|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-222 |
8.92e-149 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 434.99 E-value: 8.92e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:PRK07561 121 VVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTDFRLQVAQKDGVVFKP---TNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAA 157
Cdd:PRK07561 201 EEYWDIHADLTTPRGDAFEARLTHLDGKKFAPvdlLNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEA 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117956951 158 STRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSK 222
Cdd:PRK07561 281 SRKLGFSVKKTMRIAQRLYEAGYITYMRTDSTNLSQEAINAARGYIGDNYGKKYLPEKPRQYSSK 345
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-223 |
5.66e-117 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 343.62 E-value: 5.66e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:COG0550 105 VVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRGLSAGRVQSPALRLIVEREREIEAFVP 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTdFRLQVAQKDGVVFKptNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAASTR 160
Cdd:COG0550 185 EEYWTIEATFKTGGGE-FTAKLVKIDGKKIL--DEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRK 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117956951 161 LGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSKE 223
Cdd:COG0550 262 LGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSEDAVAAAREYIEALYGKEYLPEKPRVYKTSK 324
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
1-223 |
3.06e-102 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 308.16 E-value: 3.06e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:TIGR01051 104 IVFNEITKKAIRAALKNPREIDMNLVNAQQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTdFRLQVAQKDGVVFKP---TNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAA 157
Cdd:TIGR01051 184 EEYWTIDATFQKGEET-FEALLTEVNGKKLKAgsdLDEAEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEA 262
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117956951 158 STRLGYGVKKTMMLAQRLYEA--------GYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSKE 223
Cdd:TIGR01051 263 SRKLGFSAKKTMMIAQRLYEGvstgdgtiGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPKRYKSKE 336
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
20-219 |
5.72e-66 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 209.02 E-value: 5.72e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 20 ELSMDGVNAQQARRFMDRVVGFMVSPLLWKKV--ARGLSAGRVQSVAVKLLVEREREIKAFIPEEFW*IHANTQtqsKTD 97
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkgNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLK---DGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 98 FRLQVAQKDGVVFKptNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYE 177
Cdd:pfam01131 78 GVFANAKWKRGRIF--DKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 117956951 178 -AGYITYMRTDSTNLSSEA-VETLREYIGSEYGEaYLPASKLVY 219
Cdd:pfam01131 156 kHGLITYPRTDSTYLSDDAtLKAILEYLTKNYGK-YLPYAPRLL 198
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
23-222 |
7.42e-66 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 207.84 E-value: 7.42e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 23 MDGVNAQQARRFMDRVVGFMVSPLLWKKVAR--GLSAGRVQSVAVKLLVEREREIKAFIPEEFW*Ihantqtqsktdfrl 100
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRkgVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEI-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 101 qvaqKDGVVfkptnqadtmaaVSVlenaafevckrEDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGY 180
Cdd:cd00186 67 ----KEAVV------------VSV-----------EKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGL 119
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 117956951 181 ITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSK 222
Cdd:cd00186 120 ITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGRRN 161
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
1-84 |
1.10e-41 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 136.56 E-value: 1.10e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVAR-GLSAGRVQSVAVKLLVEREREIKAFI 79
Cdd:smart00436 4 IEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIKNFV 83
|
....*
gi 117956951 80 PEEFW 84
Cdd:smart00436 84 PKPYW 88
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-222 |
8.92e-149 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 434.99 E-value: 8.92e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:PRK07561 121 VVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTDFRLQVAQKDGVVFKP---TNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAA 157
Cdd:PRK07561 201 EEYWDIHADLTTPRGDAFEARLTHLDGKKFAPvdlLNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEA 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117956951 158 STRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSK 222
Cdd:PRK07561 281 SRKLGFSVKKTMRIAQRLYEAGYITYMRTDSTNLSQEAINAARGYIGDNYGKKYLPEKPRQYSSK 345
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-223 |
5.66e-117 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 343.62 E-value: 5.66e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:COG0550 105 VVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRGLSAGRVQSPALRLIVEREREIEAFVP 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTdFRLQVAQKDGVVFKptNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAASTR 160
