|
Name |
Accession |
Description |
Interval |
E-value |
| emrD |
PRK11652 |
multidrug transporter EmrD; |
33-418 |
0e+00 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 559.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:PRK11652 9 LLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVL 192
Cdd:PRK11652 89 VALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVFVWLLLLVGFKESLPSYKREHnPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSC 272
Cdd:PRK11652 169 LLLGAGVTFSMARWMPETRPADARRT-RVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLSSMTVSI 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 273 YFVAPIPGYLLGALIAGKQTKTQ-RTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEP 351
Cdd:PRK11652 248 LFILPIPAAFFGAWFAGRPNKRFsTLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGMLFPLATSGAMEP 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120558890 352 FPRQAGIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIASLHYAKDQNDTHQNLM 418
Cdd:PRK11652 328 FPYLAGTAGALLGGLQNIGSGLAALLSAMLPQTGQFSLGLLMTLMGLLILLCWLPLATRMSHQGQPV 394
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
34-407 |
2.76e-92 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 282.93 E-value: 2.76e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLA 193
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 194 GFGVFVWLLLLVGFKESLPSYKREHNP--IIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVS 271
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPLLssLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 272 CYFVAPIPGYLLGALIAGKQTK---TQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAA 348
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRrfgPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 349 LEPFPRQAGIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIASLHYA 407
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-374 |
2.73e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 146.66 E-value: 2.73e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVL 192
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVFVWLLLLVGFKESLPSYKRehnPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSC 272
Cdd:COG2814 171 AVLALLALLLLLRLLPESRPAARA---RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 273 YFVAPIPGYLLGALIAGKQTKtqRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPF 352
Cdd:COG2814 248 LLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
330 340
....*....|....*....|...
gi 120558890 353 P-RQAGIAGALLGGLQNFGAGLA 374
Cdd:COG2814 326 PpEARGRASGLYNSAFFLGGPLA 348
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
33-407 |
2.54e-36 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 137.13 E-value: 2.54e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:TIGR00710 6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVL 192
Cdd:TIGR00710 86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVFVWLLLLVGFKESLPSYKREHNPIIAS-YRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVS 271
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPYEARIQISTYFEtFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 272 CYFVAPI-----PGYLLGALIAGKQTKTQRTVyqGVALLGTGALFMLIPGIFLLVStWSLLVGSVLFFS-GAGMLFPTLT 345
Cdd:TIGR00710 246 LLFALNIiamifGGFLNGRFIKKWGAKSLLRM--GLILFAVSAVLLEITAILGLGS-WAMIIGPMMFVGiGNSMISSIAM 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 120558890 346 SAALEPFPRQAGIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIASLHYA 407
Cdd:TIGR00710 323 AYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYL 384
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
51-399 |
3.65e-36 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 136.20 E-value: 3.65e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 51 FVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQ 130
Cdd:PRK11102 10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 131 GLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKES 210
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 211 LPSYKREH---NPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVAPIPGYLLGALI 287
Cdd:PRK11102 170 LPKERRQPfhlRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFLFVMTII 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 288 AGKQTKTqrtvYQGVALLGTGALFMLIPGIFLLVST------WSLLVGSVLFFSGAGMLFPTLTSAALEPFPRQAGIAGA 361
Cdd:PRK11102 250 NSRFVRR----VGALNMLRFGLWIQFIMGIWLVVSAlldlgfWALVVGVAAFVGCVSMISSNAMAVILDEFPHMAGTASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 120558890 362 LLGGLQnFGAG------LAALSM-SVMPMGGqlSIGLLSTMMVIL 399
Cdd:PRK11102 326 LAGTLR-FGIGaivgalLSLAPFtSAWPMVW--SMAFCSILSILF 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
33-404 |
4.28e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 111.12 E-value: 4.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMvacGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:cd17474 3 AVFFATLL---AVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMtAYFGWQAVYWVL 192
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVFVWLLLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSC 272
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 273 YFVAPIPGYLLGALIAGKQTKTQrtvYQGVALLGTGALFMLIP--GIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALE 350
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKR---FGARRILVIGLLLYALSllLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTE 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 120558890 351 PFPRQA-GIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17474 316 LAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
37-402 |
4.68e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 111.13 E-value: 4.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 37 LVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAAR 116
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 117 AQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFG 196
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 197 VFVWLLLLVGFKESLPSYKREHN---PIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCY 273
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 274 FVAPIPGYLLGALIAGKqtKTQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPFP 353
Cdd:cd17325 241 FGAQGLASALSQPPAGK--LSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 120558890 354 RQA-GIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIA 402
Cdd:cd17325 319 PEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAA 368
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
34-390 |
7.01e-27 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 110.34 E-value: 7.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVAcgqMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:cd17321 1 LLLAVFLAA---LDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLA 193
