NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|158322290|gb|ABW33705|]
View 

interleukin 1 receptor-like 1 isoform 1, partial [Homo sapiens]

Protein Classification

toll/interleukin-1 receptor domain-containing protein( domain architecture ID 581355)

toll/interleukin-1 receptor (TIR) domain-containing protein adopts a flavodoxin fold and may play a role in signal transduction as a phosphorylation-independent conformational switch protein

CATH:  3.40.50.10140
Gene Ontology:  GO:0007165|GO:0005515
PubMed:  34868065|29395922
SCOP:  4003648

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIR super family cl23801
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 9-69 6.43e-11

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


The actual alignment was detected with superfamily member pfam01582:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 54.29  E-value: 6.43e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158322290    9 YVVYPrnyksSTDGASRVEHFVHQILPDVleNKCGYTLCIYGRDMLPGEDVVTAVETNIRK 69
Cdd:pfam01582   1 YDVFL-----SFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEK 54
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 9-69 6.43e-11

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 54.29  E-value: 6.43e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158322290    9 YVVYPrnyksSTDGASRVEHFVHQILPDVleNKCGYTLCIYGRDMLPGEDVVTAVETNIRK 69
Cdd:pfam01582   1 YDVFL-----SFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEK 54
TIR smart00255
Toll - interleukin 1 - resistance;
6-69 5.44e-09

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 48.47  E-value: 5.44e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158322290     6 YDAYVVYPRNyksstdgasrvEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRK 69
Cdd:smart00255   2 YDVFISYSGK-----------EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEK 54
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 9-69 6.43e-11

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 54.29  E-value: 6.43e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 158322290    9 YVVYPrnyksSTDGASRVEHFVHQILPDVleNKCGYTLCIYGRDMLPGEDVVTAVETNIRK 69
Cdd:pfam01582   1 YDVFL-----SFRGSDTREWFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEK 54
TIR smart00255
Toll - interleukin 1 - resistance;
6-69 5.44e-09

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 48.47  E-value: 5.44e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 158322290     6 YDAYVVYPRNyksstdgasrvEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRK 69
Cdd:smart00255   2 YDVFISYSGK-----------EDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH