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Conserved domains on  [gi|147742279|gb|ABQ50522|]
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Resolvase, N-terminal domain (plasmid) [Staphylococcus aureus subsp. aureus JH9]

Protein Classification

recombinase family protein( domain architecture ID 10133033)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0000150|GO:0003677|GO:0006310
PubMed:  21645851
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 2-128 4.21e-57

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


:

Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 176.13  E-value: 4.21e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   2 KIGYARVSTGLQNLNLQEDRLNTHG-CEKIFNDHMSGSKSKRPGLDKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNEL 80
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 147742279  81 NERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAG 128
Cdd:cd03768   81 REKGVSLRSLTEGI--DTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
140-184 4.68e-09

Helix-turn-helix domain of resolvase;


:

Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 50.05  E-value: 4.68e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 147742279  140 GRPEKLKKKDLNLLKTLYDNGTPIKTIAEQWQVSRTTIYRYLNKL 184
Cdd:pfam02796   1 GRPPKLNEEDINEVITLLEEGISIKQIAKIFGISRSTVYRYLAAS 45
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 2-128 4.21e-57

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 176.13  E-value: 4.21e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   2 KIGYARVSTGLQNLNLQEDRLNTHG-CEKIFNDHMSGSKSKRPGLDKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNEL 80
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 147742279  81 NERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAG 128
Cdd:cd03768   81 REKGVSLRSLTEGI--DTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-183 1.46e-49

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 165.20  E-value: 1.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   1 MKIGYARVSTGLQ---NLNLQEDRL----NTHGCE--KIFNDH-MSGSKSKRPGLDKAIEFARSG--DTIVVWRLDRLGR 68
Cdd:COG1961    3 RAAGYARVSTDDQeglSLERQREALrayaEKAGWEivRIYVDEgVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279  69 NMEDLITLVNELNERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLKKK 148
Cdd:COG1961   83 NLADLLELVEELKERGVRLISLTEGI--DTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRPPYGYRD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147742279 149 DLNLLK------------TLYDNGTPIKTIAEQWQ------VSRTTIYRYLNK 183
Cdd:COG1961  161 PKKLVIdeeeaevvrrifELYLEGKSLREIARELNergiptWSRSTVYRILKN 213
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 3-138 1.33e-48

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 155.12  E-value: 1.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279    3 IGYARVSTGLQN--LNLQEDRLNTHGCEK----IFNDH-MSGSKSKRPGLDKAIEFARS--GDTIVVWRLDRLGRNMEDL 73
Cdd:pfam00239   2 IGYARVSTEDQDdsLERQLEALRAYAACNgkivEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147742279   74 ITLVNELNERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRY 138
Cdd:pfam00239  82 LTLVEELREKGVDLVSLDEGI--DTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 3-138 8.74e-45

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 145.46  E-value: 8.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279     3 IGYARVSTGLQ---NLNLQEDRL----NTHGCE--KIFNDH-MSGSKSKRPGLDKAIEFARSGD--TIVVWRLDRLGRNM 70
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALrayaERNGWEvvRIYEDEgVSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147742279    71 EDLITLVNELNERGVSFHSLEENITmDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRY 138
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEGIL-DTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGRW 148
recomb_XisF NF041201
fdxN element excision recombinase XisF;
2-142 2.48e-24

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 98.88  E-value: 2.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   2 KIGYARVSTGLQN-----LNLQEDRLNTHGCEKIFNDHMSGSKSKRPGLDKAIEFARSG--DTIVVWRLDRLGRNMEDLI 74
Cdd:NF041201   1 IVGYARVSTREQAddghaLEQQIARLKKAGASEIFFDIESGRSDKRKGFNQLLKLVKSGkvTEIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147742279  75 TLVNELNERGVSFHSLEENItMDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRP 142
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPL-DDLSSPGGWFTINQLAALAEFESRLLSERVRHGLEYFREQKKAHPKP 147
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
1-182 5.47e-13

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 64.35  E-value: 5.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   1 MKIGYARVSTGLQNLNLQEDRLNTHgCEK-------IFNDHMSGSKS-KRPGLDKAIEFARSGDTIVVWRLDRLGRNMED 72
Cdd:PRK13413   1 MIYAYIRVSTDKQTVENQRFEITNF-AEKnnltidkWIEETISGTKSyKDRKLGKLLKKMRKGDILIVSELSRLGRNLME 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279  73 LITLVNELNERGVSFHSLEENITMDKSSSTGQLLFhLFAAFAEFERNLILERSSAGRIAARARGRYGGRP------EKLK 146
Cdd:PRK13413  80 IMSILNICMEKEVIVYTIKEGYELGDDINSKVLAF-AFGLSAEIERNLISQRTKEALARKKAEGVTLGRPkgstpkKYKL 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 147742279 147 KKDLNLLKTLYDNGTPIKTIAEQWQVSRTTIYRYLN 182
Cdd:PRK13413 159 TGKEEKIKKLLDKGTSKSEIARKLGVSRTTLARFLK 194
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
140-184 4.68e-09

