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Conserved domains on  [gi|115646574|gb|ABJ17082|]
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RT01042p [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10603440)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 5.29e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 5.29e-07
                          10        20
                  ....*....|....*....|....*.
gi 115646574  243 ELARHKRSHSGVKPYKCDYCSKCFAR 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-277 9.87e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 9.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115646574 193 GERGYLCTFGNCEKIYAKPAHLKAH-LRRHLGEKPYVCSWPDCVWRFSRSDelarhkrshsgvKPYKCDYCSKCFARSDH 271
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNG 413


                 ....*.
gi 115646574 272 LTKHRK 277
Cdd:COG5189  414 LKYHRK 419
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 5.29e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 5.29e-07
                          10        20
                  ....*....|....*....|....*.
gi 115646574  243 ELARHKRSHSGVKPYKCDYCSKCFAR 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-277 9.87e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 9.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115646574 193 GERGYLCTFGNCEKIYAKPAHLKAH-LRRHLGEKPYVCSWPDCVWRFSRSDelarhkrshsgvKPYKCDYCSKCFARSDH 271
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNG 413


                 ....*.
gi 115646574 272 LTKHRK 277
Cdd:COG5189  414 LKYHRK 419
ZnF_C2H2 smart00355
zinc finger;
257-279 2.37e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 2.37e-03
                           10        20
                   ....*....|....*....|...
gi 115646574   257 YKCDYCSKCFARSDHLTKHRKVH 279
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 5.29e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 5.29e-07
                          10        20
                  ....*....|....*....|....*.
gi 115646574  243 ELARHKRSHSGVKPYKCDYCSKCFAR 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 193-277 9.87e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 9.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115646574 193 GERGYLCTFGNCEKIYAKPAHLKAH-LRRHLGEKPYVCSWPDCVWRFSRSDelarhkrshsgvKPYKCDYCSKCFARSDH 271
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEKMNIFSAKD------------KPYRCEVCDKRYKNLNG 413


                 ....*.
gi 115646574 272 LTKHRK 277
Cdd:COG5189  414 LKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-263 1.14e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115646574 203 NCEKIYAKPAHLKAHLR--RHLGE--KPYVCSWPDCVWRFSRSDELARHKRSHSGVKPYKCDYCS 263
Cdd:COG5048  294 QCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLN 358
ZnF_C2H2 smart00355
zinc finger;
257-279 2.37e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.75  E-value: 2.37e-03
                           10        20
                   ....*....|....*....|...
gi 115646574   257 YKCDYCSKCFARSDHLTKHRKVH 279
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-277 2.81e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.81e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115646574 203 NCEKIYAKPAHLKAHLRRHLGEKPYVCSWPDCVWRFSRSDELARHKRSHSGVKPykcDYCSKCFARSDHLTKHRK 277
Cdd:COG5048   38 NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPS---DLNSKSLPLSNSKASSSS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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