Cdd:COG0550 185 EEYWTIEATFKTGGGE-FTAKLVKIDGKKIL--DEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRK 261
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117956951 161 LGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSKE 223
Cdd:COG0550 262 LGFSAKKTMSIAQRLYEVGLITYMRTDSVRLSEDAVAAAREYIEALYGKEYLPEKPRVYKTSK 324
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-222 |
2.36e-110 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 330.67 E-value: 2.36e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:PRK06599 111 VVFNEITKKAVQEAIENPRDIDMDLVDAQQARRALDYLVGFKLSPLLWKKVRRGLSAGRVQSVALRLICEREDEIEAFIP 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTDFRLQVAQKDG---VVFKPTNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAA 157
Cdd:PRK06599 191 QEYWTIEADLATSNGEPFTAKLVEVNGkklEKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEA 270
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117956951 158 STRLGYGVKKTMMLAQRLYEA--------GYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSK 222
Cdd:PRK06599 271 SRKLGFSAKKTMRIAQKLYEGidlgegtvGLITYMRTDSVRLSNEALDEARKYITKKYGKEYLPAKPRVYKKK 343
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
1-223 |
3.06e-102 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 308.16 E-value: 3.06e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:TIGR01051 104 IVFNEITKKAIRAALKNPREIDMNLVNAQQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVP 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQTQSKTdFRLQVAQKDGVVFKP---TNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAA 157
Cdd:TIGR01051 184 EEYWTIDATFQKGEET-FEALLTEVNGKKLKAgsdLDEAEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEA 262
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117956951 158 STRLGYGVKKTMMLAQRLYEA--------GYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSKE 223
Cdd:TIGR01051 263 SRKLGFSAKKTMMIAQRLYEGvstgdgtiGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPKRYKSKE 336
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-222 |
6.07e-75 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 240.82 E-value: 6.07e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIP 80
Cdd:PRK08780 112 VVFTEITPRAIKEAMAKPRDIASDLVDAQQARRALDYLVGFNLSPLLWRKIQRGLSAGRVQSPALRMIVEREEEIEAFIA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 81 EEFW*IHANTQtQSKTDFRLQVAQKDGVVFKP---TNQADTMAAVSVLENAA---FEVCKREDRPTSSKPSAPFITSTLQ 154
Cdd:PRK08780 192 REYWSIEADCA-HPSQPFNAKLIKLDGQKFEQftiTDGDTAEAARLRIQQAAqgtLHVTDVESKERKRNPAPPFTTSTLQ 270
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117956951 155 QAASTRLGYGVKKTMMLAQRLYEA---------GYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSK 222
Cdd:PRK08780 271 QEASRKLGFTTRRTMQVAQKLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASLPDQPNTYKTK 347
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
20-219 |
5.72e-66 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 209.02 E-value: 5.72e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 20 ELSMDGVNAQQARRFMDRVVGFMVSPLLWKKV--ARGLSAGRVQSVAVKLLVEREREIKAFIPEEFW*IHANTQtqsKTD 97
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkgNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLK---DGG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 98 FRLQVAQKDGVVFKptNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYE 177
Cdd:pfam01131 78 GVFANAKWKRGRIF--DKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 117956951 178 -AGYITYMRTDSTNLSSEA-VETLREYIGSEYGEaYLPASKLVY 219
Cdd:pfam01131 156 kHGLITYPRTDSTYLSDDAtLKAILEYLTKNYGK-YLPYAPRLL 198
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
23-222 |
7.42e-66 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 207.84 E-value: 7.42e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 23 MDGVNAQQARRFMDRVVGFMVSPLLWKKVAR--GLSAGRVQSVAVKLLVEREREIKAFIPEEFW*Ihantqtqsktdfrl 100
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRkgVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEI-------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 101 qvaqKDGVVfkptnqadtmaaVSVlenaafevckrEDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGY 180
Cdd:cd00186 67 ----KEAVV------------VSV-----------EKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGL 119
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 117956951 181 ITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPASKLVYGSK 222
Cdd:cd00186 120 ITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGRRN 161
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-223 |
7.94e-66 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 217.77 E-value: 7.94e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVAR--GLSAGRVQSVAVKLLVEREREIKAF 78
Cdd:PRK06319 107 ISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQRrsGVSAGRVQSVALKLVVDREKAIEAF 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 79 IPEEFW*IHANTQT-QSKTDFRLQVAQKDGV--------------VFKPTNQADTMAAVSVLENAAFEVCKREDRPTSSK 143
Cdd:PRK06319 187 VPVEYWNIRVHLKDpKTQKTFWAHLYSVDGKkwekeipegktedeVLLINSKEKADHIVELLESATYTVTRVESKEKRRN 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 144 PSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEA---------GYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLPA 214
Cdd:PRK06319 267 AYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYEGvdldsegatGLITYMRTDSVRTDPEALKQVRKYIEGTFGKEFLPS 346
|
....*....
