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Conserved domains on  [gi|157400313|gb|ABV53785|]
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NADH dehydrogenase (ubiquinone) MWFE subunit, isoform B [Drosophila melanogaster]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1( domain architecture ID 11239517)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I); believed not to be involved in catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MWFE pfam15879
NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone ...
 2-55 1.62e-17

NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.


:

Pssm-ID: 464920  Cd Length: 55  Bit Score: 70.26  E-value: 1.62e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157400313    2 WFEILPGAVIITTLLSVPIYAMYGLDKLMIGNAFRRNMDERFSRVMYQRDFRLT 55
Cdd:pfam15879   1 WFEALPPFGIITVMFGVPGYGLAAIHKLQNGGKPRRYNLDQWDRQMMERDRRLT 54
PRK11778 super family cl36055
putative inner membrane peptidase; Provisional
 93-121 2.27e-04

putative inner membrane peptidase; Provisional


The actual alignment was detected with superfamily member PRK11778:

Pssm-ID: 236978 [Multi-domain]  Cd Length: 330  Bit Score: 39.04  E-value: 2.27e-04
                         10        20
                 ....*....|....*....|....*....
gi 157400313  93 EKERKLREKQLKKEEKLREKQLKEEEKQK 121
Cdd:PRK11778  63 KKELKAWHKAQKKKEKQEAKAAKAKSKPR 91
 
Name Accession Description Interval E-value
MWFE pfam15879
NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone ...
 2-55 1.62e-17

NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.


Pssm-ID: 464920  Cd Length: 55  Bit Score: 70.26  E-value: 1.62e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157400313    2 WFEILPGAVIITTLLSVPIYAMYGLDKLMIGNAFRRNMDERFSRVMYQRDFRLT 55
Cdd:pfam15879   1 WFEALPPFGIITVMFGVPGYGLAAIHKLQNGGKPRRYNLDQWDRQMMERDRRLT 54
PRK11778 PRK11778
putative inner membrane peptidase; Provisional
 93-121 2.27e-04

putative inner membrane peptidase; Provisional


Pssm-ID: 236978 [Multi-domain]  Cd Length: 330  Bit Score: 39.04  E-value: 2.27e-04
                         10        20
                 ....*....|....*....|....*....
gi 157400313  93 EKERKLREKQLKKEEKLREKQLKEEEKQK 121
Cdd:PRK11778  63 KKELKAWHKAQKKKEKQEAKAAKAKSKPR 91
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 65-122 4.84e-03

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 35.39  E-value: 4.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157400313  65 EQIPDEEVKKEEKDPNE---DSDDPAiVKKREKERK---LREKQLKKEEKLREKQLKEEEKQKK 122
Cdd:PTZ00399 526 EWLPNLGIRIEDKPDGPsvwKLDDKE-ELQREKEEKealKEQKRLRKLKKQEEKKKKELEKLEK 588
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 90-115 8.84e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 34.47  E-value: 8.84e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 157400313   90 KKREKERKLR----EKQLKKEEKLREKQLK 115
Cdd:pfam07946 293 KKKEREEKLAklspEEQRKYEEKERKKEQR 322
 
Name Accession Description Interval E-value
MWFE pfam15879
NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone ...
 2-55 1.62e-17

NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.


Pssm-ID: 464920  Cd Length: 55  Bit Score: 70.26  E-value: 1.62e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157400313    2 WFEILPGAVIITTLLSVPIYAMYGLDKLMIGNAFRRNMDERFSRVMYQRDFRLT 55
Cdd:pfam15879   1 WFEALPPFGIITVMFGVPGYGLAAIHKLQNGGKPRRYNLDQWDRQMMERDRRLT 54
PRK11778 PRK11778
putative inner membrane peptidase; Provisional
 93-121 2.27e-04

putative inner membrane peptidase; Provisional


Pssm-ID: 236978 [Multi-domain]  Cd Length: 330  Bit Score: 39.04  E-value: 2.27e-04
                         10        20
                 ....*....|....*....|....*....
gi 157400313  93 EKERKLREKQLKKEEKLREKQLKEEEKQK 121
Cdd:PRK11778  63 KKELKAWHKAQKKKEKQEAKAAKAKSKPR 91
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 65-122 4.84e-03

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 35.39  E-value: 4.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157400313  65 EQIPDEEVKKEEKDPNE---DSDDPAiVKKREKERK---LREKQLKKEEKLREKQLKEEEKQKK 122
Cdd:PTZ00399 526 EWLPNLGIRIEDKPDGPsvwKLDDKE-ELQREKEEKealKEQKRLRKLKKQEEKKKKELEKLEK 588
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 90-115 8.84e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 34.47  E-value: 8.84e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 157400313   90 KKREKERKLR----EKQLKKEEKLREKQLK 115
Cdd:pfam07946 293 KKKEREEKLAklspEEQRKYEEKERKKEQR 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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