Cdd:cd17321 78 CALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 194 GFGVFVWLLllvgfkeslpsykrehnpiiasyrhvlrHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCY 273
Cdd:cd17321 158 PIGLVALLL----------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 274 FVAPIPGYLLGALIAGKQTKT---QRTVYQGVALLGTGALFMLIpgIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALE 350
Cdd:cd17321 210 LLPLALAMLVAAPLAGRLADRfgpRLVLVAGLLLTAVGLLLLAL--LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALS 287
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 120558890 351 PFPR-QAGIAGALLGGLQNFGAGLA-ALSMSVMPMGGQLSIG 390
Cdd:cd17321 288 SVPKeKAGAASGILNTARQLGGALGvALLGALLTAGLSANLG 329
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
36-399 |
3.75e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 108.41 E-value: 3.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 36 MLVFMVACGQMAQTIFVPA--LPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQglLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLA 193
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 194 GFGVFVwLLLLVGFKESLPSYKREHNPIIASYRHVLRHRG-FRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSC 272
Cdd:cd17324 161 VLALLA-ALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRlRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 273 YFVAPIPGyLLGALIAGKQTKtqRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPF 352
Cdd:cd17324 240 LLLFGVAG-VVGSPLAGRLAD--RGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 120558890 353 PRQAGIAGALLGGLQNFGAGL-AALSMSVMPMGGQLSIGLLSTMMVIL 399
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALgAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-375 |
1.98e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 103.27 E-value: 1.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 37 LVFMVACGQMAQTIFVPALPQ-IALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAA 115
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 116 RAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGF 195
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 196 GVFVWLLLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVL--YGQYLGLPPFIVSCY 273
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLplYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 274 FVAPIPGYLLGALIAGK-QTKTQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPF 352
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRlSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 120558890 353 P-RQAGIAGALLGGLQNFGAGLAA 375
Cdd:pfam07690 321 PkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
34-376 |
2.04e-23 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 100.73 E-value: 2.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLA 193
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 194 GFGVFVWLLLLVGFkeslpsykrehnPIIasyrhvlrhrgfrAYLSSLIATFAGI--AAFEAIAGVLYGQYlGLPPFIVS 271
Cdd:cd17323 161 IISGFCLILIFLFL------------PIV-------------LLLGLYVGLVYAIlyLFLTAFPYVFGEVY-GFSPGEVG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 272 CYFVAPIPGYLLGALIAGKQ----TKTQRTVYQGVALLGTGALFMLIPGIFLLVST-------------WSLLVGSVLFF 334
Cdd:cd17323 215 LMYLPIGIGALIGSIIGGRLsdyyYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLfifgwtiyphihwIVPIIGSAFFG 294
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 120558890 335 SGAGMLFPTLTSAALEPFPRQAGIAGALLGGLQNFGAGLAAL 376
Cdd:cd17323 295 FGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPL 336
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
54-404 |
5.50e-23 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 99.71 E-value: 5.50e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 54 ALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLG 133
Cdd:PRK10473 25 GLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 134 TASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKESLPS 213
Cdd:PRK10473 105 AGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 214 YKREHNPIIASYRHVLRHRGFrayLSSLIATFAGIAA---FEAIAGVLY--------GQY------LGLPPFIVScyFVA 276
Cdd:PRK10473 185 RAPAASSKPRENSESLLNRFF---LSRLVITTLSVTViltFVNTSPVLLmeqmgfsrGEYaiimalTAGVSMTVS--FST 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 277 PipgYLLGALiagkqtkTQRTvyqgvaLLGTGALFMLIPGIFLLVST--WSLLVGSVLFFSGAGMLFPTLTSAALEPFPR 354
Cdd:PRK10473 260 P---FALGIF-------KPRT------LMLTSQVLFLAAGITLALSPshAVSLFGITLICAGFSVGFGVAMSQALGPFSL 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 120558890 355 QAGIAGALLGGLQNFGAGLAALSMsvmpmgGQLSIGLLSTMMVILVIASL 404
Cdd:PRK10473 324 RAGVASSTLGIAQVCGSSLWIWLA------AVLGISAWNMLIGILIACSI 367
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
44-406 |
1.28e-22 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 98.81 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 44 GQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQL 123
Cdd:PRK11043 18 GFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 124 IFASLIQGLGTASAGALCRSIPRDHYFGDnlvKFNSYVS--MAVVFL-PLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVW 200
Cdd:PRK11043 98 LVLRFVQAVGVCSAAVIWQALVIDRYPAQ---KANRVFAtiMPLVALsPALAPLLGAWLLNHFGWQAIFATLFAITLLLI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 201 LLLLVgFKESLPSYKREHNPIiaSYRHVLRHrgfRAYLSSLIATFAGIAAFEAiagvlygqYLGLPPFIVSCYFVAP--- 277
Cdd:PRK11043 175 LPTLR-LKPSKKARKQSQDAL--TFKQLLKS---KTYLGNVLIFAACSAAFFA--------WLTGSPFILEQMGYSPadi 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 278 ----IP--------GYLLGALIagKQTKTQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLT 345
Cdd:PRK11043 241 glsyVPqtiaflvgGYGCRAAL--QKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 120558890 346 SAALEPFPRQAGIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGllSTMMVILVIASLHY 406
Cdd:PRK11043 319 AQALRPFPQATGKAAALQNTLQLGLCFLASLLVSALISTPLLTTG--SVMLSTVVLVALGY 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
34-381 |
6.81e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.49 E-value: 6.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLA 193
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 194 GFGVFVWLLLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPP----FI 269
Cdd:COG2223 167 ILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAatagLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 270 VSCYFVAPIPGYLLGALIAGKQTKtqRTVYQGVALLGTGALFMLipgIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAAL 349
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGG--RRVLLIVFALMALGLLLL---ALALGSLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350
....*....|....*....|....*....|...
