|
Name |
Accession |
Description |
Interval |
E-value |
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
93-425 |
1.34e-173 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 488.64 E-value: 1.34e-173
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 93 LQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKGNYDQPLELASPVD 172
Cdd:TIGR02966 1 LSALLSRFRAAAQALPDAVVVLDEEGQIEWCNPAAERLLGLRWPDDLGQRITNLIRHPEFVEYLAAGRFSEPLELPSPIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 173 DRLRLQFNITRYGNREHLLLVRDVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRWLRALQQMNQQ 252
Cdd:TIGR02966 81 SERVLEIRIAPYGEEQKLLVARDVTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEWNRALEIMLEQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 253 AGRMQHLLNDLLLLARLETSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPGLQLKGSEAELRSAFSNLVFN 332
Cdd:TIGR02966 161 SQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 333 AVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDIS 412
Cdd:TIGR02966 241 AIKYTPEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIE 320
|
330
....*....|...
gi 145569026 413 STPGQGSRFSCHF 425
Cdd:TIGR02966 321 SELGKGSTFSFIF 333
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
26-422 |
8.80e-136 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 396.69 E-value: 8.80e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 26 ITGEYAWVLVIGLSGYLVWTLRQLLRLQRWLHrADPDEPPPDSAGIWGDVFDNLYQMQRRDLRLRGELQGIIDRAQGSTA 105
Cdd:PRK11006 27 FFGYLPWFLLASVTGLLIWHFWNLLRLSWWLW-VDRSMTPPPGRGSWEPLFYGLYQMQLRNRKRRRELGNLIKRFRSGAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 106 ALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKGNYDQPLELasPVDDRLRLQFNITRYG 185
Cdd:PRK11006 106 SLPDAVVLTTEEGNIFWCNGLAQQLLGFRWPEDNGQNILNLLRYPEFTQYLKTRDFSRPLTL--VLNNGRHLEIRVMPYT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 186 NREHLLLVRDVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLEtLLENAEAVNPRWLRALQQMNQQAGRMQHLLNDLLL 265
Cdd:PRK11006 184 EGQLLMVARDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLE-MMQDQPLEGALREKALHTMREQTQRMEGLVKQLLT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 266 LARLETSSRPTDNQPVAVGLLLQSIISDARALSGNRgHLISLDADPGLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHV 345
Cdd:PRK11006 263 LSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGK-HTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITV 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145569026 346 RWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:PRK11006 342 RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFS 418
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
74-425 |
1.65e-89 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 276.82 E-value: 1.65e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 74 DVFDNLYQMQRRDLRLRGELQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFK 153
Cdd:COG5002 38 LLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAAL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 154 EYFDKGNYDQPLELASPVDDRLRLQFNITRYGNREhlllvRDVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLE 233
Cdd:COG5002 118 LLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVE-----RDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 234 NAEAVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLETSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDA-DPG 312
Cdd:COG5002 193 GAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLpEDP 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 313 LQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTG 392
Cdd:COG5002 273 LLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTG 352
|
330 340 350
....*....|....*....|....*....|...
gi 145569026 393 LGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:COG5002 353 LGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
192-425 |
3.78e-64 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 206.30 E-value: 3.78e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 192 LVRDVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLET 271
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 272 SSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPGL-QLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGD 350
Cdd:COG2205 82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145569026 351 EVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRasSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:COG2205 162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSR--GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
165-425 |
2.56e-62 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 204.37 E-value: 2.56e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 165 LELASPVDDRLRLQFNITRYGNREHLLLVRDVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENaeaVNPRWLR 244
Cdd:COG0642 69 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE---LDEEQRE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 245 ALQQMNQQAGRMQHLLNDLLLLARLETSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPGL-QLKGSEAELR 323
Cdd:COG0642 146 YLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLpTVRGDPDRLR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 324 SAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRasSTGGTGLGLAIVKHVLL 403
Cdd:COG0642 226 QVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSR--RGGGTGLGLAIVKRIVE 303
|
250 260
....*....|....*....|..
gi 145569026 404 RHQGRLDISSTPGQGSRFSCHF 425
Cdd:COG0642 304 LHGGTIEVESEPGKGTTFTVTL 325
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-429 |
1.34e-59 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 189.72 E-value: 1.34e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHV 401
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*...
gi 145569026 402 LLRHQGRLDISSTPGQGSRFSCHFQNSQ 429
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFPSSR 108
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
31-425 |
8.64e-52 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 179.77 E-value: 8.64e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 31 AWVLVIGLSGYLVWTLRQLLRLQRWLHRADPDEPPP----DSAGIWGDVFDNLYQM---QRRDL-RLRGELQGIIDraqg 102
Cdd:COG5000 22 ALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPvtgdDEIGELARAFNRMTDQlkeQREELeERRRYLETILE---- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 103 staALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDK---GNYDQPLELasPVDDRLRLQF 179
Cdd:COG5000 98 ---NLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREaleRGWQEEIEL--TRDGRRTLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 180 NITRYGNREHLLLVRDVTRLHQLEQMR--KDFVANVSHELRTPLTVIAGYLETL----LENAEAVNPRWLRALQQMNQQA 253
Cdd:COG5000 173 RASPLRDDGYVIVFDDITELLRAERLAawGELARRIAHEIKNPLTPIQLSAERLrrklADKLEEDREDLERALDTIIRQV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 254 GRMQHLLNdllllarlETSS--RPTDNQPVAVGL--LLQSIISDARALSGNRGHLISLDADPGL-QLKGSEAELRSAFSN 328
Cdd:COG5000 253 DRLKRIVD--------EFLDfaRLPEPQLEPVDLneLLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLIN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 329 LVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYrvdSSRASstgGTGLGLAIVKHVLLRHQGR 408
Cdd:COG5000 325 LLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TTKPK---GTGLGLAIVKKIVEEHGGT 398
|
410
....*....|....*..
gi 145569026 409 LDISSTPGQGSRFSCHF 425
Cdd:COG5000 399 IELESRPGGGTTFTIRL 415
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
106-422 |
4.94e-42 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 151.92 E-value: 4.94e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 106 ALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHP-----AFKEYFDKGN--YDQPLELASPVDDRLRLQ 178
Cdd:COG3852 15 SLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDsplreLLERALAEGQpvTEREVTLRRKDGEERPVD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 179 FNITRYGNREH----LLLVRDVTR-------LHQLEQMR--KDFVANVSHELRTPLTVIAGYLETLLENAEavNPRWLRA 245
Cdd:COG3852 95 VSVSPLRDAEGeggvLLVLRDITErkrlereLRRAEKLAavGELAAGLAHEIRNPLTGIRGAAQLLERELP--DDELREY 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 246 LQQMNQQAGR-------MqhllndllllarlETSSRPTDN--QPVAVGLLLQSIISDARALSGnRGHLISLDADPGL-QL 315
Cdd:COG3852 173 TQLIIEEADRlnnlvdrL-------------LSFSRPRPPerEPVNLHEVLERVLELLRAEAP-KNIRIVRDYDPSLpEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 316 KGSEAELRSAFSNLVFNAVKYTPDGGSVHVR------------WWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYrvdSS 383
Cdd:COG3852 239 LGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlgglRPRLYV--RIEVIDNGPGIPEEILDRIFEPFF---TT 313
|
330 340 350
....*....|....*....|....*....|....*....
