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Conserved domains on  [gi|189169572|gb|ACD79854|]
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adenylate kinase, partial [Vibrio sp. FAL5133]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11478412)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0050145|GO:0016310|GO:0046872
PubMed:  2841070
SCOP:  3002021

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-136 2.38e-85

adenylate kinase; Reviewed


:

Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 248.14  E-value: 2.38e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGL----KEMGIAVDYVV 76
Cdd:PRK00279  32 GDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVI 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:PRK00279 112 EIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKR 171
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-136 2.38e-85

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 248.14  E-value: 2.38e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGL----KEMGIAVDYVV 76
Cdd:PRK00279  32 GDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVI 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:PRK00279 112 EIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKR 171
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-136 7.20e-81

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 236.56  E-value: 7.20e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM----GIAVDYVV 76
Cdd:COG0563   32 GDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALDELlaelGIKLDAVI 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:COG0563  112 ELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKR 171
ADK pfam00406
Adenylate kinase;
1-136 4.64e-75

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 221.03  E-value: 4.64e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM---GIAVDYVVE 77
Cdd:pfam00406  28 GDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELlerGIKLDYVIE 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 189169572   78 FDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:pfam00406 108 FDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKR 166
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-136 5.97e-63

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 191.29  E-value: 5.97e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQ-DDCEKGFLLDGFPRTIPQADGLKEMG-IAVDYVVEF 78
Cdd:TIGR01351  31 GDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENGFILDGFPRTLSQAEALDALLeEPIDAVIEL 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 189169572   79 DVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:TIGR01351 111 DVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKR 168
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-136 2.04e-58

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 2.04e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM---GIAVDYVVE 77
Cdd:cd01428   31 GDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELldeGIKPDKVIE 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 189169572  78 FDVADDVIVERMAGRRAHLPSGRTYHnvynppkeEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:cd01428  111 LDVPDEVLIERILGRRICPVSGRVYH--------LGKDDVTGEPLSQRSDDNEETIKKR 161
 
Name Accession Description Interval E-value
adk PRK00279
adenylate kinase; Reviewed
 1-136 2.38e-85

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 248.14  E-value: 2.38e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGL----KEMGIAVDYVV 76
Cdd:PRK00279  32 GDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALdemlKELGIKLDAVI 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:PRK00279 112 EIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQRADDNEETVRKR 171
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1-136 7.20e-81

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 236.56  E-value: 7.20e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM----GIAVDYVV 76
Cdd:COG0563   32 GDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALDELlaelGIKLDAVI 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:COG0563  112 ELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQRADDNEETVRKR 171
ADK pfam00406
Adenylate kinase;
1-136 4.64e-75

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 221.03  E-value: 4.64e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM---GIAVDYVVE 77
Cdd:pfam00406  28 GDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELlerGIKLDYVIE 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 189169572   78 FDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:pfam00406 108 FDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNEETVKKR 166
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1-136 5.97e-63

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 191.29  E-value: 5.97e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQ-DDCEKGFLLDGFPRTIPQADGLKEMG-IAVDYVVEF 78
Cdd:TIGR01351  31 GDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQnDDNENGFILDGFPRTLSQAEALDALLeEPIDAVIEL 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 189169572   79 DVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:TIGR01351 111 DVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDDTEEVVKKR 168
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1-136 2.04e-58

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 179.35  E-value: 2.04e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM---GIAVDYVVE 77
Cdd:cd01428   31 GDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELldeGIKPDKVIE 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 189169572  78 FDVADDVIVERMAGRRAHLPSGRTYHnvynppkeEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:cd01428  111 LDVPDEVLIERILGRRICPVSGRVYH--------LGKDDVTGEPLSQRSDDNEETIKKR 161
PLN02674 PLN02674
adenylate kinase
 1-136 6.40e-46

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 149.27  E-value: 6.40e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM----GIAVDYVV 76
Cdd:PLN02674  63 GDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAQKLDEMlakqGAKIDKVL 142

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:PLN02674 143 NFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRKDDTAAVLKSR 202
PLN02842 PLN02842
nucleotide kinase
 1-136 5.03e-34

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 123.43  E-value: 5.03e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDD-CEKGFLLDGFPRTIPQADGLKEMGIAVDYVVEFD 79
Cdd:PLN02842  29 GDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDaKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLD 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189169572  80 VADDVIVERMAGRRAHLPSGRTYHNVYNPPkeegKDDITGEELVVRDDDKEETVRAR 136
Cdd:PLN02842 109 VPDEILIDRCVGRRLDPVTGKIYHIKNFPP----ESEEIKARLITRPDDTEEKVKAR 161
adk PRK02496
adenylate kinase; Provisional
 1-92 2.34e-33