gi 120558890 350 EPFP-RQAGIAGALLGGLQNFGAGLAALSMSVM 381
Cdd:COG2223 322 DIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-404 |
7.61e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 96.09 E-value: 7.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVL 192
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVF-----VWLLLLVGFKESLPSYkrehnpiiasyrhvlrhrGFRAYLSSLIATFAGIAAFEAIagvlygqylglpp 267
Cdd:COG2271 171 GLPGLLlallrFWLLALAYFLVYFALY------------------GFLTWLPTYLVEVRGLSLAQAG------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 268 FIVSCYFVAPIPGYLLGALIAGKQTKTQRTVYQGVALLGTGALFMLipgiFLLVSTWSLLVGSVLFFSGAGMLFPTLTSA 347
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLL----ALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 348 ALEPFPRQ-AGIAGALLGGLQNFGAGLAALSMSVM--PMGGQLSIGLLSTMMVILVIASL 404
Cdd:COG2271 296 AAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLldATGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
36-396 |
9.31e-22 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 96.11 E-value: 9.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 36 MLVFMvacGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAA 115
Cdd:cd17503 3 LGAFM---AILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 116 RAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGF 195
Cdd:cd17503 80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 196 GVFVWLLLlvgfkeslpsykrehnPIIASyrHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIvSCYFV 275
Cdd:cd17503 160 GILALLLA----------------PLLDL--RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFE-SGLVL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 276 APIP-GYLLGALIAGKQTKT---QRTVYQGVALLGTGALFMLipGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEP 351
Cdd:cd17503 221 APGGlASAILSPLVGRLLDKfgpRLLLLAGLLLLALGTLLLA--FLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNS 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 120558890 352 FPR-QAGIAGALLGGLQNFGAGLA-ALSMSVMPMGGQLSIGLLSTMM 396
Cdd:cd17503 299 LPPeQIGDATALFNTIRQLGGSIGtALLATLLTNRTQFHHSRLSELL 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
33-313 |
6.24e-21 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 92.18 E-value: 6.24e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVL 192
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVFVWLLLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSC 272
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 120558890 273 YFVAPIPGYLLGALIAGKQTKTQRTVYQGVALLGTGALFML 313
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
76-210 |
1.46e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 81.54 E-value: 1.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 76 YLIAYGLFQFVYGPLS----DRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFG 151
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 152 DNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKES 210
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
37-375 |
3.55e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 79.54 E-value: 3.55e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 37 LVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAAR 116
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 117 AQHFNQLIFASLIQGLGTASAGaLCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFG 196
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 197 VFVWLLLlvgfkeslpsykrehnPIIAsyRHVLRHRGFraYLSSLIATFAGIAAFEAIAGVLY------GQYLGLPPFIV 270
Cdd:cd17504 160 VLLAALV----------------PLID--LRLLRRRNV--LLANITALLAGFGMFMVFQLLPQllqlptPTGFGLGITEA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 271 SCYFVAPIPGYLLGALIAGKQTK---TQRTVYQGVALLGTGALFMLipgiFLLVSTWSLLVGSVLFFSGAGMLFPTLTSA 347
Cdd:cd17504 220 GLLLLPGALVMLIAGPLAGRLIArvgPRRVLLIGLVISAVGLLLLA----LLHSSLWALVVALLLIGIGLGLAFASLPNI 295
|
330 340
....*....|....*....|....*....
gi 120558890 348 ALEPFPR-QAGIAGALLGGLQNFGAGLAA 375
Cdd:cd17504 296 VVESVPPdRTGIATGMNTVLRTIGSAIGP 324
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
46-404 |
9.40e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.24 E-value: 9.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 46 MAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIF 125
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 126 ASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAY--FGWQAVYWVLAGFGVFVWLLL 203
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 204 LVGFKESLPSYKREHNP-----IIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVAPI 278
Cdd:cd06174 170 LLVVPDPPESARAKNEEassksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 279 PGYLLGALIAGKQTKTQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPFPRQAGI 358
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGT 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 120558890 359 AGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd06174 330 AFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
33-376 |
1.27e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.99 E-value: 1.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRdHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVL 192
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIK-RWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 193 AGFGVFVWLLLLVGFKESLPSykREHNPIIASYRHVLRHRgfRAYLSSLIATFAGIAAFEAIA-GVLYGQYLGLPP---- 267
Cdd:COG2807 178 ALLALLALLLWLPLLRRRPAA--AAAAPAAASLRSLWRSP--LAWLLTLFFGLQSLLYYAVVAwLPPILRDAGLSAatag 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 268 FIVSCYFVAPIPGYLLGALIAGKqTKTQRTVyqgvaLLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSA 347
Cdd:COG2807 254 LLLSLFQLAGIPGSLLVPLLADR-LGDRRPL-----LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTL 327
|
330 340
....*....|....*....|....*....
gi 120558890 348 ALEPFPRQAGiAGALLGGLQNFGAGLAAL 376
Cdd:COG2807 328 IGLRARTPAE-AAALSGMAQSVGYLLAAL 355
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
53-344 |
1.38e-15 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 77.94 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 53 PALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGL 132
Cdd:PRK15403 37 PGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 133 GTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKESLP 212
Cdd:PRK15403 117 SICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVK 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 213 SYKREHNP--IIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVAPIPGYLLGALIAGK 290
Cdd:PRK15403 197 RGAVPFSAksVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAWTQVPVFGAVIVANAIVAR 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 291 QTK---TQRTVYQGVALLGTGaLFMLIPGIFLL--VSTWSLLvGSVLFFSGAGMLFPTL 344
Cdd:PRK15403 277 FVKdptEPRFIWRAVPIQLVG-LALLIVGNLLWphVWLWSVL-GTSLYAFGIGLIFPTL 333
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
33-408 |
6.26e-15 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 76.05 E-value: 6.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVAcgqMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:COG0738 12 AIYLLFFLWG---FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGdnlvKFNSYVSMAVVFLPL---IAPFLGSIMTAYFGWQAVY 189
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE----TAASRLNLLHAFFSLgalLGPLLGGLLILLGLSLSWH 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 190 WVLAGFGVFVWLLLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAI---AGVLYGQYLGLP 266
Cdd:COG0738 165 LPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIgdwLPLYLKDVLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 267 P----FIVSCYFVAPIPGYLLGALIAGKQtkTQRTVYQGVALLGTGALFMLIpgifLLVSTWSLLVGSVLFFSGAGMLFP 342
Cdd:COG0738 245 EataaLGLSLFWGGMTIGRFLGGFLLKRF--GPVRLLRLSALLAAVGLLLAL----LAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 120558890 343 TLTSAALEPFPRQAGIAGALLGGLQNFGAGLAALSMSVMP--MGGQLSIGLLSTMMVILVIASLHYAK 408
Cdd:COG0738 319 TIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAdaFGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
76-346 |
6.89e-15 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 75.72 E-value: 6.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 76 YLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLG--TASAGALCRSIPRDHyfgdN 153
Cdd:cd17472 41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGaiSSVVMALLADLTREE----N 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 154 LVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKESLPsYKREHNPIIASYRHVLRHRG 233
Cdd:cd17472 117 RTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK-IVQISEKEKKKLKKLLKNKR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 234 F-RAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPP-FIVscYFVAPIPGYLLGAL---IAGKQTKTQRTVYQGVALLGTG 308
Cdd:cd17472 196 LlRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQlWKV--YLPAILIGFILMVPfviYAEKKGKMKQVFVSSILLIAVG 273
|
250 260 270
....*....|....*....|....*....|....*...