gi 145569026 384 RAsstGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:COG3852 314 KE---KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFR 349
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
109-422 |
2.54e-38 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 146.05 E-value: 2.54e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 109 DAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPafkeyfdkGNYDQPLELASPvdDRLRLQFNitrygNRE 188
Cdd:NF033092 269 DGVIATDRRGRVILINDPALEMLNVSRETVLGQSILDVLGLE--------EEYTLRDLLEEQ--DSLLLDFS-----TEE 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 189 HLLLVR---------------------DVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENA---EAVNPRWLR 244
Cdd:NF033092 334 EPLILRanfsviqresgfingliavlhDVTEQEKIEQERREFVANVSHELRTPLTTMRSYLEALADGAwkdPELAPRFLG 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 245 ALQQ-----------------MNQQAGRMqhllndllllarletssrptDNQPVAVGLLLQSIIsdaralsgNRGHLIS- 306
Cdd:NF033092 414 VTQNetermirlvndllqlsrMDSKDYKL--------------------NKEWVNFNEFFNYII--------DRFEMILk 465
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 307 ------------------LDADPGLQLkgseaelrsaFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQK 368
Cdd:NF033092 466 nknitfkrefpkrdlwveIDTDKITQV----------LDNIISNAIKYSPEGGTITFRLLETHNRIIISISDQGLGIPKK 535
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 145569026 369 HLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:NF033092 536 DLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIY 589
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
4-422 |
5.45e-36 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 138.38 E-value: 5.45e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 4 DWQGALVRRLLLLLGGCLLLGLITGEYAWVLVIGLSGYLVWTLRQLLRLQRWLHRADPDEPPPDSAGIWGDVFDNLYQMQ 83
Cdd:COG4251 68 LLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLAL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 84 RRDLRLRGELQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKGNYDQ 163
Cdd:COG4251 148 ALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 164 PLELASPVDDR----LRLQFNITRYGNREHLLLVRDVT-----RLHQLEQMRKD---FVANVSHELRTPLTVIAGYLETL 231
Cdd:COG4251 228 LLLLLLLLVLLllliLLLLLLILVLELLELRLELEELEeeleeRTAELERSNEEleqFAYVASHDLREPLRKISGFSQLL 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 232 LEN-AEAVNPRWLRALQQMNQQAGRMQhllndllllarlE----------TSSRPTDNQPVAVGLLLQSIISDARALSGN 300
Cdd:COG4251 308 EEDyGDKLDEEGREYLERIRDAAERMQ------------AliddllaysrVGRQELEFEPVDLNELLEEVLEDLEPRIEE 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 301 RGhlISLDADPGLQLKGSEAELRSAFSNLVFNAVKYTPDG--GSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFY 378
Cdd:COG4251 376 RG--AEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGepPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQ 453
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 145569026 379 RVDSSRASStgGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:COG4251 454 RLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGATFY 495
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
106-425 |
1.34e-33 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 131.64 E-value: 1.34e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 106 ALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPA---FKEYFDKGNYDQPLE-----LASPVDDRLRL 177
Cdd:COG5809 149 HSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDqenVAAFISQLLKDGGIAqgevrFWTKDGRWRLL 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 178 QFN---ITRYGNREHLLLV-RDVTRLHQLEQ-MRK--------DFVANVSHELRTPLTVIAGYLETLLENAEAVNPRW-- 242
Cdd:COG5809 229 EASgapIKKNGEVDGIVIIfRDITERKKLEElLRKseklsvvgELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYld 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 243 --LRALQQMNQ-----------QAGRMQhllndllllarletssrPTDNQPvavglLLQSIIS--DARALSGN-RGHLIS 306
Cdd:COG5809 309 imLSELDRIESiiseflvlakpQAIKYE-----------------PKDLNT-----LIEEVIPllQPQALLKNvQIELEL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 307 LDADPglQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVrwwgdEVGAH------LSVEDSGIGIEQKHLPRLTERFYrv 380
Cdd:COG5809 367 EDDIP--DILGDENQLKQVFINLLKNAIEAMPEGGNITI-----ETKAEdddkvvISVTDEGCGIPEERLKKLGEPFY-- 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 145569026 381 dssrasST--GGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:COG5809 438 ------TTkeKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
317-425 |
1.55e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 121.60 E-value: 1.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 317 GSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDsSRASSTGGTGLGLA 396
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100
....*....|....*....|....*....
gi 145569026 397 IVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
181-420 |
1.29e-32 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 128.41 E-value: 1.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 181 ITRYGNREHLLLVRDVTR----LHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRWLRALQQMNQQAGRM 256
Cdd:NF012163 211 VTPTSNDELGKLAQDFNQlastLEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDGIRKFTPESLDSLQAEVGTLTKL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 257 QHLLNDLLLLARLETSSRPTDNQPVAvglLLQSIISDARALSGNRGHLISLDADPGLQLKGSEAELRSAFSNLVFNAVKY 336
Cdd:NF012163 291 VDDLHDLSMSDEGALAYQKASVDLVP---LLEVEGGAFRERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRY 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 337 TPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPG 416
Cdd:NF012163 368 TDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPL 447
|
....
gi 145569026 417 QGSR 420
Cdd:NF012163 448 GGLR 451
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
109-422 |
2.32e-32 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 129.32 E-value: 2.32e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 109 DAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLV-RHPAFKEY----FDKGNYDQPLELASPVDDR-LRLQFNIT 182
Cdd:PRK11360 273 DGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFpPNTPFASPlldtLEHGTEHVDLEISFPGRDRtIELSVSTS 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 183 RYGNREH-----LLLVRDVTRLHQL-EQMRK--------DFVANVSHELRTPLTVIAGYLETLLEnaEAVNPRWLRALQQ 248
Cdd:PRK11360 353 LLHNTHGemigaLVIFSDLTERKRLqRRVARqerlaalgELVAGVAHEIRNPLTAIRGYVQIWRQ--QTSDPPSQEYLSV 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 249 MNQQAGRMQHLLNDLLLLarletsSRPTD--NQPVAVGLLLQSIISDARALSGNRGHLISLDADPGLQLKGSEAE-LRSA 325
Cdd:PRK11360 431 VLREVDRLNKVIDQLLEF------SRPREsqWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWADPElLKQV 504
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 326 FSNLVFNAVKYTPDGGSVHVRWWGDEVG-AHLSVEDSGIGIEQKHLPRLTERFYrvdSSRASstgGTGLGLAIVKHVLLR 404
Cdd:PRK11360 505 LLNILINAVQAISARGKIRIRTWQYSDGqVAVSIEDNGCGIDPELLKKIFDPFF---TTKAK---GTGLGLALSQRIINA 578
|
330
....*....|....*...
gi 145569026 405 HQGRLDISSTPGQGSRFS 422
Cdd:PRK11360 579 HGGDIEVESEPGVGTTFT 596
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
80-422 |
4.30e-30 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 119.52 E-value: 4.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 80 YQMQRRDLRLRGELQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKG 159
Cdd:COG4191 2 LRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 160 NYDQPLELASPVDDRLRLQFNITRYGNREHLL-----LVRDVTRLHQLE-------------QMrkdfVANVSHELRTPL 221
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELErditeLERAEEELRELQeqlvqseklaalgEL----AAGIAHEINNPL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 222 TVIAGYLETLLENAEAV--NPRWLRALQQMNQQAGRMQhllndllllarlETS------SRPTDNQPVAVGL--LLQSII 291
Cdd:COG4191 158 AAILGNAELLRRRLEDEpdPEELREALERILEGAERAA------------EIVrslrafSRRDEEEREPVDLneLIDEAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 292 SDARALSGNRGHLISLDADPGL-QLKGSEAELRSAFSNLVFNAVKYTPDG--GSVHVRWWGDEVGAHLSVEDSGIGIEQK 368
Cdd:COG4191 226 ELLRPRLKARGIEVELDLPPDLpPVLGDPGQLEQVLLNLLINAIDAMEEGegGRITISTRREGDYVVISVRDNGPGIPPE 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 145569026 369 HLPRLTERFYrvdssrasST----GGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:COG4191 306 VLERIFEPFF--------TTkpvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFT 355
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
322-426 |
3.53e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 109.89 E-value: 3.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGG-SVHVRWWGDEVGA---HLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAI 397
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEvTLRVSLEEEEEDGvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 145569026 398 VKHVLLRHQGRLDISSTPGQGSRFSCHFQ 426
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
202-420 |
1.53e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 116.87 E-value: 1.53e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 202 LEQMRK---------DFVANVSHELRTPLTVIAGYLETLLEN--AEAVnprwLRALQQMNQQAGRMQHLLNDLLLLARLE 270
Cdd:PRK11100 243 LESMRVklegkayveQYVQTLTHELKSPLAAIRGAAELLQEDppPEDR----ARFTGNILTQSARLQQLIDRLLELARLE 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 271 TSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPgLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGD 350
Cdd:PRK11100 319 QRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDD-ARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVD 397
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145569026 351 EVGAHLSVEDSGIGIEQKHLPRLTERFY---RVDSSRASstggTGLGLAIVKHVLLRHQGRLDISSTPGQGSR 420