gi 117956951 215 SKLVYGSKE 223
Cdd:PRK06319 347 SPNVYTTKK 355
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
1-84 |
1.10e-41 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 136.56 E-value: 1.10e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVAR-GLSAGRVQSVAVKLLVEREREIKAFI 79
Cdd:smart00436 4 IEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIKNFV 83
|
....*
gi 117956951 80 PEEFW 84
Cdd:smart00436 84 PKPYW 88
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
3-212 |
3.99e-37 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 137.41 E-value: 3.99e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 3 FNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARG-LSAGRVQSVAVKLLVEREREIKafipe 81
Cdd:COG1110 787 FHEVTRKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLGWIIERYEESR----- 861
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 82 efw*ihantqtQSKTDF-RLQVAQKDGVVFKPTNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQAASTR 160
Cdd:COG1110 862 -----------KSKKYLiILTLENGRLELSIEDLKEAEEVRKALEKEVKVKVKKVEEEEEELNPLPPYTTDTLLRDASRR 930
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 117956951 161 LGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYL 212
Cdd:COG1110 931 LGLSAEETMRLAQDLFESGLITYHRTDSTRVSDAGIAVAKEYISERFGEEYF 982
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
3-212 |
5.82e-37 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 136.88 E-value: 5.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 3 FNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVA-RGLSAGRVQSVAVKLLVEREREIKAFIPE 81
Cdd:TIGR01054 756 FHEVTRRAILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFNkRWLSAGRVQTPVLGWIIDRYRESREKRGY 835
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 82 Efw*IHANtqtqsKTDFRLQVAQKDGVVFKPTNQADTMAAVSVLENaafevcKREDRPtsskPSAPFITSTLQQAASTRL 161
Cdd:TIGR01054 836 L--LIFAL-----ESDFRLGLEHDNRLEAKEFEKDLTWLDVEDIAE------REEERN----PLPPYTTDTMLEDANRKL 898
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 117956951 162 GYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYL 212
Cdd:TIGR01054 899 GLSVKETMQIAQELFENGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEYF 949
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
3-189 |
2.66e-36 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 134.74 E-value: 2.66e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 3 FNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVG------FMVSPllwKKVARG--LSAGRVQSVAVKLLVERERE 74
Cdd:PRK07219 135 FSSLTKKEIRKAFENPDEIDFNLADAGEARQIIDLYWGaaltrfLSLSV---RQLGRWdfLSVGRVQTPTLAFIVDRERE 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 75 IKAFIPEEFW*IHANTQTQsktdfrlqvAQKDGVVFKPTNQADTMAAVSVlENAAFE---------VCKREDRPTSSKPS 145
Cdd:PRK07219 212 IRAFDPEDYWKIEALLDKE---------AQYFYRDLIGGHEAEKFWDEEE-AEEIYEklkgakeatVSSVKKRERTISPP 281
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 117956951 146 APFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDST 189
Cdd:PRK07219 282 APFNTTEFLREASKIFGISPKRAMEIAEKLYTAGYISYPRTDNT 325
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
136-213 |
1.19e-33 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 121.20 E-value: 1.19e-33
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117956951 136 EDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYLP 213