gi 120558890 309 ALFMLipgiFLLVSTWSLLVGSVLFFSGAGMLFPTLTS 346
Cdd:cd17472 274 FLLLL----FAATSLWLLIIGLIIFFIGFNLLEALLPS 307
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
34-371 |
4.79e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 72.60 E-value: 4.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVAcgqMAQTIFVPALPQIALSLNvDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:cd17502 1 LMLALFLAA---LDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLA 193
Cdd:cd17502 77 CGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 194 GFGVFVWLLLlvgfkeslpsykrehnpiiasyrhvlrhrgfRAYLSSLIATFAGIAAFEAIAG--VLYGQY-LGLPPFIV 270
Cdd:cd17502 157 PIGGLALALL-------------------------------RTILLSSIFGFLFGGALFGLIYylPLYFQLvLGDSATKS 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 271 SCYFVAPIPGYLLGALIAGKQTKTQRTVYQgvaLLGTGALFMLIPGIFLLVSTWSLLVGSVLFFS-----GAGMLFPTLT 345
Cdd:cd17502 206 GVRLLPLIIGLVIGSIISGALISKTGRYKP---LIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLillglGLGIGFQQPL 282
|
330 340
....*....|....*....|....*..
gi 120558890 346 SAALEPFPR-QAGIAGALLGGLQNFGA 371
Cdd:cd17502 283 VAVQNAVPPaDVGVATATNTFFRSLGG 309
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
53-388 |
1.55e-12 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 68.81 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 53 PALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGL 132
Cdd:PRK15402 34 PGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 133 GTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKESLP 212
Cdd:PRK15402 114 GLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 213 SYKREH--NPIIASYRHVLRHRGFRAylSSLIATFAGIA--AFEAIAGVLYGQYLGLPPFIvscYFVAPIPgyLLGALIA 288
Cdd:PRK15402 194 RVGEKLslKELGRDYKLVLKNRRFVA--GALALGLVSLPllAWIALSPVILISGEQLSSYE---YGLLQVP--VFGALIA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 289 GKQT--------KTQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPFPRQAGIAG 360
Cdd:PRK15402 267 GNLTlarltsrrPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYAFGIGLANAGLYRLTLFSSDVSKGTVS 346
|
330 340
....*....|....*....|....*...
gi 120558890 361 ALLGglqnfgaglaALSMSVMPMGGQLS 388
Cdd:PRK15402 347 AAMG----------MLSMLIFTVGIELS 364
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
34-404 |
4.77e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 66.85 E-value: 4.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVACGQMaqtIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM 113
Cdd:cd17489 1 ILLANFFFFLSFY---LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 114 AARAQHFNQLIFASLIQGLG-----TASAGALCRSIPRDHyFGDNLvkfnSYVSMAVVFLPLIAPFLGSIMTAYFGWQAV 188
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGwgaftTAAATLVADIIPPSR-RGEGI----GYYGLATTLAMALGPALGLFLYQHLGFAVL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 189 YWVLAGFGVFVWLLLLvGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIA--TFAGIAAFEAiagvLYGQYLGLP 266
Cdd:cd17489 153 FIVAAVLALLALLLVF-LVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLAsiAYGAISTFLP----LYAAERGIS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 267 pfIVSCYFVAPIPGYLLGALIAGKQTKTQRTVYQGVALLGTGALFMLIpgIFLLVSTWSLLVGSVLFFSGAGMLFPTLTS 346
Cdd:cd17489 228 --NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL--LSFAGSPWMLLLAAVLYGLGFGLLFPALQA 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 347 AAL-EPFPRQAGIAGALLGGLQNFGAGLAALSMSVMPMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17489 304 LAVdLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
34-216 |
1.97e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 65.48 E-value: 1.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 34 IFMLVFMVACGQMA---QTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILG 110
Cdd:TIGR00711 1 LLLTIVLMLGTFMAvldSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 111 AFMAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYW 190
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170 180
....*....|....*....|....*.
gi 120558890 191 VLAGFGVFVWLLLLVGFKESLPSYKR 216
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASE 186
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-404 |
2.14e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 2.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 42 ACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRK-----TPLLIGIGIFILGAFMAAR 116
Cdd:cd06173 9 LLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrllilADLLRALLAAVLALLALLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 117 AQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWV-LAGF 195
Cdd:cd06173 89 SLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAInALSF 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 196 GVFVWLLLLVGFKESLPSYKREHNP---IIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSC 272
Cdd:cd06173 169 LLSALLLLFIRRPPPAAPGESSSLLlrdLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 273 YFVAPIPGYLLGALIAGKqtKTQRTVYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPF 352
Cdd:cd06173 249 LLAAFGVGALLGALLLGR--LSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 120558890 353 P-----RQAGIAGALLGGLQNFGAGLAALSMSVmpMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd06173 327 PdelrgRVFSVYNALNSGAMPLGALLAGLLADA--LGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
37-404 |
7.32e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.28 E-value: 7.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 37 LVFMVACGQMAQTIFVPALPQIALS-LNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAA 115
Cdd:cd17473 4 LLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 116 RAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMtAYFGWQAVYWVLaGF 195
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVY-LL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 196 GVFVWLLLLVGFKEslpSYKREHNPIIASYRHVLRHRGFRAYLsSLIATFAGIAAFEAIA---GVLYGQYLGLPPFIVSC 272
Cdd:cd17473 162 ALPVLILVLLFLPE---PARKSKSAASPGAATAAALPWKRVLP-IYFLAFLAMLLFYVIPiqlPFLLQERGGGSAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 273 YFVAPIPGYLLGALIAGKQTK---TQRTVYQGVALLGTGALfmlipGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAAL 349
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLKRrlgKRRLLAIGFALMALGFL-----LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAM 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 350 EPFPRQA-GIAGALLGGLQNFGAGLAAL---SMSVMPMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17473 313 SLVPPELrGRAMGIVTSAFFLGQFLSPLvlgPLVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
49-189 |
1.45e-09 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 59.75 E-value: 1.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 49 TIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASL 128
Cdd:PRK10504 27 TIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 120558890 129 IQGLGTA---SAGALC--RSIPRDHYFGdnlvkfnsyvSMAVVFL-----PLIAPFLGSIMTAYFGWQAVY 189
Cdd:PRK10504 107 LQGVGGAmmvPVGRLTvmKIVPREQYMA----------AMTFVTLpgqvgPLLGPALGGLLVEYASWHWIF 167
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
45-374 |
1.63e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 59.20 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 45 QMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLI 124
Cdd:cd17476 11 QAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 125 FASLIQGLGTA-----SAGALCRSIPRDHYFgdNLVkFNSYVSMAVVFLpLIAPFLGSIMTAYFGWQAVYWVLAGFGVFV 199
Cdd:cd17476 91 ICRALQGLGPAfllpnAMALLGRTYPPGPRK--NIV-FSLFGATAPLGF-ALGGVFGGLFAQLAWWPWIFWFLAILAAIV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 200 WLLLLVGFkeslpsykrehnpiiasyrhvlrHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVAPIP 279
Cdd:cd17476 167 AVAAIFWT-----------------------SPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 280 GYLLGALIAGKQTKTQRTVYqgvaLLGTGALFMLIPGIFLLV-----STWSLLVGSVLFFS-GAGMLFPTLTSAALEPFP 353
Cdd:cd17476 224 GGVLAAITVGFLIARLPPSY----IMAISMVAFLVGPILFATmpvhqTYWAQAFPAMIVAPfGMDFSFPAATIIASNAVP 299
|
330 340
....*....|....*....|..
