110433411 181 CGKDSTQEEFFHTFNTLID 199
Cdd:cd00009   98 RGAQNALLRVLETLNDLRI 116
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 106-199 1.29e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 51.61  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   106 NPLFLYGGVGLGKTHLMHAIGWYIKQnnPSRKVIYMSAEKFMYQFVKALRNKEVISFKEKFRSV---------------D 170
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGP--PGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGElrlrlalalarklkpD 80

                           90       100
                   ....*....|....*....|....*....
gi 110433411   171 VLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLL 109
 
Name Accession Description Interval E-value
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 1-199 5.97e-86

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 260.15  E-value: 5.97e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411    1 PTNFVRDWIKSKYSMVILQLFQHYNNTIKSIEIITKELPgitqTVIALPTKTFADIGSSELNAENIFSTLDVRFTFDNFV 80
Cdd:TIGR00362  39 PNEFVKEWIEKNYLDLIEELLQELFGAEIEIEFTVGEDE----EELEPNSKKPEPAPPEAPAPPSSASGLNPKYTFDNFV 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   81 VGAPNELAYAAARAVAESSGavSESNPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQFVKALRNKEVI 160
Cdd:TIGR00362 115 VGKSNRLAHAAALAVAENPG--KAYNPLFIYGGVGLGKTHLLHAIGNEILENNPNAKVLYVSSEKFTNDFVNALRNNKME 192

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 110433411  161 SFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:TIGR00362 193 EFKEKYRSVDLLLIDDIQFLAGKERTQEEFFHTFNALHE 231
dnaA PRK00149
chromosomal replication initiator protein DnaA;
1-199 1.73e-77

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 237.34  E-value: 1.73e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   1 PTNFVRDWIKSKYSMVILQLFQhynntiksieiitkelpgitqtvialptktfadigsselnaenifstLDVRFTFDNFV 80
Cdd:PRK00149  44 PNRFVKDWIEKNYLDLIEEALQ-----------------------------------------------LNPKYTFDNFV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  81 VGAPNELAYaaaravaESSGAVSES-----NPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQFVKALR 155
Cdd:PRK00149  77 VGKSNRLAH-------AAALAVAENpgkayNPLFIYGGVGLGKTHLLHAIGNYILEKNPNAKVVYVTSEKFTNDFVNALR 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 110433411 156 NKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:PRK00149 150 NNTMEEFKEKYRSVDVLLIDDIQFLAGKERTQEEFFHTFNALHE 193
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
70-199 1.16e-70

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 216.60  E-value: 1.16e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  70 LDVRFTFDNFVVGAPNELAYaaaravaESSGAVSES-----NPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAE 144
Cdd:COG0593    1 LNPRYTFDNFVVGPSNRLAH-------AAALAVAEWpgkayNPLFLYGGVGLGKTHLLHAIGNEALENNPGARVVYLTAE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110433411 145 KFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:COG0593   74 EFTNDFINAIRNNTIEEFKEKYRSVDVLLIDDIQFLAGKEATQEEFFHTFNALRE 128
Bac_DnaA pfam00308
Bacterial dnaA protein;
70-199 8.29e-62

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 191.39  E-value: 8.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   70 LDVRFTFDNFVVGAPNELAYAAARAVAESSGAVSesNPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAEKFMYQ 149
Cdd:pfam00308   1 LNPRYTFENFVIGPSNRFAHAAALTVAKAPGKAY--NPLFIYGGVGLGKTHLLHAIGNYALQNAPNLRVVYLTAEEFLND 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 110433411  150 FVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:pfam00308  79 FVDAIRDNKTNQFKEKYRNVDVLLIDDIQFLAGKEGTQEEFFHTFNALHE 128
dnaA PRK14086
chromosomal replication initiator protein DnaA;
70-197 6.66e-43

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 151.52  E-value: 6.66e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  70 LDVRFTFDNFVVGAPNELAYAaaravaeSSGAVSES-----NPLFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSAE 144
Cdd:PRK14086 281 LNPKYTFDTFVIGASNRFAHA-------AAVAVAEApakayNPLFIYGESGLGKTHLLHAIGHYARRLYPGTRVRYVSSE 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110433411 145 KFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTL 197
Cdd:PRK14086 354 EFTNEFINSIRDGKGDSFRRRYREMDILLVDDIQFLEDKESTQEEFFHTFNTL 406
PRK12422 PRK12422
chromosomal replication initiator protein DnaA;
67-197 2.13e-29

chromosomal replication initiator protein DnaA;


Pssm-ID: 183521 [Multi-domain]  Cd Length: 445  Bit Score: 112.62  E-value: 2.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  67 FSTLDVRFTFDNFVVGAPNELAYAAARAVAESSGAVSES--NPLFLYGGVGLGKTHLMHAIGWYIKQNNpsRKVIYMSAE 144
Cdd:PRK12422 101 YGELDPLMTFANFLVTPENDLPHRILQEFTKVSEQGKGFpfNPIYLFGPEGSGKTHLMQAAVHALRESG--GKILYVRSE 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110433411 145 KFMYQFVKALRNKEVISFKEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFNTL 197
Cdd:PRK12422 179 LFTEHLVSAIRSGEMQRFRQFYRNVDALFIEDIEVFSGKGATQEEFFHTFNSL 231
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 106-199 2.11e-14