Cdd:PRK11100 398 GEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRKS----TGLGLAFVREVARLHGGEVTLRNRPEGGVL 466
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
317-425 |
2.23e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 107.84 E-value: 2.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 317 GSEAELRSAFSNLVFNAVKYTPDGGSVHVR-WWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYRVDSSrasSTGGTGLGL 395
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGEL--TLTVEDNGIGIPPEDLPRIFEPFSTADKR---GGGGTGLGL 75
|
90 100 110
....*....|....*....|....*....|
gi 145569026 396 AIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:pfam02518 76 SIVRKLVELLGGTITVESEPGGGTTVTLTL 105
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
192-421 |
2.08e-27 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 113.97 E-value: 2.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 192 LVRDVTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLET 271
Cdd:NF040691 257 LQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVIHDSRDDFDPATARSAELLHTELDRFESLLSDLLEISRFDA 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 272 SSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPG-LQLKGSEAELRSAFSNLVFNAVKYTpDGGSVHVRWWGD 350
Cdd:NF040691 337 GAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTpVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQD 415
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145569026 351 EVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRF 421
Cdd:NF040691 416 DTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQF 486
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
92-426 |
2.29e-26 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 110.98 E-value: 2.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 92 ELQGIIDraqgstaALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAG---HPIGNLVRHPAFKEYFDKgnyDQPLELA 168
Cdd:COG5805 158 RLQTLIE-------NSPDLICVIDTDGRILFINESIERLFGAPREELIGknlLELLHPCDKEEFKERIES---ITEVWQE 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 169 SPVDDRLRLQFN------------ITRYGNREHLL-LVRDVTRLHQLEQM--RKD-------FVANVSHELRTPLTVIAG 226
Cdd:COG5805 228 FIIEREIITKDGriryfeavivplIDTDGSVKGILvILRDITEKKEAEELmaRSEklsiagqLAAGIAHEIRNPLTSIKG 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 227 YLETLLENAEavNPRWLraLQQMNQQAGRMqhllndllllarlET-------SSRP--TDNQPVAVGLLLQSIIS----D 293
Cdd:COG5805 308 FLQLLQPGIE--DKEEY--FDIMLSELDRI-------------ESiiseflaLAKPqaVNKEKENINELIQDVVTlletE 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 294 ARaLSGNRGHLISLDADPGLQlkGSEAELRSAFSNLVFNAVKYTPDGG--SVHVRWWGDEVgaHLSVEDSGIGIEQKHLP 371
Cdd:COG5805 371 AI-LHNIQIRLELLDEDPFIY--CDENQIKQVFINLIKNAIEAMPNGGtiTIHTEEEDNSV--IIRVIDEGIGIPEERLK 445
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 145569026 372 RLTERFYrvdssrASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHFQ 426
Cdd:COG5805 446 KLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
203-425 |
2.45e-26 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 110.49 E-value: 2.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 203 EQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRWLRALQQmnqQAGRMQHLLNDLLLLARLETSSRPTDNQPVA 282
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELEAIQDGVRKFTPESVASLQA---EVGTLTKLVDDLHQLSLSDEGALAYRKTPVD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 283 VGLLLQSIISDARALSGNRGHLISLDADPGLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSG 362
Cdd:PRK10549 314 LVPLLEVAGGAFRERFASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145569026 363 IGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:PRK10549 394 PGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVEL 456
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
198-421 |
8.26e-26 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 109.01 E-value: 8.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 198 RLHQLEQMRKDFVANVSHELRTPLTVIAGYLETLLENaEAVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLETSSRPTD 277
Cdd:TIGR01386 233 RLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQ-PRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALE 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 278 NQPVAVGLLLQSIISDARALSGNRGHLISLDADpgLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLS 357
Cdd:TIGR01386 312 RVRLDLAAELAKVAEYFEPLAEERGVRIRVEGE--GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVS 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145569026 358 VEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISStPGQGSRF 421
Cdd:TIGR01386 390 VSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAES-PDGKTRF 452
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
87-425 |
1.14e-25 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 107.63 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 87 LRLRGELQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLkkpQDAGHPIGNLVRhpafkEYFDKGNYDQPLE 166
Cdd:COG3290 73 LKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLA-----EVLETGERDEEIL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 167 LASPVDD--RLRLQFNITRYGnreHLLLVRDVTRLHQLEQ-----------MRKdfvanVSHELRTPLTVIAGYLEtLLE 233
Cdd:COG3290 145 LNGRVLVvnRVPIRDDGRVVG---AVATFRDRTELERLEEelegvkelaeaLRA-----QRHDFRNHLHTISGLLQ-LGE 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 234 NAEAVnpRWLRALQQMNQQagrmqhllndllllaRLETSSRPTDNQPVAVglLLQSIISDARALSgnrghlISLDADPGL 313
Cdd:COG3290 216 YDEAL--EYIDEISEELQE---------------LIDSLLSRIGNPVLAA--LLLGKAARARERG------IDLTIDIDS 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 314 QLKG---SEAELRSAFSNLVFNAV----KYTPDGGSVHV--RWWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYrvdSSR 384
Cdd:COG3290 271 DLPDlplSDTDLVTILGNLLDNAIeaveKLPEEERRVELsiRDDGDEL--VIEVEDSGPGIPEELLEKIFERGF---STK 345
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 145569026 385 ASstGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:COG3290 346 LG--EGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-420 |
9.44e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 95.22 E-value: 9.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHV 401
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNI 84
|
90
....*....|....*....
gi 145569026 402 LLRHQGRLDISSTPGQGSR 420
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLR 103
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
164-421 |
1.38e-23 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 102.54 E-value: 1.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 164 PLELaspvdDRLRLQFNitrygnreHLL-LVRDV-TRlhqleqmRKDFVANVSHELRTPLTVIAGYLETLLenAEAVNPR 241
Cdd:PRK09835 238 PIEL-----EQLVLSFN--------HMIeRIEDVfTR-------QSNFSADIAHEIRTPITNLITQTEIAL--SQSRSQK 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 242 WLRALQQMN-QQAGRMQHLLNDLLLLARLETSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPgLQLKGSEA 320
Cdd:PRK09835 296 ELEDVLYSNlEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDP-CQVAGDPL 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 321 ELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKH 400
Cdd:PRK09835 375 MLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKS 454
|
250 260
....*....|....*....|.
gi 145569026 401 VLLRHQGRLDISSTPgQGSRF 421
Cdd:PRK09835 455 IVVAHKGTVAVTSDA-RGTRF 474
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
184-418 |
6.57e-23 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 100.37 E-value: 6.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 184 YGNREhlllVRDVTR--------LHQLEQMRKDFVANVSHELRTPLTVIA----------GYL-ETLLENAEAVNP---- 240
Cdd:PRK09467 203 YGASE----VRSVTRafnqmaagIKQLEDDRTLLMAGVSHDLRTPLTRIRlatemmseedGYLaESINKDIEECNAiieq 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 241 --RWLRALQQMNQQAGRmqhllndllllarletssrptdnqpvavgllLQSIISDARALSGNRGHLISLDADPG-LQLKG 317
Cdd:PRK09467 279 fiDYLRTGQEMPMEMAD-------------------------------LNALLGEVIAAESGYEREIETALQPGpIEVPM 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 318 SEAELRSAFSNLVFNAVKYTpdGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASStgGTGLGLAI 397
Cdd:PRK09467 328 NPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAI 403
|
250 260
....*....|....*....|.
gi 145569026 398 VKHVLLRHQGRLDISSTPGQG 418
Cdd:PRK09467 404 VKRIVDQHNGKVELGNSEEGG 424
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-418 |
3.11e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 85.07 E-value: 3.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPdgGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHV 401
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90
....*....|....*..
gi 145569026 402 LLRHQGRLDISSTPGQG 418
Cdd:cd16949 79 IEQHGGKIKASNRKPGG 95
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
196-425 |
3.89e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 91.18 E-value: 3.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 196 VTRL-HQLEQMRKdFVANVSHELRTPLTVIAGYLEtLLEnaeavnprwlralQQMNQQAG-------RMQHLLNDLLLLA 267
Cdd:PRK10755 127 VSRLtSTLDQERL-FTADVAHELRTPLAGIRLHLE-LLE-------------KQHHIDVApliarldQMMHTVEQLLQLA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 268 RLETSSRPTDNQPVAvglLLQSII----SDARALSGNRG-HLISLDADPGLQLKGSEAELRSAFSNLVFNAVKYTPDGGS 342
Cdd:PRK10755 192 RAGQSFSSGHYQTVK---LLEDVIlpsqDELSEMLEQRQqTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGST 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 343 VHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDssraSSTGGTGLGLAIVKHVLLRHQGRLDISS-TPGQGSRF 421
Cdd:PRK10755 269 ITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRA 344
|
....