gi 120558890 354 RQ-AGIAGALLGGLQNFGAGLA 374
Cdd:cd17476 300 REyQGLAGSLVNTVVNYGISIG 321
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
33-402 |
3.04e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.42 E-value: 3.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVAcgqmaqTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:cd17341 6 LSFFLGFMVW------FLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQH-FNQLIFASLIQGLGTASAGALCRSI----PRDHYFGDNLVKF---NSYVSMAVVFLPLIApFLGSIMTAYFG 184
Cdd:cd17341 80 ALALAVSsYWGLLVLGFLLGFAGANFASGQPWAsfwfPKEKIGGAAGGIAgagNMGVAVSQLLAPLIA-GAIVFDGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 185 WQAVYWVLAGFGVFVWLLLLVgFKESLPSYKREHNPIIASYRHVLRHRgfRAYLSSL--IATFAGIAAFEAIAGVLYGQY 262
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLL-FGDDLPTGKASALEFLKVQLAVLKNY--RTWILSLlyGVTFGSFVGFSNVLPTYFKTR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 263 LGLPPFIVSCY-FVAPIPGYL---LGALIAGKQTKTQRTVYQGVaLLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAG 338
Cdd:cd17341 236 FGLPLVTAGILaALFPLAGALarpAGGWLSDRFGGRRRLWWLFI-VMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAG 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 120558890 339 MLFPTLTSAALEPFPRQAGIAGALLGGLQNFGAGLAAL---SMSVMPMGGQLSIGLLSTMMVILVIA 402
Cdd:cd17341 315 AGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLlfgSSALMTGSGVGAFSLFGVLAVACTLL 381
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
37-355 |
8.51e-09 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 56.85 E-value: 8.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 37 LVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLL-IGIGIFILGAFMAA 115
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 116 RAQHFNQLIFASLIQGLGTASAGALCrsIPRDHYFG-DNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAG 194
Cdd:cd17490 81 LFPSPWGLLIARFLSGIAAATWVSFT--VLYASYFPpDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 195 FGVfVWLLLLVGFKESLPSyKREHNPIIASYRHVLRHR-----GFRAYLSSLIaTFAGIAAFEAIAGVLYGQYLGLPPFI 269
Cdd:cd17490 159 AGV-LGFILSLFIKEERRE-KKPVLTELKELLSVLKDKkllffSLLAILQQMI-TFSTTFGFTPLIAKQLGASSFQLGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 270 VSCYFVAPIPGYLLGALIAGKQTKTQRTVYQGVALLgtGALFMLIPgifLLVSTWSLLVGSVLFFSGAGMLFPTLTSAAL 349
Cdd:cd17490 236 SIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLL--GAYCFLIP---FAPNLTLLYLLQALNGFGTGILFPLLMSLSI 310
|
....*.
gi 120558890 350 EPFPRQ 355
Cdd:cd17490 311 EGVPAE 316
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
54-211 |
1.07e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.60 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 54 ALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLG 133
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 120558890 134 TASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKESL 211
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESI 196
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
82-376 |
1.29e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 82 LFQFVYGPLSD----RIGRKTP-LLIGIGIFILGAFMAARAQHFNQ----------LIFASLIQGLGTASAGALCRSIPR 146
Cdd:COG2211 61 ITDPLIGALSDrtrtRWGRRRPwILIGAIPLALSFVLLFTAPDLSPtgkliyalvtYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 147 DHyfgDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYF------GWQAVYWVLAGFGVFVWLLLLVGFKESlPSYKREHNP 220
Cdd:COG2211 141 DY---EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKER-PVPEEEKVS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 221 IIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVS----CYFVAPIPGYLLGALIAGKQTKtqR 296
Cdd:COG2211 217 LKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGlllaLYFLAALLGAPLWPRLAKRFGK--K 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 297 TVYQGVALLgtGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTS--------AALEPFPRQAGIAGALLGGLQN 368
Cdd:COG2211 295 KAFIIGLLL--AALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAmladvvdyDEWKTGRRREGLYFGIFTFAIK 372
|
....*...
gi 120558890 369 FGAGLAAL 376
Cdd:COG2211 373 LGQALAGA 380
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
66-404 |
3.20e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 3.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 66 ASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASAGALCRSIP 145
Cdd:cd17329 34 ASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 146 RDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYfGWQAVYWVLAGFGVFVWLLLLVGFKESLPSYKREHN-PIIAS 224
Cdd:cd17329 114 ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKtEILRG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 225 YRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVapipgyLLGALIAGKQTKTQRTV--YQGV 302
Cdd:cd17329 193 YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLA------LNALLIVLLQFPVARLVerFRLR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 303 ALLGTGALFMLIP-GIFLLVSTWSLLVGSVLFFSGAGML-FPTLTSAALEPFPRqagiagALLGGLQNFGAGLAALSMSV 380
Cdd:cd17329 267 KILMIGILLFAIGfAVLAFANTLAVLILAMIVLTLGEMLvFPAVQTLVAALAPP------DKRGSYMGFYALAWGLGRAI 340
|
330 340
....*....|....*....|....