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLD 78
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
1-223 |
1.64e-29 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 115.24 E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 1 VVFNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVAR-G---LSAGRVQSVAVKLLVEREREIK 76
Cdd:PRK07220 134 VRYSAITKKEIERAFSNPVEVDFNLADAGHSRQVIDLVWGAALTRYISLAAGRlGkmfLSVGRVQSPTLALIVDREKERE 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 77 AFIPEEFW*IHANTQTQSKTdFrlqVAQKDGVVFKPTNQADtmAAVSVLENAAfEVCKREDRPTSSKPSAPFITSTLQQA 156
Cdd:PRK07220 214 AFVPTPYWEIYATLENNGET-F---VAQHSTRRFWEKEEAD--RVFEKLGKTA-EVTEVEKGTKTDKPPTPFNTTEFISA 286
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117956951 157 ASTrLGYGVKKTMMLAQRLYEAGYITYMRTDST------NLsSEAVETLREYIGSEYGEAYLPASKLV--YGSKE 223
Cdd:PRK07220 287 ANS-IGFSAANAMRIAESLYTNGYISYPRTDNTvypeslDL-REQIEIFAEGPFGEYAQKLLEKGELVptRGKKE 359
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
55-201 |
1.14e-27 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 109.87 E-value: 1.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 55 LSAGRVQSVAVKLLVEREREIKAFIPEEFW*IHAntQTQSKTDFRLQVAQKDGVVFKPT---NQADTMAAVSVLENAAFE 131
Cdd:PRK07726 187 LSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEA--HLTPGERFTAKWQPSEPYQDEEGrllDRPLAEQVVARIQGQPAK 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117956951 132 VCKREDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYE-AGYITYMRTDSTNLSSEAVETLRE 201
Cdd:PRK07726 265 VTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYEtHKLITYPRTDSRYLPEDMVATLPE 335
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
3-189 |
1.31e-25 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 104.16 E-value: 1.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 3 FNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARG----LSAGRVQSVAVKLLVEREREIKAF 78
Cdd:PRK14973 135 FSAITKEEIVTAFAEPTDLDFALAAAGEARQIIDLIWGASLTRFISLAAHRGgdniLSVGRVQSPTLAMIVDREKEIEAF 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 79 IPEEFW*IHANTQTQSK-----------TDFRLQVAQKDGVVfkptnqaDTMAAVSVLENaafevcKREDR-PTsskpsa 146
Cdd:PRK14973 215 VPEKYWMLSLATEKDGEgiearhthgrfTDSAAAEAAYDATK-------EPLVVTEVKEG------HKVDRaPT------ 275
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 117956951 147 PFITSTLQQAAStRLGYGVKKTMMLAQRLYEAGYITYMRTDST 189
Cdd:PRK14973 276 PFDTTTFIVAAS-RLGFSAANAMRIAEDLYMNGYISYPRTDNT 317
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
3-191 |
1.76e-21 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 91.98 E-value: 1.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 3 FNEITKNAIQQAFEKPGELSMDGVNAQQARRFMDRVVGFMVSPLLWK--KVARG----LSAGRVQSVAVKLLVEREREIK 76
Cdd:PRK05776 132 FSALTKSDIRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMSsvRDASGkrviLSAGRVQSPTLKYVVEREIERN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 77 AFIPEEFW*IHANTQTQSKTdFRLQVAQKDgvvFKPTNQADTMAAvSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQA 156
Cdd:PRK05776 212 LFVPLPYFSVSIIIEKNGYE-FTLKYENKK---FETKEEAKEILE-EIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVE 286
|
170 180 190
....*....|....*....|....*....|....*
gi 117956951 157 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNL 191
Cdd:PRK05776 287 AARIYGFSPYKTQSIAEDLYLDGLISYPRTNSQKL 321
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