gi 145569026 422 SCHF 425
Cdd:PRK10755 345 WVWL 348
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-420 |
4.28e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 85.15 E-value: 4.28e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEvGAHLSVEDSGIGIEQKHLPRLTERFYRVDSsraSSTGGTGLGLAIVKHV 401
Cdd:cd16940 14 LFLLLRNLVDNAVRYSPQGSRVEIKLSADD-GAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSIVKRI 89
|
90
....*....|....*....
gi 145569026 402 LLRHQGRLDISSTPGQGSR 420
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLE 108
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-421 |
7.14e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 84.30 E-value: 7.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDG--GSVHVrWWGDEVGAH-LSVEDSGIGIEQKHLPRLTERFYRVDSSRASstGGTGLGLAIV 398
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrpPRIEV-GAEDVGEEWtFYVRDNGIGIDPEYAEKVFGIFQRLHSREEY--EGTGVGLAIV 77
|
90 100
....*....|....*....|...
gi 145569026 399 KHVLLRHQGRLDISSTPGQGSRF 421
Cdd:cd16921 78 RKIIERHGGRIWLESEPGEGTTF 100
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
199-424 |
1.49e-19 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 90.43 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 199 LHQLEQMRKDFVANVSHELRTPLTVIAGYLEtLLENAEAVNPrwlralQQMNQQAGRMQHLLNDLLLLARLETSSRPTDN 278
Cdd:PRK10604 205 INALIASKKQLIDGIAHELRTPLVRLRYRLE-MSDNLSAAES------QALNRDIGQLEALIEELLTYARLDRPQNELHL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 279 QPVAVGLLLQSIISDARALsgNRGHLISLD-ADPGLQLKGSEAELRSAFSNLVFNAVKYTpdGGSVHVRWWGDEVGAHLS 357
Cdd:PRK10604 278 SEPDLPAWLSTHLADIQAV--TPEKTVRLDtPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLI 353
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145569026 358 VEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCH 424
Cdd:PRK10604 354 VEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFS 420
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-418 |
1.72e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 83.27 E-value: 1.72e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTpdGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRasSTGGTGLGLAIVKHV 401
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQRI 76
|
90
....*....|....*..
gi 145569026 402 LLRHQGRLDISSTPGQG 418
Cdd:cd16950 77 SDAHGGSLTLANRAGGG 93
|
|
| PhoR |
pfam11808 |
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members ... |
26-90 |
7.09e-19 |
|
Phosphate regulon sensor protein PhoR; This family is only found in bacteria. Family members include PhoR. A member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokinase/phospho-PhoB phosphatase that donates a phosphoryl group to PhoB when environmental Pi is limiting and removes the phosphoryl group from phosphorylated PhoB (PhoB-P) when environmental Pi is abundant.
Pssm-ID: 432090 Cd Length: 84 Bit Score: 80.73 E-value: 7.09e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145569026 26 ITGEYAWVLVIGLSGYLVWTLRQLLRLQRWLhRADPDEPPPDSAGIWGDVFDNLYQMQRRDLRLR 90
Cdd:pfam11808 21 LFGHLAAALLLALLAYLAWHLYQLLRLSRWL-WRPRKLTPPDGSGLWGEIFYGLYRLQRRNRRRR 84
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
187-422 |
1.90e-18 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 86.84 E-value: 1.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 187 REHLLLVRDVTRLHQLEQMrKDFVANVSHELRTPLTVIAGYLETLLEN--AEAVNPRWLR-ALQQMNQqagrmqhllndl 263
Cdd:COG5806 183 IENILLRKELQRAEKLEVV-SELAASIAHEVRNPLTVVRGFIQLLQEPelSDEKRKQYIRiALEELDR------------ 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 264 lllarLE-------TSSRPTDNQ--PVAVGLLLQSIISDARALSGNRGHLISLDADPGLQLKGSEAELRSAFSNLVFNAV 334
Cdd:COG5806 250 -----AEaiitdylTFAKPQPEKleKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGI 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 335 KYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYrvdssrasST--GGTGLGLAIVKHVLLRHQGRLDIS 412
Cdd:COG5806 325 EAMPNGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF--------STkeKGTGLGTMVSYRIIEAMNGTIRVE 396
|
250
....*....|
gi 145569026 413 STPGQGSRFS 422
Cdd:COG5806 397 SEVGKGTTFT 406
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
328-421 |
2.82e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 79.84 E-value: 2.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLVFNAVKYTPDGGSVHVRW-WGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQ 406
Cdd:cd16925 11 NLLSNAFKFTPDGGRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVELHG 90
|
90
....*....|....*
gi 145569026 407 GRLDISSTPGQGSRF 421
Cdd:cd16925 91 GTVTVSDAPGGGALF 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
187-425 |
3.41e-17 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 82.69 E-value: 3.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 187 REHLLLVRDVTRLHQ-----LEQMR-KDFV-ANVSHELRTPLTVIAGYLETL-LENAEAVNPRWLRALQQMNQQA----- 253
Cdd:PRK09303 125 QELLQLSDELFVLRQenetlLEQLKfKDRVlAMLAHDLRTPLTAASLALETLeLGQIDEDTELKPALIEQLQDQArrqle 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 254 --GRMQHLLNDLLLLARLETSSRPtdnQPVAVGLLLQSIISDARALSGNRGHLISLD---------ADPGLqlkgseaeL 322
Cdd:PRK09303 205 eiERLITDLLEVGRTRWEALRFNP---QKLDLGSLCQEVILELEKRWLAKSLEIQTDipsdlpsvyADQER--------I 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 323 RSAFSNLVFNAVKYTPDGGSVHVrwwgdeVGAH-------LSVEDSGIGIEQKHLPRLTERFYRVDssRASSTGGTGLGL 395
Cdd:PRK09303 274 RQVLLNLLDNAIKYTPEGGTITL------SMLHrttqkvqVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGL 345
|
250 260 270
....*....|....*....|....*....|
gi 145569026 396 AIVKHVLLRHQGRLDISSTPGQGSRFscHF 425
Cdd:PRK09303 346 SVCRRIVRVHYGQIWVDSEPGQGSCF--HF 373
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
194-422 |
4.17e-17 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 83.84 E-value: 4.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 194 RDVT--RLHQ--LEQMRKD---FVANVSHELRTPLTVIAGYLETLLEnaEAVNPRWLRALQQMNQQAGRMQHLLNDLLLL 266
Cdd:PRK11091 264 RDITerKRYQdaLEKASRDkttFISTISHELRTPLNGIVGLSRILLD--TELTAEQRKYLKTIHVSAITLGNIFNDIIDM 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 267 ARLETSSRPTDNQPVAvgllLQSIISDARALSG----NRGhlISLDADPGLQL-KGSEAE---LRSAFSNLVFNAVKYTP 338
Cdd:PRK11091 342 DKMERRKLQLDNQPID----FTDFLADLENLSGlqaeQKG--LRFDLEPLLPLpHKVITDgtrLRQILWNLISNAVKFTQ 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 339 DGGsVHVRWWGDEvGAHLS--VEDSGIGIEQKHLPRLTERFYRV-DSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTP 415
Cdd:PRK11091 416 QGG-VTVRVRYEE-GDMLTfeVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEE 493
|
....*..
gi 145569026 416 GQGSRFS 422
Cdd:PRK11091 494 GKGSCFT 500
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-425 |
1.02e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 75.40 E-value: 1.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTgGTGLGLAIVKHV 401
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQE-STGMGLYLVKKL 84
|
90 100
....*....|....*....|....*.