gi 120558890 381 MPMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17329 341 GPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
44-220 |
5.53e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 54.94 E-value: 5.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 44 GQMAQTIFVPALPQIALSLNVDASQLQA---VMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHF 120
Cdd:cd06179 6 AYFAQLFGVTLPAAVLPFIVADLGPSSNstwISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 121 NQLIFASLIQGLGTASAG----ALCRSIPRdhyfgdnlvKFNSYVSMAVVFLPLIAPFLGSIMTAYF------GWQAVYW 190
Cdd:cd06179 86 NMLIGGQALIGIGAGTQGlgaaVASELVPN---------KYRGLVQGVVNLVASPGSALGPLIAGALveanaaGWRWIFY 156
|
170 180 190
....*....|....*....|....*....|
gi 120558890 191 VLAGFGVFVWLLLLVGFKesLPSYKREHNP 220
Cdd:cd06179 157 INAIFNALALILLFFFYH--PPPRPQLHGS 184
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
54-381 |
5.54e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.50 E-value: 5.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 54 ALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLG 133
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 134 TASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVfVWLLLlvgfkeslps 213
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGL-LLAVL---------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 214 ykrehnpiiasyrhvlrhrgFRAYLSSLIATFAGiaaFEAIAGVLYGQYLGLPPFIVSCY--------FVAPIP------ 279
Cdd:cd17319 174 --------------------WWFYLRQVWGLALG---YFGINYALYGLLTWLPTYLKQARgfslkqvgLLAAIPflagai 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 280 GYLLGALIAGKQTKTQRTVYQGVALLGTGALFMLIPgifLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPFPR-QAGI 358
Cdd:cd17319 231 GMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAY---LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAAT 307
|
330 340
....*....|....*....|...
gi 120558890 359 AGALLGGLQNFGAGLAALSMSVM 381
Cdd:cd17319 308 AGGLINSGGNLGGFVAPLLIGYL 330
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
33-207 |
7.53e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 7.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSL-NVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGA 111
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 112 FMAARAQHFNQLIFASLIQGLGTASAGA-----LCRSIPRDHYfGDNLVKFNSYVSMAVVflplIAPFLGSIMTAYFGWQ 186
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPatlalLADIVPPEGR-GTAMGLFNTAFSLGMV----LGPLLGGFLYDAFGFA 354
|
170 180
....*....|....*....|.
gi 120558890 187 AVYWVLAGFGVFVWLLLLVGF 207
Cdd:cd17325 355 TPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
46-404 |
7.56e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 46 MAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIF 125
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 126 ASLIQGLGTA----SAGALCRsiprdHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWL 201
Cdd:cd17478 90 LVALAGIGSAafhpEGARLAS-----QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 202 LLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIA---TFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVAPI 278
Cdd:cd17478 165 LLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLrswVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 279 PGYLLGALIAGKQtkTQRTVYQgVALLGTGALFMLipgiFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPFPRQAGI 358
Cdd:cd17478 245 IGTLIGGPLSDRF--GRRRVII-ASLLLAAPFLLL----FLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGL 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 120558890 359 AGALLGGLQNFGAGLAAlsMSVMPMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17478 318 ASGLMMGLSFGLGGIGA--PVLGALADAFGLESVLLILALLPLLGA 361
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
54-141 |
1.41e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 49.87 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 54 ALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLG 133
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
....*...
gi 120558890 134 TASAGALC 141
Cdd:cd17359 103 VGGASALV 110
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
54-205 |
3.25e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.74 E-value: 3.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 54 ALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLG 133
Cdd:cd17365 21 VAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 120558890 134 TASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLV 205
Cdd:cd17365 101 LGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRG 172
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-404 |
7.53e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 47.70 E-value: 7.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVAcgqMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVygpLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:cd17333 3 ISFFSNGLTD---ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGF---LMKRLGRRRTLILGLLLISLALA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQLIFASLIQGLGT----ASAGALCRSIpRDHYFGDNLVKFNSYVSMAVVFLPLIApflGSIMTAYFGWQAV 188
Cdd:cd17333 77 LIFATPSIYLFVVLMFLAGLGAgildTGANTFVGAL-FEESSATRLNVLHGFFGLGALIGPLIA---TSLLTSELSWSWA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 189 YWVLAGFGVFVWLLLLVGFKESLPSYKREHNPIIASYRHVLRHRGFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPP- 267
Cdd:cd17333 153 YLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHv 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 268 ------FIVSCYFVAPIPGYLLGALIagKQTKTQRTVYQGVALLGTGALFMLIPGIFLLVstwsLLVGSVLFFSGAGMLF 341
Cdd:cd17333 233 sdglagYLLSGFWVGITIGRLLGGPI--SRRIKPHTLLVLSGSGALLGLLILLLAPTLVV----GLVATALLGLFMAALF 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120558890 342 PTLTSAALEPFPRQAGIAGALLGGLQNFGAGLAALSMSVM--PMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17333 307 PTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIaeAVGIQTAMLLITILYAIIFVLAL 371
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
51-379 |
2.24e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.21 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 51 FVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGI---GIFILG-AFMAARAQHFNQLIFA 126
Cdd:TIGR00881 14 FALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLilcAIVNLFfGFSTSLWVMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 127 SLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPliaPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVG 206
Cdd:TIGR00881 94 GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLP---PLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 207 FKES-----LPSYKREHNPIIASY---------------RHVLRHRgFRAYLSsliatFAGIAAFEAIAGVL-------- 258
Cdd:TIGR00881 171 LRDSpqscgLPPAEEMPNEEPDGDaekkeeeltkkqiflQYVLLNK-VLWYIS-----LGYVFVYVVRTGILdwsplylt 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 259 --YGQYLGLPPFIVSCYFVAPIPGYLLGALIAGKQTKTQRtvyqGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFS- 335
Cdd:TIGR00881 245 qeKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRR----GPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFAl 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 120558890 336 -----GAGMLFPTLTSAALepFPRQAGIAGALLGGLQNFGAGLAALSMS 379
Cdd:TIGR00881 321 gflvyGPQMLIGVIASELA--PKKAAGTAAGFVGFFAYLGGILAGLPLG 367
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
50-241 |
2.63e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.14 E-value: 2.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 50 IFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLI 129
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 130 QGLG----TASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWvLAGFGVFVWLLLLV 205
Cdd:cd17371 97 AGLGfggeWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFL-LGALPALLVLFIRR 175
|
170 180 190
....*....|....*....|....*....|....*.