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 115.23  E-value: 2.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADG----LKEMGIAVDYVV 76
Cdd:PRK02496  33 GDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFldelLQEIGQSGERVV 112

                         90
                 ....*....|....*.
gi 189169572  77 EFDVADDVIVERMAGR 92
Cdd:PRK02496 113 NLDVPDDVVVERLLAR 128
PRK14528 PRK14528
adenylate kinase; Provisional
 1-92 8.88e-29

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 103.55  E-value: 8.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADG----LKEMGIAVDYVV 76
Cdd:PRK14528  33 GDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADAldalLKNEGKSIDKAI 112

                         90
                 ....*....|....*.
gi 189169572  77 EFDVADDVIVERMAGR 92
Cdd:PRK14528 113 NLEVPDGELLKRLLGR 128
PRK14532 PRK14532
adenylate kinase; Provisional
 1-125 2.97e-28

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 102.21  E-value: 2.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM----GIAVDYVV 76
Cdd:PRK14532  32 GDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAAGGAIFDGFPRTVAQAEALDKMlasrGQKIDVVI 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 189169572  77 EFDVADDVIVERMAGRRAhlpsgrtyhnvynppkEEGKDDITGEELVVR 125
Cdd:PRK14532 112 RLKVDDEALIERIVKRFE----------------EQGRPDDNPEVFVTR 144
PRK13808 PRK13808
adenylate kinase; Provisional
 1-94 9.86e-28

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 104.20  E-value: 9.86e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADG----LKEMGIAVDYVV 76
Cdd:PRK13808  32 GDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANGFILDGFPRTVPQAEAldalLKDKQLKLDAVV 111

                         90
                 ....*....|....*...
gi 189169572  77 EFDVADDVIVERMAGRRA 94
Cdd:PRK13808 112 ELRVNEGALLARVETRVA 129
PRK14530 PRK14530
adenylate kinase; Provisional
 1-136 4.32e-26

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 97.55  E-value: 4.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRA-----AIKAGTELGKqAKSVIDAGQLVSDEIILGLIKERIAQDDcekGFLLDGFPRTIPQADGLKEMgIAVDYV 75
Cdd:PRK14530  35 GDALRAnkqmdISDMDTEYDT-PGEYMDAGELVPDAVVNEIVEEALSDAD---GFVLDGYPRNLEQAEYLESI-TDLDVV 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189169572  76 VEFDVADDVIVERMAGRRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:PRK14530 110 LYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGELIQRDDDTEETVRER 170
PLN02459 PLN02459
probable adenylate kinase
 1-136 1.04e-25

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 97.61  E-value: 1.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERI--AQDDCEKGFLLDGFPRTIPQADGLKEMgIAVDYVVEF 78
Cdd:PLN02459  61 GDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLeaGEEEGESGFILDGFPRTVRQAEILEGV-TDIDLVVNL 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 189169572  79 DVADDVIVERMAGRRAHLPSGRTYhNV------------------YNPPKEegkddiTGEELVVRDDDKEETVRAR 136
Cdd:PLN02459 140 KLREEVLVEKCLGRRICSECGKNF-NVadidlkgedgrpgivmppLLPPPE------CASKLITRADDTEEVVKAR 208
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-136 9.26e-24

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 91.78  E-value: 9.26e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQ--DDCEKGFLLDGFPRTIPQADGLKEMgIAVDYVVEF 78
Cdd:PTZ00088  38 GNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKvtDDCFKGFILDGFPRNLKQCKELGKI-TNIDLFVNI 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 189169572  79 DVADDVIVERMAGRRAHLPSGRTYhNVYN--------PPKEEGKDDIT---GEELVVRDDDKEETVRAR 136
Cdd:PTZ00088 117 YLPRNILIKKLLGRRICNTCNRNF-NIAHirsdpydmPPILPPADCEGckgNPKLQKRSDDTEEIVAHR 184
PRK14529 PRK14529
adenylate kinase; Provisional
 1-132 1.66e-23