gi 145569026 402 L--LRHQgrLDISSTPGQGSRFSCHF 425
Cdd:cd16948 85 CdkLGHK--IDVESEVGEGTTFTITF 108
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
198-422 |
1.18e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 82.38 E-value: 1.18e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 198 RLHQLEQMRK----------DFVANVSHELRTPLTVIAGYLEtLLENAEaVNPRWLRALQQMNQ---------------- 251
Cdd:PRK15347 380 RTQALAEAKQraeqankrksEHLTTISHEIRTPLNGVLGALE-LLQNTP-LTAEQMDLADTARQctlsllaiinnlldfs 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 252 --QAGRMQhllndlllLARLETSSRPTDNQpvaVGLLLQSiisdaRALSgnrgHLISL----DADPGLQLKGSEAELRSA 325
Cdd:PRK15347 458 riESGQMT--------LSLEETALLPLLDQ---AMLTIQG-----PAQS----KSLTLrtfvGAHVPLYLHLDSLRLRQI 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 326 FSNLVFNAVKYTPDGG-SVHVRwwgdEVGAHL--SVEDSGIGIEQKHLPRLTERFYRVDSSRAsstgGTGLGLAIVKHVL 402
Cdd:PRK15347 518 LVNLLGNAVKFTETGGiRLRVK----RHEQQLcfTVEDTGCGIDIQQQQQIFTPFYQADTHSQ----GTGLGLTIASSLA 589
|
250 260
....*....|....*....|
gi 145569026 403 LRHQGRLDISSTPGQGSRFS 422
Cdd:PRK15347 590 KMMGGELTLFSTPGVGSCFS 609
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
209-421 |
1.31e-16 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 82.52 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 209 FVANVSHELRTPLTVIAGYLETLLENaeAVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLET-----SSRPTDnqpvav 283
Cdd:TIGR02956 467 FLATMSHEIRTPLNGILGTLELLGDT--GLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAghlsiSPRPFD------ 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 284 gllLQSIISDARAL--SGNRGHLISLDADPGLQL----KGSEAELRSAFSNLVFNAVKYTpDGGSVHVR-WWGDEVGAHL 356
Cdd:TIGR02956 539 ---LNALLDDVHHLmvSRAQLKGIQLRLNIPEQLpnwwQGDGPRIRQVLINLVGNAIKFT-DRGSVVLRvSLNDDSSLLF 614
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145569026 357 SVEDSGIGIEQKHLPRLTERFYRVDSSRASstGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRF 421
Cdd:TIGR02956 615 EVEDTGCGIAEEEQATLFDAFTQADGRRRS--GGTGLGLAISQRLVEAMDGELGVESELGVGSCF 677
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
203-421 |
1.74e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 81.88 E-value: 1.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 203 EQMRKDFVANVSHELRTPLTVIAGYLETLLENAeaVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLETSSRPT--DNQP 280
Cdd:PRK11466 441 SQAKSAFLAAMSHEIRTPLYGILGTAQLLADNP--ALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNVsvSDEP 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 281 VAVGLLLQSIIsdaRALSGN-RGHLISLDADPGLQ----LKGSEAELRSAFSNLVFNAVKYTpDGGSVHVRWWGDEVGAH 355
Cdd:PRK11466 519 FEPRPLLESTL---QLMSGRvKGRPIRLATDIADDlptaLMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQWL 594
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145569026 356 LSVEDSGIGIEQKHLPRLTERFYRVDSSRasstGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRF 421
Cdd:PRK11466 595 VEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCF 656
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
197-418 |
1.87e-16 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 80.85 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 197 TRLHQLEQMRKDFVANVSHELRTPLTVIAGYLET--LLENAEAVNPRwlrALQQMNQQAGRMQHLLNDLLLLARLETSSR 274
Cdd:PRK10337 228 ARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVaqLSDDDPQARKK---ALLQLHAGIDRATRLVDQLLTLSRLDSLDN 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 275 PTDNQPVAVGLLLQSIISDARALSGNRGHLISLDA-DPGLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDevg 353
Cdd:PRK10337 305 LQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLnAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR--- 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145569026 354 aHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASstgGTGLGLAIVKHVLLRHQGRLDISSTPGQG 418
Cdd:PRK10337 382 -NFTVRDNGPGVTPEALARIGERFYRPPGQEAT---GSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-421 |
2.84e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 74.00 E-value: 2.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 320 AELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYrvdSSRASSTGgTGLGLAIVK 399
Cdd:cd16943 2 SQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGEG-TGLGLSLSY 77
|
90 100
....*....|....*....|..
gi 145569026 400 HVLLRHQGRLDISSTPGQGSRF 421
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRF 99
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-416 |
6.81e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 73.26 E-value: 6.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFY---RVDSSRASstggTGLGLAIV 398
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSGQKS----TGLGLAFV 80
|
90
....*....|....*...
gi 145569026 399 KHVLLRHQGRLDISSTPG 416
Cdd:cd16945 81 QEVAQLHGGRITLRNRPD 98
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
202-407 |
7.28e-16 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 79.21 E-value: 7.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 202 LEQM---RKDFVANVSHELRTPLTviagyletLLENAEAVNPRWL-------------RALQQM-NQ--QAGRMQHLlnd 262
Cdd:PRK09470 236 LERMmtsQQRLLSDISHELRTPLT--------RLQLATALLRRRQgeskelerieteaQRLDSMiNDllVLSRNQQK--- 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 263 llllarletSSRPTDNQPVAvgLLLQSIISDARALSGNRGHLISLDADPG-LQLKGSEAELRSAFSNLVFNAVKYTPDgg 341
Cdd:PRK09470 305 ---------NHLERETFKAN--SLWSEVLEDAKFEAEQMGKSLTVSAPPGpWPINGNPNALASALENIVRNALRYSHT-- 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145569026 342 SVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQG 407
Cdd:PRK09470 372 KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRG 437
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
203-425 |
9.04e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 79.69 E-value: 9.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 203 EQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRWLRALQQMNQQAgrmqhllndllllarlETSSRPTDN---- 278
Cdd:PRK10490 661 EQLRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIRQQV----------------LNTTRLVNNlldm 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 279 ---QPVAVGL-----LLQSIISDA-RALS-GNRGHLISLDADPGLQLKGSEAEL-RSAFSNLVFNAVKYTPDGGSVHVRW 347
Cdd:PRK10490 725 ariQSGGFNLrkewlTLEEVVGSAlQMLEpGLSGHPINLSLPEPLTLIHVDGPLfERVLINLLENAVKYAGAQAEIGIDA 804
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145569026 348 WGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDssRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFscHF 425
Cdd:PRK10490 805 HVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACF--RV 878
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-413 |
1.54e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 72.03 E-value: 1.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRasSTGGTGLGLAIVKHV 401
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAKAI 78
|
90
....*....|..
gi 145569026 402 LLRHQGRLDISS 413
Cdd:cd16923 79 IELHGGSASAEY 90
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
201-422 |
2.17e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 78.48 E-value: 2.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 201 QLEQMRKDFVANVSHELRTPLTVIAGYLETLleNAEAVNPRWLRALQQMNQqagrmqhllndllllarletSSrptdnqp 280
Cdd:PRK10841 442 QASQSKSMFLATVSHELRTPLYGIIGNLDLL--QTKELPKGVDRLVTAMNN--------------------SS------- 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 281 vavGLLLQsIISD---------------ARALSGNR--GHLIS----------------LDADPGLQLKGSEAELRSAFS 327
Cdd:PRK10841 493 ---SLLLK-IISDildfskieseqlkiePREFSPREviNHITAnylplvvkkrlglycfIEPDVPVALNGDPMRLQQVIS 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLVFNAVKYTPDGGSV-HVRWWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQ 406
Cdd:PRK10841 569 NLLSNAIKFTDTGCIVlHVRVDGDYL--SFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMD 646
|
250
....*....|....*.