gi 120558890 206 GFKESlpsykrehnPIIASYRHVLRHRGFRAYLSSL 241
Cdd:cd17371 176 FVKEP---------PQWQAARAARRHFADRPSLREL 202
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
41-404 |
3.01e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.65 E-value: 3.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 41 VACGQMAQTIFVPALPQI---ALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARA 117
Cdd:cd17330 5 VFLDALGFGIVFPVLPFYvreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 118 QHFNQLIFASLIQGLGTASAGAlCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGV 197
Cdd:cd17330 85 RNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 198 FVWLLLLVGFKESlpsykrehnpiiasyrhvlrhrgFRAYLSSLIATFAGIAAFEAIAGVLYGQYLGLPPFIVSCYFVAP 277
Cdd:cd17330 164 LNLVLVLFFLPPL-----------------------RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 278 IPGYLLGALIAGKQTK---TQRTVYQGVALLGTGALFMLIPGIFLLvstwsLLVGSVLFFSGAGMLFPTLTSAALEPFP- 353
Cdd:cd17330 221 IAGILAQLLLIPRLAKrlgERKLLRLGLLLAIIGLLLLPFASSVPL-----LVLAAAILAFGTGIVFPALSALLSKSVPs 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 120558890 354 RQAGIAGALLGGLQNFGAGLAALSMSVM--PMGGQLSIGLLSTMMVILVIASL 404
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLysFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
46-209 |
6.71e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.92 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 46 MAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKtpLLIGIGIFILGAFMAAR--AQHFNQL 123
Cdd:cd17328 13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRK--WILAVGILIWSAATLLSsfAPNFWQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 124 IFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYF-GWQAVYWVLAGFGVFVWLL 202
Cdd:cd17328 91 LLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAIL 170
|
....*..
gi 120558890 203 LLVGFKE 209
Cdd:cd17328 171 LLLFVRE 177
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
49-202 |
9.72e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 9.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 49 TIFVPALPQIA--LSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFA 126
Cdd:cd17316 16 FLIGFVAPVLAaeFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 127 SLIQGLGTASAGALCRSI----PRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLL 202
Cdd:cd17316 96 RFLQGIGIGGEYPGASTYvaefAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLL 175
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
59-144 |
1.26e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 59 ALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASAG 138
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
....*.
gi 120558890 139 ALCRSI 144
Cdd:cd17370 306 SIERAA 311
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
35-144 |
1.32e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.12 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 35 FMLVFMVACGQMAQTIFVPALPQIALS-LNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILG--A 111
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGllL 310
|
90 100 110
....*....|....*....|....*....|...
gi 120558890 112 FMAARAQHFNQLIFASLIQGLGTASAGALCRSI 144
Cdd:COG2211 311 LFFLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-209 |
1.35e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALpqIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGR--KTPLLIGIGIFILG 110
Cdd:COG2271 184 LLALAYFLVYFALYGFLTWLPTY--LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 111 AFMAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYW 190
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170
....*....|....*....
gi 120558890 191 VLAGFGVFVWLLLLVGFKE 209
Cdd:COG2271 342 LLAALALLAALLALLLLRE 360
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
53-141 |
2.04e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 43.33 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 53 PALPQIALSLNV--DASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQ 130
Cdd:cd17315 18 GALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90
....*....|.
gi 120558890 131 GLGTASAGALC 141
Cdd:cd17315 98 GLGVGLASVLV 108
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
85-218 |
2.69e-04 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 43.12 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 85 FVYGPLSDRIGRKtPLLIGIGIF-ILGAFMAARAQHFNQLIFASLIQGLGTASAGAlcrsipRDHYFGDNLVKFNSYVSM 163
Cdd:pfam06609 96 LMMGRLTDRFGRR-PFVIATHIIgLVGAIVGCTANKFNTLLAAMTLLGVAAGPAGA------SPLFIGELMSNKTKFLGL 168
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 164 AVVFLPLIA-----PFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKEslPSYKREH 218
Cdd:pfam06609 169 LIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIWYHP--PSFAQLH 226
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
88-381 |
7.48e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.38 E-value: 7.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 88 GPLSDRIG-RKTPLLIGIGIFILGAFMAARAQHFNQ-LIFASLIQGLGTASAG---ALCRSIpRDHYFGDNLVKFNSYVS 162
Cdd:cd17471 53 GRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVlLLVGVVLLSLGAAAFPqlfALAREY-ADRSSGRDATLFNSVLR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 163 MAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKEslPSYKREHNPIIASYRHVLRHRGFRAYLSSLI 242
Cdd:cd17471 132 AAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPS--VKPPAQKATPASSLVKAPVNRRLLLLFAAFT 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 243 ATFAGIAAFeAIAGVLY-GQYLGLPPFIVSCYF-VAP---IPGYLLGALIAGKQTKTqrtvyqgvALLGTGALFMLI--P 315
Cdd:cd17471 210 LLFAANSMY-IIAMPLYvTNELGGSESWVGLLFgLAAaleIPIMLLAGLLAKRFGKR--------RLLLAGFLAGVLfyL 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 120558890 316 GIFLLVSTWSLLVGSVL------FFSGAGMLFptltsaALEPFPRQAGIAGALLGGLQNFGAGLAALSMSVM 381
Cdd:cd17471 281 GLALATSLWQLIALQLLnaifigITAGLGISY------FQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVI 346
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
33-203 |
8.75e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 8.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGA- 111
Cdd:cd17477 189 IAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAAl 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 112 FMAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWV 191
Cdd:cd17477 269 LLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF 348
|
170
....*....|..