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 90.93  E-value: 1.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDcEKGFLLDGFPRTIPQA----DGLKEMGIAVDYVV 76
Cdd:PRK14529  32 GAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG-KNGWLLDGFPRNKVQAeklwEALQKEGMKLDYVI 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 189169572  77 EFDVADDVIVERMAGRRAHLPSGRTYHNVY-NPPKEEGKD-DITGEELVVRDDDKEET 132
Cdd:PRK14529 111 EILLPREVAKNRIMGRRLCKNDNNHPNNIFiDAIKPDGDVcRVCGGELSTRADDQDEE 168
PRK14527 PRK14527
adenylate kinase; Provisional
 1-136 4.88e-23

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 88.69  E-value: 4.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKgFLLDGFPRTIPQADG----LKEMGIAVDYVV 76
Cdd:PRK14527  38 GDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVR-VIFDGFPRTLAQAEAldrlLEELGARLLAVV 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572  77 EFDVADDVIVERMAGRRAhlpsgrtyhnvynppkEEGkdditgeelvvRDDDKEETVRAR 136
Cdd:PRK14527 117 LLEVPDEELIRRIVERAR----------------QEG-----------RSDDNEETVRRR 149
PRK14531 PRK14531
adenylate kinase; Provisional
 1-92 2.16e-22

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 87.17  E-value: 2.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIaQDDCEKGFLLDGFPRTIPQADGLK----EMGIAVDYVV 76
Cdd:PRK14531  34 GDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL-KALNSGGWLLDGFPRTVAQAEALEplleELKQPIEAVV 112

                         90
                 ....*....|....*.
gi 189169572  77 EFDVADDVIVERMAGR 92
Cdd:PRK14531 113 LLELDDAVLIERLLAR 128
PRK14526 PRK14526
adenylate kinase; Provisional
 1-136 3.29e-22

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 87.21  E-value: 3.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEMGIAVDyVVEFDV 80
Cdd:PRK14526  32 GDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKALDKFLPNIK-IINFLI 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189169572  81 ADDVIVERMAGRRAHLPSGRTYhNVYN-PPKEEGKDDITGEELVVRDDDKEETVRAR 136
Cdd:PRK14526 111 DEELLIKRLSGRRICKSCNNIF-NIYTlPTKEKGICDVCKGDLYQRKDDKEESLKTR 166
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1-136 7.34e-17

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 72.93  E-value: 7.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERI-AQDDCEKGFLLDGFPRTIPQADGLKEMGIAVDYVVEFD 79
Cdd:TIGR01360  35 GDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMvAALGTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFD 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 189169572   80 VADDVIVERMAGRRAhlPSGrtyhnvynppkeegkdditgeelvvRDDDKEETVRAR 136
Cdd:TIGR01360 115 CSEDTMVKRLLKRAE--TSG-------------------------RVDDNEKTIKKR 144
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 92-127 1.38e-15

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 65.56  E-value: 1.38e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 189169572   92 RRAHLPSGRTYHNVYNPPKEEGKDDITGEELVVRDD 127
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
AAA_17 pfam13207
AAA domain;
1-105 2.51e-15

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 67.65  E-value: 2.51e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKAGTelGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADGLKEM------GIAVDY 74
Cdd:pfam13207  27 GDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDGHPRIKTPAGYLPGLpvevlrELKPDA 104

                          90       100       110
                  ....*....|....*....|....*....|.
gi 189169572   75 VVEFDVADDVIVERMAGRRAhlpSGRTYHNV 105
Cdd:pfam13207 105 IILLEADPEEILERRLKDRT---RGRDDDSE 132
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1-105 9.68e-15

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 67.01  E-value: 9.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572    1 GDMLRAAIKA-GTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKGFLLDGFPRTIPQADG---LKEMGIAVDYVV 76
Cdd:TIGR01359  31 GDLLRAEIKReGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKKFLIDGFPRNEENLEAwekLMDNKVNFKFVL 110

                          90       100
                  ....*....|....*....|....*....
gi 189169572   77 EFDVADDVIVERMAGRRAhlPSGRTYHNV 105
Cdd:TIGR01359 111 FFDCPEETMIKRLLKRGQ--TSGRVDDNI 137
PLN02200 PLN02200
adenylate kinase family protein
 1-92 4.22e-08

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 49.89  E-value: 4.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189169572   1 GDMLRAAIKAGTELGKQAKSVIDAGQLVSDEIILGLIKERIAQDDCEKgFLLDGFPRTIPQADGLKEM-GIAVDYVVEFD 79
Cdd:PLN02200  75 GDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK-FLIDGFPRTEENRIAFERIiGAEPNVVLFFD 153

                         90
                 ....*....|...
gi 189169572  80 VADDVIVERMAGR 92
Cdd:PLN02200 154 CPEEEMVKRVLNR 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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