Helix-turn-helix domain of resolvase;


Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 50.05  E-value: 4.68e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 147742279  140 GRPEKLKKKDLNLLKTLYDNGTPIKTIAEQWQVSRTTIYRYLNKL 184
Cdd:pfam02796   1 GRPPKLNEEDINEVITLLEEGISIKQIAKIFGISRSTVYRYLAAS 45
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
 157-181 8.92e-05

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 38.46  E-value: 8.92e-05
                         10        20
                 ....*....|....*....|....*
gi 147742279 157 YDNGTPIKTIAEQWQVSRTTIYRYL 181
Cdd:cd00569   18 LAAGESVAEIARELGVSRSTLYRYL 42
transpos_IS607 NF033518
IS607 family transposase;
3-68 4.04e-03

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 36.46  E-value: 4.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147742279   3 IGYARVSTGLQ--NLNLQEDRLNT----HG--CEKIFNDHMSGSKSKRPGLDKAIEFARSGD--TIVVWRLDRLGR 68
Cdd:NF033518  57 VIYARVSSADQkdDLERQVARLTQyataKGwqVDEVVTDIGSGLNEKRKGLLKLLDDILNGEvsRVVVEHKDRLTR 132
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 2-128 4.21e-57

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 176.13  E-value: 4.21e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   2 KIGYARVSTGLQNLNLQEDRLNTHG-CEKIFNDHMSGSKSKRPGLDKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNEL 80
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 147742279  81 NERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAG 128
Cdd:cd03768   81 REKGVSLRSLTEGI--DTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-183 1.46e-49

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 165.20  E-value: 1.46e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   1 MKIGYARVSTGLQ---NLNLQEDRL----NTHGCE--KIFNDH-MSGSKSKRPGLDKAIEFARSG--DTIVVWRLDRLGR 68
Cdd:COG1961    3 RAAGYARVSTDDQeglSLERQREALrayaEKAGWEivRIYVDEgVSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279  69 NMEDLITLVNELNERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLKKK 148
Cdd:COG1961   83 NLADLLELVEELKERGVRLISLTEGI--DTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRPPYGYRD 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147742279 149 DLNLLK------------TLYDNGTPIKTIAEQWQ------VSRTTIYRYLNK 183
Cdd:COG1961  161 PKKLVIdeeeaevvrrifELYLEGKSLREIARELNergiptWSRSTVYRILKN 213
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 3-138 1.33e-48

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 155.12  E-value: 1.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279    3 IGYARVSTGLQN--LNLQEDRLNTHGCEK----IFNDH-MSGSKSKRPGLDKAIEFARS--GDTIVVWRLDRLGRNMEDL 73
Cdd:pfam00239   2 IGYARVSTEDQDdsLERQLEALRAYAACNgkivEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147742279   74 ITLVNELNERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRY 138
Cdd:pfam00239  82 LTLVEELREKGVDLVSLDEGI--DTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGKL 144
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 3-138 8.74e-45

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 145.46  E-value: 8.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279     3 IGYARVSTGLQ---NLNLQEDRL----NTHGCE--KIFNDH-MSGSKSKRPGLDKAIEFARSGD--TIVVWRLDRLGRNM 70
Cdd:smart00857   2 AGYARVSTDDQadgSLERQLEALrayaERNGWEvvRIYEDEgVSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147742279    71 EDLITLVNELNERGVSFHSLEENITmDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRY 138
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEGIL-DTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGRW 148
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 5-128 2.12e-26

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 98.10  E-value: 2.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   5 YARVSTGLQN----LNLQEDRL----NTHGCE--KIFNDHMSGSKS--KRPGLDKAIEFARSG--DTIVVWRLDRLGRNM 70
Cdd:cd00338    2 YARVSTDKQEqgdsLERQREALreyaARNGLEvvGEYEDAGSSATSlvDRPGLQRLLADVKAGkiDVVLVEKLDRLSRNL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147742279  71 EDLITLVNELNERGVSFHSLEENItmDKSSSTGQLLFHLFAAFAEFERNLILERSSAG 128
Cdd:cd00338   82 VDLLELLELLEAHGVRVVTADGEI--DLDSEDGRLMLGILAAMAEEESKLISERTKRG 137
recomb_XisF NF041201
fdxN element excision recombinase XisF;
2-142 2.48e-24