gi 145569026 407 GRLDISSTPGQGSRFS 422
Cdd:PRK10841 647 GDISVDSEPGMGSQFT 662
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
187-421 |
3.06e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 77.52 E-value: 3.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 187 REHLLLVRDVTRLHQLEQMrKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRwlRALQQ-MNQQAGRMQHLLNDLLL 265
Cdd:PRK10364 219 RSRQLLQDEMKRKEKLVAL-GHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEA--HQLAQvMAKEADRLNRVVSELLE 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 266 LarletsSRPTD--NQPVAVGLL----LQSIISDARAlsgnRGHLISLDADPGLQLKGSEAE-LRSAFSNLVFNAVKYTP 338
Cdd:PRK10364 296 L------VKPTHlaLQAVDLNDLinhsLQLVSQDANS----REIQLRFTANDTLPEIQADPDrLTQVLLNLYLNAIQAIG 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 339 DGGSVHV--RWWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYrvdssrASSTGGTGLGLAIVKHVLLRHQGRLDISSTPG 416
Cdd:PRK10364 366 QHGVISVtaSESGAGV--KISVTDSGKGIAADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEG 437
|
....*
gi 145569026 417 QGSRF 421
Cdd:PRK10364 438 KGATF 442
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
200-421 |
3.25e-15 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 77.80 E-value: 3.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 200 HQLEQMRK-----DFVANVSHELRTPLTVIAGYLEtLLENAEAVNPRWLRALQQMNQQAGRMQHLLNDLLllarleTSSR 274
Cdd:PRK13837 439 RRLEHARRleavgTLASGIAHNFNNILGAILGYAE-MALNKLARHSRAARYIDEIISAGARARLIIDQIL------AFGR 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 275 PTDN--QPVAVGLLLQSIISDARAlSGNRGHLISLDADP-GLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDE 351
Cdd:PRK13837 512 KGERntKPFDLSELVTEIAPLLRV-SLPPGVELDFDQDQePAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAK 590
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 352 VGAH---------------LSVEDSGIGIEQKHLPRLTERFYrvdSSRAsstGGTGLGLAIVKHVLLRHQGRLDISSTPG 416
Cdd:PRK13837 591 LRAPkvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVG 664
|
....*
gi 145569026 417 QGSRF 421
Cdd:PRK13837 665 RGTRF 669
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
68-422 |
4.30e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 77.85 E-value: 4.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 68 SAGIWGdvFDNLYQMQRRDLrLRGELQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNlv 147
Cdd:PRK09959 549 SSLLWG--FYLLRSVRRRKV-IQGDLENQISFRKALSDSLPNPTYVVNWQGNVISHNSAFEHYFTADYYKNAMLPLEN-- 623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 148 RHPAFKEYF------------DKGNYDQPLELASPVDDR-LRLQFNITRYGNREHLLLV---RDVTR----LHQLEQMRK 207
Cdd:PRK09959 624 SDSPFKDVFsnahevtaetkeNRTIYTQVFEIDNGIEKRcINHWHTLCNLPASDHAVYIcgwQDITEtrdlIHALEVERN 703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 208 ----------DFVANVSHELRTPLTVIAGYLEtLLENAEAVNPRWLRALQQMNQQAGRMQHLLNDLLLLARLETSSRPTD 277
Cdd:PRK09959 704 kainatvaksQFLATMSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQ 782
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 278 NQPVAVGLLLQSIISDARALSGNRGHLISLDAD-PGLQL-KGSEAELRSAFSNLVFNAVKYTPDGGS------VHVRwwG 349
Cdd:PRK09959 783 PQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfPDHYLvKIDPQAFKQVLSNLLSNALKFTTEGAVkittslGHID--D 860
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145569026 350 DEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASStgGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:PRK09959 861 NHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHPGIGTTFT 931
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-414 |
1.72e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 69.03 E-value: 1.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRaSSTGGTGLGLAIVKHV 401
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYIAKNL 83
|
90
....*....|...
gi 145569026 402 LLRHQGRLDISST 414
Cdd:cd16975 84 VEKHGGSLIIENS 96
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
286-425 |
6.49e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 68.43 E-value: 6.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 286 LLQSIISDARALSGNRGHLISLDADPGLQLKGSEAELRSAFSNLVFNAVKYTpdGGSVHVRWWGDEVGAHLSVEDSGIGI 365
Cdd:cd16954 2 LLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGV 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 366 EQKHLPRLTERFYRVDSSRAsstgGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:cd16954 80 PESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
317-422 |
1.57e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.15 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 317 GSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLA 396
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95
|
90 100
....*....|....*....|....*.
gi 145569026 397 IVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEKTVFT 121
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-424 |
2.43e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 65.91 E-value: 2.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 325 AFSNLVFNAVKYTPDGGSVHVRWWGDEvgAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLR 404
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGR--LTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALW 81
|
90 100
....*....|....*....|
gi 145569026 405 HQGRLDISSTPGQGSRFSCH 424
Cdd:cd16939 82 HGGHVECDDSELGGACFRLT 101
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
203-258 |
1.50e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.23 E-value: 1.50e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 145569026 203 EQMRKDFVANVSHELRTPLTVIAGYLETLLENAEAvNPRWLRALQQMNQQAGRMQH 258
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLD-DEEQREYLERIREEAERLLR 55
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
328-426 |
4.99e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 67.95 E-value: 4.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLVFNAVKYTpDGGSVHVR-----WWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVL 402
Cdd:PRK11107 415 NLVGNAIKFT-ESGNIDILvelraLSNTKVQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLV 493
|
90 100
....*....|....*....|....
gi 145569026 403 LRHQGRLDISSTPGQGSRFSCHFQ 426
Cdd:PRK11107 494 NEMGGDISFHSQPNRGSTFWFHLP 517
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
185-431 |
1.67e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 65.81 E-value: 1.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 185 GNREHL---------LLVRDVTRLHQLEQMRKD----FVANVSHELRTPLTVIAGYLETL-------LENAEavnPRWLR 244
Cdd:PRK10815 232 GEREQLdpnppreltSLVRNLNRLLKNERERYTkyrtTLTDLTHSLKTPLAVLQSTLRSLrsgkqmsVEQAE---PIMLE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 245 ALQQMNQQAGRMQHLLNDLLLLArleTSSRptDNQPVAVglLLQSIISDARALSGNRGHLISLDADPGLQLKGSEAELRS 324
Cdd:PRK10815 309 QISRISQQIGYYLHRASMRSEHN---LLSR--ELHSVAP--LLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFME 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 325 AFSNLVFNAVKYTPDGGSVHVRWWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYRVDSSRAsstgGTGLGLAIVKHVLLR 404
Cdd:PRK10815 382 VMGNVLDNACKYCLEFVEISARQTDEHL--HIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQ 455
|
250 260
....*....|....*....|....*..
gi 145569026 405 HQGRLDISSTPGQGSRFSCHFQNSQVP 431
Cdd:PRK10815 456 YEGKISAGDSPLGGARMEVIFGRQHST 482
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
205-258 |
3.22e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 58.38 E-value: 3.22e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 145569026 205 MRKDFVANVSHELRTPLTVIAGYLETLLEnaEAVNPRWLRALQQMNQQAGRMQH 258
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD--EKLDEEQREYLETILRSAERLLR 52
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
205-258 |
3.00e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 55.65 E-value: 3.00e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 145569026 205 MRKDFVANVSHELRTPLTVIAGYLETLLENAEAVNPRwlRALQQMNQQAGRMQH 258
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQR--EYLETILREAERLLR 52
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-420 |
1.22e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.62 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNA---VKYTPDG-GSVHVRWWGDEVGA-HLSVEDSGIGIEQKHLPRLTERfYRVDSSRasstgGTGLGLA 396
Cdd:cd16944 5 ISQVLTNILKNAaeaIEGRPSDvGEVRIRVEADQDGRiVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTGLGLA 78
|
90 100
....*....|....*....|....
gi 145569026 397 IVKHVLLRHQGRLDISSTPGQGSR 420
Cdd:cd16944 79 IVKKIMEEHGGRISLSNREAGGAC 102
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
106-416 |
6.96e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 57.01 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 106 ALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAF-----KEYFDKGNYDQPLELASPVDDR-LRLQF 179
Cdd:PRK11073 15 SLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLnielmRESLQAGQGFTDNEVTLVIDGRsHILSL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 180 NITRYGNREHLLLVRDV---TRL------HQLEQMRKDFVANVSHELRTPLTVIAGYLEtLLENAEAvNPRWLRALQQMN 250
Cdd:PRK11073 95 TAQRLPEGMILLEMAPMdnqRRLsqeqlqHAQQVAARDLVRGLAHEIKNPLGGLRGAAQ-LLSKALP-DPALTEYTKVII 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 251 QQAGRMQHLLNDLLLlarletSSRPTDNQPVAVGLLLQSIisdARALSGNRGHLISL--DADPGL-QLKGSEAELRSAFS 327
Cdd:PRK11073 173 EQADRLRNLVDRLLG------PQRPGTHVTESIHKVAERV---VQLVSLELPDNVRLirDYDPSLpELAHDPDQIEQVLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLVFNAVK-YTPDGGSVHVRWWGD----------EVGAHLSVEDSGIGIEqkhlPRLTER-FYRVDSSRassTGGTGLGL 395
Cdd:PRK11073 244 NIVRNALQaLGPEGGTITLRTRTAfqltlhgeryRLAARIDIEDNGPGIP----PHLQDTlFYPMVSGR---EGGTGLGL 316
|
330 340
....*....|....*....|.
