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Conserved domains on  [gi|237502149|gb|ACQ94742|]
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putative transcriptional regulator, ArsR family [Tolumonas auensis DSM 9187]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-101 1.62e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 1.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   4 QEVDTIIKALANPARRDILSWLKNPEVefpeqtssyadgvCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYY 83
Cdd:COG0640    8 EELAELFKALADPTRLRILRLLAEGEL-------------CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 237502149  84 QRNEAVIDEFTAHIKQAL 101
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-101 1.62e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 1.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   4 QEVDTIIKALANPARRDILSWLKNPEVefpeqtssyadgvCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYY 83
Cdd:COG0640    8 EELAELFKALADPTRLRILRLLAEGEL-------------CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 237502149  84 QRNEAVIDEFTAHIKQAL 101
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-91 8.79e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 70.95  E-value: 8.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   6 VDTIIKALANPARRDILSWLKNPEVefpeqtssyadgvCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQ- 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGEL-------------CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRl 67


                 ....*..
gi 237502149  85 RNEAVID 91
Cdd:NF033788  68 ADEHVAE 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-88 1.70e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 62.70  E-value: 1.70e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 237502149  10 IKALANPARRDILSWLKNpevefpeqtssyaDGVCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQRNEA 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-------------GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-93 8.25e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 57.99  E-value: 8.25e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 237502149    44 CVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQRNEAVIDEF 93
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-79 5.59e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 52.93  E-value: 5.59e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 237502149    7 DTIIKALANPARRDILSWLKNPEvefpeqtssyadGVCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQ 79
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 43-84 2.84e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 39.80  E-value: 2.84e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 237502149  43 VCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQ 84
Cdd:PRK10141  31 LCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYR 72
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
4-101 1.62e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 1.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   4 QEVDTIIKALANPARRDILSWLKNPEVefpeqtssyadgvCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYY 83
Cdd:COG0640    8 EELAELFKALADPTRLRILRLLAEGEL-------------CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYY 74

                         90
                 ....*....|....*...
gi 237502149  84 QRNEAVIDEFTAHIKQAL 101
Cdd:COG0640   75 RLADEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-91 8.79e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 70.95  E-value: 8.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   6 VDTIIKALANPARRDILSWLKNPEVefpeqtssyadgvCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQ- 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGEL-------------CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRl 67


                 ....*..
gi 237502149  85 RNEAVID 91
Cdd:NF033788  68 ADEHVAE 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-88 1.70e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 62.70  E-value: 1.70e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 237502149  10 IKALANPARRDILSWLKNpevefpeqtssyaDGVCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQRNEA 88
Cdd:cd00090    1 LKALSDPTRLRILRLLLE-------------GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA 66
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-93 8.25e-13

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 57.99  E-value: 8.25e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 237502149    44 CVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQRNEAVIDEF 93
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-79 5.59e-11

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 52.93  E-value: 5.59e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 237502149    7 DTIIKALANPARRDILSWLKNPEvefpeqtssyadGVCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQ 79
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
9-91 1.90e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 49.96  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   9 IIKALANPARRDILSWLKNpevefpeqtssyaDGVCVGQIYLRAGLSQSTVSAHLATLQRAGLL-TSKRLGQ-----WVY 82
Cdd:COG4189   12 VLKALASETRLRILRLLAE-------------EPLNVNELAEALGLPKSTVSYHIRKLEEAGLIrTEYKPGKrgrqkICY 78


                 ....*....
gi 237502149  83 YQRNEAVID 91
Cdd:COG4189   79 LRVDKILIV 87
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-101 8.29e-09

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 48.88  E-value: 8.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 237502149   1 MNNQEVDTIIKALANPARRDILSWLKnpevefpeQTSSYadgvcVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQ- 79
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLS--------EEPAY-----VSELARELGVSRQAVYKHLRKLEEAGLVESYREGRe 68

                         90       100       110
                 ....*....|....*....|....*....|.
gi 237502149  80 ----WVYYQRNEAVI-----DEFTAHIKQAL 101
Cdd:COG1777   69 dgraRKYYRLSAFRLevtltPDLFARLAREL 99
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
8-83 5.45e-08

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 47.57  E-value: 5.45e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 237502149   8 TIIKALANPARRDILS-WLKNPEVEFPEqtssyadgvcvgqIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYY 83
Cdd:COG3398   89 KILAYLRRETPRRILLyLLENPGATNKE-------------LAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRY 152
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-72 3.71e-06

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 40.50  E-value: 3.71e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 237502149   15 NPARRDILSWL-KNPEvefpeqtssyadgvCVGQIYLRAGLSQSTVSAHLATLQRAGLL 72
Cdd:pfam01022   1 DPTRLKILKLLaEGEL--------------CVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 43-84 2.84e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 39.80  E-value: 2.84e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 237502149  43 VCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKRLGQWVYYQ 84
Cdd:PRK10141  31 LCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYR 72
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 15-76 2.97e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 2.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 237502149   15 NPARRDILSWLKNpevefpeqtssyADGVCVGQIYLRAGLSQSTVSAHLATLQRAGLLTSKR 76
Cdd:pfam12802   4 TPAQFRVLLALAR------------NPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
37-73 7.67e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 34.02  E-value: 7.67e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 237502149  37 SSYADGVCVGQIYLRAGLSQSTVSAHLATLQRAGLLT 73
Cdd:COG1414   19 AEAGGGLSLSELARRLGLPKSTVHRLLATLEEEGYVE 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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