4-203 |
2.43e-18 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 82.97 E-value: 2.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 4 NEITKNAIQQAFEK--PGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARG-----LSAGRVQSVAVKLLVEREREIK 76
Cdd:TIGR01056 134 SSLVDSSIRKAFKNlrPKSETEGLYKSGVARARADWLVGINLTRAFTKLGREAgndgvLSVGRVQTPTLAMVVKRENEIK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 77 AFIPEEFW*IHANTQTQSKtDFRLQVAQKDGVVFKPTNQADTMAAVSVLENAAFEVCKREDRPTSSKPSAPFITSTLQQA 156
Cdd:TIGR01056 214 NFVGKPFYEVSATINKDEQ-EFTTEWQPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQED 292
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 117956951 157 ASTRLGYGVKKTMMLAQRLYEAG-YITYMRTDSTNLSSEAVETLREYI 203
Cdd:TIGR01056 293 ANKRFGISAKRTLDIAQKLYETHkLITYPRTDSRYLPEDEKEMLLEVL 340
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
6-212 |
2.34e-16 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 77.29 E-value: 2.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 6 ITKNAIQQAFEK--PGELSMDGVNAQQARRFMDRVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFIPEE- 82
Cdd:PTZ00407 168 ITEDGIRKAMRErhVEACDYDLANAAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILINEREDKIKAFLESNk 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 83 -FW*IHANTQTQSKTDFRL-QV-----AQKDGvvfkPTNQADTMAAVSVLENAAFEVCK-----REDRPTSSK--PSAPF 148
Cdd:PTZ00407 248 sTFEVQAMCQFPSPHGTTFsQVvtitpDRKGG----ASHWATEAEARRCLEQWKLNNCTgfsvpLEPKPQPSVvpPPQPF 323
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117956951 149 ITSTLQQAASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSSEAVETLREYIGSEYGEAYL 212
Cdd:PTZ00407 324 TMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYAAVKKEFGKEFL 387
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
58-216 |
1.51e-15 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 75.09 E-value: 1.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 58 GRVQSVAVKLLVEREREIKAFIPEEFW*IHANtqtqsktdFRLQVAQKDGVVFKPT---NQADTMAAVSVL-ENAAFE-- 131
Cdd:PRK08173 194 GRVQTPTLSIVVEREEKIRRFVPRDYWEVRAE--------FVAAAGFYEGRWFDPKfkkDEFDPEKRASRLwSEAAAEai 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 132 VCKREDRPTS----SKPS---AP--FITSTLQQAASTRLGYGVKKTMMLAQRLYEA-GYITYMRTDSTNLSSEAVETLRE 201
Cdd:PRK08173 266 VAACRGKPGTvteeSKPStqlSPllFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKQ 345
|
170
....*....|....*.
gi 117956951 202 YIGS-EYGEAYLPASK 216
Cdd:PRK08173 346 TLEMlKESNNYLPHAK 361
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
56-201 |
9.90e-15 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 72.68 E-value: 9.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 56 SAGRVQSVAVKLLVEREREIKAFIPEEFW*IHANtqtqsktdFRLQVAQKDGVVFKPT----------------NQADTM 119
Cdd:PRK14724 200 TVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAG--------FHAEAGEYLGKWFDPQwkkasddpearadrvwSEREAR 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117956951 120 AAVSVLENAAFEVCKrEDRPTSSKPSAPFITSTLQQAASTRLGYGVKKTMMLAQRLYEA-GYITYMRTDSTNLSSEAVET 198
Cdd:PRK14724 272 AIADAVRGKAATVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPV 350
|
...
gi 117956951 199 LRE 201
Cdd:PRK14724 351 AKQ 353
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
1-18 |
7.03e-04 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 38.31 E-value: 7.03e-04
|
| |