gi 120558890 192 LAGFGVFVWLLL 203
Cdd:cd17477 349 LAAVALLFLLFL 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
65-376 |
9.85e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 9.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 65 DASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFAS-LIQGLGTASAGALCRS 143
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 144 IPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGF-GVFVWLLLLVGFKESLPSYKREHNPII 222
Cdd:cd17355 116 TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLaLLVLVPVLLLLRRRPADLALRAYDDAS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 223 -----ASYRHVLRHRGFRAYLSSLIATFAGIAAFeAIAGVLYGQYLGLPPFIVSCYFVAPIPGYLLGALIAGKQTKTQRT 297
Cdd:cd17355 196 paspgSTLKEALRSASFWLLALAFFLCGFAVVGL-IVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 298 VYQGVALLGTGALFMLIPGIFLLVSTWSLLVGSVLFFSGAGMLFPTLTSAALEPFPRQAGIAGALLGGLQNFGAGLAAL 376
Cdd:cd17355 275 RRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPW 353
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
88-232 |
1.32e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 40.63 E-value: 1.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 88 GPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASAGALCRSIPRDHYFGDN-LVKFNSYVSMAVV 166
Cdd:cd17384 52 GPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKeRGKAMGIALGGLA 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120558890 167 FLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKeslPSYKREHNPIIASYRHVLRHR 232
Cdd:cd17384 132 LGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQ---PSVKSEESEEGTPWKTLLKDP 194
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-205 |
2.20e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 36 MLVFMVACGQMAQTIFVPALPQIA-LSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMA 114
Cdd:COG2223 209 LLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 115 ARAQH-FNQLIFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFL-GSIMTAYFGWQAVYWVL 192
Cdd:COG2223 289 ALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLfGALLDATGSYTAAFLVF 368
|
170
....*....|...
gi 120558890 193 AGFGVFVWLLLLV 205
Cdd:COG2223 369 AVLALVALVLTLL 381
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
65-213 |
2.52e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.00 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 65 DASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASAGalcrsi 144
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIW------ 198
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 145 prdhyfgdnlvkfnsyvsmaVVFLPLIAPFLGSIMTAYFG------WQAVYWVLAGFGVFV----WLLLLVgfkeSLPS 213
Cdd:TIGR00898 199 --------------------VQAVVLNTEFLPKKQRAIVGtliqvfFSLGLVLLPLVAYFIpdwrWLQLAV----SLPT 253
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
36-106 |
3.07e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.59 E-value: 3.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 120558890 36 MLVFMVACGQMAQTIFVPALPQIA-LSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKtPLLIGIGI 106
Cdd:cd17367 227 LVVGLTAGGTLAFYTWTTYLQKFLvNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRR-PLLLFFGI 297
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
85-137 |
4.61e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.19 E-value: 4.61e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 120558890 85 FVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASA 137
Cdd:TIGR01299 220 FFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGA 272
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
49-135 |
4.66e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 39.33 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 49 TIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASL 128
Cdd:PRK14995 23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRA 102
|
....*..
gi 120558890 129 IQGLGTA 135
Cdd:PRK14995 103 LLAIGAA 109
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
50-262 |
4.88e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.77 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 50 IFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGP----LSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIF 125
Cdd:cd17388 17 LIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 126 ASLIQGLgTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMtAYFGWQAVYWVLAGFGVFVWLLLLV 205
Cdd:cd17388 97 GRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLL-GEISPRAPFLVAAGLNGLNFLLGLF 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 120558890 206 GFKESLPSYKR------EHNPiIASYRHVLRHRGfrayLSSLIATFAGIAAFEAIAG---VLYGQY 262
Cdd:cd17388 175 VLPESLPPERRrafrwrRANP-FGSLRWLTGFPG----LLGLLAVFFLIQLIGQVPAttwVLFTED 235
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
78-209 |
6.47e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.40 E-value: 6.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 78 IAYGLFQFVYGPLSDRIGRKTPLL---IGIGIFILGAfmaARAQHFNQLIFASLIQGLGTASAGA----LCRSIPRDHYf 150
Cdd:cd17391 47 LVSAIFSPIWGRLADRYGRKPMLLrasLGMAIVIGLM---AFVTNVWQLLILRLLQGVFSGYVPNatalIASQTPKEKS- 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 120558890 151 GDNLvkfnSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGVFVWLLLLVGFKE 209
Cdd:cd17391 123 GWAL----GTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKE 177
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
85-137 |
8.25e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 38.24 E-value: 8.25e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 120558890 85 FVYGPLSDRIGRKTPLLIGIGIFILGAFMAARAQHFNQLIFASLIQGLGTASA 137
Cdd:cd17363 52 FVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGS 104
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
46-205 |
9.62e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 46 MAQTIFVPALPQIALSLNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAFM--AARAQHFNQL 123
Cdd:cd17380 13 ADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 124 IFASLIQGLGT-----ASAGALCRSIPRDhyfgdNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWVLAGFGvF 198
Cdd:cd17380 93 ILSRILLGLGEgvhfpSMTSLFSRWVPVS-----ERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLG-L 166
|
....*..
gi 120558890 199 VWLLLLV 205
Cdd:cd17380 167 LWALVWL 173
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
33-204 |
9.81e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 37.97 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 33 LIFMLVFMVACGQMAQTIFVPALPQIAlslNVDASQLQAVMACYLIAYGLFQFVYGPLSDRIGRKTPLLIGIGIFILGAF 112
Cdd:cd17353 218 LWLMFFLNATAGLMLIGQAKPIGQEFA---GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMF 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120558890 113 MAARAQHFNQL-IFASLIQGLGTASAGALCRSIPRDHYFGDNLVKFNSYVSMAVVFLPLIAPFLGSIMTAYFGWQAVYWV 191
Cdd:cd17353 295 LLPFIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFII 374
|
170
....*....|...
gi 120558890 192 LAGFGVFVWLLLL 204
Cdd:cd17353 375 AAALSLVALALAL 387
|
|
| |