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 98.88  E-value: 2.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   2 KIGYARVSTGLQN-----LNLQEDRLNTHGCEKIFNDHMSGSKSKRPGLDKAIEFARSG--DTIVVWRLDRLGRNMEDLI 74
Cdd:NF041201   1 IVGYARVSTREQAddghaLEQQIARLKKAGASEIFFDIESGRSDKRKGFNQLLKLVKSGkvTEIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147742279  75 TLVNELNERGVSFHSLEENItMDKSSSTGQLLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRP 142
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPL-DDLSSPGGWFTINQLAALAEFESRLLSERVRHGLEYFREQKKAHPKP 147
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
1-182 5.47e-13

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 64.35  E-value: 5.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   1 MKIGYARVSTGLQNLNLQEDRLNTHgCEK-------IFNDHMSGSKS-KRPGLDKAIEFARSGDTIVVWRLDRLGRNMED 72
Cdd:PRK13413   1 MIYAYIRVSTDKQTVENQRFEITNF-AEKnnltidkWIEETISGTKSyKDRKLGKLLKKMRKGDILIVSELSRLGRNLME 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279  73 LITLVNELNERGVSFHSLEENITMDKSSSTGQLLFhLFAAFAEFERNLILERSSAGRIAARARGRYGGRP------EKLK 146
Cdd:PRK13413  80 IMSILNICMEKEVIVYTIKEGYELGDDINSKVLAF-AFGLSAEIERNLISQRTKEALARKKAEGVTLGRPkgstpkKYKL 158

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 147742279 147 KKDLNLLKTLYDNGTPIKTIAEQWQVSRTTIYRYLN 182
Cdd:PRK13413 159 TGKEEKIKKLLDKGTSKSEIARKLGVSRTTLARFLK 194
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
140-184 4.68e-09

Helix-turn-helix domain of resolvase;


Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 50.05  E-value: 4.68e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 147742279  140 GRPEKLKKKDLNLLKTLYDNGTPIKTIAEQWQVSRTTIYRYLNKL 184
Cdd:pfam02796   1 GRPPKLNEEDINEVITLLEEGISIKQIAKIFGISRSTVYRYLAAS 45
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 4-90 7.26e-09

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 52.33  E-value: 7.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147742279   4 GYARVSTGLQNLNLQEDRLNTHGCEK------IFNDHMSGSKSKRPGLDKAIEFARSGDTIVVWRLDRLGR-NMEDLITL 76
Cdd:cd03767    3 AYLRASTDEQDATRAKESLEAFATERgfyiagFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRlPLDDWETL 82

                         90
                 ....*....|....
gi 147742279  77 VNELNERGVSFHSL 90
Cdd:cd03767   83 KASIAAKGLRVVSL 96
HTH_Hin_like cd00569
Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of ...
 157-181 8.92e-05

Helix-turn-helix domain of Hin and related proteins; This domain model summarizes a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed helical bundle. The principal DNA-protein interface is formed by the third helix, the recognition helix, inserting itself into the major groove of the DNA. A diverse array of HTH domains participate in a variety of functions that depend on their DNA-binding properties. HTH_Hin represents one of the simplest versions of the HTH domains; the characterization of homologous relationships between various sequence-diverse HTH domain families remains difficult. The Hin recombinase induces the site-specific inversion of a chromosomal DNA segment containing a promoter, which controls the alternate expression of two genes by reversibly switching orientation. The Hin recombinase consists of a single polypeptide chain containing a C-terminal DNA-binding domain (HTH_Hin) and a catalytic domain.


Pssm-ID: 259851 [Multi-domain]  Cd Length: 42  Bit Score: 38.46  E-value: 8.92e-05
                         10        20
                 ....*....|....*....|....*
gi 147742279 157 YDNGTPIKTIAEQWQVSRTTIYRYL 181
Cdd:cd00569   18 LAAGESVAEIARELGVSRSTLYRYL 42
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
3-74 2.33e-04

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 39.98  E-value: 2.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147742279   3 IGYARVSTGLQ--NLNLQEDRLNTHGCEK-----IFNDHMSGSKSKRPGLDKAIEFARSgDTIVVWRLDRLGRNMEDLI 74
Cdd:COG2452   51 VIYARVSSADQkdDLERQVERLEEYATAKgyqdeVIKDVGSGLNYKRKGLLKLLERIEV-ERVVVEHKDRLARFGFELL 128
transpos_IS607 NF033518
IS607 family transposase;
3-68 4.04e-03

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 36.46  E-value: 4.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147742279   3 IGYARVSTGLQ--NLNLQEDRLNT----HG--CEKIFNDHMSGSKSKRPGLDKAIEFARSGD--TIVVWRLDRLGR 68
Cdd:NF033518  57 VIYARVSSADQkdDLERQVARLTQyataKGwqVDEVVTDIGSGLNEKRKGLLKLLDDILNGEvsRVVVEHKDRLTR 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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