gi 145569026 396 AIVKHVLLRHQGRLDISSTPG 416
Cdd:PRK11073 317 SIARNLIDQHSGKIEFTSWPG 337
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
196-421 |
8.77e-09 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 57.45 E-value: 8.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 196 VTRLHQLEQMRKDFVANVSHELRTPLTVIAGYLETL------------LENAEAVNPRWLRALQQMNqQAGRMqhllndl 263
Cdd:TIGR03785 475 VARLRQYTHYLENMSSRLSHELRTPVAVVRSSLENLelqaleqekqkyLERAREGTERLSMILNNMS-EATRL------- 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 264 lllarlETSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPgLQLKGSEAELRSAFSNLVFNAVKYTPDGGSV 343
Cdd:TIGR03785 547 ------EQAIQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETP-LVMRGSPELIAQMLDKLVDNAREFSPEDGLI 619
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145569026 344 HVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTP-GQGSRF 421
Cdd:TIGR03785 620 EVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQqNDGVVF 698
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-422 |
1.18e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 52.46 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLVFNA---VKYTPDGG-SVHVRWWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYrvdsSRASSTGGTGLGLAIVKHVLL 403
Cdd:cd16976 7 NLLQNAldaMGKVENPRiRIAARRLGGRL--VLVVRDNGPGIAEEHLSRVFDPFF----TTKPVGKGTGLGLSISYGIVE 80
|
90
....*....|....*....
gi 145569026 404 RHQGRLDISSTPGQGSRFS 422
Cdd:cd16976 81 EHGGRLSVANEEGAGARFT 99
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-421 |
1.43e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 52.40 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLVFNAVK----YTPDGGSVHVRWWGDEVGA-HLSVEDSGIGIEQKHLPRLTERFYrvdSSRASstgGTGLGLAIVKHVL 402
Cdd:cd16920 7 NLVRNGIEamseGGCERRELTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFY---TTKSE---GLGMGLSICRSII 80
|
90
....*....|....*....
gi 145569026 403 LRHQGRLDISSTPGQGSRF 421
Cdd:cd16920 81 EAHGGRLSVESPAGGGATF 99
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-416 |
3.49e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 51.25 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGG-----------SVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLterFYRVDSSRAsstGG 390
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTI---FYPMVSGRE---NG 74
|
90 100
....*....|....*....|....*.
gi 145569026 391 TGLGLAIVKHVLLRHQGRLDISSTPG 416
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQPG 100
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
322-421 |
4.41e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.03 E-value: 4.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTP-DGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGLAIVKH 400
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100
....*....|....*....|....*
gi 145569026 401 VLLRHQGRL--DISSTPGQ--GSRF 421
Cdd:cd16953 81 IIEAHGGISvaENHNQPGQviGARF 105
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
195-425 |
1.18e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 53.91 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 195 DVTR-------LHQLEQMRK--DFVANVSHELRTPLTVIAGYLETLLENAEAVNP---RWLRALQQMNQQAGRmqhllnd 262
Cdd:PRK13557 143 DVSRrrdaedaLRQAQKMEAlgQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDAdrgRMARSVENIRAAAER------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 263 llllarletSSRPT------------DNQPVAVGLLLQSIISDA-RALSGnrGHLISLDADPGL---QLKGSEAELrsAF 326
Cdd:PRK13557 216 ---------AATLTqqllafarkqrlEGRVLNLNGLVSGMGELAeRTLGD--AVTIETDLAPDLwncRIDPTQAEV--AL 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 327 SNLVFNAVKYTPDGGSVHVRWWGDEVGAH---------------LSVEDSGIGIEQKHLPRLTERFYrvdsSRASSTGGT 391
Cdd:PRK13557 283 LNVLINARDAMPEGGRVTIRTRNVEIEDEdlamyhglppgryvsIAVTDTGSGMPPEILARVMDPFF----TTKEEGKGT 358
|
250 260 270
....*....|....*....|....*....|....
gi 145569026 392 GLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:PRK13557 359 GLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
322-425 |
5.27e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 48.14 E-value: 5.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 322 LRSAFSNLVFNAVKYTPDGGSVHVR----WWGDEVGAH-----------LSVEDSGIGIEQKHLPRLTERFYrvdsSRAS 386
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIEtsnqRVDADYALNyrdlipgnyvcLEVSDTGSGMPAEVLRRAFEPFF----TTKE 76
|
90 100 110
....*....|....*....|....*....|....*....
gi 145569026 387 STGGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:cd16919 77 VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
213-414 |
5.58e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.00 E-value: 5.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 213 VSHELRTPLTVIAGYLETLLENAEAVNPRWLRA-LQQMNQQAGRMQHLLNDLlllarlETSSRPTDNQPVAVglLLQSII 291
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQENYAQLPTsLDKIEGLIERMDKIIKSL------RQFSRKSDTPLQPV--DLRQVI 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 292 SDARAL--SGNRGHLISLDADPGLQLKGSEAELRSAFSNLVFNAVKYTPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQkh 369
Cdd:COG4192 512 EQAWELveSRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPL-- 589
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 145569026 370 LPRLTERFYrvdssrASSTGGTGLGLAIVKHVLLRHQGRLDISST 414
Cdd:COG4192 590 VDKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLAST 628
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
81-204 |
8.67e-07 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 50.93 E-value: 8.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 81 QMQRRDLRLRGELQGIIDraqgstaALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKGn 160
Cdd:COG3829 1 AEELELKELEEELEAILD-------SLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPNSPLLEVLKTG- 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 145569026 161 ydQPLELASPVDDRLRLQFNITRY-----GNREH-LLLVRDVTRLHQLEQ 204
Cdd:COG3829 73 --KPVTGVIQKTGGKGKTVIVTAIpifedGEVIGaVETFRDITELKRLER 120
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-422 |
9.27e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 46.90 E-value: 9.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 328 NLV---FNAVKYTPDGGS-VHV--RWWGDEVgaHLSVEDSGIGIEQKHLPRLTERFYrvdSSRAssTGGTGLGLAIVKHV 401
Cdd:cd16915 7 NLIdnaLDALAATGAPNKqVEVflRDEGDDL--VIEVRDTGPGIAPELRDKVFERGV---STKG--QGERGIGLALVRQS 79
|
90 100
....*....|....*....|.
gi 145569026 402 LLRHQGRLDISSTPGQGSRFS 422
Cdd:cd16915 80 VERLGGSITVESEPGGGTTFS 100
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
329-418 |
1.84e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.02 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 329 LVFNAVKY----TPDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFyrvdssrASSTGGTGLGLAIVKHVLLR 404
Cdd:COG2972 344 LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKL 416
|
90
....*....|....*..
gi 145569026 405 HQG---RLDISSTPGQG 418
Cdd:COG2972 417 YYGeeyGLEIESEPGEG 433
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
273-416 |
2.95e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 49.52 E-value: 2.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 273 SRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPgLQLKGSEAE---LrsAFSNLVFNAVKY---TPDGGSVHVR 346
Cdd:COG3920 351 YQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPD-VELPADAAVplgL--ILNELVTNALKHaflSGEGGRIRVS 427
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 347 WWGDEVGAHLSVEDSGIGIeqkhlprlterfyrvdSSRASSTGGTGLGLAIVKHVLLRHQGRLDISSTPG 416
Cdd:COG3920 428 WRREDGRLRLTVSDNGVGL----------------PEDVDPPARKGLGLRLIRALVRQLGGTLELDRPEG 481
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
106-156 |
1.68e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 42.39 E-value: 1.68e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 145569026 106 ALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVrHPAFKEYF 156
Cdd:smart00091 9 SLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI-HPEDRERV 58
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
107-215 |
4.33e-05 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 42.24 E-value: 4.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 107 LKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKgnYDQPLELASPVDDRLRLQfniTRYGN 186
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRER--LENLLSGGEPVTLEVRLR---RKDGS 75
|
90 100
....*....|....*....|....*....