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 67.17  E-value: 2.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411 106 NPLFLYGGVGLGKTHLMHAIGWYIKqnNPSRKVIYMSAEKFMYQFVKA----LRNKEVISFKEKFRSVDVLMIDDIQFI- 180
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELF--RPGAPFLYLNASDLLEGLVVAelfgHFLVRLLFELAEKAKPGVLFIDEIDSLs 97

                         90
                 ....*....|....*....
gi 110433411 181 CGKDSTQEEFFHTFNTLID 199
Cdd:cd00009   98 RGAQNALLRVLETLNDLRI 116
DnaA_homol_Hda TIGR03420
DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). ...
 75-195 1.36e-13

DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274571 [Multi-domain]  Cd Length: 226  Bit Score: 66.83  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   75 TFDNFVVGaPNELAYAAAravaESSGAVSESNPLFLYGGVGLGKTHLMHAIGWYIKQNnpSRKVIYMSAeKFMYQFVkal 154
Cdd:TIGR03420  13 TFDNFYAG-GNAELLAAL----RQLAAGKGDRFLYLWGESGSGKSHLLQAACAAAEER--GKSAIYLPL-AELAQAD--- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 110433411  155 rnKEVISFKEKFrsvDVLMIDDIQFICGKDSTQEEFFHTFN 195
Cdd:TIGR03420  82 --PEVLEGLEQA---DLVCLDDVEAIAGQPEWQEALFHLYN 117
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
102-177 3.87e-09

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 54.40  E-value: 3.87e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110433411 102 VSESNPLFLYGGVGLGKTHLMHAIGWY-IKQNnpsRKVIYMSAEKFMYQFVKALRNKEVISFKEKFRSVDVLMIDDI 177
Cdd:COG1484   96 IERGENLILLGPPGTGKTHLAIALGHEaCRAG---YRVRFTTAPDLVNELKEARADGRLERLLKRLAKVDLLILDEL 169
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 106-199 1.29e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 51.61  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411   106 NPLFLYGGVGLGKTHLMHAIGWYIKQnnPSRKVIYMSAEKFMYQFVKALRNKEVISFKEKFRSV---------------D 170
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGP--PGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGElrlrlalalarklkpD 80

                           90       100
                   ....*....|....*....|....*....
gi 110433411   171 VLMIDDIQFICGKDSTQEEFFHTFNTLID 199
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLL 109
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 108-177 6.66e-06

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 45.66  E-value: 6.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110433411 108 LFLYGGVGLGKTHLMHAIGWYIKQNnpSRKVIYMSAEKFMYQFVKA-LRNKEVISFKEK-FRSVDVLMIDDI 177
Cdd:PRK06835 186 LLFYGNTGTGKTFLSNCIAKELLDR--GKSVIYRTADELIEILREIrFNNDKELEEVYDlLINCDLLIIDDL 255
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 108-177 2.16e-05

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 44.09  E-value: 2.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110433411 108 LFLYGGVGLGKTHLMHAIGWYIKQNNPSRKVIYMSaekfmyQFVKALRNKevI---SFKEK---FRSVDVLMIDDI 177
Cdd:PRK08939 159 LYLYGDFGVGKSYLLAAIANELAKKGVSSTLLHFP------EFIRELKNS--IsdgSVKEKidaVKEAPVLMLDDI 226
PRK08084 PRK08084
DnaA inactivator Hda;
75-195 1.99e-04

DnaA inactivator Hda;


Pssm-ID: 181224 [Multi-domain]  Cd Length: 235  Bit Score: 40.82  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110433411  75 TFDNFVVGAPNELAYAAARAVAESSGAVsesnpLFLYGGVGLGKTHLMHAIGWYIKQNNpsRKVIYMSAEKFMYqFVKAL 154
Cdd:PRK08084  20 TFASFYPGDNDSLLAALQNALRQEHSGY-----IYLWSREGAGRSHLLHAACAELSQRG--RAVGYVPLDKRAW-FVPEV 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 110433411 155 RnkevisfkEKFRSVDVLMIDDIQFICGKDSTQEEFFHTFN 195
Cdd:PRK08084  92 L--------EGMEQLSLVCIDNIECIAGDELWEMAIFDLYN 124
DnaA_N pfam11638
DnaA N-terminal domain; This family of proteins represents the N-terminal domain of DnaA, a ...
 1-22 1.62e-03

DnaA N-terminal domain; This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known. It is also found in three copies in some proteins. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerization.


Pssm-ID: 463316 [Multi-domain]  Cd Length: 65  Bit Score: 35.72  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|..
gi 110433411    1 PTNFVRDWIKSKYSMVILQLFQ 22
Cdd:pfam11638  43 PNRFVRDWVEEHYLDRILELWQ 64
PRK08903 PRK08903
DnaA regulatory inactivator Hda; Validated
 75-125 3.59e-03

DnaA regulatory inactivator Hda; Validated


Pssm-ID: 236347 [Multi-domain]  Cd Length: 227  Bit Score: 36.88  E-value: 3.59e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 110433411  75 TFDNFVVGAPNELAYAAARAVAESSGAVSesnpLFLYGGVGLGKTHLMHAI 125
Cdd:PRK08903  16 TFDNFVAGENAELVARLRELAAGPVADRF----FYLWGEAGSGRSHLLQAL 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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