gi 145569026 187 REHLLLVrdVTRLHQLEQMRKDFVANVSH 215
Cdd:cd00130 76 VIWVLVS--LTPIRDEGGEVIGLLGVVRD 102
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
330-425 |
2.15e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.84 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 330 VFNAVKYTPdGGSVHVRWWGDEVGAHLSVEDSGIGIEQkhlprlterfyrvdssrASSTGGTGLGLAIVKHVLLRHQGRL 409
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDG-----------------PAPPGGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*.
gi 145569026 410 DISSTPGQGSRFSCHF 425
Cdd:cd16917 71 TIGSRPGGGTRVTARL 86
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
320-400 |
3.21e-04 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 40.28 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 320 AELRSAFSNLVFNAVKYT---PDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRlterfyrvdssRASSTGGTGLGLA 396
Cdd:COG2172 33 DDLVLAVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD-----------PYSTLAEGGRGLF 101
|
....
gi 145569026 397 IVKH 400
Cdd:COG2172 102 LIRR 105
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
320-420 |
3.43e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 40.05 E-value: 3.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 320 AELRSAFSNLVFNAVKYTPDGG-SVHVRWWGDEVGAHLSVEDSGIGIeqkhlPRLTERFyrvdSSRASSTGGTGLGLAIV 398
Cdd:cd16934 24 AEIATAVTELARNLLKHAGGGQvLLEVVAEGGRVALEILAVDQGPGI-----ADVDEAL----RDGFSTGGGLGLGLGGV 94
|
90 100
....*....|....*....|..
gi 145569026 399 KhvllRHQGRLDISSTPGQGSR 420
Cdd:cd16934 95 R----RLADEFDLHSAPGRGTV 112
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
91-150 |
5.88e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 39.32 E-value: 5.88e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 91 GELQGIIDraqgstaALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHP 150
Cdd:pfam00989 1 EDLRAILE-------SLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEE 53
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-419 |
7.65e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 38.60 E-value: 7.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 329 LVFNAVKY--TPDGGSVHVRWWGDEV---GAHLSVEDSGIGIEQKHLPRLterfyrvdssRASSTGGTGLGLAIVKHVL- 402
Cdd:cd16955 9 LVENAIVHgiQEKKGKGVVKISVKKQlknRLHIAVEDNGIGISPKVIERV----------EQDEMPGNKIGLLNVHQRLk 78
|
90
....*....|....*..
gi 145569026 403 LRHQGRLDISSTPGQGS 419
Cdd:cd16955 79 LGYGEGLHIRSRPDPGT 95
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
105-166 |
1.00e-03 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 41.33 E-value: 1.00e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145569026 105 AALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFDKGNYDQPLE 166
Cdd:COG3283 87 EALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLKGFNFSRWLESNEPRPQSE 148
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
390-422 |
1.23e-03 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 39.49 E-value: 1.23e-03
10 20 30
....*....|....*....|....*....|...
gi 145569026 390 GTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:cd16916 142 GRGVGMDVVKRSIESLGGTIEVESEPGQGTTFT 174
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
117-197 |
1.51e-03 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 37.83 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 117 DGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHP----AFKEYFDKGNYDQPLELASPVDDRLRLQFNITRYGNRE---- 188
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPedseRLREALREGKAVREFEVVLYRKDGEPFPVLVSLAPIRDdgge 80
|
90
....*....|..
gi 145569026 189 ---HLLLVRDVT 197
Cdd:pfam13426 81 lvgIIAILRDIT 92
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
221-425 |
1.93e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.60 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 221 LTVIAGYLETLLENAEAVNPRWLRALQQMNQQAGRMQHllndllllarlETSS-----RPTDNQPVAVGLLLQSIISDAR 295
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAREELEEIRELAREALA-----------ELRRlvrglRPPALDDLGLAAALEELAERLL 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 296 ALSGnrghlISLDadpgLQLKGSEAELRSAFSNLVF--------NAVKYTPdGGSVHVRWWGDEVGAHLSVEDSGIGIEQ 367
Cdd:COG4585 138 RAAG-----IRVE----LDVDGDPDRLPPEVELALYrivqealtNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDP 207
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 145569026 368 KHLPrlterfyrvdssrasstgGTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFSCHF 425
Cdd:COG4585 208 EAAP------------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATL 247
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
88-204 |
2.34e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 39.62 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 88 RLRGELQGIIDRAQGSTAALKDAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFD------KGNY 161
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLEllraalAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 145569026 162 DQPLELA------SPVDDRLRLQFNITRYGNREHLLLV-RDVTRLHQLEQ 204
Cdd:COG2202 81 VWRGELRnrrkdgSLFWVELSISPVRDEDGEITGFVGIaRDITERKRAEE 130
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-423 |
3.99e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 36.63 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 329 LVFNAVKYT----PDGGSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTErfyrvdsSRASSTGGTGLGLAIVKH---V 401
Cdd:cd16957 9 LVENAIRHAfpkrKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGK-------TTVTSEKGTGTALENLNRrliG 81
|
90 100
....*....|....*....|..
gi 145569026 402 LLRHQGRLDISSTPGQGSRFSC 423
Cdd:cd16957 82 LFGSEACLHIESEVHGGTEVWF 103
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
390-422 |
4.78e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.39 E-value: 4.78e-03
10 20 30
....*....|....*....|....*....|...
gi 145569026 390 GTGLGLAIVKHVLLRHQGRLDISSTPGQGSRFS 422
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFT 413
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
109-206 |
5.26e-03 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 38.47 E-value: 5.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 109 DAVIMLDSDGNLEWWNPAANRLLGLKKPQDAGHPIGNLVRHPAFKEYFD---------KGNYDQPLELASPVDDRLRLQF 179
Cdd:COG2202 148 DGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLEllrrlleggRESYELELRLKDGDGRWVWVEA 227
|
90 100 110
....*....|....*....|....*....|.
gi 145569026 180 NITRYGNREH----LLLVRDVTRLHQLEQMR 206
Cdd:COG2202 228 SAVPLRDGGEvigvLGIVRDITERKRAEEAL 258
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
106-162 |
6.40e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 35.22 E-value: 6.40e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 145569026 106 ALKDAVIMLDSDGNLEWWNPAANRLLGlkkPQDAGHPIGNLVRHPAFKEYFDKGNYD 162
Cdd:pfam13188 9 SSPDGILVLDEGGRIIYVNPAALELLG---YELLGELLGELLDLLDPLLEDALELLR 62
|
|
| ActS_PrrB_HisK |
NF033792 |
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, ... |
198-395 |
9.09e-03 |
|
ActS/PrrB/RegB family redox-sensitive histidine kinase; This redox-responsive histidine kinase, found in alpha-proteobacteria, shows strong sequence conservation, including the notable motif [VA]AAAAHELGTPxTI. It always acts as a partner to an ActR/PrrA/RegA family global response regulator transcription factor in a two-component sensory transduction system. Lineage-specific names and gene symbols given to this histidine kinase reflect downstream regulator changes such as entry into stationary phase, anaerobic expression of photosynthesis genes, and survival of exposure to low pH.
Pssm-ID: 468186 [Multi-domain] Cd Length: 423 Bit Score: 38.27 E-value: 9.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 198 RLHQLEQMrkdfVANVSHELRTPLTVIAgyletL----LENAEAVNPRWLRALQQMNQQA-------GRMqhllndllll 266
Cdd:NF033792 198 HLSALDGL----AAAAAHELGTPLATIA-----LvakeLERELPDDPPLREDAELLRSQAercrdilRRL---------- 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145569026 267 arletSSRPTDNQPVAVGLLLQSIISDARALSGNRGHLISLDADPGlqlKGSE------AELRSAFSNLVFNAVKYTpdG 340
Cdd:NF033792 259 -----TSLGEEGDAHLDRLPLSALIEEAAAPHRGFGKEIEVVVAGD---PGEEpvirrnPEILYGLGNLIENAVDFA--R 328
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 145569026 341 GSVHVRWWGDEVGAHLSVEDSGIGIEQKHLPRLTERFYRVDSSRASSTGGTGLGL 395
Cdd:NF033792 329 STVTVTASWDAESVTITIEDDGPGFPPDVLSRIGEPYVTTRRGEERRPGGGGLGL 383
|
|
| |
